LEA.135 expression: identifies low-risk patients with breast ductal carcinoma in situ.

Abstract:

:The expression of a cell surface-associated sialoglycoprotein (LEA.135), which has been shown to be significantly associated with decreased incidence of recurrence and increased overall survival of patients with primary invasive breast carcinoma, was evaluated in a retrospective study to identify subsets of patients with breast ductal carcinoma in situ (DCIS) who are at high risk of subsequently developing invasive breast carcinoma. The study was carried out by an immuno-histochemical method on formalin-fixed and paraffin-embedded tissue sections from 63 patients initially with DCIS. Pathological parameters such as DCIS histological type, nuclear grade, as well as time and type of recurrence (either a second DCIS or the diagnosis of locally invasive breast carcinoma) together with follow-up in years were available for the cohort of patients. A comparison of recurrence was made of patients whose tumor cells exhibited LEA.135 expression (24 +/- 8% recurring by 7 years), compared with those patients whose specimens showed the absence of LEA.135 expression (41 +/- 10% recurring by 7 years). A statistically significant univariant association between LEA.135 expression and the absence of recurrence of DCIS or development of locally invasive breast carcinoma was observed, suggesting a favorable prognostic significance of LEA. 135 expression (log-rank p = 0.032). It is worthy of mention that none of the LEA. 135-positive patients developed recurrence as DCIS or locally invasive breast carcinoma (0.24 +/- 0.08) after 5 years of the initial diagnosis of DCIS, whereas those from LEA. 135-negative progressively increased their recurrence at 5 years (0.30 +/- 0.09), 7 years (0.41 +/- 0.10) and 10 years (0.63 +/- 0.12). The results of this pilot study show that LEA.135 expression is significantly associated with a favorable prognosis of patients with DCIS, leading to a decreased incidence of recurrence.

journal_name

Anticancer Res

journal_title

Anticancer research

authors

Baltayan A,Naritoku WY,Chaiwun B,Tsao-Wei DD,Groshen S,Hern RA,Gusterson BA,Taylor CR,Imam SA

subject

Has Abstract

pub_date

2002-09-01 00:00:00

pages

2933-7

issue

5

eissn

0250-7005

issn

1791-7530

journal_volume

22

pub_type

杂志文章
  • Dual targeting of tumor vasculature: combining Avastin and vascular disrupting agents (CA4P or OXi4503).

    abstract:BACKGROUND:This study evaluated the therapeutic efficacy of combining vascular disrupting agents with antiangiogenic agents. MATERIALS AND METHODS:Human clear cell renal carcinoma (Caki-1) tumors were established in nude mice. Treatments consisted of Avastin (2 mg/kg) administered twice a week; CA4P (100 mg/kg) or OXi...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Siemann DW,Shi W

    更新日期:2008-07-01 00:00:00

  • A possible clinical adaptation of CRM197 in combination with conventional chemotherapeutic agents for ovarian cancer.

    abstract:AIM:Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a promising target for cancer therapy. We have already started a phase I study of CRM197, a specific HB-EGF inhibitor, for advanced ovarian cancer. In this study, we evaluated possible clinical adaptations of CRM197 in combination with conventio...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Tsujioka H,Fukami T,Yotsumoto F,Ueda T,Hikita S,Takahashi Y,Kondo H,Kuroki M,Miyamoto S

    更新日期:2011-07-01 00:00:00

  • Citric acid induces cell-cycle arrest and apoptosis of human immortalized keratinocyte cell line (HaCaT) via caspase- and mitochondrial-dependent signaling pathways.

    abstract::Citric acid is an alpha-hydroxyacid (AHA) widely used in cosmetic dermatology and skincare products. However, there is concern regarding its safety for the skin. In this study, we investigated the cytotoxic effects of citric acid on the human keratinocyte cell line HaCaT. HaCaT cells were treated with citric acid at 2...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Ying TH,Chen CW,Hsiao YP,Hung SJ,Chung JG,Yang JH

    更新日期:2013-10-01 00:00:00

  • Gn-RH antagonist possible response, after Gn-RH agonist failure in a man with metastatic prostate cancer.

