New in vitro line from a human (B) non-Hodgkin lymphoma.

abstract：:Norcantharidin[3], the demethylated product of cantharidin[1] has been used for the treatment of hepatoma, carcinomas of esophagus and gastric cardia, leukopenia and hepatitis. Since the enzyme xanthine oxidase is involved in the diseases mentioned above, and the reactive oxygen species produced by the enzyme induces ...

journal_title：Anticancer research

authors： Tsauer W,Lin JG,Lin PY,Hsu FL,Chiang HC

更新日期：1997-05-01 00:00:00

abstract：:The effects of two gallium (Ga) compounds, Ga chloride (GaCl3) and tris(8-quinolinolato)Ga (III) on the viability of A549 human malignant lung adenocarcinoma cells were investigated. The results demonstrated that both drugs reduced the viability of A549 cells but to different extents. The inhibitory effects of tris(8-...

journal_title：Anticancer research

authors： Collery P,Lechenault F,Cazabat A,Juvin E,Khassanova L,Evangelou A,Keppler B

更新日期：2000-03-01 00:00:00

abstract：:In experimental and clinical phase II trials GnRH agonists were shown to possess antitumor activity in ovarian cancer. The outcome of prostatic cancer was also improved experimentally by a combination of cytostatic chemotherapy and GnRH analogs. Encouraged by these results, we administered micro-encapsulated triptorel...

journal_title：Anticancer research

authors： Medl M,Peters-Engel C,Fuchs G,Leodolter S

更新日期：1993-11-01 00:00:00

abstract：UNLABELLED:BACKGROUD/AIM: We previously demonstrated that high protein expression of excision repair cross-complementation group-1 (ERCC1) was associated with poor disease-free survival in patients who received adjuvant cisplatin-based chemotherapy or chemoradiotherapy with cisplatin, and was shown to be an independent...

journal_title：Anticancer research

authors： Torii Y,Kato R,Minami Y,Hasegawa K,Fujii T,Udagawa Y

更新日期：2014-01-01 00:00:00

abstract：:Mammalian cells transfected with the S. cerevisiae APN1 protein acquire resistance to oxidizing agents, the damage of which is mainly repaired via DNA base excision repair (BER). We have recently hypothesized that this effect might be linked to the possible capacity of APN1 to accelerate mammalian BER by its 3' dieste...

journal_title：Anticancer research

authors： Bogliolo M,Cappelli E,D'Osualdo A,Rossi O,Barbieri O,Kelley MR,Frosina G

更新日期：2003-09-01 00:00:00

abstract：BACKGROUND:Pathological examination of sentinel lymph nodes (SLNs) and non-SLNs in colon cancer is frequently not performed to the same extent. We examined whether non-SLNs were truly negative in tumors with tumor-negative SLNs using reverse transcriptase-polymerase chain reaction (RT-PCR). PATIENTS AND METHODS:RT-PCR...

journal_title：Anticancer research

authors： Kelder W,Braat A,van den Berg A,Platteel I,Hollema H,Groen H,Plukker J

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND:Patients with advanced pancreatic carcinoma have a risk of relapse after primary therapy, and the prognosis for these patients remains bleak. The effect of immuno-cell therapy in advanced pancreatic carcinoma, with or without other standard therapies, was examined. PATIENTS AND METHODS:Forty-six patients wi...

journal_title：Anticancer research

authors： Kaneko T,Goto S,Kato A,Akeyama A,Tomonaga M,Fujimoto K,Miyamoto Y,Eriguchi M,Egawa K

更新日期：2005-11-01 00:00:00

abstract：:A female patient with stage IV-M1c (distant lymph node and breast metastases), chemotherapy-refractory melanoma was treated with the cytotoxic T-lymphocyte antigen 4 (CTLA-4)-inhibitory monoclonal antibody ipilimumab. At first evaluation following induction treatment, there was marked increase in the volume of the lym...

journal_title：Anticancer research

authors： Wilgenhof S,Morlion V,Seghers AC,Du Four S,Vanderlinden E,Hanon S,Vandenbroucke F,Everaert H,Neyns B

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:In the present study, we examined the relationships between microsatellite status and Ki-67 labeling index, a proliferative marker, in colorectal cancers in order to clarify the common biological profiles of familial and sporadic cases of MSI (microsatellite inability)-positive tumors. PATIENTS AND METHODS:...

journal_title：Anticancer research

authors： Takagi S,Kumagai S,Kinouchi Y,Hiwatashi N,Nagashima F,Takahashi S,Shimosegawa T

更新日期：2002-11-01 00:00:00

abstract：:Rats were inoculated subcutaneously into both flanks with a transplantable adenocarcinoma of the colon. They were treated intravenously with either 5-FUrd (5-fluorouridine) or 5-FdUrd (5-fluoro-2'-deoxyuridine) with or without addition of dipyridamole 20 and 30 min later, respectively, for 3 consecutive days. Dipyrida...

