Increased reduction of nitroblue tetrazolium by human blood monocytes following post-operative radiation therapy for breast cancer.

abstract：:Primary cultures from 30 human gliomas (26 high grade, 3 low grade, and one oligoastrocytoma) were studied to examine the mixture of cells that make up the outgrowth, and their interactions. GFAP + ve Fibronectin - ve cells had a predominantly process forming (PF) morphology and formed complex networks around explants...

journal_title：Anticancer research

authors： Franks AJ,Burrow HM

更新日期：1986-07-01 00:00:00

abstract：:The immune system is part of the homeostasis system. Our research is focused on ways to maintain health, with an emphasis on the role of macrophages. We have hypothesized that tissue macrophages form a systemic network which we believe contributes to the homeostasis system, and have named it the 'macrophage network.' ...

journal_title：Anticancer research

authors： Taniguchi Y,Yoshioka N,Nishizawa T,Inagawa H,Kohchi C,Soma G

更新日期：2009-03-01 00:00:00

abstract：:Recently, two new tumor markers for bladder cancer have been introduced: NMP22 test and BTA TRAK assay. This study was designed to evaluate the urinary values of these two proteins using quantitative enzyme immunoassays in well microplates. Urine samples from 47 healthy subjects, 26 with benign genitourinary disorders...

journal_title：Anticancer research

authors： Abbate I,D'Introno A,Cardo G,Marano A,Addabbo L,Musci MD,Pagliarulo A,Correale M,Quaranta M

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND/AIM:To clarify whether renal dysfunction affects the incidence of adverse events associated with oxaliplatin, the present study was designed to investigate the relationship between creatinine clearance (Ccr) and the incidence of oxaliplatin-related adverse events. PATIENTS AND METHODS:A total of 287 CRC pat...

journal_title：Anticancer research

authors： Watanabe D,Fujii H,Yamada Y,Iihara H,Ishihara T,Matsuhashi N,Takahashi T,Yoshida K,Suzuki A

更新日期：2020-01-01 00:00:00

abstract：:The etiologic variables involved in the increased incidence of colorectal carcinoma in patients with chronic ulcerative colitis have not been defined. Sulfasalazine is the most commonly used medication in the treatment of ulcerative colitis. It is not known whether the pharmacologic treatment of ulcerative colitis alt...

journal_title：Anticancer research

authors： Andrianopoulos GD,Nelson RL,Barch DH,Nyhus LM

更新日期：1989-11-01 00:00:00

abstract：BACKGROUND/AIM:Polyamines are important for the growth of eukaryotic cells. At high levels, they promote proliferation, invasion and migration of tumour cells. Polyamine metabolism is an important new target for anticancer therapy. Some polyamine analogues can have an inhibitory effect on tumour cells. The aim of this ...

journal_title：Anticancer research

authors： Ploskonos MV,Syatkin SP,Neborak EV,Hilal A,Sungrapova KY,Sokuyev RI,Blagonravov ML,Korshunova AY,Terentyev AA

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:No investigation of amrubicin monotherapy in pre-treated advanced non-small cell lung cancer (NSCLC) patients has yet been reported. PATIENTS AND METHODS:The records were reviewed of NSCLC patients who had received amrubicin monotherapy between 2003 and 2007 with the following eligibility criteria:previousl...

journal_title：Anticancer research

authors： Igawa S,Takahashi T,Nakamura Y,Tsuya A,Ono A,Shukuya T,Murakami H,Endo M,Yamamoto N

更新日期：2008-11-01 00:00:00

abstract：UNLABELLED:Gastric carcinoma occurs in response to chronic inflammation of gastric mucosa infected with Helicobacter pylori. It is not known how cytokines affect the growth and progression of gastric carcinoma. MATERIALS AND METHODS:We measured tissue concentrations of the proinflammatory cytokines interleukin (IL)-1b...

journal_title：Anticancer research

authors： Kai H,Kitadai Y,Kodama M,Cho S,Kuroda T,Ito M,Tanaka S,Ohmoto Y,Chayama K

更新日期：2005-03-01 00:00:00

abstract：BACKGROUND/AIM:Malignant mesothelioma is a rare malignancy with limited therapeutic options. Exome-based next-generation sequencing (NGS) techniques may direct the future of molecular targeting and improve systemic therapies for patients with mesothelioma. MATERIALS AND METHODS:Eleven patients with NGS testing were se...

journal_title：Anticancer research

authors： Ugurluer G,Chang K,Gamez ME,Arnett AL,Jayakrishnan R,Miller RC,Sio TT

更新日期：2016-05-01 00:00:00

abstract：:The expression of the proto-oncogene c-myc has been strongly implicated in the regulation of apoptosis. Since we have previously shown apoptosis to occur in HL-60 leukemic cells exposed to the prodrug Mafosfamide (ASTA Z 7557), the present study was undertaken to examine the levels of c-myc mRNA transcripts in such ce...

