Clinical Value of Serum p53 Antibody in the Diagnosis and Prognosis of Esophageal Squamous Cell Carcinoma.

abstract：BACKGROUND:We report the prognostic significance of peripheral and tumor-infiltrating Th1, Th2, Tc1 and Tc2 cells in lung cancer patients. MATERIALS AND METHODS:We evaluated the rates of interferon (IFN)-gamma+/CD4+ cells (Th1), interleukin (IL)-4+ /CD4+ cells (Th2), IFN-gamma+/CD8+ cells (Tc1), IL-4+ /CD8+ cells (Tc2...

journal_title：Anticancer research

authors： Ito N,Suzuki Y,Taniguchi Y,Ishiguro K,Nakamura H,Ohgi S

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND:Therapy for patients with hepatic metastases from colorectal cancer (CRC) remains controversial and may be improved by regional oxaliplatin which proved to be effective when administered systemically to patients with advanced CRC. METHODS:During the current study, which aims to determine the maximum tolerat...

journal_title：Anticancer research

authors： Kern W,Beckert B,Lang N,Waggershauser T,Braess J,Schalhorn A,Hiddemann W

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND:Malignant gliomas still present a medical challenge, despite decades of continuous extensive research with optimization of surgical techniques, radiotherapy and systemic treatments. PATIENTS AND METHODS:From 1999 to 2004, 104 patients with WHO grade III and IVgliomas underwent surgery and received concomita...

journal_title：Anticancer research

authors： Eberlein KH,Nagel B,Franz K,Imhoff D,Seifert V,Boettcher HD,Mose S

更新日期：2006-11-01 00:00:00

abstract：:During postnatal development, the formation of new blood vessels is possible only through angiogenesis. The initial growth of solid neoplasms, including childhood brain tumors, during the genetically determined stages of carcinogenesis, even at clinically undetectable sizes (a few mm3), depends upon the continuous for...

journal_title：Anticancer research

authors： Bodey B,Bodey B Jr,Siegel SE,Kaiser HE

更新日期：1998-05-01 00:00:00

abstract：BACKGROUND/AIM:We investigated the effect of aspirin on colorectal cancer (CRC) risk among subgroups of women with and without risk factors for CRC. PATIENTS AND METHODS:Using data from the Women's Health Initiative, we estimated hazard ratios for CRC in association with aspirin use, with stratifications by cardiovasc...

journal_title：Anticancer research

authors： Seaton ME,Peters U,Johnson KC,Kooperberg C,Bafford A,Zubair N

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND AND AIM:The Seventh American Joint Committee on Cancer (AJCC)/TNM classification defined that the classification for adenocarcinoma of the esophagogastric junction (AEG) was included in the esophageal category. However, there still remain various classifications in AEG such as the Seventh AJCC/TNM of the eso...

journal_title：Anticancer research

authors： Kawaguchi T,Komatsu S,Ichikawa D,Kubota T,Okamoto K,Shiozaki A,Fujiwara H,Konishi H,Morimura R,Murayama Y,Kuriu Y,Ikoma H,Nakanishi M,Sakakura C,Otsuji E

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND/AIM:Androgens are essential for the growth of most prostate cancers (PCa). As a result, androgen ablation is the mainstay of the treatment of PCa. Proteins of the polycomb and trithorax family are master epigenetic regulators of cell type specific gene expression including androgen receptor. MATERIALS AND M...

journal_title：Anticancer research

authors： Wang S,Tailor K,Kwabi-Addo B

更新日期：2020-05-01 00:00:00

abstract：:We have investigated the combined effects of 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] and its fluoroanalog 26,26,26,27,27,27-hexafluoro-1,25-(OH)2D3 [F6-1,25-(OH)2D3] with sodium butyrate (NaB) on growth and differentiation of HL-60 human promyelocytic leukemia cells. F6-1,25-(OH)2D3 was 10-fold more active than 1,25-(...

journal_title：Anticancer research

authors： Yoshida M,Tanaka Y,Eguchi T,Ikekawa N,Saijo N

更新日期：1992-11-01 00:00:00

abstract：BACKGROUND:Several studies have reported an association between Hashimoto's disease and thyroid carcinoma although the cause/effect relationship is still controversial. CASE REPORT:In this paper we report the case of a 38-year-old female who first presented with a clinical history of Hashimoto's thyroiditis. Ultrasoun...

journal_title：Anticancer research

authors： Pisani T,Bononi M,Pantellini F,Vecchione A,Giovagnoli MR

更新日期：2002-11-01 00:00:00

abstract：:The widespread use of endoscopy and imaging in combination with the continuous update of the staging systems for neuroendocrine tumors has led to an increase in the incidence of small intestinal neuroendocrine tumors (si-NENs) globally. Despite high survival rates, severe complications may occur even in early stages d...

