Could Patients Older than 75 Years Benefit from a Systematic Breast Cancer Screening Program?

abstract：:TRAIL, Tumor necrosis factor-related apoptosis-inducing ligand), a member of the TNF family, is known to be cytotoxic for a high proportion of tumor cell lines. However, successful application of TRAIL in tumor therapy may depend on finding other agents that can potentiate its antitumor effects. The present study show...

journal_title：Anticancer research

authors： Młynarczuk I,Hoser G,Grzela T,Stokłosa T,Wójcik C,Malejczyk J,Jakóbisiak M

更新日期：2001-03-01 00:00:00

abstract：BACKGROUND:Prognosis of renal cell carcinoma (RCC) differs within the same stage and grade. Our aim was to investigate the incidence of COX-2 in primary RCC tumors at different stages according to the occurrence of metastasis, and the impact of this biomarker on the survival of RCC patients. PATIENTS AND METHODS:The c...

journal_title：Anticancer research

authors： Kankuri-Tammilehto MK,Söderström KO,Pelliniemi TT,Vahlberg T,Pyrhönen SO,Salminen EK

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND:Antibodies against human epidermal growth factor receptor 2 (HER2) affect metastatic breast cancer cells and cardiac myocytes. Guidelines recommend evaluation of cardiac ejection fraction (EF) every 3 months despite little supporting evidence for this need. We assessed the impact of EF screening on clinical ...

journal_title：Anticancer research

authors： Mescher C,Ding C,Defor T,Konety S,Blaes A

更新日期：2017-07-01 00:00:00

abstract：:Using serum-free conditions, human monocyte-derived dendritic cells (MoDCs) tend to mature insufficiently in a T(H)1-polarizing direction under approved and standardized clinical conditions. However, for the initiation of an efficient tumour antigen-specific cytotoxic T-cell response, the induction of a distinct T(H)1...

journal_title：Anticancer research

authors： Hildenbrand B,Lorenzen D,Sauer B,Hertkorn C,Freudenberg MA,Peters JH,Nesselhut T,Unger C,Azemar M

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND:Despite the key role of mutational analysis in targeted therapy, the difficulty in acquisition of adequate tumor tissues for molecular genotyping in advanced non-small cell lung cancer (NSCLC) has led to the need for a fast and efficient method for detecting genetic alterations for targeted therapy. PATIENT...

journal_title：Anticancer research

authors： Maeng CH,Lee HY,Kim YW,Choi MK,Hong JY,Jung HA,Lee KS,Kim H,Kwon OJ,Sun JM,Ahn JS,Park K,Um SW,Ahn MJ

更新日期：2013-11-01 00:00:00

abstract：:Transferrin was covalently conjugated to adriamycin (Trf-adr) by the formation of a schiff base. This conjugate was found to bind to cell membrane trf receptors in a variety of human tumor cell lines. The Trf-adr conjugate was found to be active against sensitive and resistant cell lines e.g. Lovo, HL-60, H-meso and H...

journal_title：Anticancer research

authors： Singh M,Atwal H,Micetich R

更新日期：1998-05-01 00:00:00

abstract：:Cancer cells are known to shed extracellular membrane vesicles both in vitro and in vivo. To analyse their possible involvement in the metastatic behaviour of tumours, we measured the Matrigel invasion capability and amounts of vesicles shed by four human tumour cell lines (8701-BC, MCF-7, MDA-MB-231 and HT-1080), and...

journal_title：Anticancer research

authors： Ginestra A,La Placa MD,Saladino F,Cassarà D,Nagase H,Vittorelli ML

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND:Certain viruses, notably human papillomavirus (HPV), cytomegalovirus (CMV), herpes simplex virus (HSV) and Epstein-Barr virus (EBV), are known to produce tumors in animals and cell transformation in vitro and they have been implicated in the pathogenesis of human cancers. All these viruses are also known to ...

journal_title：Anticancer research

authors： Chang F,Syrjänen S,Shen Q,Cintorino M,Santopietro R,Tosi P,Syrjänen K

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND/AIM:Neoplastic spindle cells (NSCs) are believed to play a role in cancer invasion and metastasis, as well as in poor prognosis. The clinicopathological characteristics and prognostic relevance of NSCs was investigated in gallbladder cancer. MATERIALS AND METHODS:Specimens were obtained from 62 patients wit...

journal_title：Anticancer research

authors： Midorikawa R,Hisaka T,Sakai H,Nomura Y,Goto Y,Sato T,Kawahara R,Ishikawa H,Fujita F,Yasunaga M,Tanigawa M,Naito Y,Akiba J,Yano H,Tanaka H,Akagi Y,Okuda K

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:The osteoclast-specific active TRAP 5b isoform is detectable in serum and claimed to be a specific marker of bone resorption. The present study was undertaken to evaluate the usefulness of TRAP 5b as a serum marker of bone resorption in breast cancer patients with bone metastases. MATERIALS AND METHODS:TRAP...

