Primary human tumor cells and continuous cell lines differ in clonal growth in soft agar.

abstract：:Berlin-Druckrey (BD-IV) rats were used to evaluate the level of neoplastic transformation, initiation of DNA damage and repair following treatment with N-ethyl-N-nitrosourea (ENU). ENU, a potent neurocarcinogen in the Sprague-Dawley (CD) and BDIX rat strains, was a less potent neurocarcinogen when administered to 30 d...

journal_title：Anticancer research

authors： D'Ambrosio SM,Su C,Chang MJ,Oravec C,Stoica G,Koestner A

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND/AIM:Interleukin-32 (IL32) has been newly-identified as a proinflammatory cytokine. In the present study, we aimed to clarify the clinical role of IL32-positive cells in esophageal squamous cell cancer (ESCC) and regulatory T-cell (Treg) infiltration in the stroma. A total of 179 patients with ESCC who underw...

journal_title：Anticancer research

authors： Nabeki B,Ishigami S,Uchikado Y,Sasaki K,Kita Y,Okumura H,Arigami T,Kijima Y,Kurahara H,Maemura K,Natsugoe S

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:This study sought to better define the immunological impact of combining neoadjuvant total androgen suppression (TAS) with radiotherapy (xRT) in treating prostate cancer. MATERIALS AND METHODS:Subjects selected (n = 37) were stage I-II prostate cancer patients meeting the eligibility requirements for RTOG p...

journal_title：Anticancer research

authors： Johnke RM,Edwards JM,Kovacs CJ,Evans MJ,Daly BM,Karlsson UL,Lee TK,Allison RR,Arastu HH,Cariveau MJ,O'Brien KF

更新日期：2005-07-01 00:00:00

abstract：BACKGROUND:The purpose of the study was to test the feasibility of laser scanning cytometry (LSC) to simultaneously measure estrogen receptor (ER) and nucleolin (NU) expression in the nuclei of the same individual breast cancer cells. MATERIALS AND METHODS:Cancer cells from 64 breast tumors were labeled with anti-NU a...

journal_title：Anticancer research

authors： Masiuk M,Urasinska E,Domagala W

更新日期：2004-03-01 00:00:00

abstract：BACKGROUND:Cancer-related acute disseminated intravascular coagulation (DIC) is uncommon, but it is a severe complication resulting in a very dismal prognosis. Choosing the appropriate chemotherapy agents to treat the underlying cancer and stop the acute DIC process effectively, while avoiding chemotherapy-induced myel...

journal_title：Anticancer research

authors： Lin PH,Lu YS,Lin CH,Chang DY,Huang CS,Cheng AL,Yeh KH

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND:Basic conventional prognostic factors for breast cancer include the age of the patient, tumor grade, regional lymph nodes status, and estrogen (ER) and progesterone (PR) receptor status. Positivity of the HER2 receptor (c-erbB-2) seems to be a new prognostic and predictive factor. Prognostic factors seem to ...

journal_title：Anticancer research

authors： Finek J,Holubec L Jr,Topolcan O,Elgrova L,Skalova A,Pecen L

更新日期：2007-07-01 00:00:00

abstract：:Bone only metastasis in patients with estrogen receptor (ER) positive breast cancer reported to have favorable response to chemotherapy, favorable prognosis, and an "indolent" course. Therefore, we assessed the ability of MG-63 osteoblast-like human osteosarcoma cells (MG-63 cells) and MG-63 conditioned media (CM) to ...

journal_title：Anticancer research

authors： Choki I,Sourla A,Reyes-Moreno C,Koutsilieris M

更新日期：1998-11-01 00:00:00

abstract：AIM:The purpose of this study was to identify patient-, facility-, disease-, and treatment-specific characteristics that increase mortality in patients with upper limb osteosarcoma. PATIENTS AND METHODS:The National Cancer Data Base (NCDB) was queried for bone cancer. With Cox regression, the demographic, facility, tu...

journal_title：Anticancer research

authors： Restrepo DJ,Huayllani MT,Boczar D,Sisti A,Spaulding AC,Carter RE,Moran SL,Parker AS,Perdikis G,Forte AJ

更新日期：2019-09-01 00:00:00

abstract：:A 70-year-old man with a growing liver tumor had undergone subtotal gastrectomy with pancreaticoduodenectomy for gastric cancer (T4b P0 H0 N1, Stage IIIB) 30 months before admission to our hospital. Enhanced computed tomography revealed two hypervascular nodules in segments 4 and 8. After histological diagnosis of sma...

journal_title：Anticancer research

authors： Kinoshita K,Beppu T,Miyata T,Kuramoto K,Yoshida Y,Umesaki N,Kitano Y,Nakagawa S,Okabe H,Nitta H,Imai K,Hayashi H,Yamashita YI,Komori H,Horino K,Misumi A,Baba H

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND/AIM:The Glasgow Prognostic Score (GPS), an inflammation-based prognostic score, has been shown to predict the clinical outcomes of a variety of cancer types. The aim of this study was to determine whether the GPS predicts clinical outcomes of patients with pancreatic cancer treated with adjuvant chemotherapy...

