Down-regulation of WAVE2, WASP family verprolin-homologous protein 2, in gastric cancer indicates lymph node metastasis and cell migration.

abstract：BACKGROUND/AIM:Amentoflavone has been shown to be effective against a variety of cancer cells, but its role in bladder cancer remains unclear. Thus, the aim of this study is to evaluate whether amentoflavone may induce toxicity effect of bladder cancer. MATERIALS AND METHODS:Herein, we evaluated amentoflavone effects ...

journal_title：Anticancer research

authors： Chiang CH,Yeh CY,Chung JG,Chiang IT,Hsu FT

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND/AIM:Up-regulation of metallo-proteinase (MMP) proteins has been shown in various types of solid cancers and the genotype of MMP1 has been associated with the risk of solid cancers. The contribution of MMP1 genotype to lung cancer has been investigated in various countries, though, to our knowledge, not in Ta...

journal_title：Anticancer research

authors： Shen TC,Chang WS,Tsai CW,Chao CY,Lin YT,Hsiao CL,Hsu CL,Chen WC,Hsia TC,Bau DT

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Interleukin 32 (IL32) is an intracellular pluripotent cytokine produced by epithelial cells, monocytes, T-lymphocytes and natural killer cells and seems to be involved in the pathogenesis of cancer and inflammatory diseases. Our purpose was to assess the role of protein expression and genetic polymorphisms o...

journal_title：Anticancer research

authors： Shamoun L,Kolodziej B,Andersson RE,Dimberg J

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:The effectiveness of mammographic screening in women aged over 50 years has been confirmed in the United States and Europe, but its effectiveness in women aged from 40 to 49 years remains controversial. The optimum age for effective screening of subjects for breast cancer by mammography in Japan was studied ...

journal_title：Anticancer research

authors： Morimoto T,Sasa M,Yamaguchi T,Kondo H,Akaiwa H,Sagara Y

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND/AIM:Epidermal growth factor receptor (EGFR) mutation testing is standard-of-care for advanced non-small cell lung cancer (NSCLC). Outcomes of second-/third-line compared to first-line tyrosine kinase inhibitors (TKIs) have shown conflicting results. We investigated utilization of molecular diagnostics and th...

journal_title：Anticancer research

authors： Sluga R,VAN DEN Borne BEEM,Roepman P,Peters BJM,Kastelijn EA,Schramel FMNH

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Intraosseous lipoma remains a poorly-characterized tumor. In paticular, the natural course of intracalcaneus lipoma after conservative treatment and the appropriate surgical modalities are still quite controversial. PATIENTS AND METHODS:We reviewed six symptomatic patients who underwent curettage of intraca...

journal_title：Anticancer research

authors： Muramatsu K,Tominaga Y,Hashimoto T,Taguchi T

更新日期：2014-02-01 00:00:00

abstract：:The characteristics of Nepalese breast cancer in relation to reproductive factors have not been studied. One hundred and nine Nepalese breast cancer patients were compared with 108 Japanese breast cancer patients and the expression of estrogen (ER) and progesterone receptor (PgR) was evaluated immunohistochemically in...

journal_title：Anticancer research

authors： Singh Y,Sayami P,Sayami G,Nakagawa H,Koreeda T,Hatano T,Tsubura A

更新日期：2002-01-01 00:00:00

abstract：:Human primary breast cancers were analysed for somatic loss of heterozygosity (LOH) at chromosome 18 with 15 polymorphic microsatellite markers. LOH was observed in 148 of the 228 cases analyzed, (65%). Three smallest common deletion regions (SCDR) were detected on the long arm of chromosome 18. The marker D18S51 at t...

journal_title：Anticancer research

authors： Huiping C,Eiriksdottir G,Sigurdsson A,Sigurgeirsdottir JR,Barkardottir RB,Egilsson V,Ingvarsson S

更新日期：1998-03-01 00:00:00

abstract：:The need for dependable prognostic markers in colorectal cancer, both in the advanced as well the as adjuvant setting, is greater than ever. The introduction of new chemotherapeutic agents in the clinic, with different mechanisms of action as well as different side-effect profiles, has made this even more important. A...

journal_title：Anticancer research

authors： Papamichael D

更新日期：2001-11-01 00:00:00

abstract：:The use of salvage chemotherapy in advanced non small cell lung cancer (NSCLC) is controversial. However, many patients need to be treated in order to achieve relief of their symptoms. Docetaxel (taxotere) is one of the most active drugs for the treatment of advanced NSCLC and several studies have also shown its effec...

journal_title：Anticancer research

authors： Gridelli C,Frontini L,Barletta E,Rossi A,Barzelloni ML,Scognamiglio F,Guida C,Gatani T,Fiore F,De Bellis M,Marfella A,Manzione L

更新日期：2000-03-01 00:00:00

abstract：:Prospective studies of dose adaptation of continuous 5FU infusion combined with cisplatin have shown that pharmacologically guided dosing was feasible in the treatment of head and neck carcinomas. Adaptative dosing results in reduced haematological toxicity, but few data are available for clinical response rate. Preli...

