Prognostic Impact of Proximal Versus Distal Localization in Extremity Long Bone Osteosarcomas.

Abstract:

BACKGROUND/AIM:This study aimed to identify the prognostic factors and outcomes of osteosarcoma (OS) located in proximal versus distal extremity long bones. PATIENTS AND METHODS:A nationwide cohort comprising all Norwegian high-grade OSs in extremity long bones between 1982 and 2009 was investigated. RESULTS:The univariate analysis results identified no significant differences in survival between patients with OS in proximal long bones (101 cases) as a group in comparison to patients with OS in the distal part of these bones (120 cases). However, proximal femur and primary metastasis were both independent adverse prognostic factors for sarcoma-specific survival in multivariate analyses, while elevated LDH and secondary OS were inferior prognostic factors for event-free survival. Adequate surgery and chemotherapy had a positive impact on survival. CONCLUSION:OS of the proximal femur had an unfavorable outcome in comparison to OS in other anatomical locations in extremity long bones.

journal_name

Anticancer Res

journal_title

Anticancer research

authors

Berner K,Bruland ØS

doi

10.21873/anticanres.13365

subject

Has Abstract

pub_date

2019-05-01 00:00:00

pages

2459-2466

issue

5

eissn

0250-7005

issn

1791-7530

pii

39/5/2459

journal_volume

39

pub_type

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