A Study of Angiogenesis Markers in Patients with Renal Cell Carcinoma Undergoing Therapy with Sunitinib.

abstract：BACKGROUND/AIM:To predict pCR during neoadjuvant chemotherapy is still difficult. The aim of this study was to evaluate the optimal tumor reduction rate and modalities for predicting pCR after two cycles of docetaxel. PATIENTS AND METHODS:We analyzed 52 patients with HER2-positive or triple-negative breast cancer. The...

journal_title：Anticancer research

authors： Kuba S,Maeda S,Matsumoto M,Yamanouchi K,Iwata T,Morita M,Sakimura C,Otsubo R,Yano H,Sato S,Kanetaka K,Nagayasu T,Eguchi S

更新日期：2020-04-01 00:00:00

abstract：:A 56-year-old Caucasian smoker male patient underwent right orchiectomy and spermatic cord resection for intrascrotal transilluminating mass. Histology findings suggested diagnosis of metastasis from Renal Cell Carcinoma (RCC). After positive CT-scan for primary neoplasm, total left nephrectomy was accomplished. Patie...

journal_title：Anticancer research

authors： Lauro S,Lanzetta G,Bria E,Trasatti L,Costarelli L,Vecchione A

更新日期：1998-11-01 00:00:00

abstract：:Ten patients with advanced renal cell carcinoma were given combined chemoendocrine treatment with tegafur and tamoxifen. Patients were orally administered 800 mg/body tegafur and 20 mg/body tamoxifen daily. One patient was assessed as CR, three as PR, two as NC and four as PD. One out of two patients with estrogen rec...

journal_title：Anticancer research

authors： Wada T,Nishiyama K,Maeda M,Hara S,Tanaka N,Yasutomi M,Kurita T

更新日期：1995-07-01 00:00:00

abstract：BACKGROUND:To study the neuropathology and selected tumour markers of malignant gliomas, an animal glioma model was developed using the implantation of human glioblastoma clone U87 into rat brains. MATERIALS AND METHODS:The U87 cell suspension, or precultured U87 tumour spheroids, were inoculated into the brain of 4-w...

journal_title：Anticancer research

authors： Strojnik T,Kavalar R,Lah TT

更新日期：2006-07-01 00:00:00

abstract：:We have previously reported that polaprezinc in sodium alginate suspension (P-AG) inhibited the incidence of oral mucositis induced by radiochemotherapy in patients with head and neck cancer. The present study was designed to investigate whether P-AG prevents oral mucositis in all patients (36 patients) with hematolog...

journal_title：Anticancer research

authors： Hayashi H,Kobayashi R,Suzuki A,Ishihara M,Nakamura N,Kitagawa J,Kanemura N,Kasahara S,Kitaichi K,Hara T,Tsurumi H,Moriwaki H,Itoh Y

更新日期：2014-12-01 00:00:00

abstract：:BRCA1 acts as a tumour suppressor and germ-line mutations within this gene are found in a large proportion of families with breast cancer. The aim of our study was to unravel the mechanism of action of genistein, the major soy phytoestrogen, in BRCA1-mutant human breast cancer cell lines. Four breast cancer cell lines...

journal_title：Anticancer research

authors： Privat M,Aubel C,Arnould S,Communal Y,Ferrara M,Bignon YJ

更新日期：2010-06-01 00:00:00

abstract：:A study on clinical and histological features of prognostic significance was performed in 45 patients with Ph1+ -CML who showed median survival of 36 months. The histological features were evaluated by morphometry of iliac crest biopsies. Among the variables correlated with prognosis, we eliminated those without prima...

journal_title：Anticancer research

authors： Thiele J,Fohlmeister I,Vonneguth B,Zankovich R,Fischer R

更新日期：1986-11-01 00:00:00

abstract：BACKGROUND:Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) play a key role in extracellular matrix (ECM) turnover and remodeling. Changes in their expression levels have been observed in various tumor types. However, their clinical significance and prognostic importance in the progr...

journal_title：Anticancer research

authors： Honkavuori M,Talvensaari-Mattila A,Puistola U,Turpeenniemi-Hujanen T,Santala M

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:The overexpression of syndecan-1 in breast carcinomas correlates with poorer prognosis and an aggressive phenotype. The effect of syndecan-1 expression on tumor response to neoadjuvant chemotherapy was determined in locally advanced breast cancer. PATIENTS AND METHODS:Semi-quantitative syndecan-1 immunohist...

journal_title：Anticancer research

authors： Götte M,Kersting C,Ruggiero M,Tio J,Tulusan AH,Kiesel L,Wülfing P

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:The doxorubicin-docetaxel combination is active in breast cancer; the aim of the present study was to evaluate the complete response rate and safety profile of the doxorubicin and docetaxel regimen as first-line chemotherapy in metastatic breast cancer patients. PATIENTS AND METHODS:Forty-three patients ent...

journal_title：Anticancer research

authors： Mattioli R,Lippe P,Massacesi C,Cappelletti C,Nacciarriti D,Bisonni R,Graziano F,Menichetti ET,Imperatori L,Testa E,Laici G,Balletra A,Silva RR

