Effects of 5'-DFUR and lentinan on cytokines and PyNPase against AH66 ascites hepatoma in rats.

abstract：BACKGROUND/AIM:Primary Non-Hodgkin's lymphoma of the gallbladder (PNHL-GB) is extremely rare and data on clinical characteristics, optimal management and outcomes of these patients are limited to anecdotal reporting. We, therefore, sought to examine these patients using a population-based database. MATERIALS AND METHO...

journal_title：Anticancer research

authors： Ayub A,Rehmani S,Al-Ayoubi AM,Lewis E,Santana-Rodríguez N,Raad W,Bhora F,Kim G

更新日期：2017-05-01 00:00:00

abstract：:A copper complex with superoxide dismutase mimetic activity, Cu(II)2 (3,5-diisopropylsalicylate)4 (CuDIPS), was tested for activity against mammary cancer in female C3H/HeNCR mice. Initiation of treatment at 20 or at 30 weeks of age had a limited beneficial effect on survival rates. Further, a small, but not statistic...

journal_title：Anticancer research

authors： Crispens CG Jr,Sorenson JR

更新日期：1992-07-01 00:00:00

abstract：BACKGROUND:The pS2 protein is involved in the maintenance of the integrity of the gastrointestinal tract. In breast cancer pS2 can be demonstrated in at least half of the tumors and probably reflects the functional status of ER. Several features make it likely that pS2 is involved in growth regulation. PATIENTS AND ME...

journal_title：Anticancer research

authors： Jansen RL,Hupperets PS,Arends JW,Joosten-Achjanie SR,Volovics A,Hillen HF,Schouten HC

更新日期：1998-01-01 00:00:00

abstract：:Selective delivery of a high level of Mitomycin C (MMC) in intraperitoneal disseminated lesions was studied using a new dosage form of MMC, called MMC-CH. Intracavitary MMC-CH delivered a much higher level of MMC selectively to intraperitoneal tissues, with a much lower level of MMC in the whole body, in comparison wi...

journal_title：Anticancer research

authors： Hagiwara A,Takahashi T,Lee R,Ueda T,Takeda M,Itoh T

更新日期：1986-09-01 00:00:00

abstract：BACKGROUND:Satraplatin (JM216; bis-acetatoammine-dichlorocyclohexylamine platinum (IV)) is a platinum (Pt) complex developed in an attempt to circumvent tumour resistance and which can be administered by the oral route. The fate of platinum delivered by this oral formulation administered at various doses under the 5 or...

journal_title：Anticancer research

authors： Vouillamoz-Lorenz S,Buclin T,Lejeune F,Bauer J,Leyvraz S,Decosterd LA

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND:Prediction of biological behavior is crucial for selection of new therapeutic modalities in GIST. Here, we aimed to assess whether KIT and PDGFRA mutations have survival impact in gastrointestinal stromal tumors (GIST). PATIENTS AND METHODS:Fifty-five Brazilian patients with completely resected GIST were ex...

journal_title：Anticancer research

authors： Braggio E,Braggio Dde A,Small IA,Lopes LF,Valadão M,Gouveia ME,Moreira Ados S,Linhares E,Romano S,Bacchi CE,Renault IZ,Guimarães DP,Ferreira CG

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:The efficacy of positron emission tomography with 18F fluoro-2-deoxy-D-glucose (FDG-PET) is obscure in evaluating viability or the extent of colorectal hepatic metastasis (CHM), down-staged by chemotherapy. PATIENTS AND METHODS:A retrospective lesion-by-lesion analysis was performed for seven consecutive pa...

journal_title：Anticancer research

authors： Takahashi S,Kuroki Y,Nasu K,Nawano S,Konishi M,Nakagohri T,Gotohda N,Saito N,Kinoshita T

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND:The possibilities and limitations of computer tomography (CT) examination for detecting primary gastric cancer tumors have been poorly understood. The aim of the present study was to evaluate the pre-operative assessment of gastric cancer tumors using 32-multidetector row-CT. PATIENTS AND METHODS:A prospect...

journal_title：Anticancer research

authors： Kikuchi S,Futawatari N,Sakuramoto S,Watanabe M,Kubota K,Sasaki M,Murata K,Kida M

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND/AIM:To describe real clinical outcomes when using systemic therapy to treat non-small cell lung cancer (NSCLC) patients who have anaplastic lymphoma kinase (ALK) fusion gene mutation. PATIENTS AND METHODS:We performed a retrospective chart review from April 2008 to March 2019 sourced from 16 medical institu...

journal_title：Anticancer research

authors： Okauchi S,Numata T,Nawa T,Ichimura H,Saito T,Hayashihara K,Yamada H,Satoh H,Endo T,Inage Y,Kaburagi T,Kiyoshima M,Yamada Y,Tamura T,Saito K,Inagaki M,Hizawa N,Sato Y,Shiozawa T,Sekine I,Ishikawa H,Kurihima K,S

更新日期：2020-02-01 00:00:00

abstract：:An in vitro cell line (HT 58) has been established from a human (B) NHL xenograft. The lymphoma cells in culture retained their lymphoblastic appearance, DNA-content, IgM/lambda monoclonality and many immunophenotypic markers. The clonal chromosomal abnormalities involved the chromosomes 1, 2, 3 and 14. The cells expr...