journal_title：Anticancer research

authors： Davidoff AN,Mendelow BV

更新日期：1993-07-01 00:00:00

abstract：BACKGROUND:Cyclin D1 is a key protein involved in cell cycle regulation. A common A870G single nucleotide polymorphism in exon 4 of the cyclin D1 gene (CCND1) has an effect on the transcription of two different cyclin D1 mRNAs. Association of the genetic polymorphism of A870G of CCND1 with several cancer risks has been...

journal_title：Anticancer research

authors： Koike H,Suzuki K,Satoh T,Ohtake N,Takei T,Nakata S,Yamanaka H

更新日期：2003-11-01 00:00:00

abstract：BACKGROUND:Zoledronate (Zol), an anti-osteoclastic and anticancer drug, is used to control bone metastasis in several cancer types, including non-small cell lung cancer (NSCLC). However, the mechanisms behind Zol resistance in NSCLC are unclear. MATERIALS AND METHODS:Zol-resistant cell lines were developed by repeated...

journal_title：Anticancer research

authors： Aoyagi T,Morii T,Ohtsuka K,Ohnishi H,Tajima T,Yoshiyama A,Mochizuki K,Satomi K,Ichimura S

更新日期：2013-12-01 00:00:00

abstract：:The design of treatment for patients with squamous cell carcinoma of the head and neck (SCCHN) is based on prognostic factors, today essentially performance status and TNM status. It becomes increasingly important to optimise treatment and find the appropriate level of treatment and resource consumption for each patie...

journal_title：Anticancer research

authors： Wennerberg J

更新日期：1996-07-01 00:00:00

abstract：BACKGROUND:Despite having disseminated cancer, not all patients are eligible for palliative chemotherapy or targeted therapies. AIM:To study reasons for withholding palliative chemotherapy, to survey which alternatives were offered and to study survival outcomes. MATERIALS AND METHODS:Medical records of 346 patients ...

journal_title：Anticancer research

authors： Randén M,Runesdotter S,Strang P

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Multidrug resistance (MDR) is one of the major obstacles limiting the efficacy of cancer chemotherapy. Through screening a series of natural products, we have previously identified six naturally occurring bisbenzylisoquinoline alkaloids (BBIs) that possess potent activity to reverse P-glycoprotein (gp)-media...

journal_title：Anticancer research

authors： Zhu X,Sui M,Fan W

更新日期：2005-05-01 00:00:00

abstract：AIM:This retrospective observational study evaluated the role of hypo-fractionated stereotactic radiotherapy (SRT) in patients with oligo-progressive metastatic renal cell carcinoma (mRCC) treated with first-line oral tyrosine kinase inhibitors (TKI). Data on local control, delay of further progression, and safety are ...

journal_title：Anticancer research

authors： Gebbia V,Girlando A,DI Grazia A,Fazio I,Borsellino N,Piazza D,Serretta V,Pergolizzi S,Pontoriero A,Firenze A,Valerio MR

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND/AIM:5-Aminolevulinic acid (5-ALA), a precursor of protoporphyrin IX (PpIX), is now used for photodynamic therapy (PDT) of pre-cancers of the skin and photodynamic diagnosis (PDD) of brain tumors. Sonodynamic therapy (SDT) of cancers with ultrasound has been studied using 5-ALA as a sonosensitizer. In this ar...

journal_title：Anticancer research

authors： Shimamura Y,Tamatani D,Kuniyasu S,Mizuki Y,Suzuki T,Katsura H,Yamada H,Endo Y,Osaki T,Ishizuka M,Tanaka T,Yamanaka N,Kurahashi T,Uto Y

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:Principal caregivers (PCs) of cancer patients experience high levels of stress that may significantly impact their quality of life (QoL). PCs' QoL during early phases of the disease (when patients were still on chemotherapy) were assessed. PATIENTS AND METHODS:The PCs of all patients meeting the inclusion c...

journal_title：Anticancer research

authors： Pellegrino R,Formica V,Portarena I,Mariotti S,Grenga I,Del Monte G,Roselli M

更新日期：2010-11-01 00:00:00

abstract：:Two rat yolk sac tumour cell lines with different radiosensitivities were used to quantify the extent of apoptosis following irradiation by using a DNA fragmentation assay in vitro. Apoptosis was also confirmed by fluorescence analysis of nuclear morphological changes by using Hoechst 33258. A radiosensitive cell line...

journal_title：Anticancer research

authors： Mitsuhashi N,Ishikawa H,Saito Y,Takahashi T,Sakurai H,Nozaki M,Akimoto T,Hasegawa M,Maebayashi K,Niibe H

更新日期：1997-09-01 00:00:00

abstract：AIM:To determine the effectiveness of postoperative concurrent daily low-dose cisplatin-based chemoradiation (CCRT) in patients with high-risk cervical cancer. PATIENTS AND METHODS:Patients with stage IB, IIA, or IIB cervical cancer who were initially treated with radical hysterectomy and pelvic lymphadenectomy, and w...