journal_title：Anticancer research

authors： el Hag IA,Roos G,Jönsson PE,Stenram U

更新日期：1990-01-01 00:00:00

abstract：:The role of serum tumor markers in lung cancer has not been defined. It is widely believed that almost all neoplasms produce at least a few substances, but the identity of most of the known substances has not been correlated with a positive role in either the diagnosis or prognosis of patients with these neoplasms. We...

journal_title：Anticancer research

authors： Tarro G,Esposito C,Perna A,Claudio PP,Giordano A

更新日期：1998-07-01 00:00:00

abstract：:Recently, it has been reported that total clearance (CLtot) of vancomycin is significantly higher in patients with malignancies compared to those without malignancies. In the present study, to clarify the mechanism of this enhancement in malignancy, we adopted rat animal models, using chemical carcinogen-induced osteo...

journal_title：Anticancer research

authors： Shimada I,Iwata C,Taga S,Teramachi H,Nomura M,Miyamoto K,Tsuciya H,Wada T,Kimura K,Matsushita R

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND/AIM:The present study aimed to identify hypoxia-regulated microRNAs (HRMs) in vitro and investigate the clinical role of candidate HRMs in patients with gastroesophageal cancer (GEC). MATERIALS AND METHODS:microRNA expression changes induced by hypoxia in human GEC cell lines were measured with microarrays ...

journal_title：Anticancer research

authors： Winther M,Alsner J,Sørensen BS,Wittrup CF,Tramm T,Baeksgaard L,Hofland K,Holtved E,Nordsmark M

更新日期：2016-02-01 00:00:00

abstract：:We have previously reported that polaprezinc in sodium alginate suspension (P-AG) inhibited the incidence of oral mucositis induced by radiochemotherapy in patients with head and neck cancer. The present study was designed to investigate whether P-AG prevents oral mucositis in all patients (36 patients) with hematolog...

journal_title：Anticancer research

authors： Hayashi H,Kobayashi R,Suzuki A,Ishihara M,Nakamura N,Kitagawa J,Kanemura N,Kasahara S,Kitaichi K,Hara T,Tsurumi H,Moriwaki H,Itoh Y

更新日期：2014-12-01 00:00:00

abstract：:The presence of steroid receptors in breast cancer is usually considered as a good indicator for responsiveness to antiestrogen treatment. However, not all estrogen-receptor (ER) positive tumors respond to tamoxifen, probably owing to the natural heterogeneity of breast cancer, which after tamoxifen treatment can resu...

journal_title：Anticancer research

authors： Coradini D,Biffi A,Pirronello E,Di Fronzo G

更新日期：1995-03-01 00:00:00

abstract：BACKGROUND:We evaluated the effect of in vivo electrogene therapy (EGT), a newly-developed gene transfer method using electroporation on the induction of anti-cancer immunity. MATERIALS AND METHODS:The in vivo EGT was carried out by direct injection of plasmid DNAs encoding mouse interleukin-2 (IL-2) and granulocyte-m...

journal_title：Anticancer research

authors： Chi CH,Wang YS,Lai YS,Chi KH

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND/AIM:AKT, also known as protein kinase B (PKB), is an established therapeutic target in cancer and its inhibitors are increasingly designed. The anti-cancer potential of a compound class naphthoquinones has been constantly realized. The current work aimed to explore AKT1 inhibitors from 1,4-naphthoquionone de...

journal_title：Anticancer research

authors： Rehan M,Mostafa M

更新日期：2019-07-01 00:00:00

abstract：:We investigated the anti-metastatic effect of PKC412, a selective inhibitor of protein kinase C (PKC), on a spontaneous metastatic mouse model, which was prepared by inoculation with B16-BL6 mouse melanoma cells into the footpad of the right hind leg. At two weeks after inoculation, the primary tumor was amputated com...

journal_title：Anticancer research

authors： Nakamura K,Yoshikawa N,Yamaguchi Y,Kagota S,Shinozuka K,Kunitomo M

更新日期：2003-03-01 00:00:00

abstract：BACKGROUND/AIM:The significance of microvascular invasion (MVI) of hepatocellular carcinoma (HCC) after radiofrequency ablation (RFA) is unknown. PATIENTS AND METHODS:We studied 149 patients with solitary small-sized HCC (≤3 cm) who underwent hepatectomy, and developed a predictive model of MVI using independent facto...

journal_title：Anticancer research

authors： Imai K,Yamashita YI,Yusa T,Nakao Y,Itoyama R,Nakagawa S,Okabe H,Chikamoto A,Ishiko T,Baba H

更新日期：2018-02-01 00:00:00

abstract：AIM:We examined whether the perioperative systemic inflammation score (SIS), which describes systemic inflammation and/or malnutrition, affected the tumor recurrence and survival in advanced gastric cancer patients. PATIENTS AND METHODS:The study retrospectively analyzed 160 patients with stage II/III gastric cancer w...