journal_title：Anticancer research

authors： Kopper L,Bankfalvi A,Mihalik R,Nagy P,Fulop C,Sarmay G

更新日期：1991-07-01 00:00:00

abstract：BACKGROUND/AIM:Exposure of the skin to sunshine is the major natural source of vitamin D. In order to imitate this natural production of vitamin D for patients with chronic kidney disease, hemodialysis patients were exposed three times a week to radiation of the front part of both legs to normalize the vitamin D status...

journal_title：Anticancer research

authors： Krause R,Stange R,Roth HJ,Kaase H,Michalsen A,Holick MF

更新日期：2018-02-01 00:00:00

abstract：:In a recent paper entitled "Circulating 25-Hydroxyvitamin D and the Risk of Pancreatic Cancer," Stolzenberg-Solomon et al. reported that the odds ratio for diagnosis of pancreatic cancer shows a "statistically significant" precipitous jump of more than a factor of 2 at the highest presented concentrations of >100 nmol...

journal_title：Anticancer research

authors： Baggerly LL,Garland CF

更新日期：2012-03-01 00:00:00

abstract：:Gn-RH agonists or surgical castration are considered standard treatment for patients affected by metastatic prostate cancer. Despite greater cost, chemical castration is often considered the treatment of choice as it is psychologically better tolerated. We report our experience of one patient undergoing treatment with...

journal_title：Anticancer research

authors： Rocco B,Ferrari M,Scardino E,Matei DV,Verweij F,Varela R,De Cobelli O

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Despite improvements in chemotherapy and surgery in the treatment of osteosarcoma, satisfactory results are still difficult to achieve. New therapeutic modalities need to be developed for the improvement of these treatments. TRAIL (TNF-related apoptosis inducing ligand) is known as a selective apoptosis indu...

journal_title：Anticancer research

authors： Takeda S,Iwai A,Nakashima M,Fujikura D,Chiba S,Li HM,Uehara J,Kawaguchi S,Kaya M,Nagoya S,Wada T,Yuan J,Rayter S,Ashworth A,Reed JC,Yamashita T,Uede T,Miyazaki T

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND:Treatment for advanced pancreatic cancer is still very unsatisfactory. Treosulfan is an alkylating agent used for conventional, as well as high-dose chemotherapy regimens, whereby plasma concentrations over 500 μg/ml can be achieved. We investigated the effects of treosulfan on pancreatic cancer cell lines. ...

journal_title：Anticancer research

authors： Nitsch E,Mina S,Brammer I,Pace A,Schuch G,Bokemeyer C,Zander A,Kröger N,Ayuk F

更新日期：2014-04-01 00:00:00

abstract：AIM:Eudragit® E 100 (EE100) was used to improve the transfection efficiency of polyethylenimine (PEI). MATERIALS AND METHODS:Mobility of PEI-DNA complexes with and without EE100 were visualized by agarose gel electrophoresis and their transfection efficiencies were investigated in KB human oral carcinoma cells by flow...

journal_title：Anticancer research

authors： Kanthamneni N,Yung B,Lee RJ

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Pulmonary complications (PCs) after esophagectomy for patients with esophageal cancer have been correlated with prolonged hospital stays and in-hospital mortality. Previous studies have shown that minimally-invasive esophagectomy (MIE) is associated with a lower rate of PCs compared to conventional open surg...

journal_title：Anticancer research

authors： Kubo N,Ohira M,Yamashita Y,Sakurai K,Toyokawa T,Tanaka H,Muguruma K,Shibutani M,Yamazoe S,Kimura K,Nagahara H,Amano R,Ohtani H,Yashiro M,Maeda K,Hirakawa K

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND/AIM:The deacetylase sirtuin1 (SIRT1) inhibits tumor suppressor p53 and may promote tumorigenesis; however, SIRT1 effects on leukemia cells are controversial. The aim of this study was to clarify the activity of SIRT1 in leukemia cells. MATERIALS AND METHODS:The effects of SIRT1 inhibition or activation and ...

journal_title：Anticancer research

authors： Okasha SM,Itoh M,Tohda S

更新日期：2020-06-01 00:00:00

abstract：:Mutations affecting the mechanistic target of rapamycin (MTOR) signalling pathway are frequent in human cancer and have been identified in up to 15% of pancreatic neuroendocrine tumours (NETs). Grade A evidence supports the efficacy of MTOR inhibition with everolimus in pancreatic NETs. Although a significant proporti...

journal_title：Anticancer research

authors： Backman S,Norlén O,Eriksson B,Skogseid B,Stålberg P,Crona J

更新日期：2017-02-01 00:00:00

abstract：:Angiosarcoma of the breast is a malignant tumour of vascular endothelial cells. It is a rare and difficult tumour to treat. The authors report a case of cutaneous radiation-associated angiosarcoma treated with paclitaxel chemotherapy. A few days after drug administration, bleeding of skin lesions was observed and the ...

