Combined Applications of Repurposed Drugs and Their Detrimental Effects on Glioblastoma Cells.

abstract：:Glioblastoma multiforme (GBM) is the most aggressive intracranial tumor characterized with infaust prognosis. Despite advances in neurosurgical and radiotherapeutic techniques and chemotherapy, the median overall survival ranges between 12-15 months from diagnosis. The main cause of treatment failure is considered the...

journal_title：Anticancer research

authors： Ondracek J,Fadrus P,Sana J,Besse A,Loja T,Vecera M,Radova L,Smrcka M,Slampa P,Slaby O

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:Histological parameters as well as the status of sentinel lymph node are known to be strong prognostic factors in patients with melanoma. PATIENTS AND METHODS:In this study, we retrospectively analyzed 1,384 patients who were diagnosed with head and neck melanoma between 1976 and 2010 regarding prognostic f...

journal_title：Anticancer research

authors： Uslu U,Schuler G,Breuninger H

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:This report presents results of a study delineating changing trends in radical external beam radiotherapy usage for prostate cancer between the 1996-1998 and 1999-2001 Patterns of Care Study (PCS) survey periods in Japan. MATERIALS AND METHODS:Out of the 694 patients comprising the 1996-1998 and 1999-2001 P...

journal_title：Anticancer research

authors： Ogawa K,Nakamura K,Onishi H,Sasaki T,Koizumi M,Shioyama Y,Komiyama T,Miyabe Y,Teshima T,Japanese Patterns of Care Study Working Subgroup of Prostate Cancer.

更新日期：2005-09-01 00:00:00

abstract：BACKGROUND:In our previous study, it was suggested that nitrotyrosine, a product of nitrogen species, found in esophageal squamous cell carcinoma (ESCC), may contribute to the progression of esophageal cancer. MATERIALS AND METHODS:To clarify whether nitrotyrosine expression is associated with apoptosis and/or angioge...

journal_title：Anticancer research

authors： Kato H,Miyazaki T,Yoshikawa M,Nakajima M,Fukai Y,Masuda N,Ojima H,Tsukada K,Nishida Y,Kuwano H

更新日期：2001-09-01 00:00:00

abstract：BACKGROUND:Tumor angiogenesis is considered a multi-pathway process, while p21(WAF1/CiP1) is a CDK inhibitor involved in cell division and survivaL Herein the tumor environment effect on endothelial p21(WAF1/Cip1) expression is examined. MATERIALS AND METHODS:The EA.hy 926 endothelial cell line and tumor-conditioned m...

journal_title：Anticancer research

authors： Vrekoussis T,Stathopoulos EN,Kafousi M,Saridaki Z,Sanidas E,Zoras O

更新日期：2005-07-01 00:00:00

abstract：:The purpose of this study was to elucidate the behavior of signal transduction activity in rat and human carcinoma cells. Signal transduction activity was measured by the steady-state activity of the three enzymes involved in the conversion of 1-phosphatidylinositol (PI) to IP3, PI 4-kinase, PI 4-phosphate 5-kinase, a...

journal_title：Anticancer research

authors： Weber G,Shen F,Prajda N,Yeh YA,Yang H,Herenyiova M,Look KY

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND:The E-cadherin/beta-catenin complex plays a crucial role in epithelial cell-cell adhesion and in the maintenance of tissue architecture. We previously reported aberrant expression of beta-catenin in endometrial carcinomas. However, the expression and correlation of E-cadherin and beta-catenin in normal and m...

journal_title：Anticancer research

authors： Shih HC,Shiozawa T,Miyamoto T,Kashima H,Feng YZ,Kurai M,Konishi I

更新日期：2004-11-01 00:00:00

abstract：:This review describes the use of murine polyomavirus "virus-like" particles (MPyV-VLPs), free from viral genes, as vectors for gene and immune therapy and as vaccines. For large-scale MPyV-VLP manufacture, VP1 is produced in a baculovirus insect cell system, E. coli or in yeast. MPyV-VLPs bind eukaryotic DNA and intro...

journal_title：Anticancer research

authors： Tegerstedt K,Franzén AV,Andreasson K,Joneberg J,Heidari S,Ramqvist T,Dalianis T

更新日期：2005-07-01 00:00:00

abstract：BACKGROUND/AIM:Shortcomings of current methods of prostate cancer detection call for improved biomarkers. The transmembrane protease, serine 2:ets-related gene (TMPRSS2:ERG) gene fusion leads to the overexpression of ERG, an E-twenty six (ETS) family transcription factor, and is the most prevalent genetic lesion in pro...

journal_title：Anticancer research

authors： Chow A,Amemiya Y,Sugar L,Nam R,Seth A

更新日期：2012-09-01 00:00:00

abstract：AIM:To evaluate the frequency of loss of mediator of DNA damage checkpoint protein 1 (MDC1) protein expression in endometrial cancer (EC) and to determine whether loss of MDC1 is associated with certain clinicopathological parameters. MATERIALS AND METHODS:MDC1 expression was examined in 426 samples of EC. The nuclear...

