The effect of antiestrogens on TGF-beta-mediated chemotaxis of human breast cancer cells.

abstract：:The prognosis of patients with pancreatic cancer is very poor because of late diagnosis and the lack of response to various therapies. Pancreatic cancer is generally resistant to chemotherapy and is highly fatal. Gemcitabine (GEM) appears to be the only effective agent for treatment of pancreatic cancer. However, a hi...

journal_title：Anticancer research

authors： Kuramitsu Y,Taba K,Ryozawa S,Yoshida K,Zhang X,Tanaka T,Maehara S,Maehara Y,Sakaida I,Nakamura K

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:Phytoestrogens are known to prevent tumor induction. But their molecular mechanisms of action are largely unknown. This study aimed to examine the effect of genistein and quercetin on proliferation and apoptosis in HER2-expressing breast cancer cells. MATERIALS AND METHODS:The antiproliferative effects of p...

journal_title：Anticancer research

authors： Seo HS,Choi HS,Choi HS,Choi YK,Um JY,Choi I,Shin YC,Ko SG

更新日期：2011-10-01 00:00:00

abstract：AIM:To determine depression in patients with choroidal melanoma (CM) treated with proton beam radiotherapy. PATIENTS AND METHODS:This was a cross-sectional study including 50 patients with CM (50% males, mean age=49.88±6.34 years) and 46 age- and sex-matched healthy controls (52% males, mean age=48.60±8.05 years). Par...

journal_title：Anticancer research

authors： Moschos MM,Moustafa GA,Lavaris A,Damaskos C,Laios K,Karathanou E,Ladas DS,Asproudis I,Garmpis N,Kalogeropoulos C

更新日期：2018-05-01 00:00:00

abstract：:Over 600 analogues of mitomycin C (MMC) have been made in the past and more recently a number of Mitomycin A (MMA) derivatives have been prepared. Since many of the MMA type had the same organic side chain at the 7-position as previously prepared MMC analogues it was of interest to see if the biological effects of MMC...

journal_title：Anticancer research

authors： Bradner WT,Remers WA,Vyas DM

更新日期：1989-07-01 00:00:00

abstract：BACKGROUND:Recent studies have demonstrated that heparin-binding epidermal growth factor-like growth factor (HB-EGF) plays a role in carcinogenesis and carcinoma progression. In this study we investigated the expression of HB-EGF in human colonic non-neoplastic and neoplastic tissues. MATERIALS AND METHODS:We performe...

journal_title：Anticancer research

authors： Ito Y,Higashiyama S,Takeda T,Okada M,Matsuura N

更新日期：2001-03-01 00:00:00

abstract：BACKGROUND:Signaling between androgen receptor (AR) and mTOR may be crucial for prostate cancer cells to endure the low androgen and suboptimal nutrient conditions produced by androgen deprivation therapy. MATERIALS AND METHODS:AR and mTOR cross-talk was examined in LNCaP cells exposed to either high or low testostero...

journal_title：Anticancer research

authors： Wu Y,Chhipa RR,Cheng J,Zhang H,Mohler JL,Ip C

更新日期：2010-10-01 00:00:00

abstract：AIM:We hypothesized that a nomogram can accurately predict overall survival (OS) for patients with intrahepatic cholangiocarcinoma (ICC) after hepatectomy. MATERIALS AND METHODS:A nomogram to predict OS based was developed using data from 185 ICC patients who had undergone hepatectomy. The nomogram was evaluated by co...

journal_title：Anticancer research

authors： Yeh CN,Wang SY,Chen YY,Chen MH,Chiang KC,Cheng CT,Tsai CY,Wang CC,Yeh TS,Chen TC

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:Therapy for patients with hepatic metastases from colorectal cancer (CRC) remains controversial and may be improved by regional oxaliplatin which proved to be effective when administered systemically to patients with advanced CRC. METHODS:During the current study, which aims to determine the maximum tolerat...

journal_title：Anticancer research

authors： Kern W,Beckert B,Lang N,Waggershauser T,Braess J,Schalhorn A,Hiddemann W

更新日期：2000-11-01 00:00:00

abstract：:The triphenylmethane derivative, aurintricarboxylic acid (ATA), but not aurin, is a potent inhibitor of angiogenesis in the chick chorioallantoic membrane. ATA alone showed potent anti-angiogenic activity in a dose-related manner. The presence of heparin or bFGF decreased the anti-angiogenic activity of ATA. ATA also ...

journal_title：Anticancer research

authors： Gagliardi AR,Collins DC

更新日期：1994-03-01 00:00:00

abstract：:Total sialic acid (TSA) and "lipid-bound" sialic acid (LSA) were evaluated in comparison to carcinoembryonic antigen (CEA) and ferritin and neuron specific enolase (NSE) in 152 untreated patients with primary lung cancer, 107 benign pulmonary disease patients and 207 notmal controls. The mean concentrations of TSA, LS...

journal_title：Anticancer research

authors： Kakari S,Stringou E,Toumbis M,Ferderigos AS,Poulaki E,Chondros K,Dema A,Kotsovoulou V,Pavlidis N

