Abstract:
BACKGROUND:Prediction of biological behavior is crucial for selection of new therapeutic modalities in GIST. Here, we aimed to assess whether KIT and PDGFRA mutations have survival impact in gastrointestinal stromal tumors (GIST). PATIENTS AND METHODS:Fifty-five Brazilian patients with completely resected GIST were examined for KIT and PDGFRA mutations. The 5-year disease-free survival (DFS) was analyzed. RESULTS:KIT and PDGFRA mutations were identified in 74.5% and 7.3% of patients, respectively. The 5-year DFS rate for all patients was 52.8%. The 5-year DFS rate was lower in patients with tumors having in-frame deletions or concomitant in-frame deletions and insertions affecting codons 557-558 than in patients with tumors having other exon 11 KIT mutations (p=0.023). Conversely, when the patients with concomitant deletion-insertion mutations affecting codons 557-558 were excluded from the analysis, deletions involving codons 557-558 had no influence on 5-year DFS rates. CONCLUSION:Our findings indicate that a specific KIT mutation may be associated with unfavorable behavior in GIST. This finding may have implications on selecting patients for adjuvant therapy.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Braggio E,Braggio Dde A,Small IA,Lopes LF,Valadão M,Gouveia ME,Moreira Ados S,Linhares E,Romano S,Bacchi CE,Renault IZ,Guimarães DP,Ferreira CGsubject
Has Abstractpub_date
2010-06-01 00:00:00pages
2407-14issue
6eissn
0250-7005issn
1791-7530pii
30/6/2407journal_volume
30pub_type
杂志文章abstract:BACKGROUND:Oxi4503 has been shown to inhibit tumor growth and improve survival in an animal model of colorectal (CRC) liver metastases. This agent appears to selectively target the endothelial cytoskeleton with resultant vessel occlusion and tumor necrosis. MATERIALS AND METHODS:This study evaluated the pattern of tum...
journal_title:Anticancer research
pub_type: 杂志文章
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journal_title:Anticancer research
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journal_title:Anticancer research
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journal_title:Anticancer research
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journal_title:Anticancer research
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journal_title:Anticancer research
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journal_title:Anticancer research
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journal_title:Anticancer research
pub_type: 杂志文章
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pub_type: 杂志文章,评审
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journal_title:Anticancer research
pub_type: 杂志文章
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journal_title:Anticancer research
pub_type: 杂志文章,评审
doi:
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2011-11-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
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journal_title:Anticancer research
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2013-05-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
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doi:
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doi:
更新日期:2016-04-01 00:00:00
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journal_title:Anticancer research
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doi:
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journal_title:Anticancer research
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doi:
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doi:
更新日期:2015-09-01 00:00:00
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doi:
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pub_type: 杂志文章,meta分析
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