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND/AIM:Pancreatic neuroendocrine tumors (pNETs) are rare pancreatic neoplasms, and therapeutic options for pNETs are limited. Metformin is an anti-hypoglycemic drug that appears to have anticancer effects. However, little is known about the effect of metformin on pNETs. In this study, we investigated the anti-p...

journal_title：Anticancer research

authors： Yamana H,Kato K,Kobara H,Fujihara S,Fujita K,Namima D,Fujita N,Kobayashi K,Kamada H,Morishita A,Tsutsui K,Iwama H,Masaki T

更新日期：2020-01-01 00:00:00

abstract：AIM:Eudragit® E 100 (EE100) was used to improve the transfection efficiency of polyethylenimine (PEI). MATERIALS AND METHODS:Mobility of PEI-DNA complexes with and without EE100 were visualized by agarose gel electrophoresis and their transfection efficiencies were investigated in KB human oral carcinoma cells by flow...

journal_title：Anticancer research

authors： Kanthamneni N,Yung B,Lee RJ

更新日期：2016-01-01 00:00:00

abstract：AIM:The expression level of DNA repair-related genes and their association with breast cancer status among participants of the New York site of the Breast Cancer Family Registry was investigated. MATERIALS AND METHODS:RNA from mononuclear cells in 194 sister sets (n=475 women) were assayed for ATM, BRCA1, MSH2, MUTYH ...

journal_title：Anticancer research

authors： Kappil MA,Liao Y,Terry MB,Santella RM

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:WAVE2 plays a crucial role in actin polymerisation and cell migration. We aimed to investigate the expression and cellular functions of WAVE2 in human gastric cancer (GC). MATERIALS AND METHODS:The level of WAVE2 was determined using quantitative PCR (Q-PCR) in a cohort of human gastric tissues. Expression ...

journal_title：Anticancer research

authors： Jia S,Jia Y,Weeks HP,Ruge F,Feng X,Ma R,Ji J,Ren J,Jiang WG

更新日期：2014-05-01 00:00:00

abstract：:The effects of dehydroepiandrosterone (DHEA) and 5-en-androstene-3 beta, 17 beta-diol (ADIOL) on the proliferation of MCF-7 cells were studied both in steroid - free and estradiol (E2) supplemented media. Growth was evaluated by counting the cells after six days of culture. The results show that DHEA 500 nM and ADIOL ...

journal_title：Anticancer research

authors： Boccuzzi G,Brignardello E,di Monaco M,Forte C,Leonardi L,Pizzini A

更新日期：1992-05-01 00:00:00

abstract：BACKGROUND:One of the major changes in the new TNM classification (5th edition, 1997) for gastric cancer was made in the classification of N category: the 5th edition employs the number of involved nodes and a minimum of 15 examined nodes is required for N0 classification. The validity of the new TNM classification was...

journal_title：Anticancer research

authors： Nio Y,Yamasawa K,Yamaguchi K,Itakura M,Omori H,Koike M,Kitamura Y,Tsuji M,Endo S,Ogo Y,Yano S,Sumi S

更新日期：2003-01-01 00:00:00

abstract：:In a population-based study of posterior uveal malignant melanoma (755 incidence cases), the authors found a stabilized incidence in Israel from 1961-1996. Overall, Jewish immigrants to Israel had a relative rate (RR) of 2.2 [95% confidence interval [1.5-2.6] as compared to the reference population (Israeli-born Jews ...

journal_title：Anticancer research

authors： Iscovich J,Abdulrazik M,Pe'Er J

更新日期：2001-03-01 00:00:00

abstract：:Proteoglycan epitopes recognized by poly- or monoclonal antibodies were studied at the cell surface of 3LL murine tumor cell lines with different metastatic capacity. A decreased expression of heparan sulphate and chondroitin sulphate core protein epitopes was observed in the highly metastatic variant HM compared to t...

journal_title：Anticancer research

authors： Timár J,Lapis K

更新日期：1990-05-01 00:00:00

abstract：:To elucidate the rates of appearance of hepatocellular carcinoma (HCC) and the prognosis of alcoholic liver cirrhosis upon infection with hepatitis virus, we retrospectively studied 190 consecutive patients. The patients were divided into three groups based on whether they were exposed either to hepatitis B virus (HBV...

journal_title：Anticancer research

authors： Yamanaka T,Shiraki K,Nakazaawa S,Okano H,Ito T,Deguchi M,Takase K,Nakano T

更新日期：2001-07-01 00:00:00

abstract：:The feasibility of using low-dose carboplatin (CBDCA) as a radiopotentiator in radiotherapy(RT) for non-small cell lung cancer(NSCLC) patients with unfavorable factors was studied. Fifteen patients with locally advanced and inoperable NSCLC were treated with RT in combination with daily 20 mg/m2 CBDCA. Twelve patients...

journal_title：Anticancer research

authors： Satoh H,Ohara K,Fuji H,Ishikawa H,Yamashita YT,Kamma H,Ohtsuka M,Hasegawa S