journal_title：Anticancer research

authors： Capeller B,Caffier H,Sütterlin MW,Dietl J

更新日期：2003-03-01 00:00:00

abstract：:Telomeres, the tandem-repeated hexamers at the termini of mammalian chromosomes, form protective complexes in association with specific proteins that together with telomerase, a specialised telomere-synthesizing enzyme, regulate telomere length. Telomere shortening is associated with cellular senescence and is implica...

journal_title：Anticancer research

authors： Bekaert S,De Meyer T,Van Oostveldt P

更新日期：2005-07-01 00:00:00

abstract：BACKGROUND:Lung resistance-related protein (LRP) was first detected in a non-P-glycoprotein-mediated multidrug-resistant lung cancer cell line and has been shown to be the major human vault protein. The aim of this study was to evaluate the expression of LRP in germ cell testicular tumors (GCT) and to determine the cor...

journal_title：Anticancer research

authors： Mándoky L,Géczi L,Doleschall Z,Bodrogi I,Csuka O,Kásler M,Bak M

更新日期：2004-03-01 00:00:00

abstract：BACKGROUND/AIM:Only 30-50% of patients with sentinel lymph node (SLN) metastases present with further axillary lymph node metastases. Therefore, up to 70% of patients with positive SLN are overtreated by axillary dissection (AD) and may suffer from complications such as sensory disturbances or lymphedema. According to ...

journal_title：Anticancer research

authors： Gruber I,Henzel M,Schönfisch B,Stäbler A,Taran FA,Hahn M,Röhm C,Helms G,Oberlechner E,Wiesinger B,Nikolaou K,LA Fougère C,Wallwiener D,Hartkopf A,Krawczyk N,Fehm T,Brucker S

更新日期：2018-07-01 00:00:00

abstract：:Despite its tendency to metastasize and grow multifocally, papillary thyroid carcinoma (PTC), the most common endocrine malignancy, usually displays an indolent clinical course. Although this behavior probably reflects the inherent low growth potential of PTC cells, it has been postulated that the striking inflammator...

journal_title：Anticancer research

authors： Lucas SD,Ek B,Rask L,Rastad J,Akerström G,Juhlin C

更新日期：1996-09-01 00:00:00

abstract：BACKGROUND:S-1, an oral 5-fluorouracil (5-FU)-based medicine that combines tegafur, gimeracil and oteracil potassium is commonly used as an adjuvant chemotherapeutic drug for the treatment of colorectal cancer. PATIENTS AND METHODS:We enrolled 53 patients who underwent curative resection for colorectal cancer and live...

journal_title：Anticancer research

authors： Yamauchi K,Kokuryo T,Yokoyama Y,Uehara K,Yamaguchi J,Nagino M

更新日期：2016-05-01 00:00:00

abstract：METHODS:Induction chemotherapy, consisting of 3 courses of cisplatin (30 mg/m2/i.v. 1st and 2nd day), epirubicin (30 mg/m2/i.v. 1st and 2nd day), etoposide (75 mg/m2/i.v. 1st and 2nd day) and bleomycin (15 mg/i.v. 1st and 2nd day), prior to radical hysterectomy and lymph nodes resection, was used in the primary treatme...

journal_title：Anticancer research

authors： Panetta A,Angelelli B,Martoni A

更新日期：1999-01-01 00:00:00

abstract：AIM:To investigate the prognostic significance of cancer antigen 15-3 (CA15-3) in primary breast cancer (BC). PATIENTS AND METHODS:This prospective study included 368 women: 62 patients with benign breast disease (BBD), 159 patients with invasive BC and 88 healthy blood donors (control). The median follow-up was 76 mo...

journal_title：Anticancer research

authors： Nisman B,Maimon O,Allweis T,Kadouri L,Maly B,Hamburger T,Peretz T

更新日期：2013-01-01 00:00:00

abstract：AIM:To evaluate the role of radiotherapy alone or combined with chemotherapy in the treatment of recurrent vulvar cancer, emphasising the prognostic factors and outcomes. MATERIALS AND METHODS:Twenty women with loco-regional recurrence of vulvar carcinoma were retrospectively reviewed. Eleven patients were managed wit...

journal_title：Anticancer research

authors： Raffetto N,Tombolini V,Santarelli M,Valeriani M,Galla DA,Enrici RM

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND:Early detection before scintigraphic appearance of osseous metastatic spread might improve the outcome of breast cancer patients. The amino-terminal propeptide (PINP) of type I collagen as an indicator of bone formation is a very promising candidate among all markers of bone metabolism. We investigated the u...

journal_title：Anticancer research

authors： Lüftner D,Jozereau D,Schildhauer S,Geppert R,Müller C,Fiolka G,Wernecke KD,Possinger K

更新日期：2005-05-01 00:00:00

abstract：:We have previously reported that polaprezinc in sodium alginate suspension (P-AG) inhibited the incidence of oral mucositis induced by radiochemotherapy in patients with head and neck cancer. The present study was designed to investigate whether P-AG prevents oral mucositis in all patients (36 patients) with hematolog...

