Antimicrobial activity of phenothiazines, benzo[a]phenothiazines and benz[c]acridines.

abstract：AIM:To compare clinical outcome in patients with Child-Pugh C hepatocellular carcinoma (HCC) treated with non-transplant therapies and those treated with best supportive care. PATIENTS AND METHODS:A total of 182 patients with HCC with Child-Pugh C cirrhosis were analyzed. Patients were classified into two groups: pati...

journal_title：Anticancer research

authors： Nishikawa H,Kita R,Kimura T,Ohara Y,Takeda H,Sakamoto A,Saito S,Nishijima N,Nasu A,Komekado H,Osaki Y

更新日期：2014-06-01 00:00:00

abstract：:The in vitro antioxidative activity of benzylideneascorbate (SBA) and the in vivo effect on adriamycin (ADR)-induced cardiotoxicity in a mouse model were investigated. The radical-scavenging activity of SBA was assayed in terms of reduction of chemiluminescence induced by O2-, generated in xanthine/xanthine oxidase an...

journal_title：Anticancer research

authors： Kojima S,Iizuka H,Yamaguchi H,Tanuma S,Kochi M,Ueno Y

更新日期：1994-09-01 00:00:00

abstract：BACKGROUND:In order to investigate the mechanism of the effects of the anticancer drug adamantyl maleimide (AMI) on the in vitro growth of a human gastric carcinoma cell line (SC-M1), the membrane protein conformation on the cell surface after treatment with AMI was studied. MATERIALS AND METHODS:The interaction of AM...

journal_title：Anticancer research

authors： Wang JJ,Chi CW,Lin SY,Chern YT

更新日期：1997-09-01 00:00:00

abstract：:Bright and dark field microscopy were used to examine interphase nuclei and RBG-banded human chromosomes. In dark field microscopy both chromosomes and interphase chromatin appeared to be composed of similar independent structures alternating between bright and dull light intensity. The position, colour, and number of...

journal_title：Anticancer research

authors： Rønne M,Gyldenholm AO,Storm CO

更新日期：1995-03-01 00:00:00

abstract：:Chemosensivity testing in 11 retinoblastoma (RB) cell lines identified five tumors showing cross-resistance to plant alkaloids, alkylating agents, anthracycline antibiotics, and antimetabolites, suggestive of the multidrug-resistant (MDR) phenotype described in other tumors. Only two tumors had been clinically exposed...

journal_title：Anticancer research

authors： Chan HS,Canton MD,Gallie BL

更新日期：1989-03-01 00:00:00

abstract：:To evaluate the effects of dietary fats on breast cancer growth and metastasis, KPL-1 human breast carcinoma cells which have a propensity for axillary lymph node metastasis when inoculated into the thoracic mammary fat pad of female nude mice were examined. The mice were fed one of three semipurified diets containing...

journal_title：Anticancer research

authors： Senzaki H,Iwamoto S,Ogura E,Kiyozuka Y,Arita S,Kurebayashi J,Takada H,Hioki K,Tsubura A

更新日期：1998-05-01 00:00:00

abstract：:From 1980 to 1987, 243 evaluable patients with pT1, pT2 (less than 3 centimeters in diameter), N0, M0, invasive breast cancer were treated with "quadrantectomy" with axillary dissection followed by electron beam radiation therapy (QUART) at the St. Bortolo Hospital, Vicenza. Stage II patients received adjuvant chemoth...

journal_title：Anticancer research

authors： Gasparini G,Panizzoni GA,Dal Fior S,Germani B,Dall'Antonia F,Segato G,Meli S,Pozza F

更新日期：1991-07-01 00:00:00

abstract：AIM:Despite recent improvements in treatment strategies, the results of chemotherapy in patients with advanced squamous cell carcinoma of the larynx are not satisfactory. Thus, the development of new approaches which influence specific metabolic pathways are needed. In the last decade, evidence has emerged implicating ...

