Loss of MDC1 in Endometrial Carcinoma Is Associated With Loss of MRN Complex and MMR Deficiency.

abstract：BACKGROUND/AIM:The lipophilic, orally bioavailable camptothecin analogue gimatecan is characterized by improved efficacy over conventional camptothecins on human tumor xenografts. Gimatecan produced excellent outcomes orally with prolonged, low-dose, daily treatments. The aim of this study was to assess the antitumor e...

journal_title：Anticancer research

authors： DE Cesare M

更新日期：2018-10-01 00:00:00

abstract：:The melastatin-like transient receptor potential M2 (TRPM2) channel is a Ca2+ permeable channel that is activated by reactive oxygen species (ROS), and its activation induces necrotic cell death. The effect of insertion of TRPM2 into A172 human glioblastoma cells (A172 cells) was investigated. The insertion of TRPM2 c...

journal_title：Anticancer research

authors： Ishii M,Oyama A,Hagiwara T,Miyazaki A,Mori Y,Kiuchi Y,Shimizu S

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND/AIM:The purpose of this study was to investigate the clinical, pathological, and prognostic differences between adenocarcinoma (ADC) and mucinous adenocarcinoma (MUC) in colorectal cancer (CRC). PATIENTS AND METHODS:This was a retrospective study of a Japanese high-volume cancer Center over a 10-year period...

journal_title：Anticancer research

authors： Wang L,Hirano Y,Heng G,Ishii T,Kondo H,Hara K,Obara N,Asari M,Kato T,Yamaguchi S

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND/AIMS:Our study aimed to compared 3-year results following laparoscopy-assisted proximal gastrectomy (LAPG)-double tract anastomosis (DTA) and lower esophageal sphincter-preserving LAPG (LES-LAPG). PATIENTS AND METHODS:Nine patients who underwent LES-LAPG and 23 LAPG-DTA were compared regarding 3-year follow...

journal_title：Anticancer research

authors： Kim DJ,Kim W

更新日期：2019-01-01 00:00:00

abstract：:We have examined several aspects of protein tyrosine kinase (PTK)-activity in the cytosolic and membrane fractions of both normal and malignant lymphoid cells. The expression of the PTK-encoding oncogenes fes, abl and src, was investigated with the use of antibodies generated to their respective gene products. These a...

journal_title：Anticancer research

authors： Punt CJ,Rijksen G,van Oirschot BA,Kester-Schipper GP,van der Heijden MC,Dekker AW,Staal GE

更新日期：1992-11-01 00:00:00

abstract：:Tenascin is a multifunctional extracellular matrix glycoprotein generally expressed in epithelial tumors at sites of epithelial tumor-mesenchymal tissue interface. Studies so far have indicated that mesenchymal cells are a major source of tenascin in tumor tissues. The present study evaluated biopsies and surgically r...

journal_title：Anticancer research

authors： Mori M,Muramatsu Y,Yamada K,Shrestha P,Takai Y

更新日期：1996-09-01 00:00:00

abstract：BACKGROUND:Vitamin D is known for its anti-cancerogenous potential. Prostaglandin E2 (PGE2) is a proliferation and inflammation activating agent. The production of PGE2 is dependent on the activity of cyclooxygenase-2 (COX-2). A link between vitamin D and PGE2 metabolism was recently shown. MATERIALS AND METHODS:In MD...

journal_title：Anticancer research

authors： Thill M,Reichert K,Woeste A,Polack S,Fischer D,Hoellen F,Rody A,Friedrich M,Köster F

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND/AIM:To investigate whether high-dose-rate (HDR) intracavitary brachytherapy (IBT) dose ratios can predict treatment outcomes in patients with stage IIB cervical cancer. PATIENTS AND METHODS:Ninety-three patients treated with weekly cisplatin-based concurrent chemoradiotherapy and HDR IBT were analyzed. Pote...

journal_title：Anticancer research

authors： Cho O,Noh OK,Oh YT,Chang SJ,Chun M

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:The combined effects of Human papillomavirus (HPV) and Herpes simplex type 1 (HSV-1) infections and their effects on cancer cell radioresistance are unexplored. MATERIALS AND METHODS:An HPV16-positive hypopharyngeal carcinoma cell line (UD-SCC-2) was infected with wt-HSV-1 at low multiplicity of infection (...

journal_title：Anticancer research

authors： Turunen A,Hukkanen V,Kulmala J,Syrjanen S

更新日期：2016-02-01 00:00:00

abstract：:The aim of our study was to establish a simple method for routine analysis of c-erbB-2 gene expression in tumour samples. We constructed a plasmid for the in vitro synthesis of competitor RNA to be used as an internal exogenous control during the RT-PCR detection of c-erbB-2 expression. The competitor RNA harbors a 19...

journal_title：Anticancer research

authors： Schneeberger C,Eder S,Speiser P,Zeillinger R

更新日期：1996-03-01 00:00:00

abstract：BACKGROUND:Recent experimental studies have indicated that cyclooxygenase-2 (COX-2) suppresses tumor-cell apoptosis and induces intratumoral angiogenesis. PATIENTS AND METHODS:A series of 70 endometrial cancer cases that had undergone a curative resection was studied to determine the correlation between COX-2 expressi...

