Improvement of intestinal toxicity of 5-fluorouracil by conagenin, a low molecular immunomodulator.

abstract：BACKGROUND/AIM:Prognosis for patients with head and neck squamous cell carcinoma (HNSCC) is poor in most cases and has not improved despite advances in therapy. Novel therapeutic approaches are mandatory in order to improve the situation. Everolimus, an inhibitor of mammalian target of rapamycin, as well as the multi-t...

journal_title：Anticancer research

authors： Aderhold C,Faber A,Umbreit C,Chakraborty A,Bockmayer A,Birk R,Sommer JU,Hörmann K,Schultz JD

更新日期：2015-03-01 00:00:00

abstract：AIM:The aim of the study was to identify novel biomarkers that are vital for improving management of patients with gastric cancer (GC). MATERIALS AND METHODS:An RNA-sequencing analysis was conducted using gastric tissue from patients with metastatic GC. In vitro cell functions were evaluated by siRNA-mediated knockdow...

journal_title：Anticancer research

authors： Sawaki K,Kanda M,Umeda S,Miwa T,Tanaka C,Kobayashi D,Hayashi M,Yamada S,Nakayama G,Omae K,Koike M,Kodera Y

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND/AIM:To investigate whether high-dose-rate (HDR) intracavitary brachytherapy (IBT) dose ratios can predict treatment outcomes in patients with stage IIB cervical cancer. PATIENTS AND METHODS:Ninety-three patients treated with weekly cisplatin-based concurrent chemoradiotherapy and HDR IBT were analyzed. Pote...

journal_title：Anticancer research

authors： Cho O,Noh OK,Oh YT,Chang SJ,Chun M

更新日期：2017-01-01 00:00:00

abstract：:Inflammatory bowel diseases (IBD) are associated with an increased risk of colitis-associated colorectal carcinoma (CAC). CAC is one of the most important causes of morbidity and mortality in patients with Crohn's disease and ulcerative colitis. The aim of the present review was to discuss the most important signaling...

journal_title：Anticancer research

authors： Romano M,DE Francesco F,Zarantonello L,Ruffolo C,Ferraro GA,Zanus G,Giordano A,Bassi N,Cillo U

更新日期：2016-04-01 00:00:00

abstract：:Angiogenesis, the process of generating new capillary blood vessels, is a fundamental requirement for normal physiological processes including embryogenesis, reproductive function and wound healing. Angiogenesis is also implicated in various pathological conditions including age-related retinal macular degeneration, d...

journal_title：Anticancer research

authors： Salesi N,Bossone G,Veltri E,Di Cocco B,Marolla P,Pacetti U,Larosa G,Muni R,Vecchione A

更新日期：2005-09-01 00:00:00

abstract：:To evaluate the association and interaction of genotypic polymorphism the gene for DNA-apurinic/apyrimidinic endonuclease (APEX1) with personal smoking habit and lung cancer risk in Taiwan, the polymorphic variants of APEX1, Asp(148)Glu (rs1130409), were analyzed in association with lung cancer risk, and their joint e...

journal_title：Anticancer research

authors： Chen WC,Tsai CW,Hsia TC,Chang WS,Lin LY,Liang SJ,Tu CY,Cheng WE,Chen HJ,Wang SM,Bau dT

更新日期：2013-06-01 00:00:00

abstract：:The purpose of the present study was to compare the therapeutic efficacy of the alpha-emitter Astatine-211 with the beta-emitter Iodine-131 bound to the specific monoclonal antibody MOv18. The measurements were performed in an ovarian cancer cell line (NIH:OVCAR 3) growing intraperitoneally in nude mice. Two weeks aft...

journal_title：Anticancer research

authors： Andersson H,Palm S,Lindegren S,Bäck T,Jacobsson L,Leser G,Horvath G

更新日期：2001-01-01 00:00:00

abstract：:In a randomised, double-blind study, the efficacy of sodium selenite application in combination with physical therapy to relieve congestion was investigated in a cohort of 60 cancer patients with secondary lymphedema, with special reference to the development of the incidence of erysipelas. All of the patients investi...

journal_title：Anticancer research

authors： Kasseroller R

更新日期：1998-05-01 00:00:00

abstract：:Eighteen patients with Zollinger-Ellison syndrome were studied with 111In-pentetreotide SPECT in order to localize gastrinoma, the tumour responsible for this pathology. NMR imaging was also carried out. Eight patients were operated. 111In-pentetreotide was reinjected 4 hours before operation and the radioactivity of ...

journal_title：Anticancer research

authors： Scopinaro F,Schillaci O,Delle Fave G,Danieli R,Materia A,Tavolaro R,Angeletti S,Marignani M,Massa R,Gualdi G,Polettini E,Picardi V,Basso N

更新日期：1997-05-01 00:00:00

abstract：BACKGROUND/AIM:Breast cancer treatment represents a substantial amount of health-care costs and has a negative impact on womens' psychological health. Day-Surgery managment (DS) is a favorable alternative to a classic inpatient setting. In our prospective study we evaluated DS-treatment feasibility in terms of patient ...

