Androgen-induced Epigenetic Profiles of Polycomb and Trithorax Genes in Prostate Cancer Cells.

abstract：BACKGROUND:For eradicating portal venous tumor extension and intrahepatic metastasis in hepatocellular carcinoma (HCC), anatomical resection is, in theory, preferable. PATIENTS AND METHODS:We carried-out a retrospective cohort study in 110 patients who underwent curative hepatic resection (anatomical resection; n=20, ...

journal_title：Anticancer research

authors： Yamashita Y,Imai D,Bekki Y,Takeishi K,Tsujita E,Ikegami T,Yoshizumi T,Ikeda T,Shirabe K,Ishida T,Maehara Y

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:Malignant melanoma is a life-threatening disease with a poor prognosis due to its capacity for rapid metastasis and resistance to radio- and chemo-therapy. A pharmacological compound, CP-31398, was recently found to be able to stabilize wild-type p53 and rescue mutant p53 to enhance its transcriptional activ...

journal_title：Anticancer research

authors： Luu Y,Li G

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND/AIM:Although insulin-like growth factor-1 (IGF-1) is well-implicated in cancer biology, the potential roles of IGF-1 variants in different types of cancer are largely unknown. The aim of the present study was to in vitro characterize several human cancers for their IGF-1 variant expression patterns. MATERIA...

journal_title：Anticancer research

authors： Christopoulos PF,Philippou A,Koutsilieris M

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Microparticles are known to be increased in various malignancies. In this prospective study, microparticle levels were evaluated in patients with benign and malignant ovarian lesions. PATIENTS AND METHODS:Microparticles from platelets/megakaryocytes, activated platelets and endothelial cells, tissue factor ...

journal_title：Anticancer research

authors： Rank A,Liebhardt S,Zwirner J,Burges A,Nieuwland R,Toth B

更新日期：2012-05-01 00:00:00

abstract：:HAMAs (human anti mouse antibodies) in serum of patients may be stimulated as an immunologic reaction to the application of animal protein. They are differentiated into heterophilic (species-unspecific) and mouse-specific anti-isotypic (often IgG1) or-idiotypic antibodies as well as according to the human immunoglobul...

journal_title：Anticancer research

authors： Hasholzner U,Stieber P,Meier W,Lamerz R

更新日期：1997-07-01 00:00:00

abstract：BACKGROUND/AIM:New anticancer drugs are usually tested on cancer cells in culture in a standard medium. We stimulated immune polynuclear cells by lipopolysaccharides to obtain an enriched medium (EM) containing inflammatory cytokines more closely reflecting the tumor microenvironment and tested a rhenium-diselenium (Re...

journal_title：Anticancer research

authors： Veena V,Harikrishnan A,Lakshmi B,Khanna S,Desmaele D,Collery P

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:Syndecan-1 (CD138) is expressed by the Hodgkin-Reed-Sternberg (HRS) cells of classic Hodgkin's lymphoma (cHL), but not in nodular lymphocyte-predominant HL. Syndecan-1 may be involved in the interaction between HRS cells and the cellular and stromal microenvironment typical of nodular sclerosing HL. PATIENT...

journal_title：Anticancer research

authors： Vassilakopoulos TP,Kyrtsonis MC,Papadogiannis A,Nadali G,Angelopoulou MK,Tzenou T,Dimopoulou MN,Siakantaris MP,Kontopidou FN,Kalpadakis C,Kokoris SI,Dimitriadou EM,Tsaftaridis P,Pizzolo G,Pangalis GA

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND/AIM:Protein-bound polysaccharide-K (PSK) is extracted from Coriolus versicolor (CM101) and is clinically used in combination therapy for gastrointestinal cancer and small-cell lung carcinoma. We have previously demonstrated that PSK induces apoptosis and inhibites proliferation of promyelomonocytic leukemia ...

journal_title：Anticancer research

authors： Hirahara N,Edamatsu T,Fujieda A,Fujioka M,Wada T,Tajima Y

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND/AIM:Combining an anticancer agent fenretinide (HPR) or C6-pyridinium ceramide (LCL29) with Foscan-mediated photodynamic therapy (FoscanPDT) is expected to augment anticancer benefits of each substance. We showed that treatment with FoscanPDT+HPR enhanced accumulation of C16-dihydroceramide, and that fumonisi...

journal_title：Anticancer research

authors： Boppana NB,Kraveka JM,Rahmaniyan M,Li LI,Bielawska A,Bielawski J,Pierce JS,Delor JS,Zhang K,Korbelik M,Separovic D

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:Transformed cells have abnormalities in the survival pathways contributing to drug resistance. These abnormalities include p53 mutations and increased focal adhesion kinase (FAK) expression. Because FAK regulates cell survival via p53-dependent and -independent pathways, it was hypothesized that combined the...

