当前位置： SCI文献检索 > ANTICANCER RESEARCH期刊下所有文献 > Flow cytometric analysis of proteoglycan expression on murine tumor cells with different metastatic capacity.

Flow cytometric analysis of proteoglycan expression on murine tumor cells with different metastatic capacity.

Abstract：

:Proteoglycan epitopes recognized by poly- or monoclonal antibodies were studied at the cell surface of 3LL murine tumor cell lines with different metastatic capacity. A decreased expression of heparan sulphate and chondroitin sulphate core protein epitopes was observed in the highly metastatic variant HM compared to the low metastatic counterpart LM. Interestingly, the biochemical analysis demonstrated an increased glycosaminoglycan-especially heparan sulphate-production in highly metastatic HM cells. A similar decrease in heparan sulphate proteoglycan core epitope expression was observed in the highly metastatic B16F10 cell line compared to its low metastatic variant F1. The under-representation of proteoglycan core protein epitopes at the cell surface of highly metastatic murine tumor cell lines could be interpreted by the increased glycosylation, or by the loss of those particular epitopes.

journal_name

Anticancer Res

journal_title

Anticancer research

authors

Timár J,Lapis K

subject

Has Abstract

pub_date

1990-05-01 00:00:00

pages

785-7

issue

3

eissn

0250-7005

issn

1791-7530

journal_volume

10

pub_type

杂志文章

相关文献

ANTICANCER RESEARCH文献大全
  • Oestrogen and progesterone receptor expression in patients with adenocarcinoma of the uterine cervix and correlation with various clinicopathological parameters.

    abstract：OBJECTIVE:The expression of oestrogen and progesterone receptors in patients with adenocarcinoma of the uterine cervix was examined in order to determine their influence on prognosis and to evaluate the association between the steroid receptor expression and various clinicopathologic parameters. PATIENTS AND METHODS:O...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Bodner K,Laubichler P,Kimberger O,Czerwenka K,Zeillinger R,Bodner-Adler B

    更新日期：2010-04-01 00:00:00

  • Combination of Lipitor and Celebrex inhibits prostate cancer VCaP cells in vitro and in vivo.

    abstract：BACKGROUND/AIM:Lipitor is a cholesterol-lowering drug and Celebrex is a Cyclooxygenase-2 inhibitor. We investigated the effects of Lipitor and Celebrex on human prostate cancer VCaP cells cultured in vitro and grown as orthotopic xenograft tumors in SCID mice. MATERIALS AND METHODS:Apoptosis was measured by morphologi...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Huang H,Cui XX,Chen S,Goodin S,Liu Y,He Y,Li D,Wang H,Van Doren J,Dipaola RS,Conney AH,Zheng X

    更新日期：2014-07-01 00:00:00

  • The correlation between CpG methylation on promoter and protein expression of E-cadherin in oral squamous cell carcinoma.

    abstract：BACKGROUND:Reduction of E-cadherin in most common epithelial tumors relates to metastasis, which results from the silence of E-cadherin by CpG methylation. MATERIALS AND METHODS:We examined the E-cadherin expression by immunohistochemical staining and detected methylation by methylation-specific polymerase chain react...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Yeh KT,Shih MC,Lin TH,Chen JC,Chang JY,Kao CF,Lin KL,Chang JG

    更新日期：2002-11-01 00:00:00

  • [111In-DTPA-D-Phe1]-octreotide scintigraphy in patients with hormone-refractory prostatic adenocarcinoma can predict therapy outcome with octreotide treatment: a pilot study.

    abstract：:A pilot study to evaluate the predictive value of Indium-111-labelled somatostatin analogue [DTPA-D-Phe1]-octreotide scintigraphy (OctreoScan111) in the Octreotide treatment of hormone-refractory prostatic adenocarcinoma was initiated. Ten patients were investigated with OctreoScan111 with regard to disease extension ...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Kälkner KM,Nilsson S,Westlin JE

    更新日期：1998-01-01 00:00:00

  • The Role of Re-resection for Breast Cancer Liver Metastases-a Single Center Experience.

