Triptorelin (D-Trp-6-LHRH) in combination with carboplatin-containing polychemotherapy for advanced ovarian cancer: a pilot study.

abstract：:P-glycoprotein has been identified in mast cells stabilized in culture as well as in rat peritoneal mast cells, and is primarily concentrated on the granular membrane. This study aimed to define the role of this protein in the transport and accumulation of doxorubicin in mast cell granules and in its histamine releasi...

journal_title：Anticancer research

authors： Candussio L,Decorti G,Crivellato E,Rosati AM,Traversa U,Klugmann FB

更新日期：1999-03-01 00:00:00

abstract：AIM:To assess the outcome of patients with vulvar carcinoma unfit for surgery treated with radiotherapy for primary disease and for those with recurrent disease after primary surgery. PATIENTS AND METHODS:The study was conducted on 16 patients with primary disease and 31 with recurrent disease. RESULTS:An objective r...

journal_title：Anticancer research

authors： Laliscia C,Gadducci A,Montrone S,Tana R,Morganti R,Fabrini MG

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND/AIM:The significance of microvascular invasion (MVI) of hepatocellular carcinoma (HCC) after radiofrequency ablation (RFA) is unknown. PATIENTS AND METHODS:We studied 149 patients with solitary small-sized HCC (≤3 cm) who underwent hepatectomy, and developed a predictive model of MVI using independent facto...

journal_title：Anticancer research

authors： Imai K,Yamashita YI,Yusa T,Nakao Y,Itoyama R,Nakagawa S,Okabe H,Chikamoto A,Ishiko T,Baba H

更新日期：2018-02-01 00:00:00

abstract：AIM:To examine patterns of clinical practice in locally advanced esophageal cancer among US radiation oncologists after publication of the CROSS trial. MATERIALS AND METHODS:US radiation oncologists were surveyed on 13 questions pertaining to the management of esophageal cancer. Respondents' demographics and their cli...

journal_title：Anticancer research

authors： Elliott DA,Rana SR,Nabavizadeh N,Chen Y,Kusano A,Holland JM,Mitin T

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:The sonodynamically-induced in vitro and in vivo antitumor effects of mono-l-aspartyl chlorin e6 (NPe6) was investigated. MATERIALS AND METHODS:Both in vitro and in vivo antitumor effects were tested in combination with ultrasound at 2 MHz. RESULTS:The rate of ultrasonically-induced damage on isolated sarc...

journal_title：Anticancer research

authors： Yumita N,Iwase Y,Nishi K,Ikeda T,Komatsu H,Fukai T,Onodera K,Nishi H,Takeda K,Umemura S,Okudaira K,Momose Y

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:Breast cancer is associated with inflammatory processes based on an up-regulation of cyclooxygenase-2 (COX-2) expression. The antiproliferative effects of calcitriol (1,25(OH)(2)D(3)) mediated via the vitamin D receptor (VDR) render vitamin D a promising target in breast cancer therapy. First data suggest a ...

journal_title：Anticancer research

authors： Thill M,Fischer D,Hoellen F,Kelling K,Dittmer C,Landt S,Salehin D,Diedrich K,Friedrich M,Becker S

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND/AIM:Androgens are essential for the growth of most prostate cancers (PCa). As a result, androgen ablation is the mainstay of the treatment of PCa. Proteins of the polycomb and trithorax family are master epigenetic regulators of cell type specific gene expression including androgen receptor. MATERIALS AND M...

journal_title：Anticancer research

authors： Wang S,Tailor K,Kwabi-Addo B

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND/AIM:Forodesine inhibits purine nucleoside phosphorylase, resulting in an accumulation of intracellular dGTP and consequently cell death. 9-β-D-Arabinofuranosylguanine (ara-G) is an active compound of nelarabine that is intracellularly phosphorylated to a triphosphate form, which inhibits DNA synthesis. Both ...

journal_title：Anticancer research

authors： Yamauchi T,Uzui K,Nishi R,Tasaki T,Ueda T

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:The doxorubicin-docetaxel combination is active in breast cancer; the aim of the present study was to evaluate the complete response rate and safety profile of the doxorubicin and docetaxel regimen as first-line chemotherapy in metastatic breast cancer patients. PATIENTS AND METHODS:Forty-three patients ent...

journal_title：Anticancer research

authors： Mattioli R,Lippe P,Massacesi C,Cappelletti C,Nacciarriti D,Bisonni R,Graziano F,Menichetti ET,Imperatori L,Testa E,Laici G,Balletra A,Silva RR

更新日期：2004-09-01 00:00:00

abstract：:Colchicine is an alkaloid widely used for the treatment of inflammatory diseases, such as gout. It suppresses cell division by inhibiting mitosis. We investigated the anticancer effects of colchicine on human hypopharyngeal cancer cells and the mechanisms underlying its anticancer effects. XTT cell proliferation assay...