更新日期：1991-11-01 00:00:00

abstract：BACKGROUND/AIM:Exposure of the skin to sunshine is the major natural source of vitamin D. In order to imitate this natural production of vitamin D for patients with chronic kidney disease, hemodialysis patients were exposed three times a week to radiation of the front part of both legs to normalize the vitamin D status...

journal_title：Anticancer research

authors： Krause R,Stange R,Roth HJ,Kaase H,Michalsen A,Holick MF

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Perillyl alcohol (POH) elicited anticarcinogenic effects in a number of cancer models and pharmacokinetic studies in humans revealed that PA is the major circulating metabolite following POH administration. MATERIALS AND METHODS:Effects of PA or POH alone, or in combination with radiation, on human head and...

journal_title：Anticancer research

authors： Samaila D,Toy BJ,Wang RC,Elegbede JA

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND:Tumor cells expressing excessive anionic-charged sialic acid can be potentially targeted by cationic polymers which may inhibit tumor growth. In the present study, three new families of cationic polymers were synthesized to assess their effects on prostate cancer cells. MATERIALS AND METHODS:Cationic polyme...

journal_title：Anticancer research

authors： Gakhar G,Liu H,Shen R,Scherr D,Wu D,Nanus D,Chu CC

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:CD44 is a transmembrane glycoprotein and is associated with cell-matrix and cell-cell interactions. CD44 expression was shown to be relevant to tumour progression in various types of human cancer. The objective of this study was to investigate the relationship between the expression levels of the standard fo...

journal_title：Anticancer research

authors： Al-Maghrabi J,Gomaa W,Buhmeida A,Al-Qahtani M,Al-Ahwal M

更新日期：2012-08-01 00:00:00

abstract：:A consecutive series of 128 breast cancer patients detected by breast screening were enrolled in this study to analyze their age-dependent characteristics. They were classified into three groups; 40 years or less (young): 26 patients, 41-55 years (middle-aged): 67 patients and 56 years or over (old): 35 patients. The ...

journal_title：Anticancer research

authors： Takei H,Iino Y,Horiguchi J,Maemura M,Koibuchi Y,Horii Y,Nagaoka H,Matsumoto H,Ishikita T,Yokoe T,Morishita Y

更新日期：1998-07-01 00:00:00

abstract：BACKGROUND:The effects of oxaliplatin (L-OHP) on cell cycle and apoptosis were examined. MATERIALS AND METHODS:The HT29, MCF7, Hela and A549 cell lines were treated and dual parameter flow cytometry BrdU/PI was then performed to monitor cell cycle modifications. Annexin V-FITC and PI probes were used for the detection...

journal_title：Anticancer research

authors： William-Faltaos S,Rouillard D,Lechat P,Bastian G

更新日期：2006-05-01 00:00:00

abstract：UNLABELLED:The diagnostic accuracy of fused positron emission tomography/computed tomography (PET/CT) was compared with CT alone and PET alone in the staging and re-staging of nasopharyngeal carcinoma (NPC) patients. PATIENTS AND METHODS:Eighty-six fluorine-18-2-fluoro-2-deoxy-D-glucose (FDG) PET/CT studies were retro...

journal_title：Anticancer research

authors： Chen YK,Su CT,Ding HJ,Chi KH,Liang JA,Shen YY,Chen LK,Yeh CL,Liao AC,Kao CH

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND/AIM:The importance of hadron therapy in the cancer management is growing. We aimed to refine the biological effect detection using a vertebrate model. MATERIALS AND METHODS:Embryos at 24 and 72 h postfertilization were irradiated at the entrance plateau and the mid spread-out Bragg peak of a 150 MeV proton ...

journal_title：Anticancer research

authors： Brunner S,TŐkÉs T,SzabÓ ER,Polanek R,SzabÓ IZ,Reisz Z,GubÁn BK,SzijÁrtÓ AL,Brand M,Hans S,Karsch L,Lessmann E,Pawelke J,SchÜrer M,Beyreuther E,HideghÉty K

更新日期：2020-11-01 00:00:00

abstract：:The effect of selenite on mitochondrial morphology, selenoprotein synthesis, membrane potential, phosphorylating respiration, P/O ratio and respiratory control index were evaluated relative to selenite inhibition of DNA synthesis in murine mammary epithelial cell lines. No inhibition of mitochondrial function was note...

journal_title：Anticancer research

authors： Morrison DG,Pauly DF,Berdan RC,Dishart MK,Turner DS,Oborn CJ,Medina D

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND/AIM:Osteosarcoma originates from mesenchymal stem cells with impaired bone differentiation. In the present study we investigated the effect of ascorbic acid (AsA) on osteogenic differentiation and apoptosis of the MG-63 osteosarcoma cell line. MATERIALS AND METHODS:We evaluated the expression of runt-relate...

journal_title：Anticancer research

authors： Valenti MT,Zanatta M,Donatelli L,Viviano G,Cavallini C,Scupoli MT,Dalle Carbonare L