    abstract：UNLABELLED:The aim of the present study was to evaluate the effectiveness and safety of hepatic re-resection for breast cancer liver metastases. PATIENTS AND METHODS:Between January 2004 and December 2014 seven patients were submitted to liver re-resection for breast cancer liver metastases at our Center. The main inc...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： BacalbaȘa N,Balescu I,Dima S,Popescu I

    更新日期：2015-12-01 00:00:00

  • Rare co-existence of mutation in KRAS and ALK gene re-arrangement in an adenocarcinoma patient--a case report.

    abstract：:Anaplastic lymphoma kinase (ALK) gene re-arrangements are present in approximately 4% of patients with non-small cell lung cancer (NSCLC), mostly in non-smokers with adenocarcinoma. V-KI-RAS2 Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations are more common in smokers. These molecular lesions were usually de...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Homa I,Sawicki M,Wojas-Krawczyk K,Nicoś M,Mlak R,Powrózek T,Krawczyk P,Przybylski P,Czekajska-Chehab E,Milanowski J

    更新日期：2014-07-01 00:00:00

  • Intracellular localization of tenascin in squamous cell carcinoma of oral cavity: an immunohistochemical study.

    abstract：:Tenascin is a multifunctional extracellular matrix glycoprotein generally expressed in epithelial tumors at sites of epithelial tumor-mesenchymal tissue interface. Studies so far have indicated that mesenchymal cells are a major source of tenascin in tumor tissues. The present study evaluated biopsies and surgically r...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Mori M,Muramatsu Y,Yamada K,Shrestha P,Takai Y

    更新日期：1996-09-01 00:00:00

  • High concentration of beta-defensin-2 in oral squamous cell carcinoma.

    abstract：:We have previously reported the presence of human beta-defensin-2 (HBD-2), a peptide with antimicrobial and cytotoxic properties, in oral squamous cell carcinomas. The aim of the present study was to measure the concentration of HBD-2 in abnormal tissues such as oral squamous cell carcinomas. HBD-2 was extracted from ...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Sawaki K,Mizukawa N,Yamaai T,Yoshimoto T,Nakano M,Sugahara T

    更新日期：2002-07-01 00:00:00

  • p53 status is neither a predictive nor a prognostic variable in patients with advanced ovarian cancer treated with a paclitaxel-based regimen.

    abstract：BACKGROUND:The aim of this study was to assess the relationship between p53 status and the clinical outcome of patients with advanced ovarian cancer treated with a paclitaxel-based regimen. PATIENTS AND METHODS:The investigation was conducted on 38 patients with FIGO stage III-IV ovarian cancer from whom tumor tissue ...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Gadducci A,Cianci C,Cosio S,Carnino F,Fanucchi A,Buttitta F,Conte PF,Genazzani AR

    更新日期：2000-11-01 00:00:00

  • The effect of a biological response modifier, PSK, on the intestinal immune system in tumor-bearing mice.

    abstract：:We have previously shown that oral administration of PSK not only exerts antitumor activity, but also restores immune response in tumor-bearing mice. In order to analyze the immunomodulative effect of PSK, we investigated the effects of oral PSK on the intestinal immune systems in ICR mice bearing sarcoma 180. Oral ad...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Matsunaga K,Morita I,Oguchi Y,Fujii T,Yoshikumi C,Nomoto K

    更新日期：1987-05-01 00:00:00

  • Immune response of rat spleen cells to a carcinogen and to vaccination with anti-p53 polyclonal antibodies.

    abstract：BACKGROUND:The tumor-suppressive effects of rabbit anti-p53 antibodies on chemically induced rat colon cancer were demonstrated previously (Cancer J, 10:116-120, 1997). METHODS:In this communication, the spleen's role in the immune response of rats to cancer and vaccination was evaluated histologically and immunohisto...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Ben-Hur H,Gurevich P,Zion H,Berman V,Tendler Y,Sandler B,Zinder O,Zusman I

    更新日期：1998-01-01 00:00:00

  • Inhibition of invasion of MCF-7/6 human breast carcinoma cells in vitro by Methanobacterium thermoautotrophicum extract.

