Abstract：
BACKGROUND/AIM:We evaluated urinary levels of porphyrin metabolites, such as uroporphyrin (UP) and coproporphyrin (CP), after 5-Aminolevulinic acid (ALA) administration in patients with or without pancreatic cancer (PaC). PATIENTS AND METHODS:Sixty-seven subjects with PaC, 11 with pancreatitis, and 9 with normal pancreas (NP) were enrolled. Urine samples from all subjects were collected prior to ALA administration and at more than 4 hours after ALA administration. We measured the urinary levels of UP and CP by high-performance liquid chromatography analysis. RESULTS:The PaC group showed significantly higher UP levels compared to NP groups (104.9 nmol/g Cre vs. 53.4 nmol/g Cre, p=0.014). Moreover, PaC patients with long-term survival had significantly lower urinary levels of UP at diagnosis (98.8 nmol/gCre) than the short-term survival group (125.2 nmol/gCre) (p=0.042). CONCLUSION:The urinary levels of UP after ALA administration might serve as a promising biomarker for diagnosis and prognosis prediction of PaC.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Ikeura T,Hori Y,Mitsuyama T,Miyoshi H,Shimatani M,Uchida K,Takaoka M,Ota U,Kamiya A,Takahashi K,Ishizuka M,Kaibori M,Okazaki Kdoi
10.21873/anticanres.14347subject
Has Abstractpub_date
2020-06-01 00:00:00pages
3571-3577issue
6eissn
0250-7005issn
1791-7530pii
40/6/3571journal_volume
40pub_type
杂志文章abstract：:The effect of Lonidamine (LND), an energolytic chemosensitizing agent, on the MDR (multidrug resistant) phenotype of a human breast cancer cell line (MCF-7) has been studied. The intracellular adriamycin (ADR) accumulation and distribution, the plasma membrane potential and the P170 glycoprotein phosphorylation, have ...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1995-11-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2008-09-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1984-11-01 00:00:00
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journal_title：Anticancer research
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更新日期：2000-09-01 00:00:00
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journal_title：Anticancer research
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doi：
更新日期：2009-11-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1998-07-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2007-01-01 00:00:00
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journal_title：Anticancer research
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doi：
更新日期：2006-11-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1995-01-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章,评审
doi：
更新日期：2013-08-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1999-05-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2000-05-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章,评审
doi：
更新日期：1994-01-01 00:00:00
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doi：
更新日期：2015-02-01 00:00:00
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doi：
更新日期：1997-09-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
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doi：
更新日期：2010-07-01 00:00:00
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journal_title：Anticancer research
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doi：
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journal_title：Anticancer research
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doi：
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
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journal_title：Anticancer research
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doi：
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journal_title：Anticancer research
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doi：
更新日期：1994-09-01 00:00:00
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journal_title：Anticancer research
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doi：
更新日期：2014-11-01 00:00:00
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doi：
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doi：
更新日期：2003-03-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
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pub_type： 杂志文章
doi：
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journal_title：Anticancer research
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doi：
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