journal_title：Anticancer research

authors： Moris D,Ntanasis-Stathopoulos I,Tsilimigras DI,Vagios S,Karamitros A,Karaolanis G,Griniatsos J,Papalampros A,Papaconstantinou I,Glantzounis GK,Spartalis E,Blazer DG 3rd,Felekouras E

更新日期：2018-03-01 00:00:00

abstract：:Although growth factors are acknowledged for their mitogenic activity, a number of other functions are fulfilled by such peptides. These include control of motile and invasive behaviour, angiogenesis and phenotype. Various growth factors including epidermal growth factor, fibroblast growth factor, platelet derived gro...

journal_title：Anticancer research

authors： Finn PE,Bjerkvig R,Pilkington GJ

更新日期：1997-11-01 00:00:00

abstract：:We have previously shown biopsies from human malignant melanoma, as well as a cell line (MELUR) derived from human malignant melanoma cells, to contain dexamethasone (DEX) - and medroxyprogesterone acetate (MPA) - binding macromolecules exhibiting properties of glucocorticoid receptors from well-known target organs. I...

journal_title：Anticancer research

authors： Bojar H,Fabry W

更新日期：1985-03-01 00:00:00

abstract：BACKGROUND:Y-Box-Binding (YB1) protein represents a multifunctional protein, which plays a significant role in processes of proliferation, apoptosis and control of tumour cell response to toxic agents, including chemotherapy. The present study aimed at evaluating the prognostic significance of YB1 expression in breast ...

journal_title：Anticancer research

authors： Maciejczyk A,Szelachowska J,Ekiert M,Matkowski R,Hałoń A,Lage H,Surowiak P

更新日期：2012-08-01 00:00:00

abstract：:In experimental and clinical phase II trials GnRH agonists were shown to possess antitumor activity in ovarian cancer. The outcome of prostatic cancer was also improved experimentally by a combination of cytostatic chemotherapy and GnRH analogs. Encouraged by these results, we administered micro-encapsulated triptorel...

journal_title：Anticancer research

authors： Medl M,Peters-Engel C,Fuchs G,Leodolter S

更新日期：1993-11-01 00:00:00

abstract：UNLABELLED:Anaplastic ependymoma is a rare brain tumor, induced both in the brain and the spine. The treatment relies on surgery and radiotherapy. Upon failure of these treatments, chemotherapy has modest effects. Here, we report two cases of anaplastic ependymoma with prolonged radiological and clinical responses to a...

journal_title：Anticancer research

authors： Lorgis V,Varbedian O,Ghiringhelli F

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND/AIM:Non-vascularized methods to reconstruct bone defects following tumor resection are associated with complications. As a result, the free vascularized fibular flap (FVF) has become a mainstay for reconstruction. The purpose of this study was to analyze FVF reconstruction in the upper extremity. PATIENTS A...

journal_title：Anticancer research

authors： Claxton MR,Shirley MB,Bakri K,Rose PS,Moran SL,Houdek MT

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Recently, it has become obvious that the HMGB1 protein can act as a proinflammatory and proangiogenic mediator when actively secreted by macrophages or passively released from necrotic cells playing an important role in the pathogenesis of several diseases including cancer. MATERIALS AND METHODS:The absolut...

journal_title：Anticancer research

authors： Winter N,Meyer A,Richter A,Krisponeit D,Bullerdiek J

更新日期：2009-12-01 00:00:00

abstract：:Since the discovery of cisplatin about 40 years ago, the design of innovative metal-based anticancer drugs is a growing area of research. Transition metal coordination complexes offer potential advantages over the more common organic-based drugs, including a wide range of coordination number and geometries, accessible...

journal_title：Anticancer research

authors： Pottier A,Borghi E,Levy L

更新日期：2014-01-01 00:00:00

abstract：:The growth and amino acid utilization of a mouse macrophage-like cell line J774.1 was investigated in two different culture media supplemented with 10% fetal bovine serum (FBS). The J774.1 cells grew faster, and consumed glutamine and serine at higher rates in DMEM than in RPMI1640 medium. The consumption of other ami...

journal_title：Anticancer research

authors： Thet MM,Yokote Y,Chu Q,Wang QT,Kishino K,Tamura N,Shimada J,Amano O,Kanda Y,Kunii S,Takekawa F,Hatano H,Shimada C,Hasegawa H,Sakagami H

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND:Prognosis of renal cell carcinoma (RCC) differs within the same stage and grade. Our aim was to investigate the incidence of COX-2 in primary RCC tumors at different stages according to the occurrence of metastasis, and the impact of this biomarker on the survival of RCC patients. PATIENTS AND METHODS:The c...

journal_title：Anticancer research

authors： Kankuri-Tammilehto MK,Söderström KO,Pelliniemi TT,Vahlberg T,Pyrhönen SO,Salminen EK

