Transferrin directed delivery of adriamycin to human cells.

abstract：:The compound 317615 x 2HCl, a selective protein kinase Cbeta inhibitor, was not very cytotoxic toward human CaKi1 renal cell carcinoma cells or human HT-29 colon carcinoma cells in monolayer culture. Isobologram analysis was used to determine additivity or synergy of the combination regimens. Exposure of CaKi1 cells t...

journal_title：Anticancer research

authors： Teicher BA,Menon K,Alvarez E,Galbreath E,Shih C,Faul MM

更新日期：2001-09-01 00:00:00

abstract：:Monoclonal antibodies TP-1 and TP-3, which detect an antigen expressed on the cells of human osteosarcoma, were tested by immunohistochemical staining for binding to normal and neoplastic canine tissues. In dogs, as in man, TP antibodies stained the tumor cells of all (13/13) osteosarcomas tested. Limited staining was...

journal_title：Anticancer research

authors： Haines DM,Bruland OS

更新日期：1989-07-01 00:00:00

abstract：BACKGROUND:Chronic lymphocytic leukemia (CLL) is characterized by a clonal accumulation of neoplastic lymphocytes, indicating disruption of apoptosis. PATIENTS AND METHODS:Differential methylation hybridization analysis was performed to identify novel target genes silenced by CpG island methylation in patients with CL...

journal_title：Anticancer research

authors： Schmidt-Wolf IG,Plass C,Byrd JC,Frevel K,Pietsch T,Waha A

更新日期：2016-09-01 00:00:00

abstract：:Vesnarinone (3,4-dihydro-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-2(1H)- quinolinone), a quinolinone derivative, is an orally active inotropic agent used in Japan for the treatment of chronic heart failure. Recently, it has been reported that vesnarinone induces differentiation and apoptosis in certain types of leuk...

journal_title：Anticancer research

authors： Kawai K,Konishi Y,Izumi K,Sato M,Adachi M,Hozumi M

更新日期：1998-01-01 00:00:00

abstract：PURPOSE:The present project studied the implications of using the irregular surface compensator (ISC) technique in comparison to three-dimensional conformal radiation therapy (3D-CRT) for breast cancer treatment. ISC is an electronic compensation algorithm that modulates the fluence across the radiation fields to compe...

journal_title：Anticancer research

authors： Flejmer AM,Josefsson D,Nilsson M,Stenmarker M,Dasu A

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:Apart from inactivation of the MEN1 gene, the molecular mechanisms involved in tumorigenesis of the endocrine organs and MEN1-associated non-endocrine lesions remain unknown. MATERIALS AND METHODS:In order to learn more about down-stream effects upon MEN1 gene inactivation BON1 cells were transfected with a...

journal_title：Anticancer research

authors： Lopez-Egido JR,Wang Y,Grönberg M,Grimfjärd P,Wang S,Stålberg P,Skogseid B

更新日期：2009-06-01 00:00:00

abstract：:The role of intensive pre- and postoperative chemotherapy in unresectable nonmetastatic neuroblastoma is still controversial. A preoperative regimen that included deferoxamine, cyclophosphamide, etoposide, carboplatin and thiotepa (D-CECaT) was evaluated in 10 children over one year of age at diagnosis, and this was f...

journal_title：Anticancer research

authors： Donfrancesco A,Deb G,Dominici C,De Sio L,Inserra A,Boglino C,Takahashi M,Uchino J,Helson L

更新日期：1995-09-01 00:00:00

abstract：:Human vaginal malignant melanoma represents rare gynecological malignancies of poor prognosis. We have established a melanoma tumor line in nude mice, designated Mela-1, and have examined the histological and biological characteristics of this tumor. The Mela-1 tumor has preserved the histological, histochemical and b...

journal_title：Anticancer research

authors： Sawada M,Terada N,Nishizawa Y,Ito S,Wakamatsu K,Takemura K,Yamamoto T,Ozaki M,Sakamoto H,Tanizawa O

更新日期：1994-07-01 00:00:00

abstract：:We report on a case of low-grade periductal stromal tumor of the breast with synchronous bilateral breast carcinoma. A 45-year-old woman came to our Hospital because of a palpable mass of the right breast. An approximately 5-cm mass was palpated in the upper right breast. The mammographic and sonographic findings of t...

journal_title：Anticancer research

authors： Ki SY,Lim HS,Lee JS,Park SY,Yim NY,Heo SH,Park MH,Cho JS,Shin SH

更新日期：2014-07-01 00:00:00

abstract：:Local control was compared between patients who had undergone breast-conserving therapy with and without nipple resection. We explored whether there was any difference in local control between the two treatment methods for patients with early breast cancer. A total of 333 women with breast cancer, who had undergone br...

journal_title：Anticancer research

authors： Horiguchi J,Koibuchi Y,Iijima K,Yoshida T,Takata D,Rokutanda N,Nagaoka R,Oyama T,Iino Y,Sakurai H,Morishita Y