journal_title：Anticancer research

authors： Susini T,Carriero C,Tani F,Mattioli G,Renda I,Biglia N,Nori J,Vanzi E,Bianchi S

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND/AIM:Tumor recurrence complicates more than half of patients at 5 years after primary hepatocellular carcinoma (HCC) resection. Repeat open liver resection (ROLR) is the standard procedure for patients eligible for repeat resection, whereas laparoscopic repeat liver resection (RLLR) has been proposed as an al...

journal_title：Anticancer research

authors： Machairas N,Papaconstantinou D,Stamopoulos P,Prodromidou A,Garoufalia Z,Spartalis E,Kostakis ID,Sotiropoulos GC

更新日期：2018-05-01 00:00:00

abstract：AIM:Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a promising target for cancer therapy. We have already started a phase I study of CRM197, a specific HB-EGF inhibitor, for advanced ovarian cancer. In this study, we evaluated possible clinical adaptations of CRM197 in combination with conventio...

journal_title：Anticancer research

authors： Tsujioka H,Fukami T,Yotsumoto F,Ueda T,Hikita S,Takahashi Y,Kondo H,Kuroki M,Miyamoto S

更新日期：2011-07-01 00:00:00

abstract：:The oxazaphosphorines cyclophosphamide (CP) and ifosfamide (IF) are alkylating agents that require bioactivation via cytochrome (CYP) P450 isoenzymes including CYP2C9 enzymes. The present study investigated CYP2C9 in regard to its allelic variants in 23 tumor samples (10 breast tumors, 1 breast tumor cell line, 5 brai...

journal_title：Anticancer research

authors： Knüpfer H,Stanitz D,Preiss R

更新日期：2006-01-01 00:00:00

abstract：:Cisplatin toxicity could be decreased by adjusting its dosage to each patient. For this purpose, a limited sampling method was established and validated based on a Bayesian approach taken using the values of assays during a 5-day continuous infusion of cisplatin. Using this method, a dosing model to achieve a target p...

journal_title：Anticancer research

authors： Desoize B,Dumont P,Manot L,Urien S,Dufour R,Berthiot G

更新日期：1994-11-01 00:00:00

abstract：AIM:We aimed to clarify the prognostic significance of HER2 positivity in advanced gastric cancer. PATIENTS AND METHODS:The cohort included patients with initially metastatic or recurrent gastric cancer treated with first-line modified FOLFOX-6. The HER2 status was analyzed according to modified scoring criteria speci...

journal_title：Anticancer research

authors： Kim JW,Im SA,Kim M,Cha Y,Lee KH,Keam B,Kim MA,Han SW,Oh DY,Kim TY,Kim WH,Bang YJ

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:The aim of this work was to study the constituents and cytotoxicity of the essential oils from the fruits of Angelica archangelica growing in Iceland. MATERIALS AND METHODS:Three samples of essential oils were prepared by steam distillation. Their composition was established with GC/MS. The effects of the o...

journal_title：Anticancer research

authors： Sigurdsson S,Ogmundsdottir HM,Gudbjarnason S

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND:Compliance is an essential aspect for the success of any medical intervention. Adverse events (AEs) contribute significantly to non-compliance with endocrine treatment. The Tamoxifen Exemestane Adjuvant Multinational (TEAM) trial compared five years of adjuvant exemestane therapy with the sequence of tamoxif...

journal_title：Anticancer research

authors： Bossart M,Becker M,Hadji P,Kieback DG,Hasenburg A

更新日期：2012-09-01 00:00:00

abstract：:Telomerase activity is associated with most malignant tumors. To evaluate the role of telomerase reactivation as a diagnostic and prognostic marker in oral carcinogenesis activity was investigated in mortal and immortal cell lines in eight oral leukoplakias (OL) and 46 oral squamous cell carcinomas (OSCC). Activity wa...

journal_title：Anticancer research

authors： Ries JC,Hassfurther E,Steininger H,Kloss FR,Wiltfang J,Girod SC,Neukam FW

更新日期：2001-03-01 00:00:00

abstract：AIM:To evaluate whether the congested area that develops in associating liver partition with portal vein ligation for staged hepatectomy (ALPPS) contributes to rapid future liver remnant (FLR) hypertrophy. PATIENTS AND METHODS:Eight patients undergoing liver partition and right portal vein (RPV) ligation within the FL...

journal_title：Anticancer research

authors： Kawaguchi D,Hiroshima Y,Matsuo K,Endo I,Koda K,Tanaka K

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:In the present study, we examined the relationships between microsatellite status and Ki-67 labeling index, a proliferative marker, in colorectal cancers in order to clarify the common biological profiles of familial and sporadic cases of MSI (microsatellite inability)-positive tumors. PATIENTS AND METHODS:...

journal_title：Anticancer research

authors： Takagi S,Kumagai S,Kinouchi Y,Hiwatashi N,Nagashima F,Takahashi S,Shimosegawa T