journal_title：Anticancer research

authors： Stepulak A,Luksch H,Uckermann O,Sifringer M,Rzeski W,Polberg K,Kupisz K,Klatka J,Kielbus M,Grabarska A,Marzahn J,Turski L,Ikonomidou C

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND/AIM:Elderly patients represent an important subgroup of patients with brain metastases. A survival score has been developed specifically for these patients. PATIENTS AND METHODS:A total of 544 elderly patients (aged ≥65 years) receiving whole-brain radiotherapy alone were divided into a test (n=272) and a v...

journal_title：Anticancer research

authors： Evers JN,Schild SE,Segedin B,Nagy V,Khoa MT,Trang NT,Rades D

更新日期：2014-05-01 00:00:00

abstract：:This study was designed to evaluate the utility of the bone markers total alkaline phosphatase (TAP), bone-specific alkaline phosphatase (BAP), aminoterminal propeptide of type I collagen (PINP), carboxyterminal propeptide of type I collagen (PICP), pyridinoline crosslinks (PYD), deoxypyridinoline crosslinks (DPD), cr...

journal_title：Anticancer research

authors： Ebert W,Muley T,Herb KP,Schmidt-Gayk H

更新日期：2004-09-01 00:00:00

abstract：:Polymerase chain reaction and single strand conformation polymorphism (PCR-SSCP) analysis of the p53 tumor suppressor gene (from exon 2 to 9) was performed on samples from 47 adult patients with primary myelodysplastic syndrome (MDS). Point mutation was found in 5 (11%) patients: exon 7 in 3, exon 4 in 1 and intron 5 ...

journal_title：Anticancer research

authors： Tang JL,Tien HF,Lin MT,Chen PJ,Chen YC

更新日期：1998-09-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) represents the most malignant primary brain tumor in adults with generally dismal prognosis, early clinical deterioration and high mortality. GBM is extremely invasive, characterized by intense and aberrant vascularization and high resistance to multimodal treatment. Standard therapy (sur...

journal_title：Anticancer research

authors： Polivka J Jr,Polivka J,Holubec L,Kubikova T,Priban V,Hes O,Pivovarcikova K,Treskova I

更新日期：2017-01-01 00:00:00

abstract：:Several human and murine tumor cell lines were evaluated in an in vitro cytotoxicity assay as prescreens for fermentation extracts and pure materials subsequently tested in vivo against P388 leukemia or B16 melanoma. Each material, regardless of its in vitro cytotoxicity, was evaluated in vivo. At the criteria levels ...

journal_title：Anticancer research

authors： Rose WC,Schurig JE,Meeker JB

更新日期：1988-05-01 00:00:00

abstract：BACKGROUND:Several studies have reported an association between Hashimoto's disease and thyroid carcinoma although the cause/effect relationship is still controversial. CASE REPORT:In this paper we report the case of a 38-year-old female who first presented with a clinical history of Hashimoto's thyroiditis. Ultrasoun...

journal_title：Anticancer research

authors： Pisani T,Bononi M,Pantellini F,Vecchione A,Giovagnoli MR

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND:Trastuzumab is used for the adjuvant (postoperative) treatment of (HER2)-positive early breast cancer. The duration of treatment is set at one year. The goal of our study was to examine the effective duration of trastuzumab treatment in routine clinical practice. PATIENTS AND METHODS:We performed a retrospe...

journal_title：Anticancer research

authors： Montserrat M,Leveque D,Barthelemy P,Bergerat JP

更新日期：2012-10-01 00:00:00

abstract：AIM:To evaluate the factors predicting for recurrence and to analyze survival of patients with hepatocellular carcinoma (HCC). PATIENTS AND METHODS:A total of 743 patients who were consecutively diagnosed and treated with HCC were retrospectively analyzed from January 2004 to December 2012 at our institution. We analy...

