Different expression of cyclooxygenase-2 in biliary epithelia of bile duct cancer with or without pancreaticobiliary maljunction.

abstract：:To determine the changes in biological features of the prostate during the course of local recurrence of prostate cancer after endocrine therapy, histologic grade, proliferating activity and apoptotic indices were examined in prostate specimens obtained before treatment and at recurrence. A total of 16 patients, who h...

journal_title：Anticancer research

authors： Kaibuchi T,Furuya Y,Akakura K,Masai M,Ito H

更新日期：2000-03-01 00:00:00

abstract：:Five functionalized benz(c)acridines - 5,6-dimethylbenz(c)acridine; 5,6,7-trimethylbenz(c)acridine; 7-chloro-5,6-dimethylbenz(c)acridine; 7-amino-5,6-dimethylbenz(c)acridine; 7-oxo-5,6-dimethylbenz(c)-acridine and 5,6-dimethylbenz(a)phenazine - were tested for mutagenic activity in the Ames Salmonella typhimurium assa...

journal_title：Anticancer research

authors： Walker BA,Rogan EG,Cromwell NH

更新日期：1984-11-01 00:00:00

abstract：BACKGROUND/AIM:Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is a novel clinical approach to the treatment of peritoneal carcinomatosis. A well-established, not anatomic ex vivo PIPAC model was used to investigate the influence of changes in internal pressure, distance of the Micropump(©) (MIP) to the distri...

journal_title：Anticancer research

authors： Khosrawipour V,Khosrawipour T,Falkenstein TA,Diaz-Carballo D,Förster E,Osma A,Adamietz IA,Zieren J,Fakhrian K

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND/AIM:Silica nanoparticles (nano-SiO2) are widely used in many industrial areas and there is much controversy surrounding cytotoxic effects of such nanoparticles. In order to determine the toxicity and possible molecular mechanisms involved, we conducted several tests with two breast cancer cell lines, MDA-MB-...

journal_title：Anticancer research

authors： Jeon D,Kim H,Nam K,Oh S,Son SH,Shin I

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:Histological parameters as well as the status of sentinel lymph node are known to be strong prognostic factors in patients with melanoma. PATIENTS AND METHODS:In this study, we retrospectively analyzed 1,384 patients who were diagnosed with head and neck melanoma between 1976 and 2010 regarding prognostic f...

journal_title：Anticancer research

authors： Uslu U,Schuler G,Breuninger H

更新日期：2017-07-01 00:00:00

abstract：:Aromatase inhibitors (AIs) are important therapeutic drugs for postmenopausal women with hormone receptor-positive breast cancer. However, adverse effects of AIs such as arthralgia have been extensively reported. We performed a joint prospective, multi-institutional investigation to find out whether a low-dose and sho...

journal_title：Anticancer research

authors： Kubo M,Onishi H,Kuroki S,Okido M,Shimada K,Yokohata K,Umeda S,Ogawa T,Tanaka M,Katano M

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:Ano-genital carcinoma is a polyfactorial and polygenic disease. Certain strains of human papillomavirus (HPV) have been detected in a high percentage of patients. It has been suggested that p53 polymorphisms may be relevant for the interaction with viral proteins that inactivates p53. MATERIALS AND METHODS:...

journal_title：Anticancer research

authors： Realacci M,Perrone GA,Sale P,Tafani M,Di Vito M,Perrone-Donnorso R,Zotti G,Russo MA

更新日期：2006-07-01 00:00:00

abstract：:A total of 2090 patients with endometrial carcinoma were followed-up for at least five years. The treatment modalities, as well as the results of treatment, regarding 272 patients with disease relapse are presented. The results are not encouraging. We found no statistically significant difference regarding overall sur...

journal_title：Anticancer research

authors： Lindahl B,Ranstam J,Willén R

更新日期：2012-08-01 00:00:00

abstract：:Bisphosphonates are strong inhibitors of osteoclastic bone resorption in both benign and malignant bone diseases. The nitrogen-containing bisphosphonates (N-BPs) have strong cytotoxicity via inhibition of protein prenylation in the mevalonate pathway, and also demonstrate direct cytostatic and proapoptotic effects on ...

journal_title：Anticancer research

authors： Tanaka T,Kawashima H,Ohnishi K,Matsumura K,Yoshimura R,Matsuyama M,Kuratsukuri K,Nakatani T

更新日期：2009-04-01 00:00:00

abstract：:Cells cultured as spheroids present an heterogeneity similar to that of tumours in vivo. In the spheroid peripheral layers, cells are proliferating, deeper cells are non-cycling, when in the aggregate centre, cells form often a necrotic core. A multicellular resistance is related on the cell contact to other cells or ...

journal_title：Anticancer research

authors： Desoize B,Gimonet D,Jardiller JC

更新日期：1998-11-01 00:00:00

abstract：BACKGROUND/AIM:Surgical resection for esophageal cancer has remained the gold-standard therapy provided worldwide. Subcarinal lymph-nodes are classified as peri-esophageal nodes and their dissection may be performed during a 2- or 3-stage esophagectomy. The necessity and prognostic value of subcarinal lymphadenectomy i...

