Prognostic value of the expression of Smad6 and Smad7, as inhibitory Smads of the TGF-beta superfamily, in esophageal squamous cell carcinoma.

abstract：BACKGROUND:Trastuzumab has no major side-effects except the potential for cardiac toxicity. The main objective of this study was to evaluate the association between trastuzumab-associated cardiac toxicity and two potential risk factors: alcohol intake and HER2 polymorphisms. PATIENTS AND METHODS:In a retrospective coh...

journal_title：Anticancer research

authors： Lemieux J,Diorio C,Côté MA,Provencher L,Barabé F,Jacob S,St-Pierre C,Demers E,Tremblay-Lemay R,Nadeau-Larochelle C,Michaud A,Laflamme C

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:Monoclonal Antibody (MAb) 29-13 reacts with the human sarcoma-associated antigen (SAA) p200. We report here engineering and primary characterization of a single chain antibody (scFV2913). MATERIALS AND METHODS:The scFV2913 recombinant gene, consisting of VH-linker-VK, was constructed with RT-PCR. This gene ...

journal_title：Anticancer research

authors： Chen H,Wang P,Stastny JJ,Shilkaitis A,Liao X,Das Gupta TK

更新日期：1996-11-01 00:00:00

abstract：:The content, composition and physicochemical characteristics of glycosaminoglycans in human rectum and rectum carcinoma were investigated by chemical analyses, enzymic treatments, chromatographic and electrophoretic techniques. The overall glycosaminoglycan content was increased about 2 fold in neoplastic tissues comp...

journal_title：Anticancer research

authors： Tsara ME,Papageorgacopoulou N,Karavias DD,Theocharis DA

更新日期：1995-09-01 00:00:00

abstract：BACKGROUND:Intronic microRNAs (miRNAs) are considered to be transcribed using their host gene promoter. However, about one third of intronic miRNAs are predicted to have independent promoter elements. MATERIALS AND METHODS:Human breast cancer cells were cultured under normoxia or hypoxia, and expression levels of intr...

journal_title：Anticancer research

authors： Kondo H,Shimono Y,Mukohyama J,Tanaka Y,Shibuya N,Minami H,Kakeji Y,Suzuki A

更新日期：2017-07-01 00:00:00

abstract：:Plastins are members of a family of actin-binding proteins which exhibit a tissue-specific expression pattern. L-plastin, which is specifically expressed in hematopoietic cell lineage, has been proposed to be involved in the control of cell adhesion and motility. This protein is also frequently expressed in cell lines...

journal_title：Anticancer research

authors： Lapillonne A,Coué O,Friederich E,Nicolas A,Del Maestro L,Louvard D,Robine S,Sastre-Garau X

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND:Long-acting sandostatin (S-LAR; octreotide acetate) is well tolerated and effective for symptom control and possibly disease control in gastroenteropancreatic neuroendocrine tumors (GEP-NETs). We undertook a retrospective analysis to study the efficacy and tolerability of higher doses (more than 20-30 mg/mon...

journal_title：Anticancer research

authors： Chadha MK,Lombardo J,Mashtare T,Wilding GE,Litwin A,Raczyk C,Gibbs JF,Kuvshinoff B,Javle MM,Iyer RV

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND/AIM:Since androgens affect urothelial bladder cancer (UBC), we examined whether 5α-reductases (5-AR) have genomic alterations in UBC and whether 5α-reductase inhibitors (5-ARI) affect UBC. MATERIALS AND METHODS:The cBioPortal was used to analyze genomic alternations of 5-ARs in UBC cancer genomic datasets. ...

journal_title：Anticancer research

authors： Chen CC,Huang CP,Tsai YT,Hseih TF,Shyr CR

更新日期：2017-12-01 00:00:00

abstract：AIM:The primary aim of the study was to assess the association between risk of recurrence and HER2 equivocal gene status through immunohistochemistry in patients with early breast cancer. PATIENTS AND METHODS:We retrospectively analyzed clinical and pathological data of 455 consecutive patients with early breast cance...

journal_title：Anticancer research

authors： Criscitiello C,Bagnardi V,Viale G,Disalvatore D,Rotmensz N,Esposito A,Goldhirsch A,Curigliano G

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND/AIM:No standard treatment has been established for poorly-differentiated neuroendocrine carcinomas (PDNEC). The aim of this study is to evaluate the response to the combination of three drugs. MATERIAL AND METHODS:We reviewed 21 PDNEC patients treated from 2008 to 2013 in two Institutions. Five patients wer...

journal_title：Anticancer research

authors： Bajetta E,Catena L,Biondani P,Pusceddu S,Valente M,Bianco N,Novelli E

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:HER-2/neu onco-protein is increasingly being recognized as a target for therapy in solid tumors, but data on its role in malignant melanoma is currently limited. Our study objective was to determine a relationship, if any, between HER-2/neu overexpression and malignant melanoma. PATIENTS AND METHODS:Overexp...

journal_title：Anticancer research

authors： Potti A,Hille R,Koch M

更新日期：2003-09-01 00:00:00

abstract：BACKGROUND:Chemotherapy is the commonly accepted standard therapy for most types of brain tumor, especially in medulloblastoma, primitive neuroectodermal tumor and astrocytoma. However, no efficient therapy has been established to date for glioblastoma multiforme. The aim of the present study was to analyze the activit...