    abstract::Gn-RH agonists or surgical castration are considered standard treatment for patients affected by metastatic prostate cancer. Despite greater cost, chemical castration is often considered the treatment of choice as it is psychologically better tolerated. We report our experience of one patient undergoing treatment with...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Rocco B,Ferrari M,Scardino E,Matei DV,Verweij F,Varela R,De Cobelli O

    更新日期:2005-01-01 00:00:00

  • Pooled-analysis of Lipegfilgrastim Effectiveness and Safety Among Patients With Blood Malignancies in the Real-world Setting.

    abstract:BACKGROUND/AIM:The aim of this report was to summarize the real-world experience with lipegfilgrastim as a neutropenia prophylaxis in a large cohort of lymphoma patients receiving immuno-, chemo-therapy. PATIENTS AND METHODS:Observational clinical data were derived from two phase IV studies (NADIR and LEOS) with simil...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:10.21873/anticanres.14782

    authors: Pettengell R,Wolff T,Goehler T,Cascavilla N

    更新日期:2021-01-01 00:00:00

  • Oral Squamous Cell Carcinoma-derived Sonic Hedgehog Promotes Angiogenesis.

    abstract:BACKGROUND:Sonic hedgehog (SHH) signaling is related to the pathogenesis of oral squamous cell carcinoma (OSCC), but its role in OSCC is not yet well understood. In this study, we analyzed the role of SHH signaling in OSCC. MATERIALS AND METHODS:We examined the expression pattern of SHH and its signal proteins in clin...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:10.21873/anticanres.12132

    authors: Kuroda H,Kurio N,Shimo T,Matsumoto K,Masui M,Takabatake K,Okui T,Ibaragi S,Kunisada Y,Obata K,Yoshioka N,Kishimoto K,Nagatsuka H,Sasaki A

    更新日期:2017-12-01 00:00:00

  • Induction of expression of osteopontin (OPN; secreted phosphoprotein) in metastatic, ras-transformed NIH 3T3 cells.

    abstract::We have previously shown that transfection of NIH 3T3 cells with the T24 H-ras oncogene converts the cells to a tumorigenic and metastatic phenotype, in proportion to levels of ras expression. We hypothesize that ras-induced increases in malignancy occur via altered expression of various genes. We have identified OPN ...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Chambers AF,Behrend EI,Wilson SM,Denhardt DT

    更新日期:1992-01-01 00:00:00

  • Generation of reactive oxygen intermediates (ROI) by the thionins from Viscum album L.

    abstract:BACKGROUND:Extracts from Viscum album L. are widely used as an adjuvant in complementary cancer therapy. While the mechanisms of mistletoe lectin (ML) cytotoxicity are well described, the viscotoxin (VT) effects are unclear at present. Thus, we treated human lymphocytes with VT and measured cell death-associated change...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Büssing A,Schaller G,Pfüller U

    更新日期:1998-11-01 00:00:00

  • Theoretical investigations on oncogene activation by chemicals and antioncogene inactivation by radiation.

    abstract::To activate the cancerous genetic information in the cell one has either to activate oncogenes or to inactivate antioncogenes (cancerous growth suppressing genes). These processes usually happen in the cell with the aid of external factors, especially chemical carcinogens' and radiations. It was shown with the aid of ...

    journal_title:Anticancer research

    pub_type: 杂志文章,评审

    doi:

    authors: Ladik JJ

    更新日期:1994-01-01 00:00:00

  • Serum matrix metalloproteinase-9 level associated with stromal reaction in patients with gastric cancer.

    abstract:BACKGROUND:Matrix metalloproteinase 9 (MMP-9) plays an important role in cancer invasion and metastasis. The relationship between serum MMP-9 levels and clinicopathological factors in gastric cancer patients is not clear. MATERIALS AND METHODS:Preoperative serum was obtained from 170 patients who had undergone gastrec...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Shen KH,Chi CW,Lo SS,Kao HL,Lui WY,Wu CW