更新日期：1998-11-01 00:00:00

abstract：AIM:We aimed to retrospectively investigate the outcomes and pathological effects of retrograde superselective intra-arterial chemoradiotherapy (IACRT) combined with hyperthermia on metastatic lymph nodes of patients with oral squamous cell carcinoma. PATIENTS AND METHODS:Patients with lymph node metastasis from oral ...

journal_title：Anticancer research

authors： Nozato T,Koizumi T,Hayashi Y,Iida M,Iwai T,Oguri S,Hirota M,Kioi M,Koike I,Hata M,Tohnai I,Mitsudo K

更新日期：2019-03-01 00:00:00

abstract：:A sarcomatoid carcinoma cell line (SAR-HCV) was established from a malignant liver lesion of a patient infected with hepatitis C virus. SAR-HCV cells were successfully xenografted in SCID mice. Vimentin was strongly positive in cultured SAR-HCV cells, the primary tumour lesion and the xenografts. Hepatocyte paraffin 1...

journal_title：Anticancer research

authors： Tai DI,Shen YJ,Weng WH,Chen HW,Kang CC,Chen TC,Liao SK

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:S100(+) dendritic cells and CD57(+) lymphocytes are factors reflecting the immune system's ability to suppress the progress of tumor growth. CD57(+) cells include natural killer cells and late stages of T-effector lymphocytes. We evaluated the relationship between the known clinical and histological factors ...

journal_title：Anticancer research

authors： Liska V,Vycital O,Daum O,Novak P,Treska V,Bruha J,Pitule P,Holubec L

更新日期：2012-05-01 00:00:00

abstract：OBJECTIVE:Matrix metalloproteinase-2 (MMP-2) and its tissue inhibitor (TIMP-2) are important regulators of cancer invasion and metastasis. Their associations to high-risk (HR) human papillomavirus (HPV) in cervical intra-epithelial neoplasia (CIN) and cervical cancer (CC) are unexplored and their prognostic significanc...

journal_title：Anticancer research

authors： Branca M,Ciotti M,Giorgi C,Santini D,Di Bonito L,Costa S,Benedetto A,Bonifacio D,Di Bonito P,Paba P,Accardi L,Syrjänen S,Favalli C,Syrjänen K,HPV-PathogenISS Study Group.

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND/AIM:Prognosis for patients with head and neck squamous cell carcinoma (HNSCC) is poor in most cases and has not improved despite advances in therapy. Novel therapeutic approaches are mandatory in order to improve the situation. Everolimus, an inhibitor of mammalian target of rapamycin, as well as the multi-t...

journal_title：Anticancer research

authors： Aderhold C,Faber A,Umbreit C,Chakraborty A,Bockmayer A,Birk R,Sommer JU,Hörmann K,Schultz JD

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND/AIM:Forodesine inhibits purine nucleoside phosphorylase, resulting in an accumulation of intracellular dGTP and consequently cell death. 9-β-D-Arabinofuranosylguanine (ara-G) is an active compound of nelarabine that is intracellularly phosphorylated to a triphosphate form, which inhibits DNA synthesis. Both ...

journal_title：Anticancer research

authors： Yamauchi T,Uzui K,Nishi R,Tasaki T,Ueda T

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND/AIM:Protein-bound polysaccharide-K (PSK) is extracted from Coriolus versicolor (CM101) and is clinically used in combination therapy for gastrointestinal cancer and small-cell lung carcinoma. We have previously demonstrated that PSK induces apoptosis and inhibites proliferation of promyelomonocytic leukemia ...

journal_title：Anticancer research

authors： Hirahara N,Edamatsu T,Fujieda A,Fujioka M,Wada T,Tajima Y

更新日期：2012-07-01 00:00:00

abstract：AIM:To investigate the prognostic significance of cancer antigen 15-3 (CA15-3) in primary breast cancer (BC). PATIENTS AND METHODS:This prospective study included 368 women: 62 patients with benign breast disease (BBD), 159 patients with invasive BC and 88 healthy blood donors (control). The median follow-up was 76 mo...

journal_title：Anticancer research

authors： Nisman B,Maimon O,Allweis T,Kadouri L,Maly B,Hamburger T,Peretz T

更新日期：2013-01-01 00:00:00

abstract：:The in vitro cytotoxicity and differential cellular sensitivity of a series of new N1-methyl, N1-allyl, N1-2-chloroethyl and N1-propargyl nitrosourea derivatives of diamino acids were determined in the National Cancer Institute's primary antitumor drug screen. The compounds tested showed an in vitro anticancer activit...

journal_title：Anticancer research

authors： Dulude H,Salvador R,Gallant G

更新日期：1995-05-01 00:00:00

abstract：BACKGROUND:Cytolysins are pore-forming toxins that show anticancer activity by a mechanism hitherto poorly investigated. MATERIALS AND METHODS:To investigate how cytolysins are cytotoxic to resistant cancer cells, proliferation and cell death were evaluated on U87 glioblastoma cells treated with toxin Bc2 or equinatox...

journal_title：Anticancer research

authors： Soletti RC,Alves T,Vernal J,Terenzi H,Anderluh G,Borges HL,Gabilan NH,Moura-Neto V

更新日期：2010-04-01 00:00:00