Abstract：
BACKGROUND:Giant cell tumor of the bone (GCTB) is a benign or sometimes semi-malignant neoplasm accounting for 5% of all primary bone tumors. This type of tumor has been historically considered as radioresistant, but nowadays radiotherapy (RT) is used in unresectable, recurrent or incompletely resected cases. Since the value of RT is not well defined, a national cohort study was conducted. PATIENTS AND METHODS:Six German institutions collected data from 35 patients treated during the last 35 years and analyzed them. RESULTS:From 1975-2010 16 male and 19 female patients with 39 lesions were irradiated for GCTB. The median age was 30 years and the median follow-up 65 months. Nineteen patients had undergone RT for recurrent or unresectable disease and 16 patients for non-in-sano resection. The actuarial 5-year overall and disease-free survival rates were 90% and 59%, respectively. CONCLUSION:RT is an easy, safe and effective method for the treatment of GCTB. It may provide an attractive alternative to mutilating surgery.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Kriz J,Eich HT,Mücke R,Büntzel J,Müller RP,Bruns F,Seegenschmiedt MH,Gosheger G,Micke O,German Cooperative Group on Radiotherapy for Benign Diseases (GCG-BD).subject
Has Abstractpub_date
2012-05-01 00:00:00pages
2069-73issue
5eissn
0250-7005issn
1791-7530pii
32/5/2069journal_volume
32pub_type
杂志文章,收录出版abstract：BACKGROUND/AIM:The expression of metallothionein I/II (MT-I/II) was examined in thyroids of Graves' disease (GD) and nodular goiter (NG) patients to determine its role as a potential marker of proliferation and autoimmune inflammation in the thyroid. PATIENTS AND METHODS:MT-I/II and Ki-67 antigen expression was studie...
journal_title：Anticancer research
pub_type： 杂志文章
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更新日期：2018-12-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2000-07-01 00:00:00
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pub_type： 杂志文章
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更新日期：2019-04-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
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更新日期：2004-11-01 00:00:00
abstract：BACKGROUND:Multidrug resistance, the principal mechanism by which cancer cells develop resistance to chemotherapy drugs, is a major factor in the failure of many forms of chemotherapies. AIM:The aim of the study was to investigate the effect of K-2-11 on the reversal of multidrug resistance. MATERIALS AND METHODS:The...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2010-10-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2008-01-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2010-05-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章,评审
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更新日期：2018-07-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
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更新日期：2018-03-01 00:00:00
abstract：BACKGROUND/AIM:Osteosarcoma originates from mesenchymal stem cells with impaired bone differentiation. In the present study we investigated the effect of ascorbic acid (AsA) on osteogenic differentiation and apoptosis of the MG-63 osteosarcoma cell line. MATERIALS AND METHODS:We evaluated the expression of runt-relate...
journal_title：Anticancer research
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更新日期：2014-04-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2012-03-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2015-05-01 00:00:00
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pub_type： 杂志文章
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更新日期：2020-06-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
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更新日期：2016-10-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章,评审
doi：
更新日期：1987-05-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2013-09-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1997-05-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2008-09-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2005-05-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
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更新日期：2019-04-01 00:00:00
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journal_title：Anticancer research
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doi：
更新日期：2016-03-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2008-03-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2000-05-01 00:00:00
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journal_title：Anticancer research
pub_type： 临床试验,杂志文章
doi：
更新日期：2005-03-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2002-11-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
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更新日期：2018-09-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2012-07-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2000-01-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1993-09-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1987-05-01 00:00:00