    更新日期:2000-03-01 00:00:00

  • Specific transfer factor with activity against Epstein-Barr virus reduces late relapse in endemic Burkitt's lymphoma.

    abstract::Twenty-seven children with abdominal Burkitt's lymphoma (stage III), who had achieved complete remission, were entered into a prospective controlled trial of adjunct treatment with Epstein-Barr virus (EBV)-specific transfer factor (TF). Two patients treated with TF and 2 controls relapsed early (less than or equal to ...

    journal_title:Anticancer research

    pub_type: 临床试验,杂志文章

    doi:

    authors: Neequaye J,Viza D,Pizza G,Levine PH,De Vinci C,Ablashi DV,Biggar RJ,Nkrumah FK

    更新日期:1990-09-01 00:00:00

  • Histone Deacetylase Inhibitors and Anaplastic Thyroid Carcinoma.

    abstract:BACKGROUND/AIM:Anaplastic thyroid cancer (ATC) is one of the most aggressive human malignancies, remaining generally incurable. Histone deacetylase (HDAC) seems to play a role in regulating transcription of genes involved in ATC, making HDAC inhibitors (HDACI) promising anticancer drugs for ATC. The purpose of this rev...

    journal_title:Anticancer research

    pub_type: 杂志文章,评审

    doi:10.21873/anticanres.13220

    authors: Spartalis E,Athanasiadis DI,Chrysikos D,Spartalis M,Boutzios G,Schizas D,Garmpis N,Damaskos C,Paschou SA,Ioannidis A,Tsourouflis G,Dimitroulis D,Nikiteas NI

    更新日期:2019-03-01 00:00:00

  • Pro-GA, a Novel Inhibitor of γ-Glutamylcyclotransferase, Suppresses Human Bladder Cancer Cell Growth.

    abstract:BACKGROUND/AIM:γ-Glutamylcyclotransferase (GGCT), a key enzyme involved in glutathione metabolism, catalyzes a specific reaction that generates 5-oxoproline and free amino acids from the γ-glutamyl peptide. Inhibition of GGCT is a promising therapeutic strategy for the treatment of various cancers. MATERIALS AND METHO...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:10.21873/anticanres.13297

    authors: Hanada E,Kageyama S,Murai R,Kubota S,Ii H,Nakata S,Kita H,Kawauchi A,Chano T

    更新日期:2019-04-01 00:00:00

  • Molecular mechanisms governing melanogenesis in hamster melanomas: relative abundance of tyrosinase and catalase-B (gp 75).

    abstract::Variants of the Bomirski family of hamster melanomas whose proliferative rates differ inversely with the genetically determined degree of melanogenesis were probed for two proteins critical in melanogenesis: tyrosinase and catalase-B (gp 75). The parental black tumor Ma contained both proteins in abundance. The amelan...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Slominski A,Costantino R,Howe J,Moellmann G

    更新日期:1991-01-01 00:00:00

  • Requirement of JNK signaling for self-renewal and tumor-initiating capacity of ovarian cancer stem cells.

    abstract:BACKGROUND/AIM:Activation of the c-JUN N-terminal kinase (JNK) signaling pathway has been associated with poor survival of ovarian cancer patients, but the role(s) and significance of JNK signaling in ovarian cancer cells remain poorly understood. In the present study, we aimed to investigate the role of JNK specifical...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Seino M,Okada M,Shibuya K,Seino S,Suzuki S,Ohta T,Kurachi H,Kitanaka C

    更新日期:2014-09-01 00:00:00

  • EGF-effects in vitro and in vivo on a carcinoma cell line rich in EGFR.

    abstract::T-CAR1 is a human carcinoma cell line established from a brain metastasis. The tumour cells overexpress EGFR and contain an amplified EGFR gene. In vitro in the presence of 5% human serum the tumour cells grow as adherent cells in monolayer. Shortly after exposure to EGF a large number of tumour cells round up and det...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Torp SH,Helseth E,Unsgaard G,Dalen A

    更新日期:1995-05-01 00:00:00

  • Protein kinase C inhibitor (H-7) potentiates antiproliferative effects of a polyamine biosynthesis inhibitor.

