Abstract:
BACKGROUND/AIM:We have previously reported that alternate-day S-1 had comparable effects and milder adverse events than the respective consecutive-day regimen in head and neck cancer (HNC) patients. The aim of this study was to investigate the anticancer effects of both regimens and underlying mechanisms in vitro. MATERIALS AND METHODS:Two head and neck squamous cell carcinoma (HNSCC) cell lines were treated with 5-FU given on an alternate-day or consecutive-day schedule. The relative inhibition (RI) of tumor growth was calculated. Cell cycle distributions and cyclin expression following 5-FU treatment were analyzed. RESULTS:The RI of both regimens was almost identical. The percentage of cells in S phase was significantly increased in the alternate-day group compared to the consecutive-day group (p<0.001). CONCLUSION:The cytotoxic effect of alternate-day was equivalent to that of consecutive-day. S-phase arrest was more prominently observed with the alternate-day regimen, which may help maintain 5-FU sensitivity in head and neck cancer cells.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Moro Y,Kogashiwa Y,Sakurai H,Takahashi R,Kimura T,Hirasaki M,Matsumoto Y,Sugasawa M,Kohno Ndoi
10.21873/anticanres.13810subject
Has Abstractpub_date
2019-11-01 00:00:00pages
6041-6047issue
11eissn
0250-7005issn
1791-7530pii
39/11/6041journal_volume
39pub_type
杂志文章abstract::Chloroform (CHCl3) is an established rodent carcinogen and a prevalent contaminant of chlorine-disinfected drinking water. Thus in the United States CHCl3, along with other trihalomethanes, is regulated not to exceed 100 ppb in potable water. Recently, several studies have shown that CHCl3 also has anti-cancer propert...
journal_title:Anticancer research
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pub_type: 杂志文章,多中心研究
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journal_title:Anticancer research
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