journal_title：Anticancer research

authors： Cho JH,Joo YH,Shin EY,Park EJ,Kim MS

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:A nodular lymphocyte predominant Hodgkin's lymphoma (NLPHL) is a lymphoproliferative neoplasm with a fair prognosis, but the possibility of a malignant transformation into a diffuse large B-cell lymphoma (DLBCL) is high. DLBCL progresses aggressively. Introduction of rituximab into therapy had led to improve...

journal_title：Anticancer research

authors： Gutsch J,Werthmann PG,Rosenwald A,Kienle GS

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND/AIM:The clinical significance of surgery for secondary small intestinal non-Hodgkin's lymphomas (NHL) remains unknown. This study aimed to investigate the efficacy of resection for both primary and secondary small intestinal NHL. PATIENTS AND METHODS:Twenty patients with small intestinal lymphoma who underw...

journal_title：Anticancer research

authors： Iida T,Nozawa H,Sonoda H,Toyama K,Kawai K,Hata K,Tanaka T,Nishikawa T,Sasaki K,Shuno Y,Kaneko M,Murono K,Emoto S,Ishii H,Kurokawa M,Ishihara S

更新日期：2020-04-01 00:00:00

abstract：:Molecular chaperones, many of which are heat-shock proteins (HSPs), are an important class of molecules with various functions. Pathological conditions in which chaperones become etiological and/or pathogenic factors are called chaperonopathies, and are classified into by defect, by excess, and by 'mistake'. In the la...

journal_title：Anticancer research

authors： Rappa F,Farina F,Zummo G,David S,Campanella C,Carini F,Tomasello G,Damiani P,Cappello F,DE Macario EC,Macario AJ

更新日期：2012-12-01 00:00:00

abstract：UNLABELLED:The aim of this study was to evaluate the efficacy and safety of erlotinib, an epidermal growth factor receptor tyrosine kinase inhibitor, in Japanese patients with relapsed or recurrent advanced non-small cell lung cancer (NSCLC). PATIENTS AND METHODS:This was a multicentre, open-label phase II study of er...

journal_title：Anticancer research

authors： Takahashi T,Yamamoto N,Nukiwa T,Mori K,Tsuboi M,Horai T,Masuda N,Eguchi K,Mitsudomi T,Yokota S,Segawa Y,Ichinose Y,Fukuoka M,Saijo N

更新日期：2010-02-01 00:00:00

abstract：:The response of the blood-forming and supportive stromal compartments of the marrow to a localized, fractionated course of radiotherapy [FxRT; 2.0 Gy (q24 h x 5)-->74 Gy] was examined in the C57Bl/6 mouse using the hematopoietic progenitor and the cobblestone-forming cell (CAFC) assays as end-points for the blood-form...

journal_title：Anticancer research

authors： Kovacs CJ,Evans MJ,Daly BM

更新日期：2003-05-01 00:00:00

abstract：:The androgen-signaling pathway plays a critical role in prostate cancer development and progression. We have recently demonstrated that the Wilms' tumor suppressor gene product, WT1, binds to multiple sites in the androgen receptor (AR) promoter and transcriptionally represses the AR gene promoter in vitro. We asked w...

journal_title：Anticancer research

authors： Zaia A,Fraizer GC,Piantanelli L,Saunders GF

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND/AIM:A minority of grade I meningiomas (MG1s) recur after surgical resection and their progression is associated with high grade transformation (HGT). This study aimed to characterize the clinicoradiological features of recurrent MGs (RMG) with HGT. PATIENTS AND METHODS:We identified 17 patients diagnosed wi...

journal_title：Anticancer research

authors： Yeon EK,Sung JY,DO SI,Park BJ,Kim EJ,Na K

更新日期：2019-11-01 00:00:00

abstract：:Immunocytochemical assays were performed on frozen sections of inflammatory breast carcinomas (n = 22) using the following monoclonal antibodies (MoAb): anti-pHER2/neu, cathepsin, pS2, ER, PR and MoAb Ki67. The distribution of these proteins, known as prognostic indicators, was evaluated with an image analysis system ...

journal_title：Anticancer research

authors： Charpin C,Bonnier P,Khouzami A,Vacheret H,Andrac L,Lavaut MN,Allasia C,Piana L

更新日期：1992-05-01 00:00:00

abstract：:2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a widespread environmental contaminant that induces various types of immunotoxicity. One effect of exposure to this contaminant is alteration in cell adhesiveness. Leukocyte function-associated antigen-1 (LFA-1) plays an important role not only in T-cell recruitment into s...

journal_title：Anticancer research

authors： Park SJ,Yoon WK,Son HY,Cho SW,Jung JY,Jeong KS,Kim TH,Kim SH,Ryu SY

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND:Since superparamagnetic iron oxide nanoparticles (SPION) possess unique features, they provide a huge platform for medical applications, especially for cancer diagnosis and therapy (e.g. imaging, and drug targeting). However, heterogeneous effects on mammalian cells with regard to reproductive tissue are des...

journal_title：Anticancer research

authors： Pöttler M,Hofmann S,Dürr S,Unterweger H,Wiest I,Zaloga J,Alexiou C,Jeschke U,Janko C