journal_title：Anticancer research

authors： Styczynski J,Olszewska-Slonina D,Kolodziej B,Napieraj M,Wysocki M

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND:The presence of circulating tumor cells (CTCs) in the peripheral blood is a prerequisite for the formation of distant metastases. Transforming growth factor-βeta (TGF-β) and Chemokine (C-X-C Motif) Ligand-1 (CXCL1) are cytokines involved in the colonization of distant sites by CTCs in several pre-clinical an...

journal_title：Anticancer research

authors： Divella R,Daniele A,Savino E,Palma F,Bellizzi A,Giotta F,Simone G,Lioce M,Quaranta M,Paradiso A,Mazzocca A

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:Human herpesviruses types 4 and 6 (EBV, HHV-6) are frequently found in Hodgkin 's disease (HD) and--to a certain extent--in Kikuchi-Fujimoto's disease (KFD). Both viruses are apparently related to proliferative and/or apoptotic processes as represented by HD or KFD respectively. OBJECTIVE:To correlate frequ...

journal_title：Anticancer research

authors： Krueger GR,Huetter ML,Rojo J,Romero M,Cruz-Ortiz H

更新日期：2001-05-01 00:00:00

abstract：BACKGROUND/AIM:L-type amino acid transporter 1 (LAT1) is highly expressed in various human cancers. However, the clinicopathological significance of LAT1 and 4F2 cell surface antigen (4F2hc) in patients with colorectal cancer (CRC) is unknown. The aim of this study was to clarify the prognostic significance of LAT1 exp...

journal_title：Anticancer research

authors： Ogawa H,Kaira K,Motegi Y,Yokobori T,Takada T,Katoh R,Osone K,Takahashi R,Katayama C,Oyama T,Kanai Y,Yao T,Asao T,Kuwano H,Shirabe K

更新日期：2019-05-01 00:00:00

abstract：AIM:To evaluate the frequency of loss of mediator of DNA damage checkpoint protein 1 (MDC1) protein expression in endometrial cancer (EC) and to determine whether loss of MDC1 is associated with certain clinicopathological parameters. MATERIALS AND METHODS:MDC1 expression was examined in 426 samples of EC. The nuclear...

journal_title：Anticancer research

authors： Merentitis D,Nguyen BD,Samartzis EP,Noske A,Brandt S,Dedes KJ

更新日期：2019-12-01 00:00:00

abstract：:The aims of this study were to evaluate the pharmacokinetics, tolerability and hematopoietic toxicity of mitoxantrone in elderly women. Thirteen patients with advanced breast cancer, median age of 73 years, received escalating doses of mitoxantrone 8, 10, 12 and 14 mg/m2 on day 1, q 21. There was a linear relationship...

journal_title：Anticancer research

authors： Repetto L,Vannozzi MO,Balleari E,Venturino A,Granetto C,Bason C,Simoni C,Prencipe E,Queirolo P,Esposito M,Ghio R,Rosso R

更新日期：1999-01-01 00:00:00

abstract：:The aim of this study was to compare the accuracy of 18-fluoro-2-deoxyglucose (FDG) positron emission tomography (PET) and thallium-201 (Tl-201) single photon emission computed tomography (SPECT) in differentiating recurrent/residual nasopharyngeal carcinomas (NPC) from post-radiotherapy (RT) changes in patients with ...

journal_title：Anticancer research

authors： Tsai MH,Huang WS,Tsai JJ,Chen YK,Changlai SP,Kao CH

更新日期：2003-07-01 00:00:00

abstract：:Paclitaxel has been approved as second-line therapy after anthracyclines in AIDS-Kaposi's sarcoma (KS) patients. To date, only one patient with classical KS and treated with standard dose (175 mg/m2) 3-weekly paclitaxel as first line therapy has been reported in the literature. Herein, the first case is presented of a...

journal_title：Anticancer research

authors： Silvestris N,Galetta D,Colucci G

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND/AIM:Breast cancer is the most prevalent and devastating malignant disease among women worldwide. Green tea has been extensively studied for its anti-cancer effects, however, existing literature on the correlation of other types of tea with breast cancer is very limited. MATERIALS AND METHODS:We used six dif...

journal_title：Anticancer research

authors： Shi H,Liu J,Tu Y,Freter CE,Huang C

更新日期：2018-11-01 00:00:00

abstract：:The aim of our study was to establish a simple method for routine analysis of c-erbB-2 gene expression in tumour samples. We constructed a plasmid for the in vitro synthesis of competitor RNA to be used as an internal exogenous control during the RT-PCR detection of c-erbB-2 expression. The competitor RNA harbors a 19...

journal_title：Anticancer research

authors： Schneeberger C,Eder S,Speiser P,Zeillinger R

更新日期：1996-03-01 00:00:00

abstract：:Angiogenesis is essential for tumour growth. Mostly hypervasculariced renal cell carcinoma (RCC) usually express angiogenic factors, e.g. basic fibroblast factor (bFGF), vascular endothelial growth factor, and angiogenin (ag). This study was designed to evaluate the improvement of serological angiogenesis-factors, the...