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND:CD44 is a transmembrane glycoprotein and is associated with cell-matrix and cell-cell interactions. CD44 expression was shown to be relevant to tumour progression in various types of human cancer. The objective of this study was to investigate the relationship between the expression levels of the standard fo...

journal_title：Anticancer research

authors： Al-Maghrabi J,Gomaa W,Buhmeida A,Al-Qahtani M,Al-Ahwal M

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND/AIM:Reportedly, hypertension tends to be associated with response to bevacizumab therapy, because bevacizumab suppresses vascular nitric oxide production. In this study we examined the predictive value of nitric oxide in bevacizumab-treated non-small cell lung cancer (NSCLC) patients. PATIENTS AND METHODS:F...

journal_title：Anticancer research

authors： Muto S,Takagi H,Owada Y,Inoue T,Watanabe Y,Yamaura T,Fukuhara M,Okabe N,Matsumura Y,Hasegawa T,Osugi J,Hoshino M,Higuchi M,Shio Y,Suzuki H

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:The association of TN expression, tumour grading and expression of commonly used histopathologic prognostic factors (p53 and estrogen receptor) was examined in 62 cases of invasive ductal carcinoma of the breast. MATERIAL AND METHODS:Following histological grading immunohistochemical reactions were undertak...

journal_title：Anticancer research

authors： Tökés AM,Hortoványi E,Csordás G,Kulka J,Mózes G,Hatalyák A,Kádár A

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND:The objective of this study was to evaluate the possible effects of a paclitaxel containing chemotherapy on different neuropsychological parameters in women with ovarian cancer. MATERIALS AND METHODS:Twenty-eight women with histologically documented epithelial ovarian carcinoma and treated with a combinatio...

journal_title：Anticancer research

authors： Mayerhofer K,Bodner-Adler B,Bodner K,Saletu B,Schindl M,Kaider A,Hefler L,Leodolter S,Kainz C

更新日期：2000-09-01 00:00:00

abstract：:Metastatic pancreatic malignant melanoma is considered to be a highly aggressive neoplasm, and only few metastasectomies for lesions originating from the skin or the ocular region have been reported. We report a case of resection of pancreatic metastasis of malignant melanoma originating from the nasal cavity. An isol...

journal_title：Anticancer research

authors： Sugimoto M,Gotohda N,Kato Y,Takahashi S,Kinoshita T,Shibasaki H,Kojima M,Ochiai A,Zenda S,Akimoto T,Konishi M

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:A number of association studies have focused on the effect of polymorphisms related to DNA repair or the xenobiotic pathway, on the susceptibility to gastric cancer (GC). Here, the possible association between common polymorphisms in the X-ray repair cross-complementing groups (XRCC) 1, and glutathione-S-tra...

journal_title：Anticancer research

authors： Tahara T,Shibata T,Nakamura M,Yamashita H,Yoshioka D,Okubo M,Yonemura J,Ishizuka T,Maruyama N,Kamano T,Kamiya Y,Fujita H,Nakagawa Y,Nagasaka M,Iwata M,Yamada H,Hirata I,Arisawa T

更新日期：2011-02-01 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) and v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations are common in non-small cell lung cancer (NSCLC) and colorectal cancer (CRC). The aim of the present study was to develop a simple and versatile tool to determine EGFR and KRAS mutations for pre-clinical r...

journal_title：Anticancer research

authors： Furugaki K,Yasuno H,Iwai T,Moriya Y,Harada N,Fujimoto-Ouchi K

更新日期：2014-02-01 00:00:00

abstract：AIM:To investigate the possibility of enhancing an anti-metastatic effect of 5-fluorouracil (5-FU) on colorectal cancer (CRC) cells by combining it with continuous calcium supplementation. MATERIALS AND METHODS:Optimal doses of 5-FU with/without lactate salt (CaLa) were determined via clonogenicity and 3-(4,5-dimethyl...

journal_title：Anticancer research

authors： Park M,Sundaramoorthy P,Sim JJ,Jeong KY,Kim HM

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND/AIM:Cold atmospheric plasma (CAP) attenuates tumor cell proliferation and induces apoptosis in various cell lines. While exerting marginal effects on non-neoplastic cells this unfolds promising applications in cancer therapy. The aim of the study was to analyse the effects of different CAP sources and applic...

journal_title：Anticancer research

authors： Gümbel D,Suchy B,Wien L,Gelbrich N,Napp M,Kramer A,Ekkernkamp A,Daeschlein G,Stope MB

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:No investigation of amrubicin monotherapy in pre-treated advanced non-small cell lung cancer (NSCLC) patients has yet been reported. PATIENTS AND METHODS:The records were reviewed of NSCLC patients who had received amrubicin monotherapy between 2003 and 2007 with the following eligibility criteria:previousl...

journal_title：Anticancer research

authors： Igawa S,Takahashi T,Nakamura Y,Tsuya A,Ono A,Shukuya T,Murakami H,Endo M,Yamamoto N

更新日期：2008-11-01 00:00:00