更新日期：2016-06-01 00:00:00

abstract：:We report two cases with small cell lung cancer (SCLC) receiving multicyclic dose-intensified chemotherapy (DI-CT) supported by autologous blood progenitor cell transplantation (ABPCT). Both cases were initially treated with cisplatin (CDDP), etoposide (ETP) and concurrent thoracic irradiation, however they had recurr...

journal_title：Anticancer research

authors： Fujimoto N,Ueoka H,Kiura K,Tabata M,Bessho A,Takata I,Sunami K,Hiramatsu Y,Ikeda K,Tanimoto M,Harada M

更新日期：2003-09-01 00:00:00

abstract：BACKGROUND:We previously showed the usefulness of a fused protein of human pancreatic ribonuclease1 (hRNase1) with human epidermal growth factor (hEGF) for molecular targeting of EGF receptor (EGFR)-overexpressing cells. In this study, the mechanisms underlying the inhibition of cell growth by RNase-EGF fused proteins ...

journal_title：Anticancer research

authors： Hoshimoto S,Ueda M,Jinno H,Kitajima M,Futami J,Seno M

更新日期：2006-03-01 00:00:00

abstract：:This review describes the use of murine polyomavirus "virus-like" particles (MPyV-VLPs), free from viral genes, as vectors for gene and immune therapy and as vaccines. For large-scale MPyV-VLP manufacture, VP1 is produced in a baculovirus insect cell system, E. coli or in yeast. MPyV-VLPs bind eukaryotic DNA and intro...

journal_title：Anticancer research

authors： Tegerstedt K,Franzén AV,Andreasson K,Joneberg J,Heidari S,Ramqvist T,Dalianis T

更新日期：2005-07-01 00:00:00

abstract：AIM:To investigate the relationship between erythrocyte sedimentation rate (ESR) and postoperative survival of patients with colorectal cancer (CRC). MATERIALS AND METHODS:Relationships between clinical characteristics and overall survival (OS) of patients with CRC were investigated using multivariate analysis. Receiv...

journal_title：Anticancer research

authors： Shibuya N,Ishizuka M,Takagi K,Iwasaki Y,Hachiya H,Aoki T,Kubota K

更新日期：2018-12-01 00:00:00

abstract：:Evidence exists that estrogen metabolism has a role in the pathogenesis of recurrent respiratory papillomatosis (RRP). This disease has a papillomavirus etiology and is characterized by recurrent benign tumors with a significant propensity to become malignant. We have measured the systemic transformation of estrogen u...

journal_title：Anticancer research

authors： Auborn K,Abramson A,Bradlow HL,Sepkovic D,Mullooly V

更新日期：1998-11-01 00:00:00

abstract：BACKGROUND/AIM:Silencing mediator of retinoid and thyroid receptors (SMRT) is a nuclear corepressor in thyroid and estrogen hormones pathways. The aim was to evaluate SMRT expression in relation to thyroid hormone levels and prognostic markers in breast cancer (BC). PATIENTS AND METHODS:Serum and tumor tissues were ob...

journal_title：Anticancer research

authors： Nisman B,Allweis TM,Carmon E,Kadouri L,Maly B,Maimon O,Meierovich A,Peretz T

更新日期：2020-11-01 00:00:00

abstract：:During postnatal development, the formation of new blood vessels is possible only through angiogenesis. The initial growth of solid neoplasms, including childhood brain tumors, during the genetically determined stages of carcinogenesis, even at clinically undetectable sizes (a few mm3), depends upon the continuous for...

journal_title：Anticancer research

authors： Bodey B,Bodey B Jr,Siegel SE,Kaiser HE

更新日期：1998-05-01 00:00:00

abstract：:Moxa smoke induced internucleosomal DNA fragmentation in human promyelocytic leukemic HL-60 cells, but not in other cell lines. The cytotoxic activity of Moxa smoke was significantly reduced by a popular antioxidant, N-acetyl-L-cysteine (NAC). Moxa smoke showed oxidation potential (measured by NO monitor) and produced...

journal_title：Anticancer research

authors： Hitosugi N,Ohno R,Hatsukari I,Nakamura S,Mizukami S,Nagasaka H,Matsumoto I,Satoh K,Negoro T,Hashimoto K,Sakagami H

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Extracts from Viscum album L. are widely used as an adjuvant in complementary cancer therapy. While the mechanisms of mistletoe lectin (ML) cytotoxicity are well described, the viscotoxin (VT) effects are unclear at present. Thus, we treated human lymphocytes with VT and measured cell death-associated change...

journal_title：Anticancer research

authors： Büssing A,Schaller G,Pfüller U

更新日期：1998-11-01 00:00:00

abstract：BACKGROUND/AIM:Silica nanoparticles (nano-SiO2) are widely used in many industrial areas and there is much controversy surrounding cytotoxic effects of such nanoparticles. In order to determine the toxicity and possible molecular mechanisms involved, we conducted several tests with two breast cancer cell lines, MDA-MB-...

journal_title：Anticancer research

authors： Jeon D,Kim H,Nam K,Oh S,Son SH,Shin I

更新日期：2017-11-01 00:00:00