Abstract：
BACKGROUND:For advanced gastric cancer (AGC) with peritoneal metastasis, decision-making regarding treatment change is often challenging because of the absence of measurable lesions. We attempted to clarify which criterion for treatment change contributes more to longer survival. PATIENTS AND METHODS:We retrospectively reviewed 50 patients with non-measurable peritoneal metastasis in whom first-line chemotherapy for AGC was changed based on aggravated clinical symptoms or tumor markers (TMs), or radiologically-confirmed disease progression. Prognostic factors for overall survival (OS) were investigated. RESULTS:Patients whose treatment was changed based on symptoms/TMs had significantly longer OS than patients with computed tomographic-based treatment change (p=0.04). On multivariate analysis, treatment change based on symptoms/TMs was identified as an independent prognostic factor for favorable OS (hazard ratio=0.321, 95% confidence interval=0.154-0.668, p=0.002). CONCLUSION:The present study suggests that aggravated clinical symptoms/elevated TMs could be a sensitive predictor for disease progression in patients with AGC with non-measurable peritoneal metastasis.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Hasegawa H,Fujitani K,Nakazuru S,Hirao M,Yamamoto K,Mita E,Tsujinaka Tsubject
Has Abstractpub_date
2014-09-01 00:00:00pages
5169-74issue
9eissn
0250-7005issn
1791-7530pii
34/9/5169journal_volume
34pub_type
杂志文章abstract：BACKGROUND:In a previous study we compared the influence of several growth factors on cancer cells in culture and observed that transforming growth factor-beta (TGF-beta) enhanced the invasiveness of several breast cancer cell lines. The objective of the present study was to determine the influence of three unique anti...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2002-01-01 00:00:00
abstract：:The present study assessed the immunohistochemical expression of ras p21 oncoprotein in 41 cases of benign and cancerous lesions of the prostate gland and correlated p21 expression with survival of patients operated for prostate cancer. Our results show that p21 is detected in both categories of patients, the expressi...
journal_title：Anticancer research
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
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journal_title：Anticancer research
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更新日期：2001-03-01 00:00:00
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journal_title：Anticancer research
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更新日期：2014-11-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1999-01-01 00:00:00
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journal_title：Anticancer research
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更新日期：2007-07-01 00:00:00
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journal_title：Anticancer research
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更新日期：2008-03-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1996-09-01 00:00:00
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journal_title：Anticancer research
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doi：
更新日期：2008-03-01 00:00:00
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doi：
更新日期：2011-04-01 00:00:00
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doi：
更新日期：1998-01-01 00:00:00
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journal_title：Anticancer research
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doi：
更新日期：2010-09-01 00:00:00
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doi：
更新日期：2014-08-01 00:00:00
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doi：
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journal_title：Anticancer research
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doi：
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更新日期：2018-10-01 00:00:00
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pub_type： 临床试验,杂志文章
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2005-11-01 00:00:00
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