Phytoestrogens induce apoptosis via extrinsic pathway, inhibiting nuclear factor-kappaB signaling in HER2-overexpressing breast cancer cells.

abstract：BACKGROUND:Genetic polymorphisms of carcinogen-metabolizing enzyme genes have been associated with the risk of oral squamous cell carcinoma and oral leukoplakia. The overexpression of p53 protein is the most common genetic alteration in head and neck cancer. In the present study the combined or isolated presence of glu...

journal_title：Anticancer research

authors： Duarte EC,Ribeiro DC,Gomez MV,Ramos-Jorge ML,Gomez RS

更新日期：2008-03-01 00:00:00

abstract：:The circadian rhythm-modulated delivery of anticancer drugs has been shown to reduce toxicity and improve anticancer efficacy. The aim of this phase I trial was to compare the feasibility and tolerability of carboplatin (CBDCA) administered at circadian-modulated or flat infusion rate in 24 patients with advanced canc...

journal_title：Anticancer research

authors： Natoli C,Salini V,Irtelli L,Martino MT,Garufi C,Grassadonia A,Fiorentino B,Iacobelli S

更新日期：1996-05-01 00:00:00

abstract：BACKGROUND/AIM:Insulin-like growth factor II mRNA-binding protein 3 (IMP3) plays an important role in the adhesion, invasion, and metastasis of tumor cells. Although emerging evidence suggests that IMP3 promotes tumor progression in several malignancies, the expression of IMP3 and its prognostic implication in adenocar...

journal_title：Anticancer research

authors： Kim HG,Park MS,Sung JY,Kim YW,Kim HS,Na K

更新日期：2019-09-01 00:00:00

abstract：:The effects of the gypenosides (Gyp), a component of Gynostemma pentaphyllum Makino, on the cell viability, cell cycle and induction of apoptosis were investigated in human colon cancer colo 205 cells. Gyp was cytotoxic to colo 205 cells with an IC50 of 113.5 microg/ml. The decreasing number of viable cells appeared t...

journal_title：Anticancer research

authors： Chen JC,Lu KW,Lee JH,Yeh CC,Chung JG

更新日期：2006-11-01 00:00:00

abstract：:The feasibility of using low-dose carboplatin (CBDCA) as a radiopotentiator in radiotherapy(RT) for non-small cell lung cancer(NSCLC) patients with unfavorable factors was studied. Fifteen patients with locally advanced and inoperable NSCLC were treated with RT in combination with daily 20 mg/m2 CBDCA. Twelve patients...

journal_title：Anticancer research

authors： Satoh H,Ohara K,Fuji H,Ishikawa H,Yamashita YT,Kamma H,Ohtsuka M,Hasegawa S

更新日期：1998-11-01 00:00:00

abstract：:Nineteen patients with locally advanced inoperable carcinoma of the uterine cervix (8 with stage IIb, 8 with stage IIIb and 3 with stage IV) were treated with a cisplatin (100 mg/m2), aclacinomycin (30 mg/m2) and bleomycin (20 mg/m2) combination using balloon occluded arterial infusion (BOAI), and 5 patients (2 stage ...

journal_title：Anticancer research

authors： Sawada T,Yoshimura Y,Kawakami S

更新日期：1994-11-01 00:00:00

abstract：:Human vaginal malignant melanoma represents rare gynecological malignancies of poor prognosis. We have established a melanoma tumor line in nude mice, designated Mela-1, and have examined the histological and biological characteristics of this tumor. The Mela-1 tumor has preserved the histological, histochemical and b...

journal_title：Anticancer research

authors： Sawada M,Terada N,Nishizawa Y,Ito S,Wakamatsu K,Takemura K,Yamamoto T,Ozaki M,Sakamoto H,Tanizawa O

更新日期：1994-07-01 00:00:00

abstract：:Oral mucositis is one of the main complications in non-surgical cancer treatments. It represents the major dose-limiting toxicity for some chemotherapeutic agents, for radiotherapy of the head and neck region and for some radiochemotherapy combined treatments. Many reviews and clinical studies have been published in o...

journal_title：Anticancer research

authors： Alterio D,Jereczek-Fossa BA,Fiore MR,Piperno G,Ansarin M,Orecchia R

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND:The constant overexpression of glycolysis and active mitochondrial function are critical for productive energy required for the immortal proliferation of cancer cells. The genes related to glycolysis and mitochondrial respiration might have some function during stomach carcinogenesis. MATERIALS AND METHODS:...

journal_title：Anticancer research

authors： Rho M,Kim J,Jee CD,Lee YM,Lee HE,Kim MA,Lee HS,Kim WH

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Mistletoe lectins (ML), the major biologically active components of mistletoe extracts, which are used for adjuvant cancer therapy, induce apoptosis in lymphocytes and tumor cells. In addition, ML at toxic concentrations induce the release of cytokines, but it remains unclear as to whether dying or activated...

journal_title：Anticancer research

authors： Stein GM,Pfüller U,Schietzel M,Büssing A

更新日期：2000-05-01 00:00:00

abstract：UNLABELLED:In a previous report we noted that cyclooxygenase-2 (COX-2) expression in clinical colorectal cancer is closely related to liver metastasis and survival. The aim of the present study was to clarify the role of COX-2 in liver metastasis and to examine the potential for a selective COX-2 inhibitor as a novel t...

