The combination of different types of antitumor topoisomerase II inhibitors, ICRF-193 and VP-16, has synergistic and antagonistic effects on cell survival, depending on treatment schedule.

abstract：BACKGROUND/AIM:It is well-known that inflammatory bowel disease (IBD) poses an increased, yet not definitely estimated, risk of colitis-associated colon cancer (CAC), which is considered a more aggressive and distinct in both genetic and molecular levels clinical entity compared to sporadic colorectal cancer (CRC). The...

journal_title：Anticancer research

authors： Antoniou E,Margonis GA,Angelou A,Zografos GC,Pikoulis E

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:The successful use of clonal selection through fluctuation analysis of human cancer cells as a means for studying tumor progression has been previously reported. MATERIALS AND METHODS:Three clones derived from a parental population of human prostate cancer (LNCaP) cells were selected based on proliferation,...

journal_title：Anticancer research

authors： Ware JH,Zhou Z,Kopelovich L,Kennedy AR

更新日期：2006-11-01 00:00:00

abstract：AIM:To induce cancer resistance in wild-type mice and detect if the resistance could be inherited to the progeny of the induced resistant mice. Furthermore to investigate the spectrum and immunology of this inherited cancer resistance. MATERIALS AND METHODS:Resistance to with live S180 cancer cells in BALB/c mice was ...

journal_title：Anticancer research

authors： Koch J,Hau J,Jensen HE,Rieneck K

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND/AIM:Interleukin-32 (IL32) has been newly-identified as a proinflammatory cytokine. In the present study, we aimed to clarify the clinical role of IL32-positive cells in esophageal squamous cell cancer (ESCC) and regulatory T-cell (Treg) infiltration in the stroma. A total of 179 patients with ESCC who underw...

journal_title：Anticancer research

authors： Nabeki B,Ishigami S,Uchikado Y,Sasaki K,Kita Y,Okumura H,Arigami T,Kijima Y,Kurahara H,Maemura K,Natsugoe S

更新日期：2015-05-01 00:00:00

abstract：:The antitumoral and immunostimulating properties of rViscumin (recombinant mistletoe lectin) were investigated in two mouse tumor models. After intravenous inoculation with RAW-117-P or L-1 sarcoma cells in Balb/c mice, rViscumin was given s.c. at non-toxic doses ranging from 0.3 to 150 ng rViscumin/kg. One set of exp...

journal_title：Anticancer research

authors： Schaffrath B,Mengs U,Schwarz T,Hilgers RD,Beuth J,Möckel B,Lentzen H,Gerstmayer B

更新日期：2001-11-01 00:00:00

abstract：:P53 mutation, through defects in repairing DNA damages, is associated with genomic instability. In 24 adult patients with relapsed acute lymphoblastic leukemia (ALL), the status of the p53 gene at different stages was serially followed by cytogenetic and polymerase-chain reaction/single strand conformation polymorphis...

journal_title：Anticancer research

authors： Tang JL,Tien HF,Lin MT,Chen PJ,Chen YC

更新日期：1998-03-01 00:00:00

abstract：:Cancer cells are known to shed extracellular membrane vesicles both in vitro and in vivo. To analyse their possible involvement in the metastatic behaviour of tumours, we measured the Matrigel invasion capability and amounts of vesicles shed by four human tumour cell lines (8701-BC, MCF-7, MDA-MB-231 and HT-1080), and...

journal_title：Anticancer research

authors： Ginestra A,La Placa MD,Saladino F,Cassarà D,Nagase H,Vittorelli ML

更新日期：1998-09-01 00:00:00

abstract：:Metals and metal compounds have been used in medicine for several thousands of years. In this review we summarized the anti-cancer activities of the ten most active metals: arsenic, antimony, bismuth, gold, vanadium, iron, rhodium, titanium, gallium and platinum. The first reviewed metal, arsenic, presents the anomaly...

journal_title：Anticancer research

authors： Desoize B

更新日期：2004-05-01 00:00:00

abstract：:This epidemiological study was performed to evaluate the influence of postoperative complementary treatment with lectin-standardized mistletoe extract (sME) on breast cancer patients. The design (retrolective cohort analysis with parallel groups) and conduct of the study were in agreement with current standards for pr...

journal_title：Anticancer research

authors： Schumacher K,Schneider B,Reich G,Stiefel T,Stoll G,Bock PR,Hanisch J,Beuth J

更新日期：2003-11-01 00:00:00

abstract：:To identify retinoic acid (RA) signalling pathways involved in growth and differentiation in cells of the glial lineage, two human glioma ceh lines were studied. The three RA receptors (RARs) mRNAs were constitutively expressed, and of the three RXRs, RXR beta appeared predominant. Western blotting analysis confirmed ...

journal_title：Anticancer research

authors： Carpentier AF,Leonard N,Lacombe J,Zassadowski F,Padua RA,Degos L,Daumas-Duport C,Chomienne C

更新日期：1999-07-01 00:00:00

abstract：:The aim of this study was to compare the accuracy of 18-fluoro-2-deoxyglucose (FDG) positron emission tomography (PET) and thallium-201 (Tl-201) single photon emission computed tomography (SPECT) in differentiating recurrent/residual nasopharyngeal carcinomas (NPC) from post-radiotherapy (RT) changes in patients with ...