journal_title：Anticancer research

authors： Merentitis D,Nguyen BD,Samartzis EP,Noske A,Brandt S,Dedes KJ

更新日期：2019-12-01 00:00:00

abstract：:Our investigation comprises 778 cases of resection for early gastric cancer (27.4% of all stomach resections). The rate of lymph node metastasis was 1.2% in m (mucosal cancer) group, 3.3% in sm (submucosal cancer) 1 group and 22.6% in sm 2 group. In sm 2 group, lymph node extirpation of R2 is essential. The five year ...

journal_title：Anticancer research

authors： Kito T,Yamamura Y,Kobayashi S

更新日期：1988-05-01 00:00:00

abstract：BACKGROUND:The presence of circulating tumor cells (CTCs) in the peripheral blood is a prerequisite for the formation of distant metastases. Transforming growth factor-βeta (TGF-β) and Chemokine (C-X-C Motif) Ligand-1 (CXCL1) are cytokines involved in the colonization of distant sites by CTCs in several pre-clinical an...

journal_title：Anticancer research

authors： Divella R,Daniele A,Savino E,Palma F,Bellizzi A,Giotta F,Simone G,Lioce M,Quaranta M,Paradiso A,Mazzocca A

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:The prognostic significance of mutant p53 protein, p-glycoprotein (P-gp) and glutathione S-transferase-pi (GST-pi) in patients with unresectable non-small cell lung cancer (NSCLC) has not been established. MATERIALS AND METHODS:We performed immunohistochemical staining of p53, P-gp and GST-pi using transbro...

journal_title：Anticancer research

authors： Miyatake K,Gemba K,Ueoka H,Nishii K,Kiura K,Tabata M,Shibayama T,Takigawa N,Kawaraya M,Tanimoto M

更新日期：2003-05-01 00:00:00

abstract：AIM:The current study reports the type of salvage chemotherapy following osimertinib and its treatment efficacy in patients with non-small-cell lung carcinoma (NSCLC) who acquire resistance to osimertinib. PATIENTS AND METHODS:In this retrospective cohort study, data from the medical charts of 40 patients with NSCLC t...

journal_title：Anticancer research

authors： Tone M,Inomata M,Awano N,Kuse N,Jo T,Yoshimura H,Minami J,Takada K,Miyamoto S,Izumo T

更新日期：2020-04-01 00:00:00

abstract：:The results of palliative chemotherapy in 162 patients suffering from exocrine pancreatic cancer are presented. They are mainly discussed with respect to the possibility of improving survival of exocrine pancreatic cancer patients by an efficacy-orientated sequential polychemotherapy (EOSP). In about 40% of the patien...

journal_title：Anticancer research

authors： Klapdor R,Bahlo M,Babinski A,Broemel T,Müller C,Seutter R

更新日期：2003-03-01 00:00:00

abstract：:This trial is based on the strategy of reversing O6-methylguanine-DNA methyltransferase (MGMT)-mediated nimustine resistance by depleting MGMT activity with streptozotocin (STZ) pretreatment. Eight patients with recurrent malignant gliomas refractory to previous nimustine chemotherapy were entered in this study. Patie...

journal_title：Anticancer research

authors： Zhao KM,Chen JM,Zuo HZ,Wu Y,Zhang YP

更新日期：1995-03-01 00:00:00

abstract：:The antioxidative activity and antimutagenic effects of the water-soluble beta-(1-3)-D-glucan derivatives from biotechnologically important species, in particular carboxymethyl-glucan (CM-G) and sulfoethyl-glucan (SE-G) both from the baker's yeast Saccharomyces cerevisiae, and carboxymethyl-chitin-glucan (CM-CG) from ...

journal_title：Anticancer research

authors： Krizková L,Duracková Z,Sandula J,Slamenová D,Sasinková V,Sivonová M,Krajcovic J

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND:Resveratrol (RES) inhibits cell growth, induces apoptosis and augments chemotherapeutics in multiple cancer types, although its effects on drug-resistant cancer cells are unknown. MATERIALS AND METHODS:To study the effects of resveratrol in triple-negative breast cancer cells that are resistant to the commo...

journal_title：Anticancer research

authors： Sprouse AA,Herbert BS

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:This case report describes a patient with symptomatic anaemia due to a bleeding duodenal metastasis from metastasising differentiated thyroid cancer (DTC), which was treated by partial duodenopancreatectomy (DP). CASE REPORT:A 71-year old male was sent to hospital with severe anaemia. This patient had suffe...

journal_title：Anticancer research

authors： Meyer A,Behrend M

更新日期：2006-05-01 00:00:00

abstract：:EGF/TGF-alpha and progesterone were measured in the urine of 74 ovarian carcinoma patients, 21 postmenopausal women with non-gynecological disseminated cancer, 20 premenopausal and 20 postmenopausal controls. Radically operated women excreted significantly less EGF/TGF-alpha into urine than women with residual tumour ...