journal_title：Anticancer research

authors： Yamauchi T,Watanabe M,Hasegawa H,Nishibori H,Ishii Y,Tatematsu H,Yamamoto K,Kubota T,Kitajima M

更新日期：2003-01-01 00:00:00

abstract：:Urinary gonadotropin peptide (UGP) has been measured in gynecological and urological cancers, but its usefulness in the diagnosis of cancers of digestive organs has not been investigated. In this report, UGP was measured by sandwich enzyme immunoassay in 311 patients, including 166 patients with cancers of digestive o...

journal_title：Anticancer research

authors： Motoo Y,Watanabe H,Yamaguchi Y,Mouri I,Fujii T,Yamakawa O,Satomura Y,Okai T,Sawabu N

更新日期：1996-07-01 00:00:00

abstract：BACKGROUND/AIM:NME/NM23 nucleoside diphosphate kinase 1 (NME1) is a metastasis suppressor gene, exhibiting reduced expression in metastatic cancers and the ability to suppress metastatic activity of cancer cells. We previously identified NME1-regulated genes with prognostic value in human melanoma. This study was condu...

journal_title：Anticancer research

authors： Pamidimukkala NV,Leonard MK,Snyder D,McCorkle JR,Kaetzel DM

更新日期：2018-11-01 00:00:00

abstract：:Adenovirus(ADV) mediated thymidine kinase(TK) gene therapy followed by ganciclovir(GCV) administration is widely used in different types of cancer. ACV shares the same mechanism of selective cell killing in ADV/TK positive cells as GCV and can be used at 4.5 times higher doses in patients without significant side effe...

journal_title：Anticancer research

authors： Tong XW,Engehausen DG,Kaufman RH,Agoulnik I,Contant C,Freund CT,Oehler MK,Kim TE,Hasenburg A,Woo SL,Kieback DG

更新日期：1998-03-01 00:00:00

abstract：BACKGROUND:Positron emission tomography-computed tomography (PET-CT) is currently not established in the management of recurrent ovarian cancer. Here, its value in diagnosis and therapy planning was evaluated. PATIENTS AND METHODS:Seventy patients received PET-CT for suspicion of recurrent ovarian cancer. PET-CT and s...

journal_title：Anticancer research

authors： Lenhard MS,Burges A,Johnson TR,Stieber P,Kümper C,Ditsch N,Linke R,Friese K

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND:The tumour suppressor gene 'mutated in colorectal cancer' (MCC) is silenced through promoter methylation in colorectal cancer and has been implicated as a regulator of the nuclear factor kappa B (NFκB) pathway. Therefore, we aimed to determine whether MCC modulates NFκB activation in colorectal cancer. MATE...

journal_title：Anticancer research

authors： Sigglekow ND,Pangon L,Brummer T,Molloy M,Hawkins NJ,Ward RL,Musgrove EA,Kohonen-Corish MR

更新日期：2012-01-01 00:00:00

abstract：:Neurological complications of both fluorouracil (5-FU) and its oral prodrug, capecitabine, have been described in the literature. This study reported the case of a 70-year-old female with metastatic adenocarcinoid of the rectum who developed hyperammonemic encephalopathy, following infusional 5-FU therapy, manifesting...

journal_title：Anticancer research

authors： Advani PP,Fakih MG

更新日期：2011-01-01 00:00:00

abstract：:The expression of a cell surface-associated sialoglycoprotein (LEA.135), which has been shown to be significantly associated with decreased incidence of recurrence and increased overall survival of patients with primary invasive breast carcinoma, was evaluated in a retrospective study to identify subsets of patients w...

journal_title：Anticancer research

authors： Baltayan A,Naritoku WY,Chaiwun B,Tsao-Wei DD,Groshen S,Hern RA,Gusterson BA,Taylor CR,Imam SA

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND:Lung cancer tissues are often infiltrated by B lymphocytes, but it is not clear whether these infiltrations represent tumor-specific immune response or a nonspecific reaction. MATERIALS AND METHODS:The serological analysis of recombinant cDNA expression libraries (SEREX) were previously modified using a sev...

journal_title：Anticancer research

authors： Yasuda M,Mizukami M,Hanagiri T,Shigematsu Y,Fukuyama T,Nagata Y,So T,Ichiki Y,Sugaya M,Takenoyama M,Sugio K,Yasumoto K

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND:Tumor angiogenesis is considered a multi-pathway process, while p21(WAF1/CiP1) is a CDK inhibitor involved in cell division and survivaL Herein the tumor environment effect on endothelial p21(WAF1/Cip1) expression is examined. MATERIALS AND METHODS:The EA.hy 926 endothelial cell line and tumor-conditioned m...