journal_title：Anticancer research

authors： Fety R,Rolland F,Barberi-Heyob M,Merlin JL,Conroy T,Hardouin A,Riviere A,Milano G

更新日期：1994-11-01 00:00:00

abstract：BACKGROUND/AIM:Neoplastic spindle cells (NSCs) are believed to play a role in cancer invasion and metastasis, as well as in poor prognosis. The clinicopathological characteristics and prognostic relevance of NSCs was investigated in gallbladder cancer. MATERIALS AND METHODS:Specimens were obtained from 62 patients wit...

journal_title：Anticancer research

authors： Midorikawa R,Hisaka T,Sakai H,Nomura Y,Goto Y,Sato T,Kawahara R,Ishikawa H,Fujita F,Yasunaga M,Tanigawa M,Naito Y,Akiba J,Yano H,Tanaka H,Akagi Y,Okuda K

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:This retrospective study aimed to determine the efficacy and toxicity of a combined chemotherapeutic regimen of gemcitabine and cisplatin (GC) for the treatment of metastatic urothelial carcinomas (UCs) in patients 80 years of age and over. PATIENTS AND METHODS:Twelve patients who were at least 80 years old...

journal_title：Anticancer research

authors： Tanji N,Fukumoto T,Miura N,Yanagihara Y,Azuma K,Sasaki T,Nishida T,Kikugawa T,Shimamoto K,Aoki K,Yokoyama M

更新日期：2010-09-01 00:00:00

abstract：:We report a 64-year-old woman with a 9-cm liver tumor in the left lateral section. The patient had neither hepatitis B or C virus infection, nor cirrhosis. Carbohydrate antigen 19-9 (CA 19-9) level was 1,889 U/ml. We also suspected bulky hilar lymph node metastasis, and a left lateral sectionectomy without lymph node ...

journal_title：Anticancer research

authors： Miyata T,Beppu T,Imamura YU,Hayashi H,Imai K,Chikamoto A,Yamashita YI,Fukubayashi K,Ishiko T,Baba H

更新日期：2019-04-01 00:00:00

abstract：:The effects of a bacterial vaccine, heat-killed Clostridium butyricum MII 588 cells, on the metastasis of B16-F10 melanoma in BDF1 mice was investigated. The vaccine stimulated natural killer (NK) cell cytotoxic activity against YAC-1 target cells, which peaked at 72 hr after the pretreatment, whereas maximum macropha...

journal_title：Anticancer research

authors： Chen HY,Wu SL,Yeh MY,Chen CF,Mikami Y,Wu JS

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:Tenascin-C (Tn-C) is an extracellular matrix protein with growth-, invasion- and angiogenesis-promoting activities. It is up-regulated in tumorigenesis and has been suggested to correlate with prognosis in various carcinomas, but its significance in squamous cell carcinoma of the head and neck remains unknow...

journal_title：Anticancer research

authors： Atula T,Hedström J,Finne P,Leivo I,Markkanen-Leppänen M,Haglund C

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND:Prostate cancer treated with androgen ablation eventually becomes resistant. Because the androgen receptor (AR) signaling axis affects disease progression, AR coactivator molecules could provide clinical prognostic value. This study investigates the association between AR coactivator molecules and clinical o...

journal_title：Anticancer research

authors： Mori R,Wang Q,Quek ML,Tarabolous C,Cheung E,Ye W,Groshen S,Hawes D,Togo S,Shimada H,Danenberg KD,Danenberg PV,Pinski JK

更新日期：2008-01-01 00:00:00

abstract：:50 patients with advanced breast cancer were treated with the combination of Mitoxantrone 10mg/m2 IV day 2, 5-Fluorouracil 400mg/m2 IV and Cyclophosphamide 300mg/m2 IV day 3, 4, 5, 6 of each monthly cycle. 49 patients are evaluable for toxicity and 47 for efficacy after three months of treatment. Hematologic toxicity ...

journal_title：Anticancer research

authors： Misset JL,Metz R,Gil-Delgado M,Keiling R,Cappelaere P,Armand JP,Prévot G,Grimbert J,Mathé G,Hibberd M

更新日期：1987-07-01 00:00:00

abstract：:A universal intracellular factor, the "M phase-promoting factor" (MPF), triggers the G2/M transition of the cell cycle in all organisms. In late G2, it is present as an inactive complex of tyrosine-phosphorylated p34cdc2 and unphosphorylated cyclin Bcdc13. In M phase, its activation as an active MPF displaying histone...

journal_title：Anticancer research

authors： Baratte B,Meijer L,Galaktionov K,Beach D

更新日期：1992-05-01 00:00:00

abstract：:Despite recent developments, treatment outcome in advanced non-small cell lung cancer (NSCLC) remains far from satisfactory. Vinorelbine and irinotecan have shown good single-agent activity against NSCLC. These two anticancer agents target different phases of the cell cycle: the cytotoxicity of camptothecin occurs mai...