    abstract::In this study, a protein kinase C inhibitor, H-7, was found to potentiate the antiproliferative effects of difluoromethyl ornithine (DFMO), inhibitor of the polyamine biosynthesis, on NIH 3T3 and 3T3/SV40 cells in culture. Incubation of the cells with DFMO inhibited the cell growth, whereas the addition of polyamine s...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Khan NA,Havouis R,Quemener V,Moulinoux JP

    更新日期:1992-07-01 00:00:00

  • Interferon response depends on viral transcription in human papillomavirus-containing lesions.

    abstract::Human papillomaviruses (HPVs) express various proteins which have been proven to interact with some cellular functions playing a role in cell cycle progression and differentiation. Therefore, these viral gene products might be candidates for interfering with IFN-mediated antiproliferative actions. Condyloma biopsies f...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Arany I,Goel A,Tyring SK

    更新日期:1995-11-01 00:00:00

  • Methylation state of the prostate specific membrane antigen (PSMA) CpG island in prostate cancer cell lines.

    abstract:BACKGROUND:PSMA expression varies among prostate cell lines. We examined the role of CpG methylation and histone deacetylation in PSMA transcriptional repression in prostate cell lines. MATERIALS AND METHODS:The methylation status of a PSMA CpG island was investigated in LNCaP, DU145 and PC3 prostate cell lines. Cells...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Noss KR,Singal R,Grimes SR

    更新日期:2002-05-01 00:00:00

  • Determination of clofarabine triphosphate concentrations in leukemia cells using sensitive, isocratic high-performance liquid chromatography.

    abstract:BACKGROUND/AIM:An active metabolite of the anti-leukemia agent clofarabine (Cl-F-ara-A) is an intracellular triphosphate form, Cl-F-ara-ATP. Monitoring this active form could provide crucial information for optimizing treatment regimens based on Cl-F-ara-A. A simple, isocratic HPLC method was developed. MATERIALS AND ...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Yamauchi T,Nishi R,Ueda T

    更新日期:2011-09-01 00:00:00

  • Quality of life of recently treated patients with breast cancer.

    abstract:AIM:To investigate whether the negative quality of life result of a large randomized exercise intervention study (BREX) was due to considerable spontaneous recovery after adjuvant treatments. PATIENTS AND METHODS:The change in QoL was studied in the control patients of the BREX study (Group 1) and a group of similar f...

    journal_title:Anticancer research

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:

    authors: Penttinen H,Rautalin M,Roine R,Jahkola T,Kellokumpu-Lehtinen PL,Huovinen R,Kautiainen H,Järvenpää S,Hakamies-Blomqvist L,Blomqvist C,Saarto T

    更新日期:2014-03-01 00:00:00

  • Single-source Dual-energy CT as a Part of 18F-FDG PET/CT: Direct Comparison of Iodine-related and Metabolic Parameters in Non-small Cell Lung Cancer.

    abstract:: Aim: The aim of the study was to assess possible correlation of fluorogeoxyglucose (FDG) uptake and iodine-related attenuation values derived from positron-emission tomography/computed tomography (PET/CT) using single-source dual-energy CT scan (DE-CT) in non-small cell lung cancer (NSCLC). Materi...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:10.21873/anticanres.12704

    authors: Baxa J,Matouskova T,Ludvik J,Sedlmair M,Flohr T,Schmidt B,Bejcek J,Pesek M,Ferda J

    更新日期:2018-07-01 00:00:00

  • Oolong Tea Extract Induces DNA Damage and Cleavage and Inhibits Breast Cancer Cell Growth and Tumorigenesis.

    abstract:BACKGROUND/AIM:Breast cancer is the most prevalent and devastating malignant disease among women worldwide. Green tea has been extensively studied for its anti-cancer effects, however, existing literature on the correlation of other types of tea with breast cancer is very limited. MATERIALS AND METHODS:We used six dif...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:10.21873/anticanres.12976

    authors: Shi H,Liu J,Tu Y,Freter CE,Huang C

    更新日期:2018-11-01 00:00:00

  • Pelvic Exenteration as Potential Cure and Symptom Relief in Advanced and Recurrent Gynaecological Cancer.