journal_title：Anticancer research

authors： Vrekoussis T,Stathopoulos EN,Kafousi M,Saridaki Z,Sanidas E,Zoras O

更新日期：2005-07-01 00:00:00

abstract：:Cisplatin is the most active anticancer agent for lung cancer. It has been reported that intracellular accumulation of cisplatin is important in determining resistance to cisplatin, which may be modulated by Na+, K(+)-ATPase activity. On the other hand, it is well-known that sorbitol, a metabolite of glucose mediated ...

journal_title：Anticancer research

authors： Bando T,Fujimura M,Kasahara K,Shibata K,Shirasaki H,Heki U,Iwasa K,Ueda A,Tomikawa S,Matsuda T

更新日期：1997-09-01 00:00:00

abstract：BACKGROUND:The aim of this study was to assess the relationship between p53 status and the clinical outcome of patients with advanced ovarian cancer treated with a paclitaxel-based regimen. PATIENTS AND METHODS:The investigation was conducted on 38 patients with FIGO stage III-IV ovarian cancer from whom tumor tissue ...

journal_title：Anticancer research

authors： Gadducci A,Cianci C,Cosio S,Carnino F,Fanucchi A,Buttitta F,Conte PF,Genazzani AR

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND:Intratumoural hypoxia is associated with chemoresistance in glioblastoma multiforme (GBM), a highly malignant brain tumour. Adaptive response to endoplasmic reticulum stress induced by temozolomide is a major obstacle in recurrent GBM. We investigated whether hyperoxia resensitizes temozolomide-resistant GBM...

journal_title：Anticancer research

authors： Lee D,Sun S,Ho AS,Kiang KM,Zhang XQ,Xu FF,Leung GK

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:Molecular alterations such as DNA microsatellite instability (MSI/RER), single nucleotide polymorphism (SNP) and loss of heterozygosity (LOH) can occur throughout the genome and be associated with different types of cancer. In the present study, we aimed at detecting molecular alterations within the mismatch...

journal_title：Anticancer research

authors： Arzimanoglou II,Hansen LL,Chong D,Li Z,Psaroudi MC,Dimitrakakis C,Jacovina AT,Shevchuk M,Reid L,Hajjar KA,Vassilaros S,Michalas S,Gilbert F,Chervenak FA,Barber HR

更新日期：2002-03-01 00:00:00

abstract：BACKGROUND:Tumor cells expressing excessive anionic-charged sialic acid can be potentially targeted by cationic polymers which may inhibit tumor growth. In the present study, three new families of cationic polymers were synthesized to assess their effects on prostate cancer cells. MATERIALS AND METHODS:Cationic polyme...

journal_title：Anticancer research

authors： Gakhar G,Liu H,Shen R,Scherr D,Wu D,Nanus D,Chu CC

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND/AIM:Bladder cancer (BLCA, urothelial bladder cancer) is one of the most common malignancies with increasing incidence and mortality worldwide. Poor diagnosis and the limitation of treatment is still an unmet need in clinical practice. γδ T-Cells have been paid increasing attention because of their potent cyt...

journal_title：Anticancer research

authors： Pan Y,Chiu YH,Chiu SC,Cho DY,Lee LM,Wen YC,Whang-Peng J,Hsiao CH,Shih PH

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND/AIM:To investigate the impact of inguinal lymph node dissection (ILND) following neoadjuvant chemoradiotherapy (NACRT) for rectal cancer patients with ILN metastasis. PATIENTS AND METHODS:Forty-three patients with rectal cancer underwent NACRT followed by curative surgery between January 2005 and December 2...

journal_title：Anticancer research

authors： Ueta K,Matsuda T,Yamashita K,Hasegawa H,Mukohyama J,Yamamoto M,Matsuda Y,Kanaji S,Oshikiri T,Nakamura T,Suzuki S,Kakeji Y

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND/AIM:Reportedly, hypertension tends to be associated with response to bevacizumab therapy, because bevacizumab suppresses vascular nitric oxide production. In this study we examined the predictive value of nitric oxide in bevacizumab-treated non-small cell lung cancer (NSCLC) patients. PATIENTS AND METHODS:F...

journal_title：Anticancer research

authors： Muto S,Takagi H,Owada Y,Inoue T,Watanabe Y,Yamaura T,Fukuhara M,Okabe N,Matsumura Y,Hasegawa T,Osugi J,Hoshino M,Higuchi M,Shio Y,Suzuki H

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:Experimental data at the molecular, cellular and organismal levels have implicated dietary components in cancer. Exposure to numerous growth factors, hormones and environmental agents, that can regulate signaling events, is involved in carcinogenesis. Research targets on gene-nutrient interactions may give u...

journal_title：Anticancer research

authors： Updike MS,Sawdy JC,Wang LS,Liu S,Huang YW,Ye W,Farrar WB,Lin YC,Wick M

更新日期：2007-01-01 00:00:00

abstract：:Curcumin's instability and its metabolite, tetrahydrocurcumin (THC) pose a major issue for the establishment of dependable pharmacokinetics and excretion profiles. Additional pharmacokinetic variances are associated with durations of intravenous infusions. We found that stabilizing curcumin with phosphoric acid allows...

journal_title：Anticancer research

authors： Helson L,Bolger G,Majeed M,Vcelar B,Pucaj K,Matabudul D

更新日期：2012-10-01 00:00:00