更新日期：2005-07-01 00:00:00

abstract：:Previous studies have demonstrated that berberine decreases N-acetyltransferase (NAT) activity in human leukemia HL-60 cells, however, NAT gene expression has not been investigated. In this study, berberine was selected for testing the inhibition of N-acetylation of 2-aminofluorene (AF) and NAT gene expression in huma...

journal_title：Anticancer research

authors： Lin CC,Kao ST,Chen GW,Chung JG

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND/AIM:Adenoid cystic carcinoma (SGC) is a common type of salivary gland cancer (SGC). Surgery is the first treatment choice because chemoradiotherapy is usually not effective. Therefore, new treatment modalities are urgently needed. In this study, it was investigated whether the estrogen axis could be a treatm...

journal_title：Anticancer research

authors： Sumida T,Ishikawa A,Kamata YU,Nakano H,Yamada T,Mori Y

更新日期：2016-06-01 00:00:00

abstract：:Urine and serum samples from a group of 359 individuals were studied in order to evaluate the usefulness of TPA in patients with urological cancers. Serum was taken from 110 people at 12 noon (S1), 5 pm (S2), and 8 am the following day (S3), while urine samples were collected from 73 individuals over three time interv...

journal_title：Anticancer research

authors： Costello CB,Kumar S

更新日期：1986-07-01 00:00:00

abstract：:Almost all individuals with neurofibromatosis type 1 (NF1) develop peripheral nerve sheath tumors (PNSTs), mainly benign neurofibromas, however about 10% of PNSTs will undergo transformation to malignant peripheral nerve sheath tumors (MPNSTs). Surgical treatment of PNSTs has traditionally been regarded as a standard ...

journal_title：Anticancer research

authors： Marjanska A,Galazka P,Wysocki M,Styczynski J

更新日期：2020-04-01 00:00:00

abstract：:Tumor angiogenesis seems to be an important factor in determining therapeutic effectiveness and patient prognosis. An abundance of data on tumor angiogenesis is available and it clearly shows that most human solid tumors are heterogeneously vascularized and oxygenated and contain hypoxic regions. Such regions and area...

journal_title：Anticancer research

authors： Mattern J

更新日期：2001-11-01 00:00:00

abstract：BACKGROUND:CD98 expression is high in various human neoplasms. However, the relationship of CD98 expression with the clinicopathological factors of gastric cancer (GC) remains unclear. This study examined CD98 expression and its clinicopathological impact on GC. PATIENTS AND METHODS:Three hundred and thirty-one patien...

journal_title：Anticancer research

authors： Satoh T,Kaira K,Takahashi K,Takahashi N,Kanai Y,Asao T,Horiguchi J,Oyama T

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND/AIM:There is no definite consensus regarding management of hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT). This study aimed to compare clinical outcomes according to initial treatment modality for treatment of naïve HCC combined with subsegmental (Vp1)/ segmental (Vp2) PVTT with live...

journal_title：Anticancer research

authors： Yu JI,Choi GS,Lim DH,Lee E,Joh JW,Kwon CHD,Kim JM,Kim S,Woo SY,Paik SW,Park HC

更新日期：2018-08-01 00:00:00

abstract：:Experimental biochemical modulation of 1-hexylcarbamoyl-5-fluorouracil (HCFU) with l-leucovorin (LV) was carried out using human gastric (H-111) and colon (Co-4) carcinoma xenografts serially transplanted into nude mice. Thirty-five or 70 mg/kg HCFU dissolved in 0.2 ml of 1% hydroxymethyl cellulose was administered po...

journal_title：Anticancer research

authors： Kubota T,Kase S,Furukawa T,Tanino H,Kuo TH,Saikawa Y,Nishibori H,Ishibiki K,Kitajima M,Mabuchi K

更新日期：1992-09-01 00:00:00

abstract：:Serotoninergic system activity and cytokine production have been both implicated in the pathogenesis of cancer anorexia. To verify the existence of relationships between tryptophan, cytokines and anorexia, twenty cancer and six non-neoplastic patients were studied. Plasma amino acid concentration, including tryptophan...

journal_title：Anticancer research

authors： Cangiano C,Testa U,Muscaritoli M,Meguid MM,Mulieri M,Laviano A,Cascino A,Preziosa I,Conversano L,Rossi Fanelli F

更新日期：1994-05-01 00:00:00

abstract：BACKGROUND:Tenascin-C (TNC) is an extracellular matrix glycoprotein, usually derived from myofibroblasts in the cancer microenvironment. Recently, however, the significance of tumor-derived TNC in initiation of cancer metastasis was disclosed. We investigated the clinical significance of cancer-derived TNC in colorecta...

journal_title：Anticancer research

authors： Takahashi Y,Sawada G,Kurashige J,Matsumura T,Uchi R,Ueo H,Ishibashi M,Takano Y,Akiyoshi S,Iwaya T,Eguchi H,Sudo T,Sugimachi K,Yamamoto H,Doki Y,Mori M,Mimori K