journal_title：Anticancer research

authors： Ohno S,Ohno Y,Suzuki N,Soma G,Inoue M

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND/AIM:Cold atmospheric plasma (CAP) attenuates tumor cell proliferation and induces apoptosis in various cell lines. While exerting marginal effects on non-neoplastic cells this unfolds promising applications in cancer therapy. The aim of the study was to analyse the effects of different CAP sources and applic...

journal_title：Anticancer research

authors： Gümbel D,Suchy B,Wien L,Gelbrich N,Napp M,Kramer A,Ekkernkamp A,Daeschlein G,Stope MB

更新日期：2017-10-01 00:00:00

abstract：:The immune system is part of the homeostasis system. Our research is focused on ways to maintain health, with an emphasis on the role of macrophages. We have hypothesized that tissue macrophages form a systemic network which we believe contributes to the homeostasis system, and have named it the 'macrophage network.' ...

journal_title：Anticancer research

authors： Taniguchi Y,Yoshioka N,Nishizawa T,Inagawa H,Kohchi C,Soma G

更新日期：2009-03-01 00:00:00

abstract：BACKGROUND/AIM:This cross-sectional study estimated direct cancer-related health care, productivity and informal care costs for a six-month period for different states of breast cancer (BC). PATIENTS AND METHODS:A total of 827 BC patients answered a questionnaire enquiring about informal care, work capacity, and demog...

journal_title：Anticancer research

authors： Roine E,Färkkilä N,Sintonen H,Taari K,Roine RP,Saarto T

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND/AIM:The clinical significance of surgery for secondary small intestinal non-Hodgkin's lymphomas (NHL) remains unknown. This study aimed to investigate the efficacy of resection for both primary and secondary small intestinal NHL. PATIENTS AND METHODS:Twenty patients with small intestinal lymphoma who underw...

journal_title：Anticancer research

authors： Iida T,Nozawa H,Sonoda H,Toyama K,Kawai K,Hata K,Tanaka T,Nishikawa T,Sasaki K,Shuno Y,Kaneko M,Murono K,Emoto S,Ishii H,Kurokawa M,Ishihara S

更新日期：2020-04-01 00:00:00

abstract：:We describe the case of an 80-year-old man with hepatocellular carcinoma (HCC) who developed tracheal obstruction due to peritracheal lymph node metastasis. A metastatic tumor that protruded into the airway was ablated using a neodymium yttrium-aluminium-garnet laser and then a self-expandable metallic stent (SEMS) wa...

journal_title：Anticancer research

authors： Hamai Y,Hihara J,Aoki Y,Taomoto J,Kishimoto I,Kobayashi Y,Miyata Y,Aikata H,Chayama K,Okada M

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:Giant cell tumor of the bone (GCTB) is a benign or sometimes semi-malignant neoplasm accounting for 5% of all primary bone tumors. This type of tumor has been historically considered as radioresistant, but nowadays radiotherapy (RT) is used in unresectable, recurrent or incompletely resected cases. Since the...

journal_title：Anticancer research

authors： Kriz J,Eich HT,Mücke R,Büntzel J,Müller RP,Bruns F,Seegenschmiedt MH,Gosheger G,Micke O,German Cooperative Group on Radiotherapy for Benign Diseases (GCG-BD).

更新日期：2012-05-01 00:00:00

abstract：:Surgery remains the mainstay of treatment for breast cancer, including complete or partial mastectomy and lumpectomy. Breast reconstruction has gained popularity mainly due to its tremendous impact on the psychological status of the patients. Autologous fat grafting is a well-established method used in cosmetic surger...

journal_title：Anticancer research

authors： Spartalis E,Tsilimigras DI,Charalampoudis P,Karachaliou GS,Moris D,Athanasiou A,Spartalis M,Bolkas V,Dimitroulis D,Nikiteas N

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Sonic hedgehog (SHH) signaling is related to the pathogenesis of oral squamous cell carcinoma (OSCC), but its role in OSCC is not yet well understood. In this study, we analyzed the role of SHH signaling in OSCC. MATERIALS AND METHODS:We examined the expression pattern of SHH and its signal proteins in clin...

journal_title：Anticancer research

authors： Kuroda H,Kurio N,Shimo T,Matsumoto K,Masui M,Takabatake K,Okui T,Ibaragi S,Kunisada Y,Obata K,Yoshioka N,Kishimoto K,Nagatsuka H,Sasaki A

更新日期：2017-12-01 00:00:00

abstract：:An immunohistochemical study of 155 squamous cell carcinomas of the oesophagus, squamous epithelium adjacent to the tumour (n = 80), dysplastic epithelium (n = 16) and controls (n = 23) indicates that Ki67 and p53 expression is frequently present in premalignant oesophageal lesions and their related squamous cell carc...

journal_title：Anticancer research

authors： Jaskiewicz K,De Groot KM

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND/AIM:Non-vascularized methods to reconstruct bone defects following tumor resection are associated with complications. As a result, the free vascularized fibular flap (FVF) has become a mainstay for reconstruction. The purpose of this study was to analyze FVF reconstruction in the upper extremity. PATIENTS A...