journal_title：Anticancer research

authors： Gauvin A,Bressolle F,Martineau P,Astre C,Pinguet F

更新日期：2002-03-01 00:00:00

abstract：:The antitumor effect of a polyamine biosynthetic pathway inhibitor methylglyoxal bis(cyclopentylamidinohydrazone) (MGBCP) on human osteosarcoma cell lines such as KHOS-240S, MG-63 and G-292 cells, and its effect in combination with anticancer drugs such as methotrexate (MTX), adriamycin (ADM) and 4-hydroperoxyfosfamid...

journal_title：Anticancer research

authors： Sonoda J,Hibasami H,Yamada H,Fujinami S,Nakashima K,Ogihara Y

更新日期：1995-05-01 00:00:00

abstract：:Almost all individuals with neurofibromatosis type 1 (NF1) develop peripheral nerve sheath tumors (PNSTs), mainly benign neurofibromas, however about 10% of PNSTs will undergo transformation to malignant peripheral nerve sheath tumors (MPNSTs). Surgical treatment of PNSTs has traditionally been regarded as a standard ...

journal_title：Anticancer research

authors： Marjanska A,Galazka P,Wysocki M,Styczynski J

更新日期：2020-04-01 00:00:00

abstract：:We report a case with unexpected toxicity after low-dose docetaxel chemotherapy. The patient had a history of clinically latent HCV-positive hepatic cirrhosis when she presented with inoperable pulmonary adenocarcinoma. She was recruited in a protocol combining standard radiotherapy (RT) with docetaxel (30 mg/m2 week)...

journal_title：Anticancer research

authors： Koukourakis MI,Kapsoritakis A,Maltezos E,Potamiano S,Mouzas I,Kouroumalis H

更新日期：2002-07-01 00:00:00

abstract：AIM:The aim of this study was to evaluate the ability of tissue polypeptide-specific antigen (TPS), carcinoembryonic antigen (CEA), and cancer antigen 15-3 (CA 15-3) to predict relapse in breast cancer patients, when the measurement of biomarkers is performed within 6 months after surgery. PATIENTS AND METHODS:Four hu...

journal_title：Anticancer research

authors： Svobodova S,Kucera R,Fiala O,Karlikova M,Narsanska A,Zedníková I,Treska V,Slouka D,Rousarova M,Topolcan O,Finek J

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:We investigated whether GM-CSF/IL-4 is the most efficient cytokine combination for differentiating dendritic cells (DC) in terms of its ability to elicit an antitumor immune response. MATERIALS AND METHODS:Two experimental models were examined: C57BL/6 mice bearing MC38 cells and Balb/c mice bearing cachexi...

journal_title：Anticancer research

authors： Hikino H,Kasono K,Kanzaki M,Kai T,Konishi F,Kawakami M

更新日期：2004-05-01 00:00:00

abstract：:Between 1981 and 1987, 533 patients from 9 institutions were entered in a randomized trial to assess the value of adjuvant perioperative portal infusion with Fluorouracil and Mitomycin as compared to radical surgery alone. Analysis of 469 evaluable patients at a median follow-up of 5.8 years revealed 110 recurrences i...

journal_title：Anticancer research

authors： Weber W,Laffer U,Metzger U

更新日期：1993-09-01 00:00:00

abstract：BACKGROUND:Cyclooxygenase-2 (COX-2) has been reported to play an important role in the pathogenesis of a variety of cancers. Little is known about the relationship between bile duct cancer associated with pancreaticobiliary maljunction (PBM) and COX-2. MATERIALS AND METHODS:We compared the expression of COX-2 in bile ...

journal_title：Anticancer research

authors： Watanabe O,Yoshimatsu K,Shiozawa S,Tsuchiya A,Oshibe N,Aiba M,Ogawa K

更新日期：2004-03-01 00:00:00

abstract：:Tricot et al have reported that the nucleoside analog tiazofurin can induce hematologic remissions in patients with chronic myelogenous leukemia in blast crisis (CML-BC). These reports prompted us to begin a derivative, phase II trial of tiazofurin in CML-BC to determine if the promising findings reported by these inv...

journal_title：Anticancer research

authors： Wright DG,Boosalis MS,Waraska K,Oshry LJ,Weintraub LR,Vosburgh E

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND/AIM:Occult cancers' reported rates vary from 2-12% and serous tubal intraepithelial carcinomas (STICs) have been identified in 3-12% of the prophylactically removed tubes of women carrying a BRCA mutation. The aim of this study was to evaluate the incidence of tubal minor epithelial atypia (STIL), STIC, and ...

journal_title：Anticancer research

authors： Ricciardi E,Tomao F,Aletti G,Bazzurini L,Bocciolone L,Boveri S,Landoni F,Lapresa MT,Maruccio M,Parma G,Peccatori F,Petrella MC,Zanagnolo V,Colombo N,Maggioni A

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:The aim of this study was to evaluate the role of radiation therapy alone, employing standard fractionation, in stage III-IV hypopharyngeal carcinoma. MATERIALS AND METHODS:Fourteen (38.9%) stage III and 22 (61.1%) stage IV patients with hypopharyngeal carcinoma were submitted, with curative intent, to excl...

journal_title：Anticancer research

authors： Tombolini V,Santarelli M,Raffetto N,Donato V,Valeriani M,Ferretti A,Enrici RM

更新日期：2004-01-01 00:00:00