journal_title：Anticancer research

authors： Kornberg L

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND/AIM:In this study we aimed to determine if advanced age represents a risk factor for negative perioperative and long-term outcome in patients undergoing curative surgery ductal pancreatic adenocarcinoma surgery. PATIENTS AND METHODS:Two-hundred-twenty-one consecutive patients, twelve (6%) patients ≥80 years...

journal_title：Anticancer research

authors： Marsoner K,Kornprat P,Sodeck G,Schagerl J,Langeder R,Csengeri D,Wagner D,Mischinger HJ,Haybaeck J

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:Epstein-Barr virus-associated gastric carcinoma (EBV-GC) has been characterized as a special gastric cancer subset. Lifestyle and other major factors that may contribute to EBV-GC and non-EBV-GC were investigated here. MATERIALS AND METHODS:A total of 247 patients with gastric cancer were interviewed, clini...

journal_title：Anticancer research

authors： Kim RH,Chang MS,Kim HJ,Song KS,Kim YS,Choi BY,Kim WH

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Perillyl alcohol (POH) elicited anticarcinogenic effects in a number of cancer models and pharmacokinetic studies in humans revealed that PA is the major circulating metabolite following POH administration. MATERIALS AND METHODS:Effects of PA or POH alone, or in combination with radiation, on human head and...

journal_title：Anticancer research

authors： Samaila D,Toy BJ,Wang RC,Elegbede JA

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND/AIM:AZD8055 is an inhibitor of mammalian target of rapamycin (mTOR) that can suppress both mTOR complex 1 (mTORC1) and mTORC2. This study investigated the antitumor effects of AZD8055 on colon cancer. MATERIALS AND METHODS:The effects of AZD8055 on proliferation, apoptosis, and cell cycle of colon cancer ce...

journal_title：Anticancer research

authors： Chen Y,Lee CH,Tseng BY,Tsai YH,Tsai HW,Yao CL,Tseng SH

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:Clofarabine is a second-generation nucleoside analogue. The aim of the study was the analysis of ex vivo activity of clofarabine and 14 other anticancer drugs in pediatric and adult acute lymphoblastic (ALL) and myeloid (AML) leukemia. PATIENTS AND METHODS:The ex vivo drug resistance profile was analyzed in...

journal_title：Anticancer research

authors： Styczynski J,Gil L,Derwich K,Wachowiak J,Balwierz W,Badowska W,Krawczuk-Rybak M,Matysiak M,Wieczorek M,Balcerska A,Sonta-Jakimczyk D,Stefaniak J,Kowalczyk J,Urasinski T,Sobol G,Komarnicki M,Wysocki M

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND:Taxane-based chemotherapy is useful for peritoneal dissemination control in advanced/recurrent gastric cancer; however, insufficient relative dose intensity (RDI) may preclude disease control achievement. Nab-paclitaxel, with high tumour permeability, is a promising second- or later-line treatment. PATIENTS...

journal_title：Anticancer research

authors： Kanazawa Y,Fujita I,Kakinuma D,Arai H,Matsuno K,Shimoda T,Ko K,Kato S,Uchida E

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND/AIM:Few data are available on the utility of definitive radiation therapy (RT) for pediatric craniopharyngioma. This study sought to evaluate practice patterns and patient outcomes using the Surveillance Epidemiology and End Results database from 2004-2014. MATERIALS AND METHODS:Overall survival (OS) was co...

journal_title：Anticancer research

authors： Hill TK,Baine MJ,Verma V,Alam M,Lyden ER,Lin C,Connolly EP,Zhang C

更新日期：2019-02-01 00:00:00

abstract：:Independently of tumour and treatment modulation, the host immune response status plays an important role in the clinical outcome of patients with cancer. The influence of single nucleotide polymorphisms (SNPs) and adjuvant radiotherapy (RT) on the systemic immune response status of patients with breast cancer was inv...

journal_title：Anticancer research

authors： Lewin NL,Luetragoon T,Andersson BÅ,Oliva D,Nilsson M,Strandeus M,Löfgren S,Rutqvist LE,Lewin F

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND/AIM:Lymphatic invasion (ly) may mainly reflect the selective affinity of breast cancer cells for lymph nodes. We conducted the present study to investigate whether the presence of lymphatic invasion is a predictor of sentinel lymph node (SLN) metastasis in clinically node-negative breast cancer. PATIENTS AN...

journal_title：Anticancer research

authors： Fujii T,Yajima R,Tatsuki H,Suto T,Morita H,Tsutsumi S,Kuwano H

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:Pemetrexed and erlotinib represent different agents commonly used for the second-line treatment of patients with advanced-stage non-small cell lung cancer (NSCLC). PATIENTS AND METHODS:We analyzed data of 137 patients with advanced-stage non-squamous NSCLC treated with pemetrexed or erlotinib in the second ...

journal_title：Anticancer research

authors： Fiala O,Pesek M,Finek J,Svaton M,Minarik M,Benesova L,Bortlicek Z,Kucera R,Topolcan O