    abstract：:Precultured embryonic chick heart fragments were confronted in vitro with various invasive tumor cell lines (MCF-7/6 human breast carcinoma variant, BW-O-LiI mouse T-cell lymphoma cells and MO4 virally transformed fetal mouse carcass cells) and with a non-invasive cell line (MCF-7/AZ human breast carcinoma variant). C...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Raemakers-Franken PC,Bracke ME,Van Larebeke N,Vyncke B,Mareel MM

    更新日期：1992-03-01 00:00:00

  • Quantitative Structure-Cytotoxicity Relationship of 2-Azolylchromones.

    abstract：BACKGROUND/AIM:Twenty-four 2-azolylchromones were subjected to quantitative structure-activity relationship (QSAR) analysis based on their cytotoxicity and tumor specificity, in order to find their new biological activities. MATERIALS AND METHODS:Cytotoxicity against two human oral squamous cell carcinoma cell lines a...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：10.21873/anticanres.12282

    authors： Sakagami H,Okudaira N,Uesawa Y,Takao K,Kagaya H,Sugita Y

    更新日期：2018-02-01 00:00:00

  • Association of thymidylate synthase gene polymorphism with its mRNA and protein expression and with prognosis in gastric cancer.

    abstract：:Thymidylate synthase (TS) is a target enzyme of 5-fluorouracil (5-FU). TS has a polymorphic repeated sequence in the 5'-UTR and the polymorphism is associated with TS protein expression. TS polymorphism has been reported to link with the efficacy of 5-FU-based chemotherapy in colorectal cancer. In this study, we exami...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Ishida Y,Kawakami K,Tanaka Y,Kanehira E,Omura K,Watanabe G

    更新日期：2002-09-01 00:00:00

  • Expression Pattern of Matrix Metalloproteinase 20 (MMP20) in Human Tumors.

    abstract：BACKGROUND/AIM:Matrix metalloproteinase 20 (MMP20) is a member of the family of matrix metalloproteinases. Under normal conditions the expression of MMP20 is restricted to ameloblasts and odontoblasts. In order to identify a possible expression of MMP20 under pathological conditions, we investigated three major human t...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Kraus D,Reckenbeil J,Perner S,Winter J,Probstmeier R

    更新日期：2016-06-01 00:00:00

  • Serum dehydroepiandrosterone and dehydroepiandrosterone sulfate and risk of melanoma or squamous cell carcinoma of the skin.

    abstract：BACKGROUND:Dehydroepiandrosterone (DHEA) and its analogs have potent chemoprotective actions in mouse skin tumorigenesis models. To assess this association in humans, we investigated the relationship of prediagnostic serum concentrations of DHEA and dehydroepiandrosterone sulfate (DHEAS) to the subsequent risk of devel...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Alberg AJ,Gordon GB,Genkinger JM,Hoffman SC,Selvin E,Comstock GW,Helzlsouer KJ

    更新日期：2001-11-01 00:00:00

  • Expression of MMP-2, MMP-7, MMP-9, MMP-10 and MMP-11 in human astrocytic and oligodendroglial gliomas.

    abstract：:The members of the matrix metalloproteinase family (MMP) have the ability to degrade macromolecules of the extracellular matrix and are responsible for tumor invasion and infiltration, limiting the effectiveness of the neurosurgical resection of brain tumors. Among the glial brain tumors, astrocytomas and oligodendrog...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Thorns V,Walter GF,Thorns C

    更新日期：2003-09-01 00:00:00

  • Activation of human monocyte-derived dendritic cells in vitro by Thymax, a gross thymic extract.

    abstract：BACKGROUND:We have recently demonstrated that Thymax, a gross thymic extract, induces an apoptotic effect against human breast cancer cells. In this study, the ability of Thymax to activate human dendritic cells (DCs) and the DC-directed T-cell response was examined in an in vitro culture model of peripheral blood mono...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Ghoneum M,Seto Y,Agrawal S

    更新日期：2009-11-01 00:00:00

  • Genomic Sequencing of Cancer-related Genes in Sinonasal Squamous Cell Carcinoma and Coexisting Inverted Papilloma.