更新日期：2013-05-01 00:00:00

abstract：:Plastins are members of a family of actin-binding proteins which exhibit a tissue-specific expression pattern. L-plastin, which is specifically expressed in hematopoietic cell lineage, has been proposed to be involved in the control of cell adhesion and motility. This protein is also frequently expressed in cell lines...

journal_title：Anticancer research

authors： Lapillonne A,Coué O,Friederich E,Nicolas A,Del Maestro L,Louvard D,Robine S,Sastre-Garau X

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND/AIM:The objective of this study was to determine the molecular and clinicopathological features, as well as the prognosis of patients with endometrial cancer (EC) having prior malignancy (second primary EC: SPEC) compared with those without a history of prior malignancy (first primary EC: FPEC). MATERIALS A...

journal_title：Anticancer research

authors： Haraga J,Nakamura K,Haruma T,Nyuya A,Nagasaka T,Masuyama H

更新日期：2020-07-01 00:00:00

abstract：:Gastrointestinal stromal tumors (GISTs) represent the most common mesenchymal tumor entity of the gastrointestinal tract. In fewer than 5% of cases, primary GISTs are located in the duodenum. Surgery represents the treatment of choice for localized tumor disease and remains challenging in GISTs located at the duodenum...

journal_title：Anticancer research

authors： Mrak K,Liegl-Atzwanger B,Haybaeck J,Petritsch W,Mischinger HJ,Kornprat P

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND:Sunitinib is a tyrosine kinase inhibitor (TKI) targeting tumour angiogenesis in patients with advanced renal cell carcinoma (RCC). Currently no universally agreed model exists correlating the expression of angiogenesis markers with the success of treatment. PATIENTS AND METHODS:We retrospectively analysed a...

journal_title：Anticancer research

authors： Stubbs C,Bardoli AD,Afshar M,Pirrie S,Miscoria M,Wheeley I,Porfiri E

更新日期：2017-01-01 00:00:00

abstract：:TPS was determined by immunohistochemistry in 44 different tissues (normal and pathological) from various organs such as cervix, endometrium, breast, stomach, bowel and bladder. TPS was expressed in several physiologic situations: in different phases of the endometrial cycle and in cervical metaplasia. In other organs...

journal_title：Anticancer research

authors： Giovagnoli MR,Valli C,Vecchione A,Vecchione A

更新日期：1994-03-01 00:00:00

abstract：BACKGROUND AND AIM:The clinical efficiency of cisplatin (CDDP) against gastric cancer is often limited by the development of resistance. A third-generation platinum-containing agent, oxaliplatin (L-OHP), has been introduced for treating gastric cancer. Here, we studied oxaliplatin in vitro to reveal the mechanism of ac...

journal_title：Anticancer research

authors： Tozawa K,Oshima T,Kobayashi T,Yamamoto N,Hayashi C,Matsumoto T,Miwa H

更新日期：2008-07-01 00:00:00

abstract：:Multiple components in cigarette smoke were analyzed for their ability to form active oxygen species using a spin trapping agent, 5, 5-dimethyl-1-pyrroline-N-oxide. The main source of O2 and H2O2 was ascribed to polyphenols in a particulate phase, whereas a synergistic effect was also observed between these polyphenol...

journal_title：Anticancer research

authors： Kodama M,Kaneko M,Aida M,Inoue F,Nakayama T,Akimoto H

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND/AIM:Alterations of global histone modification levels have been identified in various tumor entities, including bladder cancer (BCA). Our study was designed to investigate the value of global histone acetylation levels as diagnostic and prognostic biomarker for BCA patients. MATERIALS AND METHODS:A tissue m...

journal_title：Anticancer research

authors： Ellinger J,Schneider AC,Bachmann A,Kristiansen G,Müller SC,Rogenhofer S

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:Targeting the epidermal growth factor receptor (EGFR) improved radiotherapy outcome by 10-15% in head and neck tumors (HNSCC). We tested the therapeutic benefits of co-targeting EGFR and insulin-like growth factor-1 receptor (IGF-1R) to further enhance tumor response to radiation. MATERIALS AND METHODS:Mice...

journal_title：Anticancer research

authors： Matsumoto F,Valdecanas DN,Mason KA,Milas L,Ang KK,Raju U

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:Molecular alterations such as DNA microsatellite instability (MSI/RER), single nucleotide polymorphism (SNP) and loss of heterozygosity (LOH) can occur throughout the genome and be associated with different types of cancer. In the present study, we aimed at detecting molecular alterations within the mismatch...

journal_title：Anticancer research

authors： Arzimanoglou II,Hansen LL,Chong D,Li Z,Psaroudi MC,Dimitrakakis C,Jacovina AT,Shevchuk M,Reid L,Hajjar KA,Vassilaros S,Michalas S,Gilbert F,Chervenak FA,Barber HR

更新日期：2002-03-01 00:00:00