journal_title：Anticancer research

authors： Tomasello L,Gardin G,Boccardo F

更新日期：2006-11-01 00:00:00

abstract：:Bcl-2 oncoprotein, a member of a new category of oncogenes associated with the regulation of programmed cell death (apoptosis), has been considered to be involved in biological processes such as tumorigenesis and tumor development. To determine the role of bcl-2 oncoprotein in lung cancer, we preliminarily examined th...

journal_title：Anticancer research

authors： Higashiyama M,Doi O,Kodama K,Yokouchi H,Tateishi R

更新日期：1995-03-01 00:00:00

abstract：BACKGROUND/AIM:4H-1-Benzopyran-4-ones (chromones) provide a backbone structure for the chemical synthesis of potent anticancer drugs. In contrast to 2-(N-cyclicamino)chromones, the biological activity of 3-(N-cyclicamino)chromones has not been reported. In this study, cytotoxicity of 15 3-(N-cyclicamino)chromone deriva...

journal_title：Anticancer research

authors： Shi H,Nagai J,Sakatsume T,Bandow K,Okudaira N,Uesawa Y,Sakagami H,Tomomura M,Tomomura A,Takao K,Sugita Y

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND/AIM:Androgens are essential for the growth of most prostate cancers (PCa). As a result, androgen ablation is the mainstay of the treatment of PCa. Proteins of the polycomb and trithorax family are master epigenetic regulators of cell type specific gene expression including androgen receptor. MATERIALS AND M...

journal_title：Anticancer research

authors： Wang S,Tailor K,Kwabi-Addo B

更新日期：2020-05-01 00:00:00

abstract：AIM:Hepatic resection for hepatic ovarian cancer metastases remains controversial. The purpose of this study was to evaluate the clinical outcome of CT-guided high dose rate brachytherapy (CT-HDRBT) for minimally invasive cytoreduction of isolated metachronous ovarian cancer metastases to the liver. PATIENTS AND METHO...

journal_title：Anticancer research

authors： Collettini F,Poellinger A,Schnapauff D,Denecke T,Wust P,Braicu IE,Sehouli J,Hamm B,Gebauer B

更新日期：2011-08-01 00:00:00

abstract：:Medical oncologists are increasingly interested in identifying reliable prognostic factors for breast cancer in order to distinguish subsets of breast cancer patients and to optimize therapeutic approaches. Among them, the p53 tumor suppressor gene and bcl2 protein continue to be extensively studied, but their role re...

journal_title：Anticancer research

authors： Castiglione F,Sarotto I,Fontana V,Destefanis M,Venturino A,Ferro S,Cardaropoli S,Orengo MA,Porcile G

更新日期：1999-09-01 00:00:00

abstract：:Cytotoxicity of L-canavanive, a structural analogue of L-arginine, was tested by means of (1) inhibition of DNA synthesis in Balb/c-3T3 cell line and (2) inhibition of mitosis in peripheral blood lymphocytes in culture. The cytostatic nature of inhibition caused by L-canavanine was indicated by the complete recovery o...

journal_title：Anticancer research

authors： Naha PM

更新日期：1981-01-01 00:00:00

abstract：:We have previously reported that polaprezinc in sodium alginate suspension (P-AG) inhibited the incidence of oral mucositis induced by radiochemotherapy in patients with head and neck cancer. The present study was designed to investigate whether P-AG prevents oral mucositis in all patients (36 patients) with hematolog...

journal_title：Anticancer research

authors： Hayashi H,Kobayashi R,Suzuki A,Ishihara M,Nakamura N,Kitagawa J,Kanemura N,Kasahara S,Kitaichi K,Hara T,Tsurumi H,Moriwaki H,Itoh Y

更新日期：2014-12-01 00:00:00

abstract：:The response of the blood-forming and supportive stromal compartments of the marrow to a localized, fractionated course of radiotherapy [FxRT; 2.0 Gy (q24 h x 5)-->74 Gy] was examined in the C57Bl/6 mouse using the hematopoietic progenitor and the cobblestone-forming cell (CAFC) assays as end-points for the blood-form...

journal_title：Anticancer research

authors： Kovacs CJ,Evans MJ,Daly BM

更新日期：2003-05-01 00:00:00

abstract：PURPOSE:Despite more than four decades of fluoro-pyrimidine treatment in different cancers, the optimal schedule is still not known. The plasma half-life of 5-fluorouracil (5-FU) is extremely short and continuous infusion has gained popularity. In this study we explored whether repeated bolus 5-FU injections could impr...

journal_title：Anticancer research

authors： Berglund A,Carlsson G,Gustavsson B,Frödin JE,Ragnhammar P,Glimelius B

更新日期：2003-03-01 00:00:00

abstract：:This study was designed to determine whether circulating cancer cells in patients with gastric cancer can be identified by a RT-PCR method and to assess the clinical significance of the hematogenic dissemination of cancer cell in gastric cancer patients. A total of 41 patients with gastric cancer were enrolled in this...

journal_title：Anticancer research

authors： Nishida S,Kitamura K,Ichikawa D,Koike H,Tani N,Yamagishi H

更新日期：2000-05-01 00:00:00