    abstract：BACKGROUND:The genetic basis of sinonasal inverted papilloma (SNIP)-derived squamous cell carcinoma (SCC) has not yet been well characterized. AIM:To characterize the genetic abnormalities of SNIP and SNIP-derived SCC and to uncover their differences. MATERIALS AND METHODS:Mutations of 409 genes were analyzed using a...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：10.21873/anticanres.14752

    authors： Uchi R,Jiromaru R,Yasumatsu R,Yamamoto H,Hongo T,Manako T,Sato K,Hashimoto K,Wakasaki T,Matsuo M,Nakagawa T

    更新日期：2021-01-01 00:00:00

  • Short-term and low-dose prednisolone administration reduces aromatase inhibitor-induced arthralgia in patients with breast cancer.

    abstract：:Aromatase inhibitors (AIs) are important therapeutic drugs for postmenopausal women with hormone receptor-positive breast cancer. However, adverse effects of AIs such as arthralgia have been extensively reported. We performed a joint prospective, multi-institutional investigation to find out whether a low-dose and sho...

    journal_title：Anticancer research

    pub_type： 临床试验,杂志文章,多中心研究

    doi：

    authors： Kubo M,Onishi H,Kuroki S,Okido M,Shimada K,Yokohata K,Umeda S,Ogawa T,Tanaka M,Katano M

    更新日期：2012-06-01 00:00:00

  • Gastric Lavage Malignant Cells (yGL) and Hypohemoglobinemia (yAnemia) as New Systems of Tumor Regression Grading and Prognostic Prediction for Gastric Cancer After Neoadjuvant Treatment.

    abstract：BACKGROUND/AIM:Although reckoned necessary for survival benefit, neoadjuvant chemotherapy (NAC) of gastric cancer (GC) patients has so far provided questionable results. Consequently, searching for new and clearer systems of response to NAC, post-NAC re-evaluation and prognostic prediction appears essential. The purpos...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：10.21873/anticanres.13208

    authors： Virgilio E,Giarnieri E,Giovagnoli MR,Montagnini M,Proietti A,D'Urso R,Fegiz A,Mercantini P,Balducci G,Cavallini M

    更新日期：2019-02-01 00:00:00

  • Fumonisin B1 Inhibits Endoplasmic Reticulum Stress Associated-apoptosis After FoscanPDT Combined with C6-Pyridinium Ceramide or Fenretinide.

    abstract：BACKGROUND/AIM:Combining an anticancer agent fenretinide (HPR) or C6-pyridinium ceramide (LCL29) with Foscan-mediated photodynamic therapy (FoscanPDT) is expected to augment anticancer benefits of each substance. We showed that treatment with FoscanPDT+HPR enhanced accumulation of C16-dihydroceramide, and that fumonisi...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：10.21873/anticanres.11337

    authors： Boppana NB,Kraveka JM,Rahmaniyan M,Li LI,Bielawska A,Bielawski J,Pierce JS,Delor JS,Zhang K,Korbelik M,Separovic D

    更新日期：2017-02-01 00:00:00

  • Sunitinib First-line Treatment in Metastatic Renal Cell Carcinoma: Costs and Effects.

    abstract：BACKGROUND/AIM:Tyrosine kinase inhibitors are important in the treatment of metastatic renal cell cancer (mRCC). The aim of the study was to evaluate the costs and effects of sunitinib in mRCC. PATIENTS AND METHODS:A total of 81 mRCC patients who received first-line sunitinib therapy between 2010 and 2014 were recruit...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：10.21873/anticanres.13749

    authors： Vuorinen RL,Paunu N,Turpeenniemi-Hujanen T,Reunamo T,Jekunen A,Kataja V,Sintonen H,Purmonen T,Kellokumpu-Lehtinen PL

    更新日期：2019-10-01 00:00:00

  • Epithelial-Mesenchymal Transition in Non Small-cell Lung Cancer.

    abstract：BACKGROUND/AIM:Lung cancer is the first cause of cancer related deaths in both males and females. Epithelial-mesenchymal transition (EMT) is a reversible process by which epithelial cells transform to mesenchymal stem cells by losing their cell polarity and cell-to-cell adhesion, gaining migratory and invasive properti...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：10.21873/anticanres.11510

    authors： Tsoukalas N,Aravantinou-Fatorou E,Tolia M,Giaginis C,Galanopoulos M,Kiakou M,Kostakis ID,Dana E,Vamvakaris I,Korogiannos A,Tsiambas E,Salemis N,Kyrgias G,Karameris A,Theocharis S

