Abstract:
BACKGROUND:CD44 is a transmembrane glycoprotein and is associated with cell-matrix and cell-cell interactions. CD44 expression was shown to be relevant to tumour progression in various types of human cancer. The objective of this study was to investigate the relationship between the expression levels of the standard form of CD44 (CD44s), and clinicopathological characteristics in a subset of colorectal carcinomas (CRC). PATIENTS AND METHODS:A total of 96 cases of CRC were retrieved from the archives at the Department of Pathology at King Abdulaziz University, Jeddah, KSA. Immunohistochemistry was performed using antibodies to CD44s. A cut-off of <10% of positive neoplastic cells was used to define low expression, 10-50% to define moderate expression and >50% to define extensive expression. Statistical tests were used to determine the association of CD44s with clinicopathological characteristics in a subset of colorectal carcinomas and survival. RESULTS:Immunostaining results showed that there was no association between C44 immunoexpression and age of patients, tumour grade, depth of invasion, vascular invasion, recurrence and survival. CD44s immunolabelling was found to have an association with nodal metastasis and to be an independent predictor of nodal metastasis. CONCLUSION:Loss of CD44s immunolabelling in CRC is an independent favourable predictor of regional lymph node metastasis. On the other hand, CD44s loss has no significant association with disease recurrence or survival. Extensive in vivo and in vitro molecular studies are required to elucidate the possible mechanistic association of CD44s with tumour initiation, progression, invasion and metastasis in primary CRC, and in nodal and distant metastases.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Al-Maghrabi J,Gomaa W,Buhmeida A,Al-Qahtani M,Al-Ahwal Msubject
Has Abstractpub_date
2012-08-01 00:00:00pages
3455-61issue
8eissn
0250-7005issn
1791-7530pii
32/8/3455journal_volume
32pub_type
杂志文章abstract:BACKGROUND:To improve long-term survival by reducing toxicity in intermediate stage Hodgkin's disease patients, we compared the effects of involved field (IF) versus extended field (EF) irradiation administered after four cycles of ABVD regimen. MATERIALS AND METHODS:Two hundred and ten Hodgkin's disease patients, at ...
journal_title:Anticancer research
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:
更新日期:2004-11-01 00:00:00
abstract::We examined 11 patients (9 male and 2 female, age 41 +/- 13) presenting astrocytomas of different malignancy grade (WHO) with single voxel (PRESS) and double voxel (STABLE) spectroscopy techniques. The content of choline in the tumors was determined as a function of their grade of malignity and a significant correlati...
journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:1996-05-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:1994-03-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2012-10-01 00:00:00
abstract::The aim of our study was to establish a simple method for routine analysis of c-erbB-2 gene expression in tumour samples. We constructed a plasmid for the in vitro synthesis of competitor RNA to be used as an internal exogenous control during the RT-PCR detection of c-erbB-2 expression. The competitor RNA harbors a 19...
journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:1996-03-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2001-09-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
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更新日期:2019-02-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:10.21873/anticanres.11636
更新日期:2017-06-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:1998-09-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2006-01-01 00:00:00
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journal_title:Anticancer research
pub_type: 临床试验,杂志文章
doi:
更新日期:2005-07-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND:The efficacy and toxicity of adjuvant chemo-immunotherapy using dendritic cells and activated killer cells are not clear in post-surgical primary lung cancer patients. PATIENTS AND METHODS:Pathologically diagnosed N2 lung cancer patients were selected for postsurgical adjuvant chemo-immunotherapy. The activ...
journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2008-03-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
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更新日期:2020-07-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2007-07-01 00:00:00
abstract:BACKGROUND/AIM:Leiomyosarcoma is an extremely rare, small bowel neoplasm (2% of all gastrointestinal tumours). Early diagnosis is challenging due to the slow growth of the cancer. The biological behaviour of this group of tumours is aggressive, and the first-line treatment is surgical resection. PATIENTS AND METHODS:T...
journal_title:Anticancer research
pub_type: 杂志文章
doi:10.21873/anticanres.14420
更新日期:2020-07-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2012-08-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2007-01-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2010-07-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:10.21873/anticanres.11779
更新日期:2017-07-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2015-06-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2007-05-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2012-09-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:1989-11-01 00:00:00
abstract::The relationship between the composition of breast cyst fluid (BCF), the menstrual status and in addition some endocrine events in the history of patients (n = 131) with gross cystic breast disease was investigated. The dehydroepiandrosterone (DHA) levels in type II (K+/Na+ < 1) cysts of the follicular group were sign...
journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2000-09-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:10.21873/anticanres.13634
更新日期:2019-08-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2000-11-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2002-05-01 00:00:00
abstract::The widespread use of endoscopy and imaging in combination with the continuous update of the staging systems for neuroendocrine tumors has led to an increase in the incidence of small intestinal neuroendocrine tumors (si-NENs) globally. Despite high survival rates, severe complications may occur even in early stages d...
journal_title:Anticancer research
pub_type: 杂志文章,评审
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更新日期:2018-03-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2012-09-01 00:00:00