journal_title：Anticancer research

authors： Claxton MR,Shirley MB,Bakri K,Rose PS,Moran SL,Houdek MT

更新日期：2020-05-01 00:00:00

abstract：AIM:To evaluate the influence on relapse-free survival (RFS) and overall survival (OS) of a transitory protective stoma (TPS) at the time of complete cytoreductive surgery for advanced-stage ovarian cancer. PATIENTS AND METHODS:From our Institution, we retrospectively selected patients from 2006 to 2011 with ovarian c...

journal_title：Anticancer research

authors： Canlorbe G,Touboul C,Chargari C,Bentivegna E,Maulard A,Pautier P,Genestie C,Morice P,Gouy S

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:DMXAA (5,6-dimethylxanthenone-4-acetic acid; AS1404), a vascular disrupting agent currently in clinical trials, induces tumour endothelial cell apoptosis in vivo in mice and in cancer patients. DMXAA activates NF-kappaB in many different cell types. In this study, whether DMXAA-induced endothelial cell apopt...

journal_title：Anticancer research

authors： Woon ST,Hung SS,Wu DC,Schooltink MA,Sutherland R,Baguley BC,Chen Q,Chamley LW,Ching LM

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Immmunosuppression and infectious disease in cancer patients receiving chemotherapy is a serious problem. Immunopotentiating drugs may show a therapeutic efficacy. MATERIALS AND METHODS:The protective effect of Hochu-ekki-to (TJ-41), a Japanese traditional herbal medicine, on mitomycin C (MMC)-induced immun...

journal_title：Anticancer research

authors： Kido T,Mori K,Daikuhara H,Tsuchiya H,Ishige A,Sasaki H

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND:Preclinical studies have shown that paclitaxel and doxifluridine can act synergistically without overlapping toxicity for the treatment of advanced gastric cancer. The objectives of this study were to determine the maximum tolerated dose (MTD), the dose-limiting toxicity and the recommended Phase II dose for...

journal_title：Anticancer research

authors： Takeyoshi I,Makita F,Tanahashi Y,Yokomori T,Iwazaki S,Kawashima Y,Iwanami K,Yamada T,Kawate S,Hamada K,Sunose Y,Yoshida M,Horiguchi J,Iesato H,Kobayashi M,Morishita Y

更新日期：2005-03-01 00:00:00

abstract：:Transcatheter embolization is considered to be less effective for early-stage hepatocellular carcinomas (HCCs) without a hypervascular arterial supply. In the present case report, a 65-year-old male with hepatitis type C and non-hypervascular HCC located in the hepatic hilum was successfully treated by bland transarte...

journal_title：Anticancer research

authors： Tanaka T,Maeda S,Nishiofuku H,Masada T,Sato T,Anai H,Sakaguchi H,Kichikawa K

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:Prostate cancer treated with androgen ablation eventually becomes resistant. Because the androgen receptor (AR) signaling axis affects disease progression, AR coactivator molecules could provide clinical prognostic value. This study investigates the association between AR coactivator molecules and clinical o...

journal_title：Anticancer research

authors： Mori R,Wang Q,Quek ML,Tarabolous C,Cheung E,Ye W,Groshen S,Hawes D,Togo S,Shimada H,Danenberg KD,Danenberg PV,Pinski JK

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Although oncological results for resection of colon cancer with inferior mesenteric artery (IMA) ligation at its origin (high tie) or immediately below the left colic artery (low tie) are similar, injury of the superior hypogastric plexus may be caused when the IMA is tied at its origin, thus impairing defec...

journal_title：Anticancer research

authors： Fiori E,Crocetti D,Lamazza A,DE Felice F,Scotti GB,Sterpetti AV,Mingoli A,Sapienza P,DE Toma G

更新日期：2020-05-01 00:00:00

abstract：AIM:Despite recent improvements in treatment strategies, the results of chemotherapy in patients with advanced squamous cell carcinoma of the larynx are not satisfactory. Thus, the development of new approaches which influence specific metabolic pathways are needed. In the last decade, evidence has emerged implicating ...

journal_title：Anticancer research

authors： Stepulak A,Luksch H,Uckermann O,Sifringer M,Rzeski W,Polberg K,Kupisz K,Klatka J,Kielbus M,Grabarska A,Marzahn J,Turski L,Ikonomidou C

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND/AIM:Medullary thyroid cancer (MTC) is highly malignant, metastatic and recurrent, remaining generally incurable, and responsible for approximately 14% of all thyroid carcinoma-related deaths. MTC can metastasize to lymph nodes, trachea and distant organs, such as brain, lungs, liver and bones. MTC cells are ...

journal_title：Anticancer research

authors： Damaskos C,Garmpis N,Valsami S,Spartalis E,Antoniou EA,Tomos P,Karamaroudis S,Zoumpou T,Pergialiotis V,Stergios K,Michaelides C,Kontzoglou K,Perrea D,Nikiteas N,Dimitroulis D

更新日期：2016-10-01 00:00:00