    更新日期：2017-04-01 00:00:00

  • Prognostic significance of T helper 1 and 2 and T cytotoxic 1 and 2 cells in patients with non-small cell lung cancer.

    abstract：BACKGROUND:We report the prognostic significance of peripheral and tumor-infiltrating Th1, Th2, Tc1 and Tc2 cells in lung cancer patients. MATERIALS AND METHODS:We evaluated the rates of interferon (IFN)-gamma+/CD4+ cells (Th1), interleukin (IL)-4+ /CD4+ cells (Th2), IFN-gamma+/CD8+ cells (Tc1), IL-4+ /CD8+ cells (Tc2...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Ito N,Suzuki Y,Taniguchi Y,Ishiguro K,Nakamura H,Ohgi S

    更新日期：2005-05-01 00:00:00

  • Cytokine networks in animal models of colitis-associated cancer.

    abstract：BACKGROUND/AIM:It is well-known that inflammatory bowel disease (IBD) poses an increased, yet not definitely estimated, risk of colitis-associated colon cancer (CAC), which is considered a more aggressive and distinct in both genetic and molecular levels clinical entity compared to sporadic colorectal cancer (CRC). The...

    journal_title：Anticancer research

    pub_type： 杂志文章,评审

    doi：

    authors： Antoniou E,Margonis GA,Angelou A,Zografos GC,Pikoulis E

    更新日期：2015-01-01 00:00:00

  • Possible synergy of radiotherapy and chemo-immunotherapy in metastatic renal cell carcinoma (RCC).

    abstract：PURPOSE:Bone metastases or local recurrences are widely viewed as poor prognostic signs for successful immunotherapy for metastatic renal cell carcinoma (RCC), and even partial remission is a rarity. We assessed the efficacy of the combination of radio and chemo-immunotherapy for bone metastases or local recurrences fo...

    journal_title：Anticancer research

    pub_type： 临床试验,杂志文章

    doi：

    authors： Brinkmann OA,Bruns F,Prott FJ,Hertle L

    更新日期：1999-03-01 00:00:00

  • Induction of apoptosis in breast cancer cells by Saccharomyces cerevisiae, the baker's yeast, in vitro.

    abstract：:The present study was undertaken to evaluate the effect of phagocytosis of killed yeast on the induction of apoptosis in human metastatic breast cancer cells (MCF-7 and ZR-75-1) and non-metastatic breast cancer cells (HCC70). Heat-killed Saccharomyces cerevisiae, baker's and brewer's yeast, was cultured with cancer ce...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Ghoneum M,Gollapudi S

    更新日期：2004-05-01 00:00:00

  • Prevalent location of flat dysplastic aberrant crypt foci near lymphoid follicles in the colon of azoxymethane-treated rats.

    abstract：:In the colon of F344 rats treated with 2 x 15 mg/kg body weight of azoxymethane (AOM), the density (number of lesions/cm2/rat) of flat aberrant crypt foci (ACF) was 13-fold higher (p < 0.05) in the surface area of mucosa immediately adjacent to lymphoid follicles compared with the density of these lesions in the rest ...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Paulsen JE,Steffensen IL,Olstørn HB,Alexander J

    更新日期：2006-05-01 00:00:00

  • RT-PCR for Detecting ALK Translocations in Cytology Samples from Lung Cancer Patients.

    abstract：BACKGROUND/AIM:We evaluated the usefulness of reverse transcription-polymerase chain reaction (RT-PCR) for detecting anaplastic lymphoma kinase (ALK) translocations using cytology samples from lung cancer patients. MATERIALS AND METHODS:We analyzed ALK translocations by RT-PCR in cytology samples from lung cancer pati...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：10.21873/anticanres.11696

    authors： Nakamichi S,Seike M,Miyanaga A,Chiba M,Matsuda K,Kobayashi K,Takahashi A,Takeuchi S,Minegishi Y,Kubota K,Gemma A

    更新日期：2017-06-01 00:00:00