更新日期：2014-04-01 00:00:00

abstract：:Flunarizine, a calcium-antagonist drug that binds to calmodulin, was found to inhibit the migration of both B16 melanoma cells and M5076 macrophage-like cancer cells. The migration movement, both under agarose and through a polycarbonate filter membrane, was impaired by the drug. In M5076 macrophage-like cells Fc-depe...

journal_title：Anticancer research

authors： Sezzi ML,De Luca G,Materazzi M,Bellelli L

更新日期：1985-05-01 00:00:00

abstract：:Ten cell sublines the MDA-MB 231 human breast cell line were analyzed for their phenotypic diversity: morphology, karyotype, growth rate, clonogenicity in semisolid medium, tumorigenicity in nude mice, number and affinity of nuclear receptors for oestradiol, progesterone and glucocorticoids. Karyotypic analysis showed...

journal_title：Anticancer research

authors： Crépin M,Salle V,Raux H,Berger R,Hamelin R,Brouty-Boyé D,Israel L

更新日期：1990-11-01 00:00:00

abstract：:Arsenic trioxide (ATO) is an inorganic arsenic derivative that is very effective against acute promyelocytic leukemia. However, organic arsenic derivatives (OAD) have a more favorable toxicity profile than ATO. We herein characterized dipropil-S-glycerol arsenic (GMZ27), a novel OAD. GMZ27 had potent antiproliferative...

journal_title：Anticancer research

authors： Cheng X,Quintás-Cardama A,Golemovic M,Zingaro R,Gao MZ,Freireich EJ,Andreeff M,Kantarjian HM,Verstovsek S

更新日期：2012-07-01 00:00:00

abstract：AIM:Modern radiotherapy (RT) technique and therapy de-escalation have led to encouraging results in lymphoma management. In this study, we aimed to describe the oncological and toxicity outcome in patients with ocular adnexal lymphoma. PATIENTS AND METHODS:A total of 45 patients with 52 orbital lesions who were treate...

journal_title：Anticancer research

authors： Rehn S,Elsayad K,Oertel M,Baehr A,Eter N,Haverkamp U,Lenz G,Eich HT

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:Previously we demonstrated that injection of Interleukin-alpha (IL-1) stimulated B16 melanoma tumour growth in vivo, associated with increased intercellular adhesion molecule-1 (ICAM-1) expression on the tumour cells (Photodermatol Photoimmunol Photomed 1994; 10: 74-79, ). METHODS:In the present study, we e...

journal_title：Anticancer research

authors： McKenzie RC,Oran A,Dinarello CA,Sauder DN

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND/AIM:Intraperitoneal chemotherapy with taxanes provides high locoregional drug concentrations. Regarding their synergy with hyperthermia, results have been inconclusive. In this in vitro study, the thermal enhancement of the effect of paclitaxel and docetaxel on ovarian cancer cells under conditions mimicking...

journal_title：Anticancer research

authors： de Bree E,Katsougkri D,Polioudaki H,Tsangaridou E,Michelakis D,Zoras O,Theodoropoulos P

更新日期：2020-12-01 00:00:00

abstract：:The inhibitory activity of lignin against nitrosoguanidine (MNNG)- and acridine orange (AO)- induced mutagenesis was examined using two microbial systems: green unicellular flagellate Euglena gracilis and Salmonella typhimurium TA100 and TA97. To verify the hypothesis that the above mentioned mutagens may generate som...

journal_title：Anticancer research

authors： Ebringer L,Krizková L,Polónyi J,Dobias J,Lahitová N

更新日期：1999-01-01 00:00:00

abstract：AIM:To investigate the discordance in the programmed cell death-ligand 1 (PD-L1) expression between primary and metastatic tumors and analyze the association between the discordance and the clinical factors in non-small cell lung cancer (NSCLC) patients. PATIENTS AND METHODS:Twenty-one NSCLC patients who underwent sur...

journal_title：Anticancer research

authors： Takamori S,Toyokawa G,Okamoto I,Takada K,Kozuma Y,Matsubara T,Haratake N,Akamine T,Katsura M,Mukae N,Shoji F,Okamoto T,Oda Y,Iwaki T,Iihara K,Nakanishi Y,Maehara Y

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:The diversity of malignant salivary gland tumors challenges the study of survival rates. The current study evaluated patient survival rates using Kaplan-Meier analysis and examined the relative effects of histology, grade and stage on survival. MATERIALS AND METHODS:Using the Kaplan-Meier model, cancer-spec...

journal_title：Anticancer research

authors： Israel Y,Rachmiel A,Gourevich K,Nagler R

更新日期：2019-02-01 00:00:00

abstract：:Radiation therapy plays a critical role in women with advanced-stage cervical cancer worldwide, particularly in developing countries, and most of the time it may be the only available treatment. The efficacy of radiation largely depends on the radiosensitivity of the tumor. The high radiation dose associated with ther...

journal_title：Anticancer research

authors： Qin C,Chen X,Bai Q,Davis MR,Fang Y

更新日期：2014-09-01 00:00:00