journal_title：Anticancer research

authors： Hayashi H,Kobayashi R,Suzuki A,Ishihara M,Nakamura N,Kitagawa J,Kanemura N,Kasahara S,Kitaichi K,Hara T,Tsurumi H,Moriwaki H,Itoh Y

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:Tumour stage and the appropriate course of treatment in patients with breast cancer are primarily characterized by the state of metastasis in the axillary lymph nodes. In recent years, substantial research has focused on the prediction of lymph node status based on various pathological and molecular markers ...

journal_title：Anticancer research

authors： Mojarad S,Venturini B,Fulgenzi P,Papaleo R,Brisigotti M,Monti F,Canuti D,Ravaioli A,Woo L,Dlay S,Sherbet GV

更新日期：2013-09-01 00:00:00

abstract：:Mast cells are frequently found in close proximity to blood vessels and have been implicated in tumour angiogenesis. The aim of the present ultrastructural study was to characterize, in detail, the mutual association between mast cells and microvasculature in 9 cases of advanced gastric carcinoma. Perivascular mast ce...

journal_title：Anticancer research

authors： Caruso RA,Ieni A,Fabiano V,Basile G,Inferrera C

更新日期：2004-07-01 00:00:00

abstract：BACKGROUND/AIM:For cases of musculoskeletal sarcoma of the knee presenting to our institute, we prioritize joint preservation whenever possible. To investigate patient satisfaction and desire for joint preservation, a questionnaire survey was performed. PATIENTS AND METHODS:Surveys were mailed to 62 patients with musc...

journal_title：Anticancer research

authors： Abe K,Yamamoto N,Hayashi K,Takeuchi A,Kato S,Miwa S,Igarashi K,Inatani H,Aoki YU,Higuchi T,Taniguchi Y,Tsuchiya H

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:Motility of cancer cells is a principal cellular parameter, essentially required in the invasion and formation of distant metastasis in human cancer. Measures to stimulate or inhibit motility of cancer cells may play an important part in the understanding of metastasis biology. The aim of this study was to d...

journal_title：Anticancer research

authors： Hoppe A,Jiang WG,Wertheim D,Williams R,Harding K

更新日期：1998-07-01 00:00:00

abstract：:The objective of the present study was to investigate the effect of dietary phytosterols on the growth and metastasis of the human breast cancer MDA-MB-231 cell line xenografted in SCID mice. Two groups of animals were fed AIN-93G diet supplemented with 0.2% cholic acid and 2% sterol (cholesterol or phytosterol mixtur...

journal_title：Anticancer research

authors： Awad AB,Downie A,Fink CS,Kim U

更新日期：2000-03-01 00:00:00

abstract：BACKGROUND:Bisphosphonates (BPs) are considered the standard of care in metastatic breast cancer (MBC) patients with bone metastases. Because the survival for these patients may be prolonged compared with those patients with visceral metastases, they may be prescribed BPs for several years. The effects of this long-ter...

journal_title：Anticancer research

authors： Simmons C,Amir E,Dranitsaris G,Clemons M,Wong B,Veith R,Cole DE

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:In breast carcinomas, prolonged signalling through the TGF-beta receptor promotes latent tumour progression, metastasis and the epithelial-to-mesenchymal transition of tumour cells. Previously, it has been found that the 154 amino acid RING finger protein, RNF11, was overexpressed in high-grade breast tumour...

journal_title：Anticancer research

authors： Azmi PB,Seth AK

更新日期：2009-06-01 00:00:00

abstract：:Macrophages are thought to be the cells that initially respond to environmental information and transmit this information to other immune cells. We hypothesize that there is a "network system" consisting of various tissue macrophages; the macrophages respond to stimulation and transmit secondary information to neighbo...

journal_title：Anticancer research

authors： Nakata K,Inagawa H,Nishizawa T,Kohchi C,Taniguchi Y,Yoshioka N,Soma G

更新日期：2006-11-01 00:00:00

abstract：:The single and combined antitumor effects of adriamycin and a major histocompatibility complex non-restricted human cytotoxic T cell line (TALL-104) were evaluated in severe combined immunodeficient (SCID) mice engrafted subcutaneously with a biopsy sample from a patient with a highly metastatic gastric carcinoma. Che...

journal_title：Anticancer research

authors： Cesano A,Visonneau S,Rovera G,Santoli D

更新日期：1997-05-01 00:00:00

abstract：:Explantation and cultivation in vitro of 55 human biopsies of histologically normal urothelial tissue, and 63 biopsies from transitional cell carcinomas (TCC) revealed a primary success rate of about 75% and a secondary success rate of about 50% with no significant differences, between normal and TCC derived cultures....

journal_title：Anticancer research

authors： Kieler J,Christensen B,Ottesen S,Tromholt V,Ostrowski K

更新日期：1987-09-01 00:00:00