journal_title：Anticancer research

authors： Ridderheim M,Cajander S,Tavelin B,Stendahl U,Bäckström T

更新日期：1994-09-01 00:00:00

abstract：:1-(phenylmethyl)-4,7,10-tris-[(4'methylphenyl)-sulfonyl]-1,4,7, 10-tetraazacyclododecane proved to possess potent in vivo antineoplastic and in vitro cytotoxicity in murine and human tissue cultured cells. In Tmolt3 leukemic cells 1-(phenylmethyl)-4,7,10-tris-[(4'methylphenyl)sulfonyl]-1,4,7, 10-tetraazacyclododecane ...

journal_title：Anticancer research

authors： Hall IH,Elkins AL,Karthikeyan S,Spielvogel BF

更新日期：1997-03-01 00:00:00

abstract：BACKGROUND:Estramustine is an anti-mitotic cytostatic drug that also enhances the effect of radiotherapy. The mechanism of radiosensitization is not thoroughly known. Since both radiotherapy and estramustine induce apoptosis in prostate cancer cells, we conducted an experiment to show whether radiosensitization is medi...

journal_title：Anticancer research

authors： Ståhlberg K,Kairemo K,Erkkilä K,Pentikäinen V,Sorvari P,Taari K,Dunkel L,Rannikko S

更新日期：2005-07-01 00:00:00

abstract：BACKGROUND/AIM:We evaluated the clinical feasibility and surgical outcomes of robotic-assisted transperitoneal infrarenal para-aortic lymphadenectomy (TIPAL) in patients with gynecological malignancies. PATIENTS AND METHODS:The perioperative outcomes in 90 patients with gynecological malignancies who underwent laparos...

journal_title：Anticancer research

authors： Lee HJ,Lee YH,Chong GO,Hong DG,Lee YS

更新日期：2017-12-01 00:00:00

abstract：:Human papillomavirus (HPV)-positive tonsillar- and base of tongue cancer is increasing epidemically and has much better outcome than corresponding HPV-negative cancer and most other head and neck cancers with around 80% 3-year disease free survival with conventional radiotherapy and surgery. Consequently, most HPV-pos...

journal_title：Anticancer research

authors： Näsman A,Bersani C,Lindquist D,Du J,Ramqvist T,Dalianis T

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND/AIM:Even though prostate cancer (PCa) has good prognosis, there is a discrepancy in the risk among ethnic groups, with high morbidity in African American men. Single nucleotide polymorphisms (SNPs) in interleukin 10 (IL-10) have been associated with inflammation and cancer risk. We investigated the associati...

journal_title：Anticancer research

authors： Abbas M,Mason T,Ibad A,Khraiwesh M,Apprey V,Kanaan Y,Wilson B,Dunston G,Ricks-Santi L,Brim H

更新日期：2020-01-01 00:00:00

abstract：:The expression of epidermal growth factor (EGF) and its receptor (EGF-R) was examined immunohistochemically in 60 primary and 26 metastatic lesions of pancreatic carcinoma. EGF was stained mainly in the cytoplasm of tumor cells, and EGF-R was stained mainly on the surface of cells. The expression rates of EGF and EGF-...

journal_title：Anticancer research

authors： Uegaki K,Nio Y,Inoue Y,Minari Y,Sato Y,Song MM,Dong M,Tamura K

更新日期：1997-09-01 00:00:00

abstract：:Small cell lung cancer is known to carry a high capacity to metastasize in various sites including bone marrow. We here review the respective sensitivities of classical cyto-histological methods and of more recently described techniques such as cell cultures, immunostaining with monoclonal antibodies and magnetic reso...

journal_title：Anticancer research

authors： Trillet-Lenoir VN,Arpin D,Brune J

更新日期：1994-11-01 00:00:00

abstract：:Between 70 and 75% of ovarian carcinomas are not discovered until they have reached an advanced stage III or later. Efforts should therefore be concentrated on earlier diagnosis. Ovarian cancer is not an entirely silent disease. Today, it is known that there are key symptoms which, depending on their frequency and int...

journal_title：Anticancer research

authors： Argento M,Hoffman P,Gauchez AS

更新日期：2008-09-01 00:00:00

abstract：:The reverse transcriptase polymerase chain reaction (RT-PCR) can be of clinical relevance in identifying malignant melanoma cells in blood or tissues of patients at risk for disseminated melanoma. The diagnostic value of this marker however, is still controversial. The objective of this study was to compare and quanti...

journal_title：Anticancer research

authors： Calogero A,Hospers GA,Timmer-Bosscha H,Koops HS,Mulder NH

更新日期：2000-09-01 00:00:00

abstract：:A new cell line, CC3/CUHK3, was established from a squamous carcinoma of the uterine cervix from a Chinese patient. Light microscopy of the cell line revealed keratin and electron microscopy demonstrated tonofilaments and desmosomes, thereby confirming its epithelial nature. The population doubling time of CC3/CUHK3, ...

journal_title：Anticancer research

authors： Chew EC,Ho TH,Yeung SO,Hou HJ,Li RS,Huang DP,Wong FW

更新日期：1990-01-01 00:00:00