更新日期：2010-07-01 00:00:00

abstract：:Important strategies against cancer are based on the understanding of the mechanisms of tumor progression. To elucidate alterations regarding tumor progression, we have performed proteomic differential display analysis for the expression of intracellular proteins in the regressive murine fibrosarcoma cell clone QR-32 ...

journal_title：Anticancer research

authors： Takenawa T,Kuramitsu Y,Wang Y,Okada F,Tokuda K,Kitagawa T,Ueyama Y,Nakamura K

更新日期：2013-01-01 00:00:00

abstract：:Linomide has antitumor effects when administered in vivo but not in vitro. Recent data indicate that at least part of this effect can be attributed to anti-angiogenic properties. The aim of the present investigation was to study the anti-angiogenic effects of Linomide on early tumor-induced angiogenesis in vivo, using...

journal_title：Anticancer research

authors： Borgström P,Torres Filho IP,Hartley-Asp B

更新日期：1995-05-01 00:00:00

abstract：:The cyanoguanidine CHS 828 was recently shown to possess potent anti-tumour effects both in vitro and in vivo. The exact mechanism of action of CHS 828 is not known, but recent results have indicated that induction of programmed cell death may be one mechanism by which CHS 828 exerts its anti-tumour effects. To invest...

journal_title：Anticancer research

authors： Hansen CM,Hansen D,Holm PK,Larsson R,Binderup L

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND:It is hypothesised that hypermethylation of the CpG island in the promoter region in several tumour suppressor genes contributes one of the mechanisms for silencing or down-regulating the expression of the tumour suppressor genes. One of the putative tumour suppressor genes, the E-cadherin gene, has shown do...

journal_title：Anticancer research

authors： Kao RH,Huang LC,Hsu YH

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND:Resistance to paclitaxel (PTX) is a major concern in treating ovarian cancer. Thus, agents effective in taxane-resistant tumours are highly sought. It has recently been shown that albendazole (ABZ) is a potent inhibitor of cell proliferation, angiogenesis and tumour growth. This study was designed to examine...

journal_title：Anticancer research

authors： Chu SW,Badar S,Morris DL,Pourgholami MH

更新日期：2009-10-01 00:00:00

abstract：:Growth inhibitory activity of YM881 (SMANCS) against 3 human cultured cell lines and one rat cultured cell line derived from glioma cells was assessed quantitatively. YM881 showed potent cytotoxicity against all glioma cell lines tested; the IC50 of this drug was 1.9-8.4 micrograms/ml. YM881 may be classified as a con...

journal_title：Anticancer research

authors： Kuratsu J,Takaki S,Kochi M,Mihara Y,Ushio Y

更新日期：1991-11-01 00:00:00

abstract：:We have established a hepatocarcinoma cell line (LFCl2A) that produces voluminous tumors when injected into syngeneic Commentary rats. We have previously shown that when these cells were transfected with an episomal vector expressing the antisense IGFI cDNA the transduced cells partly lost their tumorigenic properties...

journal_title：Anticancer research

authors： Lafarge-Frayssinet C,Martin C,Van Binh PN,Achard-Ellouk S,Duc HT,Frayssinet C,Cardoso G,Desauty G,Warnet JM,Bréchot C,Sarasin A

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND/AIM:We previously identified that promoter DNA methylation of cysteine dioxygenase type 1 (CDO1) and homeobox only protein homeobox (HOPX) were both cancer specific, and have a clinical potential as prognostic biomarkers in breast cancer (BC). The present study compared the differential prognostic relevance ...

journal_title：Anticancer research

authors： Tanaka Y,Kosaka Y,Waraya M,Yokota K,Harada H,Kaida T,Kikuchi M,Minatani N,Nishimiya H,Katoh H,Sengoku N,Watanabe M,Yamashita K

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND/AIM:Locoregional recurrence (LRR) of breast cancer is reported to occur at a rate of 5%-15%. Wide excision of LRR is the recommended treatment, which can increase the probability of subsequent local control. Herein, we describe a surgical technique wherein a pedicled skin and subcutaneous flap close the skin...

journal_title：Anticancer research

authors： Shinden Y,Nagata A,Nomoto Y,Saho H,Nakajo A,Minami K,Owaki T,Ohtsuka T,Kijima Y

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:Increasing evidence suggests that COX-2 promotes carcinogenesis but it is controversial as to whether COX-2 expression is a prognostic factor for rectal carcinoma. MATERIALS AND METHODS:Data of 62 consecutive patients with rectal carcinoma in UICC-stages I-III, which were curatively resected between 1995 an...

journal_title：Anticancer research

authors： Petersen S,Haroske G,Hellmich G,Ludwig K,Petersen C,Eicheler W

更新日期：2002-03-01 00:00:00