journal_title：Anticancer research

authors： Hara K,Aoyama T,Yamada T,Nakazono M,Nagasawa S,Shimoda Y,Kumazu Y,Numata M,Hayashi T,Tamagawa H,Shiozawa M,Morinaga S,Yukawa N,Rino Y,Masuda M,Ogata T,Oshima T

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:Immune cells (lymphocytes and macrophages) provide the microenvironment for immune surveillance of metastatic prostate cancer (PCa) cells in pelvic lymph nodes. We have hypothesized that degeneration and/or apoptosis of metastatic PCa cells in pelvic lymph nodes can distinguish between aggressive and non-agg...

journal_title：Anticancer research

authors： Sinha AA,Fernandes ET,Ewing SL,Wilson MJ

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Chagas disease patients with longstanding megaesophagus have a significantly increased risk for esophageal carcinoma. MATERIALS AND METHODS:PCR-SSCP analysis and DNA sequencing of esophageal mucosa from Chagas disease patients (with or without megaesophagus) in the exons of the TP53, CDKN2A and FHIT genes w...

journal_title：Anticancer research

authors： DA Silva Manoel-Caetano F,Silveira AF,Silva AE

更新日期：2009-04-01 00:00:00

abstract：:The iron chelator deferoxamine mesylate has been shown to inhibit the growth of a variety of human malignant cell lines and the rat 13762NF mammary adenocarcinoma cell line. In vivo studies in mice have also demonstrated that an iron deficiency induced by either feeding a low iron diet or injecting the iron chelator d...

journal_title：Anticancer research

authors： Wang F,Elliott RL,Head JF

更新日期：1999-01-01 00:00:00

abstract：:Bcl-2 oncoprotein, a member of a new category of oncogenes associated with the regulation of programmed cell death (apoptosis), has been considered to be involved in biological processes such as tumorigenesis and tumor development. To determine the role of bcl-2 oncoprotein in lung cancer, we preliminarily examined th...

journal_title：Anticancer research

authors： Higashiyama M,Doi O,Kodama K,Yokouchi H,Tateishi R

更新日期：1995-03-01 00:00:00

abstract：BACKGROUND:Nuclear morphometry can be expected to improve the distinction between benign and malignant lesions. PATIENTS AND METHODS:Forty fine-needle aspiration biopsy (FNAB) samples fixed in 50% ethanol were collected at the African Oncology Institute, Sabratha, Libya, during the period 2004-2007. All diagnoses repo...

journal_title：Anticancer research

authors： Abdalla F,Boder J,Buhmeida A,Hashmi H,Elzagheid A,Collan Y

更新日期：2008-11-01 00:00:00

abstract：INTRODUCTION:The aim of this study was to determine the tissue distribution of CA-125 in normal, hyperplastic and malignant endometrium. MATERIALS AND METHODS:Endometrial tissue was obtained from women in proliferative (n = 5), early secretory (ES; n = 4) and late secretory (LS; n = 4) phase as well as glandular-cysti...

journal_title：Anticancer research

authors： Mylonas I,Makovitzky J,Richter DU,Jeschke U,Briese V,Friese K

更新日期：2003-03-01 00:00:00

abstract：BACKGROUND:The tumour suppressor gene 'mutated in colorectal cancer' (MCC) is silenced through promoter methylation in colorectal cancer and has been implicated as a regulator of the nuclear factor kappa B (NFκB) pathway. Therefore, we aimed to determine whether MCC modulates NFκB activation in colorectal cancer. MATE...

journal_title：Anticancer research

authors： Sigglekow ND,Pangon L,Brummer T,Molloy M,Hawkins NJ,Ward RL,Musgrove EA,Kohonen-Corish MR

更新日期：2012-01-01 00:00:00

abstract：:Laryngeal hyperkeratotic lesions can progress to fully developed malignant carcinoma in some cases. These premalignant lesions are proliferative disorders whose potential for further tumour progression is perhaps difficult to assess by mere histology. Immunostaining with PCNA, a protein correlated with cell proliferat...

journal_title：Anticancer research

authors： Pignataro LD,Broich G,Lavezzi AM,Biondo B,Ottaviani F

更新日期：1995-07-01 00:00:00

abstract：:The attempts to identify, isolate and characterize cancer stem cell populations are mostly dependent on cell-surface markers. In breast cancer, several putative breast cancer stem cell (BCSC) markers have already been reported, but the agreement on their phenotypic characterization is still absent. In fact, it became ...

journal_title：Anticancer research

authors： DA Cruz Paula A,Lopes C

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND/AIM:Combining an anticancer agent fenretinide (HPR) or C6-pyridinium ceramide (LCL29) with Foscan-mediated photodynamic therapy (FoscanPDT) is expected to augment anticancer benefits of each substance. We showed that treatment with FoscanPDT+HPR enhanced accumulation of C16-dihydroceramide, and that fumonisi...

journal_title：Anticancer research

authors： Boppana NB,Kraveka JM,Rahmaniyan M,Li LI,Bielawska A,Bielawski J,Pierce JS,Delor JS,Zhang K,Korbelik M,Separovic D

更新日期：2017-02-01 00:00:00