    abstract:BACKGROUND/AIM:Pelvic exenteration is a radical procedure for certain advanced or recurrent gynaecological cancers, performed with curative or palliative intent. Its validity has evolved as operative mortality and morbidity have improved. This surgery was evaluated to determine the validity of these claims. PATIENTS A...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:10.21873/anticanres.13759

    authors: Soeda S,Furukawa S,Sato T,Ueda M,Kamo N,Endo Y,Kojima M,Nomura S,Kataoka M,Fujita S,Endo H,Takahashi T,Watanabe T,Yamada H,Fujimori K

    更新日期:2019-10-01 00:00:00

  • A rapid method for the screening and typing of high risk HPVs using molecular biology techniques.

    abstract::To date over 60 different human papilloma virus (HPV) types have been described and novel HPV genomes are still being identified. The identification and taxonomy of papilloma viruses has become increasingly complex However, some types, especially HPV-16, -18 and to a lesser extent HPV-31 and -33, which are found in a ...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Troungos C,Horti M,Kittas C

    更新日期:1995-09-01 00:00:00

  • Endometrial Adenocarcinoma: Analysis of Circulating Tumour Cells by RT-qPCR.

    abstract:BACKGROUND:Endometrial adenocarcinoma is a frequently occurring cancer in women, accounting for 42,000 deaths every year. Despite treatment with standard therapy, occurrence of remote metastases and local recurrences is high. Through help of RT-qPCR minimal residual disease could be detected and characterized, facilita...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Kölbl AC,Wellens R,Koch J,Rack B,Hutter S,Friese K,Jeschke U,Andergassen U

    更新日期:2016-06-01 00:00:00

  • Association of K-ras mutations with liver metastases from colorectal carcinoma.

    abstract:BACKGROUND:Colorectal carcinomas were studied regarding early proof of liver metastases through determination of K-ras mutations. PATIENTS AND METHODS:Seventy-seven colorectal carcinomas were investigated for the presence of point mutations in codon 12 and 13 of the K-ras gene, using single-strand conformation polymor...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Tsunoda A,Iijima T,Tsunoda Y,Nakao K,Miyaki M,Kusano M

    更新日期:2004-07-01 00:00:00

  • Interaction between sodium 5,6-benzylidene-L-ascorbate and dopamine.

    abstract::The interaction between sodium 5,6-benzylidene-L-ascorbate (SBA) and dopamine was investigated by three different parameters: radical intensity, prooxidant action and cytotoxic activity. Under alkaline conditions, SBA and dopamine produced doublet and quartet ESR signals, respectively. The addition of increasing conce...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Satoh K,Ida Y,Kochi M,Sakagami H

    更新日期:1998-09-01 00:00:00

  • Correlation of cell proliferation marker (TPS), natural killer (NK) activity and tumor load serotest (PSA) in untreated and treated prostatic tumors.

    abstract::Tissue polypeptide specific antigen (TPS) is a new tumor proliferation serotest marker. The respective radioimmunodetective procedure is based on the application of monoclonal antibodies raised against one the principle epitopes of tissue polypeptide antigen (TPA). TPS is useful tool for the identification of prolifer...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Tarle M,Kovacić K,Kastelan M

    更新日期:1993-01-01 00:00:00

  • Contralateral solitary testis metastasis antedating renal cell carcinoma: a case-report and review.

    abstract::A 56-year-old Caucasian smoker male patient underwent right orchiectomy and spermatic cord resection for intrascrotal transilluminating mass. Histology findings suggested diagnosis of metastasis from Renal Cell Carcinoma (RCC). After positive CT-scan for primary neoplasm, total left nephrectomy was accomplished. Patie...

    journal_title:Anticancer research

    pub_type: 杂志文章,评审

    doi:

    authors: Lauro S,Lanzetta G,Bria E,Trasatti L,Costarelli L,Vecchione A

    更新日期:1998-11-01 00:00:00