journal_title：Anticancer research

authors： Wechsel HW,Bichler KH,Feil G,Loeser W,Lahme S,Petri E

更新日期：1999-03-01 00:00:00

abstract：BACKGROUND:In the present study, 3 cytotoxic agents were combined as front-line chemotherapy in advanced non-small cell lung cancer (NSCLC) patients. All 3 drugs have been used in other 2-agent combinations and have been shown to be effective as first-line therapy. PATIENTS AND METHODS:Sixty-one (53 male, 8 female, me...

journal_title：Anticancer research

authors： Dimitroulis J,Toubis M,Antoniou D,Marosis C,Armenaki U,Stathopoulos GP,Giamboudakis P,Veslemes M,Michalopoulou P,Christou F,Georgatou N,Grigoratou T,Karaindros D,Katis K,SOLCA Study Group.

更新日期：2006-03-01 00:00:00

abstract：:The purpose was to evaluate efficacy and safety of carbon ion radiotherapy (C-ion RT) in patients with locally advanced olfactory neuroblastomas (ONBs). This study was a sub-analysis of the Japan Carbon-Ion Radiation Oncology Study Group Study (1402 HN, UMIN000024473). Clinical data of T4 ONBs treated with C-ion RT at...

journal_title：Anticancer research

authors： Suefuji H,Koto M,Demizu Y,Saitoh JI,Shioyama Y,Tsuji H,Okimoto T,Ohno T,Nemoto K,Nakano T,Kamada T

更新日期：2018-03-01 00:00:00

abstract：:Constitutive activation of signal transducer and activator of transcription 3 (STAT3) has been indicated as a novel cancer drug target, since it plays an important role in diverse oncogenic processes including survival, cell proliferation and migration. Emerging STAT3 inhibitors have demonstrated efficacy in cancer ce...

journal_title：Anticancer research

authors： Tian J,Xiao H,Wu R,Cao Y,Li C,Xu R,Pierson CR,Finlay JL,Yang F,Gu N,Lin J

更新日期：2017-02-01 00:00:00

abstract：:A quantitative in vivo assay for BCG anticancer efficacy was developed to maximize detection of tumor-antagonistic mechanisms. Cultured S180 sarcoma cells admixed with various quantities of Mycobacterium bovis-BCG organisms were injected subcutaneously into CFW Swiss-Webster mice and response was measured as tumor inc...

journal_title：Anticancer research

authors： Klegerman ME,Zeunert PL,Lajeune J,Lou Y,Groves MJ

更新日期：1991-09-01 00:00:00

abstract：BACKGROUND:Calpains (CAPN) are intracellular, non-lysosomal cytoplasmic cysteine endopeptidases and they are expressed ubiquitously. Their endogenous specific inhibitor is calpastatin. When calcium is present, calpastatin and calpain attach to each other, inhibiting the protease. The calpain system plays an important r...

journal_title：Anticancer research

authors： Salehin D,Fromberg I,Haugk C,Dohmen B,Georg T,Bohle RM,Bauerschlag D,Maass N,Friedrich M

更新日期：2010-07-01 00:00:00

abstract：:Renal Cell Carcinoma (RCC) is characterized by high intratumoral microvascular density (iMVD) and significantly elevated serologic titers of angiogenesis factors, basic fibroblast growth factor (bFGF), vascular endothelial growth factor (vEGF) and angiogenin (Ag). The goal of the present study was to find whether a co...

journal_title：Anticancer research

authors： Wechsel HW,Feil G,Bichler KH,Beiter T,Gleichmann R

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND:Methylenetetrahydrofolate reductase (MTHFR) plays a role in DNA biosynthesis, methylation and repair in actively dividing cells by acting on folate metabolism. A common C677T polymorphism in the gene for MTHFR leads to an enzyme with decreased activity. MTHFR polymorphisms have been studied in various cancer...

journal_title：Anticancer research

authors： Kafadar AM,Yilmaz H,Kafadar D,Ergen A,Zeybek U,Bozkurt N,Kuday C,Isbir T

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND/AIM:A minority of grade I meningiomas (MG1s) recur after surgical resection and their progression is associated with high grade transformation (HGT). This study aimed to characterize the clinicoradiological features of recurrent MGs (RMG) with HGT. PATIENTS AND METHODS:We identified 17 patients diagnosed wi...

journal_title：Anticancer research

authors： Yeon EK,Sung JY,DO SI,Park BJ,Kim EJ,Na K

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND/AIM:The expression of metallothionein I/II (MT-I/II) was examined in thyroids of Graves' disease (GD) and nodular goiter (NG) patients to determine its role as a potential marker of proliferation and autoimmune inflammation in the thyroid. PATIENTS AND METHODS:MT-I/II and Ki-67 antigen expression was studie...

journal_title：Anticancer research

authors： Domoslawski P,Pula B,Olbromski M,Wojtczak B,Lukienczuk T,Podhorska-Okolow M,Dziegiel P

更新日期：2018-12-01 00:00:00