journal_title：Anticancer research

authors： Jun CH,Sim DW,Kim SH,Hong HJ,Chung MW,Myoung E,Koh HR,Cho SB,Kim HS,Choi SK,Rew JS

更新日期：2013-09-01 00:00:00

abstract：:Berlin-Druckrey (BD-IV) rats were used to evaluate the level of neoplastic transformation, initiation of DNA damage and repair following treatment with N-ethyl-N-nitrosourea (ENU). ENU, a potent neurocarcinogen in the Sprague-Dawley (CD) and BDIX rat strains, was a less potent neurocarcinogen when administered to 30 d...

journal_title：Anticancer research

authors： D'Ambrosio SM,Su C,Chang MJ,Oravec C,Stoica G,Koestner A

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND/AIM:The aim of this study was to investigate the effects of the macrophage colony-stimulating factor (M-CSF) receptor antagonist on hepatic carcinogenesis in mice. MATERIALS AND METHODS:Mice were injected with diethylnitrosamine (DEN) and treated with M-CSF receptor antagonist GW2580 (GW) or a saline vehicl...

journal_title：Anticancer research

authors： Akazawa Y,Kono H,Hara M,Furuya S,Nakata Y,Wakana H,Fukushima H,Sun C,Fujii H,Ichikawa D

更新日期：2019-09-01 00:00:00

abstract：:Leukemia inhibitory factor (LIF) is prevalently expressed in human medulloblastomas in vivo and in vitro. Blockage of LIF expression or biological function can inhibit in vitro growth and induce differentiation-like phenotypes of medulloblastoma cells (Med-3), suggesting a redifferentiation potential of Med-3 cells wh...

journal_title：Anticancer research

authors： Liu J,Guo L,Luo Y,Li JW,Li H

更新日期：2000-07-01 00:00:00

abstract：BACKGROUND:The feasibility and diagnostic reliability of sentinel lymph node biopsy of gastric carcinoma are still unclear and controversial. PATIENTS AND METHODS:To assess the applicability of the sentinel node concept to gastric carcinoma, we retrospectively analyzed the location of metastatic lymph nodes in patient...

journal_title：Anticancer research

authors： Moenig SP,Luebke T,Baldus SE,Schroeder W,Bollschweiler E,Schneider PM,Hoelscher AH

更新日期：2005-03-01 00:00:00

abstract：UNLABELLED:The aim this study was to assess the efficacy of cisplatin-epirubicin-vinorelbine, as primary chemotherapy, in reducing the tumour burden in T2-3 N0-2 breast carcinomas. Breast conservative surgery (BCS) rate, clinical and pathological complete response (pCR), toxicity and 5-year disease-free survival (DFS) ...

journal_title：Anticancer research

authors： Barni S,Visini M,Piazza E,Ionta MT,Ardizzoia A,Arnoldi E,Fava S,Pinotti G,Torretta F,Corradini G,Villa S,Nosenzo AM,Massidda B,Cazzaniga ME

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND:Once diagnosed, esophageal cancer has a very low overall 5-year survival rate. This study investigates the mechanisms behind the invasiveness and severity of esophageal squamous cell carcinoma (ESCC). MATERIALS AND METHODS:Transwell invasion chamber was used to subdivide one Taiwanese ESCC cell line, CE81T/...

journal_title：Anticancer research

authors： Chen YK,Chang WS,Wu IC,Li LH,Yang SF,Chen JY,Hsu MC,Chen SH,Wu DC,Lee JM,Huang CH,Goan YG,Chou SH,Huang CT,Wu MT

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND/AIM:We aimed to investigate the efficacy of immune-cell therapy in terms of the survival of patients with neuroendocrine carcinoma of the uterine cervix (NECC), which lacks standardized therapeutic approaches. PATIENTS AND METHODS:We identified 17 patients who were diagnosed as having NECC and treated with ...