更新日期：2016-01-01 00:00:00

abstract：:Ovarian cancer is the most lethal malignancy among gynaecological cancers. Although many anticancer agents have been developed for the treatment of ovarian cancer, it continues to have an extremely poor prognosis. Heparin-binding epidermal growth factor-like grown factor (HB-EGF) has been reported to be a rational the...

journal_title：Anticancer research

authors： Miyata K,Yotsumoto F,Fukagawa S,Kiyoshima C,Ouk NS,Urushiyama D,Ito T,Katsuda T,Kurakazu M,Araki R,Sanui A,Miyahara D,Murata M,Shirota K,Yagi H,Takono T,Kato K,Yaegashi N,Akazawa K,Kuroki M,Yasunaga S,Miyamoto S

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:A critical step in the delivery of nanomedicines to tumour cells is transporting these particles through the extracellular matrix. Tumour-specific anticancer agents, such as encapsulated drugs, proteins, and genes, show low uptake in tumour tissue. It is not clear whether the collagen network or the glycosam...

journal_title：Anticancer research

authors： Eikenes L,Tufto I,Schnell EA,Bjørkøy A,De Lange Davies C

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND/AIM:Tumor angiogenesis has been the subject of intensive research in recent years in many tumor types. Studies involving epithelial skin tumors are few to date. We evaluated tumor angiogenesis and lymphangiogenesis in cancerous and pre-cancerous lesions of the eyelids using immunohistochemical techniques. M...

journal_title：Anticancer research

authors： Tzoutzos K,Batistatou A,Kitsos G,Liasko R,Stefanou D

更新日期：2014-09-01 00:00:00

abstract：:Amitriptyline, a tricyclic antidepressant, was able to reverse the multidrug resistance efflux pump of human colon cancer subline SW 620 and multidrug resistant (mdr) mouse lymphoma cells by decreasing rhodamine 123 efflux. The inhibitory effect of amitriptyline on the efflux pump was dose dependent. An investigation ...

journal_title：Anticancer research

authors： Varga A,Nugel H,Baehr R,Marx U,Hevér A,Nacsa J,Ocsovszky I,Molnar J

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND:CD98 expression is high in various human neoplasms. However, the relationship of CD98 expression with the clinicopathological factors of gastric cancer (GC) remains unclear. This study examined CD98 expression and its clinicopathological impact on GC. PATIENTS AND METHODS:Three hundred and thirty-one patien...

journal_title：Anticancer research

authors： Satoh T,Kaira K,Takahashi K,Takahashi N,Kanai Y,Asao T,Horiguchi J,Oyama T

更新日期：2017-02-01 00:00:00

abstract：:We have previously reported the presence of human beta-defensin-2 (HBD-2), a peptide with antimicrobial and cytotoxic properties, in oral squamous cell carcinomas. The aim of the present study was to measure the concentration of HBD-2 in abnormal tissues such as oral squamous cell carcinomas. HBD-2 was extracted from ...

journal_title：Anticancer research

authors： Sawaki K,Mizukawa N,Yamaai T,Yoshimoto T,Nakano M,Sugahara T

更新日期：2002-07-01 00:00:00

abstract：BACKGROUND:For advanced gastric cancer (AGC) with peritoneal metastasis, decision-making regarding treatment change is often challenging because of the absence of measurable lesions. We attempted to clarify which criterion for treatment change contributes more to longer survival. PATIENTS AND METHODS:We retrospectivel...

journal_title：Anticancer research

authors： Hasegawa H,Fujitani K,Nakazuru S,Hirao M,Yamamoto K,Mita E,Tsujinaka T

更新日期：2014-09-01 00:00:00

abstract：:We have previously reported that polaprezinc in sodium alginate suspension (P-AG) inhibited the incidence of oral mucositis induced by radiochemotherapy in patients with head and neck cancer. The present study was designed to investigate whether P-AG prevents oral mucositis in all patients (36 patients) with hematolog...

journal_title：Anticancer research

authors： Hayashi H,Kobayashi R,Suzuki A,Ishihara M,Nakamura N,Kitagawa J,Kanemura N,Kasahara S,Kitaichi K,Hara T,Tsurumi H,Moriwaki H,Itoh Y

更新日期：2014-12-01 00:00:00

abstract：:Constitutive activation of estrogen receptor alpha (ER-alpha) expression is an early event in breast cancer tumorigenesis. However, the mechanism whereby ER-alpha is constitutively activated during transformation of normal mammary cells has not been well established. Previously, we reported that haploinsufficiency of ...

journal_title：Anticancer research

authors： Zhang X,Shen P,Coleman M,Zou W,Loggie BW,Smith LM,Wang Z

更新日期：2005-01-01 00:00:00

abstract：:The attempts to identify, isolate and characterize cancer stem cell populations are mostly dependent on cell-surface markers. In breast cancer, several putative breast cancer stem cell (BCSC) markers have already been reported, but the agreement on their phenotypic characterization is still absent. In fact, it became ...

journal_title：Anticancer research

authors： DA Cruz Paula A,Lopes C

更新日期：2017-05-01 00:00:00