journal_title：Anticancer research

authors： Sdralis EK,Davakis S,Syllaios A,Lorenzi B,Kordzadeh A,Athanasiou A,Petousis S,Liakakos T,Charalabopoulos A

更新日期：2019-08-01 00:00:00

abstract：:Phorbol ester, 12-0-Tetradecanoyl-13-Phorbol-Acetate (TPA), induces a terminal macrophage-like differentiation of cells from human acute myelogenous leukemia cell lines. We report here that blastoid cells obtained from acute nonlymphocytic leukemia (M1-M2) undergo differentiation-related changes characteristic of macr...

journal_title：Anticancer research

authors： Joshi KS,Rao SG,Joshi DS,Advani SH,Bhisey AN

更新日期：1988-11-01 00:00:00

abstract：AIM:To compare clinical outcome in patients with Child-Pugh C hepatocellular carcinoma (HCC) treated with non-transplant therapies and those treated with best supportive care. PATIENTS AND METHODS:A total of 182 patients with HCC with Child-Pugh C cirrhosis were analyzed. Patients were classified into two groups: pati...

journal_title：Anticancer research

authors： Nishikawa H,Kita R,Kimura T,Ohara Y,Takeda H,Sakamoto A,Saito S,Nishijima N,Nasu A,Komekado H,Osaki Y

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:Cancer stem cells (CSCs) are tumour-initiating cells with self-renewal properties and chemo/radio-resistance. Regulatory T-cells (Tregs) influence CSCs through several mechanisms. In different solid tumours, the presence of both cell populations correlated with poor survival. In vulvar cancer, little is know...

journal_title：Anticancer research

authors： Napoletano C,Bellati F,Ruscito I,Pernice M,Zizzari IG,Caponnetto S,Tomao F,Frigerio L,Liberati M,Rughetti A,Caserta D,Panici PB,Nuti M

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:Malignant gliomas still present a medical challenge, despite decades of continuous extensive research with optimization of surgical techniques, radiotherapy and systemic treatments. PATIENTS AND METHODS:From 1999 to 2004, 104 patients with WHO grade III and IVgliomas underwent surgery and received concomita...

journal_title：Anticancer research

authors： Eberlein KH,Nagel B,Franz K,Imhoff D,Seifert V,Boettcher HD,Mose S

更新日期：2006-11-01 00:00:00

abstract：:The proteasome inhibitor, bortezomib, is known to be effective in the therapy of various neoplasms. The objective of this study was the analysis of the ex vivo activity of bortezomib in paediatric acute lymphoblastic leukaemia (ALL), in comparison to paediatric acute myeloid leukaemia (AML). A total of 159 patients en...

journal_title：Anticancer research

authors： Szczepanek J,Pogorzala M,Konatkowska B,Juraszewska E,Badowska W,Olejnik I,Kuzmicz M,Stanczak E,Malinowska I,Stefaniak J,Sobol G,Szczepanski T,Czyzewski K,Wysocki M,Styczynski J

更新日期：2010-06-01 00:00:00

abstract：:The published literature describing the spectrum of resistance and cross-resistance to cytotoxic agents by human and murine tumour cell lines maintained in long-term culture is reviewed. The data available demonstrate that for many cytotoxic agents, especially those of higher molecular weight, cross-resistance is prop...

journal_title：Anticancer research

authors： Mattern J,Edler L,Volm M

更新日期：1989-07-01 00:00:00

abstract：BACKGROUND:Matrix metalloproteinases (MMPs) are involved with tumour invasion and metastasis. Controversial data exists concerning the prognostic value of MMP-9 in breast carcinoma. We examined, here, whether the MMP-9 immunoreactive protein would correlate with--the prognosis in breast carcinoma treated with hormonal ...

journal_title：Anticancer research

authors： Rahko E,Jukkola A,Melkko J,Paavo P,Bloigu R,Talvensaari-Mattila A,Turpeenniemi-Hujanen T

更新日期：2004-11-01 00:00:00

abstract：:Immunoreactivity of monoclonal anti-cytokeratin KL1, PKK1, K8.12 and anti-actin antibodies in 101 cases of diseased human breast lesions showed irregular keratin distribution in luminal cells of terminal ductal-lobular unit and basal layer cells of the interlobular and main duct. Actin staining was confined to myoepit...

journal_title：Anticancer research

authors： Wada T,Yasutomi M,Yamada K,Hashimura K,Kunikata M,Tanaka T,Huang JW,Mori M

更新日期：1991-11-01 00:00:00

abstract：:Iceland has a total population of 300,000 inhabitants. All patients consulting for symptoms of the lower digestive tract during a four-year period (2003-2006) were subjected to a colonoscopic examination; all polyps were endoscopically removed. Out of the total 3,037 colorectal adenomas (CRAs), 308 (10.2%) were tradit...