journal_title：Anticancer research

authors： Mitsuhashi A,Uno T,Usui H,Tate S,Hirashiki K,Kato K,Kiyohara H,Kato S,Ito H,Shozu M

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Previously, the antitumour activity of some flavone-8-acetic acid (FAA) derivatives substituted with an acid function in position 2 of the benzene ring was evaluated. The most active compound resulted the one bearing a fluorine atom in position 7 of the flavone nucleus. In this paper, we evaluated new mono- ...

journal_title：Anticancer research

authors： Carrara M,Zampiron A,Barbera M,Caputo A,Bisi A,Gobbi S,Belluti F,Piazzi L,Rampa A,Valenti P

更新日期：2005-03-01 00:00:00

abstract：:Adrenomedullin (AM) is a hypotensive polypeptide that has been shown to stimulate cyclic AMP and intracellular free Ca2+ agents that are known to induce expression of proto-oncogenes, in various cell types. Transforming growth factor-beta 1 (TGF-beta1) is a multifunctional polypeptide that regulates proliferation, dif...

journal_title：Anticancer research

authors： Kane S,Prentice MA,Mariano JM,Cuttitta F,Jakowlew SB

更新日期：2002-05-01 00:00:00

abstract：:The melastatin-like transient receptor potential M2 (TRPM2) channel is a Ca2+ permeable channel that is activated by reactive oxygen species (ROS), and its activation induces necrotic cell death. The effect of insertion of TRPM2 into A172 human glioblastoma cells (A172 cells) was investigated. The insertion of TRPM2 c...

journal_title：Anticancer research

authors： Ishii M,Oyama A,Hagiwara T,Miyazaki A,Mori Y,Kiuchi Y,Shimizu S

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND/AIM:Malignant tumors of the salivary glands are rare and heterogeneous, with more than 20 subtypes, and classified mainly by histopathology. Their diagnosis is often challenging and their etiology unknown. Here, the possible association between human polyomaviruses (PyVs) and one or more salivary gland tumor...

journal_title：Anticancer research

authors： Ramqvist T,Ursu RG,Haeggblom L,Mirzaie L,Gahm C,Hammarstedt-Nordenvall L,Dalianis T,Näsman A

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:Despite a substantial body of epidemiological evidence, there is only a limited indication that gonadotropins and steroids have growth regulating functions in ovarian cancer. To elucidate the role of gonadotropins in regulating steroid metabolism in human ovarian cancer, we analyzed the modulation of estradi...

journal_title：Anticancer research

authors： Kraemer S,Jaeger WH,Lang N

更新日期：2001-05-01 00:00:00

abstract：:In tumor cells, doxorubicin (DOX) is excreted by P-glycoprotein (P-gp) and the multidrug resistance-associated protein (mrp). Both transporters might also be involved in cellular regulatory volume decrease (RVD). To study the hepatobiliary excretion of DOX during RVD, isolated livers of Wistar and multidrug resistance...

journal_title：Anticancer research

authors： Gaugg M,Haslmayer P,Jäger W,Thalhammer T

更新日期：2001-07-01 00:00:00

abstract：PURPOSE:Investigation of the oxygenation status of organotypic multicellular spheroids (OMS) and their response to irradiation. MATERIALS AND METHODS:Tumour specimens of glioblastoma multiforme patients (n = 16) were initiated as OMS. Following 20 Gy gamma-irradiation, the cell migratory capacity was evaluated. Sphero...

journal_title：Anticancer research

authors： Sminia P,Acker H,Eikesdal HP,Kaaijk P,Enger Pø,Slotman B,Bjerkvig R

更新日期：2003-03-01 00:00:00

abstract：BACKGROUND/AIM:Bladder cancer (BLCA, urothelial bladder cancer) is one of the most common malignancies with increasing incidence and mortality worldwide. Poor diagnosis and the limitation of treatment is still an unmet need in clinical practice. γδ T-Cells have been paid increasing attention because of their potent cyt...

journal_title：Anticancer research

authors： Pan Y,Chiu YH,Chiu SC,Cho DY,Lee LM,Wen YC,Whang-Peng J,Hsiao CH,Shih PH

更新日期：2020-09-01 00:00:00

abstract：:Human immortal cells maintain their telomeres either by telomerase or by alternative lengthening of telomeres (ALT) that is based on homologous telomeric recombination. Previous studies showed that the ALT mechanism is activated in non-ALT cells when heterochromatic features are reduced. In this study, we examined the...

journal_title：Anticancer research

authors： Jung AR,Yoo JE,Shim YH,Choi YN,Jeung HC,Chung HC,Rha SY,Oh BK

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND/AIM:Intrapelvic bleeding after extended pelvic surgery is fatal, but few reports have addressed this serious situation. The objective of the present study was to evaluate the short-term clinical outcome of this complication. PATIENTS AND METHODS:This study was a retrospective medical chart review of 130 pat...

journal_title：Anticancer research

authors： Ogawa H,Mizushima T,Takemasa I,Yamamoto H,Doki Y,Mori M

更新日期：2014-06-01 00:00:00