journal_title：Anticancer research

authors： Goto S,Terao Y,Kamigaki T,Takimoto R,Naitoh K,Makita K,Yasumoto K,Okada S,Takizawa K,Yokomichi N,Suzuki N,Takeda S

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:Nuclear morphometry can be expected to improve the distinction between benign and malignant lesions. PATIENTS AND METHODS:Forty fine-needle aspiration biopsy (FNAB) samples fixed in 50% ethanol were collected at the African Oncology Institute, Sabratha, Libya, during the period 2004-2007. All diagnoses repo...

journal_title：Anticancer research

authors： Abdalla F,Boder J,Buhmeida A,Hashmi H,Elzagheid A,Collan Y

更新日期：2008-11-01 00:00:00

abstract：:Angiogenesis is critical for tumor growth and inflammation. Shiunko is a Chinese herbal ointment used for the treatment of burns in Japan. Its main ingredient is the root of Lithospermum erythrorhizon, which had been used for treating tumors and inflammation in China since the 5th century. We report here that shikonin...

journal_title：Anticancer research

authors： Hisa T,Kimura Y,Takada K,Suzuki F,Takigawa M

更新日期：1998-03-01 00:00:00

abstract：BACKGROUND:Urocortin and corticotropin-releasing factors (CRFs) and their receptors are expressed in many organs, including the central nervous system. In this study, the expression of mRNAs of urocortin 1, 2, 3, and CRF and CRF receptors 1 and 2 in malignant glioma, was examined. MATERIALS AND METHODS:The RNAs of hum...

journal_title：Anticancer research

authors： Kamada M,Ikeda K,Fujioka K,Akiyama N,Akiyoshi K,Inoue Y,Hanada S,Yamamoto K,Tojo K,Manome Y

更新日期：2012-12-01 00:00:00

abstract：AIM:To investigate frequent quantitative alterations of intestinal-type gastric adenocarcinoma. MATERIALS AND METHODS:We analyzed genome-wide DNA copy numbers of 22 samples and using CytoScan® HD Array. RESULTS:We identified 22 gene alterations that to the best of our knowledge have not been described for gastric can...

journal_title：Anticancer research

authors： Seabra AD,Araújo TM,Mello Junior FA,Di Felipe Ávila Alcântara D,De Barros AP,De Assumpção PP,Montenegro RC,Guimarães AC,Demachki S,Burbano RM,Khayat AS

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND:MYCN amplification is a powerful prognostic marker in neuroblastoma. Since MYCN status guides therapy results should be available promptly after diagnosis. MATERIAL AND METHODS:We used a differential PCR assay to analyze neuroblastoma samples obtained from 25 patients diagnosed and treated at our Institutio...

journal_title：Anticancer research

authors： Gallego S,Reventos J,Sanchez de Toledo J,Munell F

更新日期：1998-03-01 00:00:00

abstract：:Precultured embryonic chick heart fragments were confronted in vitro with various invasive tumor cell lines (MCF-7/6 human breast carcinoma variant, BW-O-LiI mouse T-cell lymphoma cells and MO4 virally transformed fetal mouse carcass cells) and with a non-invasive cell line (MCF-7/AZ human breast carcinoma variant). C...

journal_title：Anticancer research

authors： Raemakers-Franken PC,Bracke ME,Van Larebeke N,Vyncke B,Mareel MM

更新日期：1992-03-01 00:00:00

abstract：AIM:To determine depression in patients with choroidal melanoma (CM) treated with proton beam radiotherapy. PATIENTS AND METHODS:This was a cross-sectional study including 50 patients with CM (50% males, mean age=49.88±6.34 years) and 46 age- and sex-matched healthy controls (52% males, mean age=48.60±8.05 years). Par...

journal_title：Anticancer research

authors： Moschos MM,Moustafa GA,Lavaris A,Damaskos C,Laios K,Karathanou E,Ladas DS,Asproudis I,Garmpis N,Kalogeropoulos C

更新日期：2018-05-01 00:00:00