CEA, CA 15-3, and TPS as Prognostic Factors in the Follow-up Monitoring of Patients After Radical Surgery for Breast Cancer.

Abstract:

AIM:The aim of this study was to evaluate the ability of tissue polypeptide-specific antigen (TPS), carcinoembryonic antigen (CEA), and cancer antigen 15-3 (CA 15-3) to predict relapse in breast cancer patients, when the measurement of biomarkers is performed within 6 months after surgery. PATIENTS AND METHODS:Four hundred and seventy-two patients with breast cancer were evaluated. TPS, CEA, and CA 15-3 were measured in months 1, 3, and 6, after surgery. Disease recurrence was recorded between 7-12 months after surgery. Disease recurrence occurred in 60 patients, while 412 patients remained in recurrence-free status. RESULTS:TPS levels of the recurrence group differed statistically significantly in the first and sixth month after surgery compared to recurrence-free group (p=0.0339, AUC=0.6056; p<0.0001, AUC=0.7196). CEA and CA 15-3 measurements did not achieve a statistically significant difference for any month examined. CONCLUSION:TPS level in the sixth month after surgery is the best candidate biomarker to predict disease recurrence.

journal_name

Anticancer Res

journal_title

Anticancer research

authors

Svobodova S,Kucera R,Fiala O,Karlikova M,Narsanska A,Zedníková I,Treska V,Slouka D,Rousarova M,Topolcan O,Finek J

doi

10.21873/anticanres.12245

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

465-469

issue

1

eissn

0250-7005

issn

1791-7530

pii

38/1/465

journal_volume

38

pub_type

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