journal_title：Anticancer research

authors： Morinaga S,Murakawa M,Katayama Y,Yamaoku K,Aoyama T,Kanazawa A,Higuchi A,Shiozawa M,Kobayashi S,Ueno M,Morimoto M

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:NSC697923, a ubiquitin-conjugating enzyme E2 (UBE2) inhibitor, was suggested as an agent to degrade hypoxia-inducible factor 1 alpha subunit (HIF1α), a key factor in radiation resistance. We attempted to clarify whether NSC697923 could overcome radiation resistance. MATERIALS AND METHODS:Radiation resistanc...

journal_title：Anticancer research

authors： Gombodorj N,Yokobori T,Yoshiyama S,Kawabata-Iwakawa R,Rokudai S,Horikoshi I,Nishiyama M,Nakano T

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:Mistletoe lectins (ML), the major biologically active components of mistletoe extracts, which are used for adjuvant cancer therapy, induce apoptosis in lymphocytes and tumor cells. In addition, ML at toxic concentrations induce the release of cytokines, but it remains unclear as to whether dying or activated...

journal_title：Anticancer research

authors： Stein GM,Pfüller U,Schietzel M,Büssing A

更新日期：2000-05-01 00:00:00

abstract：AIM:To evaluate the tolerability and efficacy of oxaliplatin-based chemotherapy (OBC) in patients ≥ 75 years old with metastatic colorectal cancer (CRC). PATIENTS AND METHODS:We reviewed the medical records of 126 patients with unresectable stage IV CRC in terms of OBC administered as first-line chemotherapy whenever ...

journal_title：Anticancer research

authors： Fukuchi M,Ishibashi K,Tajima Y,Okada N,Yokoyama M,Chika N,Hatano S,Matsuzawa T,Kumamoto K,Kumagai Y,Baba H,Mochiki E,Ishida H

更新日期：2013-10-01 00:00:00

abstract：AIM:To compare clinical outcome in patients with Child-Pugh C hepatocellular carcinoma (HCC) treated with non-transplant therapies and those treated with best supportive care. PATIENTS AND METHODS:A total of 182 patients with HCC with Child-Pugh C cirrhosis were analyzed. Patients were classified into two groups: pati...

journal_title：Anticancer research

authors： Nishikawa H,Kita R,Kimura T,Ohara Y,Takeda H,Sakamoto A,Saito S,Nishijima N,Nasu A,Komekado H,Osaki Y

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:Antisense telomerase RNA (anti-hTR) coupled with 2',5'-linked tetraadenylate (2-5A) shows an inhibitory effect on cell growth and induces apoptosis in certain kinds of cancer. This experiment examined the anti-hTR effect on gastric and colorectal cancer cells. MATERIALS AND METHODS:Gastric cancer cells CRL-...

journal_title：Anticancer research

authors： Wong SC,Yu H,Moochhala SM,So JB

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:The activity of tyrosine kinases, although strictly regulated in normal cells, is often disturbed in cancer cells. The inhibition of a tyrosine kinase could be a target for treating cancer. MATERIALS AND METHODS:The colon cancer cell lines LS174T and HT-29 and the lung cancer cell line NCI-H292 were used. T...

journal_title：Anticancer research

authors： Saito K,Iwashita J,Murata J,Abe T

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND/AIM:Fluorescence-guided surgery (FGS) of cancer is an emerging technology. We have previously shown the importance of resecting both the tumor and the tumor microenvironment (TME) for curative FGS. We also previously developed a syngeneic model using the mouse lymphoma cell line EL-4, expressing red fluoresc...

journal_title：Anticancer research

authors： Hasegawa K,Suetsugu A,Nakamura M,Matsumoto T,Kunisada T,Shimizu M,Saji S,Moriwaki H,Bouvet M,Hoffman RM

更新日期：2016-09-01 00:00:00

abstract：:The use of gene-modified dendritic cells (DC) is a powerful tool to enhance antitumor immune responses stimulated by these cells in cancer immunotherapy. Cationized gelatin is preferably incorporated via phagocytosis and is gradually degraded by proteolysis while buffering lysosomal activity. This may be appropriate f...

journal_title：Anticancer research

authors： Inada S,Fujiwara H,Atsuji K,Takashima K,Araki Y,Kubota T,Tabata Y,Yamagishi H

更新日期：2006-05-01 00:00:00

abstract：:Complementary antitumor treatments are required to increase the cure rate achieved by surgery and/or radiotherapy by avoiding future recurrences and metastases. The growth of most solid tumors, particularly carcinomas, depends upon the simultaneous development of internal tumor vasculature to allow the proliferation o...

journal_title：Anticancer research

authors： Madarnas P,Benrezzak O,Nigam VN

更新日期：1989-07-01 00:00:00

abstract：:Metastatic pancreatic malignant melanoma is considered to be a highly aggressive neoplasm, and only few metastasectomies for lesions originating from the skin or the ocular region have been reported. We report a case of resection of pancreatic metastasis of malignant melanoma originating from the nasal cavity. An isol...

journal_title：Anticancer research

authors： Sugimoto M,Gotohda N,Kato Y,Takahashi S,Kinoshita T,Shibasaki H,Kojima M,Ochiai A,Zenda S,Akimoto T,Konishi M