journal_title：Anticancer research

authors： Rubio CA,Jónasson JG

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:Stimulation of inducible nitric oxide synthase (iNOS) and release of nitric oxide by tumor cells may play a critical role in cancer development, either by exhibiting tumoricidal effects or by promoting tumor progression. MATERIALS AND METHODS:In the present study, we investigated four ovarian carcinoma cell...

journal_title：Anticancer research

authors： Rieder J,Marth C,Totzke G,Smolny M,Seibel M,Hoffmann G

更新日期：2000-09-01 00:00:00

abstract：:Transforming growth factor beta type II receptor (TGFbeta-IIR) has been found to be altered in primary gastrointestinal carcinomas. So far relatively few facts are known about the expression of TGFbeta-IIR in primary gastric cancer. Therefore, in the present study, TGFbeta-IIR expression was analyzed in 130 primary ga...

journal_title：Anticancer research

authors： Takeno S,Wirtz HC,Lickvers K,Noguchi T,Scheven M,Willers R,Gabbert HE,Mueller W

更新日期：2002-07-01 00:00:00

abstract：:Between 70 and 75% of ovarian carcinomas are not discovered until they have reached an advanced stage III or later. Efforts should therefore be concentrated on earlier diagnosis. Ovarian cancer is not an entirely silent disease. Today, it is known that there are key symptoms which, depending on their frequency and int...

journal_title：Anticancer research

authors： Argento M,Hoffman P,Gauchez AS

更新日期：2008-09-01 00:00:00

abstract：:The role of combination chemotherapy regimens in the management of ovarian cancer patients with tumors resistant to platinum compounds has not yet been defined. This multicenter prospective phase II study evaluated the activity and toxicity of the docetaxel-plus-irinotecan combination in ovarian cancer patients whose ...

journal_title：Anticancer research

authors： Polyzos A,Kosmas C,Toufexi H,Malamos N,Lagadas A,Kosmidis C,Ginopoulos P,Ziras N,Kandilis K,Georgoulias V

更新日期：2005-09-01 00:00:00

abstract：:Normal human skin fibroblasts and cells from 2 benign (3T3 and 3T6B) and 1 malignant (3T6D) fibroblast lines were grown in the presence of C20 fatty acids in the concentration range 0-100 mg/l culture medium. The culture medium consisted of 10% FCS and 90% DMEM, the cells were dosed with various concentrations of fatt...

journal_title：Anticancer research

authors： Davidson BC,Girao LA,Giangregorio A,Murphy J

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:The area under the curve (AUC) of free carboplatin, is a major determinant of toxicity and response. A conventional pharmacokinetic study to determine AUC requires frequent blood sampling. One strategy for overcoming this problem is to apply a limited sampling model (LSM). MATERIALS AND METHODS:We developed...

journal_title：Anticancer research

authors： Miyazaki M,Fujiwara Y,Takahashi T,Isobe T,Ohune T,Tsuya T,Yamakido M

更新日期：1997-11-01 00:00:00

abstract：:Rats were inoculated subcutaneously into both flanks with a transplantable adenocarcinoma of the colon. They were treated intravenously with either 5-FUrd (5-fluorouridine) or 5-FdUrd (5-fluoro-2'-deoxyuridine) with or without addition of dipyridamole 20 and 30 min later, respectively, for 3 consecutive days. Dipyrida...

journal_title：Anticancer research

authors： el Hag IA,Roos G,Jönsson PE,Stenram U

更新日期：1990-01-01 00:00:00

abstract：:Cytotropic heterogeneous molecular lipid (CHML), which is a new anticancer agent with US patent number 5,260,067, has recently been shown to suppress tumor cell growth in multiple tumor lines and induce apoptosis in vitro (1). These results indicate that CHML may be an effective antitumor agent. In the present study, ...

journal_title：Anticancer research

authors： Zhan Q,Zhao SC,Xu Z

更新日期：2001-07-01 00:00:00

abstract：:To determine the group of patients for whom a biological response modifier is useful, the efficacy of postoperative adjuvant immunotherapy was investigated with regard to infiltration of dendritic cells (DC) in patients with advanced gastric cancer who underwent absolute curative resection. The infiltration of DC was ...

journal_title：Anticancer research

authors： Tsujitani S,Kakeji Y,Orita H,Watanabe A,Kohnoe S,Baba H,Anai H,Maehara Y,Sugimachi K

更新日期：1992-05-01 00:00:00

abstract：BACKGROUND/AIM:Gefitinib and erlotinib were shown to be particularly effective in a clinically selected subpopulation of non-small cell lung cancer patients (NSCLC): adenocarcinoma histology, non-smoking status, Asian origin and female gender have been associated with improved clinical benefit compared to the unselecte...

journal_title：Anticancer research

authors： Bonanno L,Schiavon M,Nardo G,Bertorelle R,Bonaldi L,Galligioni A,Indraccolo S,Pasello G,Rea F,Favaretto A

更新日期：2010-12-01 00:00:00