更新日期：2013-02-01 00:00:00

abstract：:To determine the group of patients for whom a biological response modifier is useful, the efficacy of postoperative adjuvant immunotherapy was investigated with regard to infiltration of dendritic cells (DC) in patients with advanced gastric cancer who underwent absolute curative resection. The infiltration of DC was ...

journal_title：Anticancer research

authors： Tsujitani S,Kakeji Y,Orita H,Watanabe A,Kohnoe S,Baba H,Anai H,Maehara Y,Sugimachi K

更新日期：1992-05-01 00:00:00

abstract：BACKGROUND:Loss of heterozygosity (LOH) may be a valuable tool for detection of malignant proceedings. The aim of our study was to investigate LOH in the serum of patients with adenocarcinoma of the distal oesophagus and the cardia for diagnostic and prognostic utility. PATIENTS AND METHODS:Matched tumour and serum sa...

journal_title：Anticancer research

authors： Wachowiak R,Kaifi JT,Schurr PG,Merkert P,Yekebas E,Schwarzenbach H,Strate T,Sauter G,Izbicki JR

更新日期：2007-01-01 00:00:00

abstract：:As a new treatment protocol for neuroblastoma, the chimeric (human/mouse) antiganglioside GD2 antibody chl4.18 is being clinically tested. To improve the therapeutic effect of the antibody alone, we are currently investigating the cytotoxicity of glucose-oxidase coupled to the antibody chl4.18 on spheroids of the neur...

journal_title：Anticancer research

authors： Heiss P,Bernatz S,Bruchelt G,Senekowitsch-Schmidtke R

更新日期：1997-07-01 00:00:00

abstract：BACKGROUND/AIM:Protein-bound polysaccharide-K (PSK) is extracted from Coriolus versicolor (CM101) and is clinically used in combination therapy for gastrointestinal cancer and small-cell lung carcinoma. We have previously demonstrated that PSK induces apoptosis and inhibites proliferation of promyelomonocytic leukemia ...

journal_title：Anticancer research

authors： Hirahara N,Edamatsu T,Fujieda A,Fujioka M,Wada T,Tajima Y

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND/AIM:Primary brain tumors are unique tumors due to their different pathobiological behavior, while they rarely metastasize outside the central nervous system. Regarding the oncogenesis of primary brain tumors, it was shown that changes in functions of p16 and mouse double minute 2 homolog (MDM2) are related t...

journal_title：Anticancer research

authors： Kafadar A,Küçükhüseyin Ö,Turan S,Yenilmez EN,Tunoglu S,Zeybek U,Kaynar MY,Kemerdere R,Yaylim I

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:It has been suggested that prognosis in familial breast cancer could be influenced by the parent of origin, with a worse prognosis when inherited paternally. This study aimed to investigate the effect of the parent of origin on prognosis. PATIENTS AND METHODS:Index patients were divided into two study group...

journal_title：Anticancer research

authors： Wendt C,Lindblom A,Arver B,VON Wachenfeldt A,Margolin S

更新日期：2017-03-01 00:00:00

abstract：:We investigated the signal transduction pathway to low-dose radiation-induced apoptosis in vitro in the human peripheral primitive neuroectodermal tumor (pPNET) cell line with wild-type p53 established in our laboratory. Apoptosis was induced by 2Gy irradiation in an almost p53-dependent manner in this model except fo...

journal_title：Anticancer research

authors： Imai R,Akimoto T,Maebayashi K,Ishikawa H,Sakurai H,Saitoh J,Hasegawa M,Mitsuhashi N,Nakano T

更新日期：2002-09-01 00:00:00

abstract：:L-Histidinol, a structural analogue of the essential amino acid L-histidine, enhances the toxicity of a variety of anticancer drugs for many tumor cells of animal origin. In this study, the effects of L-histidinol on the proliferation and anticancer drug susceptibility of two human tumor cell lines of lymphoid origin,...

journal_title：Anticancer research

authors： Warrington RC,Cheng I,Zhang L,Fang WD

更新日期：1993-11-01 00:00:00

abstract：AIM:Maximal cytoreduction to minimal residual tumor is the most important determinant of prognosis in patients with advanced stage epithelial ovarian cancer (EOC). Preoperative prediction of suboptimal cytoreduction, defined as residual tumor >1 cm, could guide treatment decisions and improve counseling. The objective ...

journal_title：Anticancer research

authors： Gerestein CG,Eijkemans MJ,Bakker J,Elgersma OE,van der Burg ME,Kooi GS,Burger CW

更新日期：2011-11-01 00:00:00

abstract：:260 CB57BL/J6 mice were used in an experimental protocol designed to investigate the effects of 4 different varieties of splenectomy on the growth rate of subcutaneously implanted GB-16 melanoma. In addition, the mean and absolute survival of the mice, the histopathology of the tumour and the effects of the same proce...

journal_title：Anticancer research

authors： Fotiadis C,Zografos G,Aronis K,Troupis TG,Gorgoulis VG,Sechas MN,Skalkeas G

更新日期：1999-09-01 00:00:00