journal_title：Anticancer research

authors： Tsai MH,Huang WS,Tsai JJ,Chen YK,Changlai SP,Kao CH

更新日期：2003-07-01 00:00:00

abstract：:The aim of this study was to investigate whether multiple injections (daily for 5 days) of the hemorheological agent pentoxifylline (PTX) affected tumor physiological parameters (i.e., tumor pO2, tumor pH, and tumor interstitial fluid pressure) during the tumor growth of FSaII murine fibrosarcoma in C3H mice. The radi...

journal_title：Anticancer research

authors： Lee I,Biaglow JE,Lee J,Cho MJ

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND:Activating Gs a mutations have been identified in most instances of fibrous dysplasia (FD). This mutation leads to consistently elevated intracellular cyclic adenosine monophosphate (cAMP) levels, with various biological consequences. The development of secondary sarcoma in FD is a rare but well-established ...

journal_title：Anticancer research

authors： Gu W,Ogose A,Matsuba A,Kawashima H,Hotta T,Kudo N,Hoshino M,Kondo N,Mera H,Endo N

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND:A number of association studies have focused on the effect of polymorphisms related to DNA repair or the xenobiotic pathway, on the susceptibility to gastric cancer (GC). Here, the possible association between common polymorphisms in the X-ray repair cross-complementing groups (XRCC) 1, and glutathione-S-tra...

journal_title：Anticancer research

authors： Tahara T,Shibata T,Nakamura M,Yamashita H,Yoshioka D,Okubo M,Yonemura J,Ishizuka T,Maruyama N,Kamano T,Kamiya Y,Fujita H,Nakagawa Y,Nagasaka M,Iwata M,Yamada H,Hirata I,Arisawa T

更新日期：2011-02-01 00:00:00

abstract：:MicroRNAs (miRNAs) constitute a dominating class of small RNAs that regulate diverse cellular functions. Due the pivotal role of miRNAs in biological processes, a deregulated miRNA expression is likely involved in human cancers. MicroRNAs possess tumor suppressor capability, as well as display oncogenic characteristic...

journal_title：Anticancer research

authors： D'Angelo B,Benedetti E,Cimini A,Giordano A

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND/AIM:Prognosis for patients with head and neck squamous cell carcinoma (HNSCC) is poor in most cases and has not improved despite advances in therapy. Novel therapeutic approaches are mandatory in order to improve the situation. Everolimus, an inhibitor of mammalian target of rapamycin, as well as the multi-t...

journal_title：Anticancer research

authors： Aderhold C,Faber A,Umbreit C,Chakraborty A,Bockmayer A,Birk R,Sommer JU,Hörmann K,Schultz JD

更新日期：2015-03-01 00:00:00

abstract：:Clinical and hematological parameters, and three derived major staging systems were compared with DNA-cytometric parameters in 73 patients with newly diagnosed multiple myeloma (MM) and correlated in univariate analysis with survival to assess their predictive value. Regarding diagnostic validity, a multi-parameter sy...

journal_title：Anticancer research

authors： Kropff M,Leo E,Steinfurth G,Esselborn H,Adler CP,Böcking A

更新日期：1994-09-01 00:00:00

abstract：BACKGROUND:Preclinical studies suggest that 1,25-dihydroxyvitamin D [1,25(OH)2D] and celecoxib inhibit prostaglandins (PGs) associated with cancer through different mechanisms. We determined if there was synergy in their use. PATIENTS AND METHODS:A total of 36 healthy women received daily for one month/menstrual cycle...

journal_title：Anticancer research

authors： Qin W,Smith C,Jensen M,Holick MF,Sauter ER

更新日期：2013-09-01 00:00:00

abstract：:Throughout the world, breast cancer is among the major causes of cancer-related death and is the most common cancer found in women. The development of cancer molecular knowledge has surpassed the novel concept of cancer biology and unraveled principle targets for anticancer drug developments and treatment strategies. ...

journal_title：Anticancer research

authors： Tungsukruthai S,Petpiroon N,Chanvorachote P

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND/AIM:Roles for mutant (mt) KRAS in the innate immune microenvironment in colorectal cancer (CRC) were explored. MATERIALS AND METHODS:Human CRC HCT116-derived, mtKRAS-disrupted (HKe3) cells that express exogenous mtKRAS and allogenic cytokine-activated killer (CAK) cells were co-cultured in 3D floating (3DF)...

journal_title：Anticancer research

authors： Nishi K,Ishikura S,Umebayashi M,Morisaki T,Inozume T,Kinugasa T,Aoki M,Nimura S,Swain A,Yoshida Y,Hasegawa S,Nabeshima K,Sakata T,Shirasawa S,Tsunoda T

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:The aim of this study was to determine the progression-free survival (PFS) and toxicity associated with adjuvant administration of carboplatin and pemetrexed for completely resected patients with stage IB, II and IIIA non-small cell lung cancer (NSCLC). PATIENTS AND METHODS:Forty-five eligible NSCLC patient...

journal_title：Anticancer research

authors： Karapanagiotou EM,Boura PG,Papamichalis G,Konstantinou M,Sepsas E,Chamalakis G,Simsiris P,Gkiozos I,Syrigos KN

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND/AIM:Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is a novel clinical approach to the treatment of peritoneal carcinomatosis. A well-established, not anatomic ex vivo PIPAC model was used to investigate the influence of changes in internal pressure, distance of the Micropump(©) (MIP) to the distri...

journal_title：Anticancer research

authors： Khosrawipour V,Khosrawipour T,Falkenstein TA,Diaz-Carballo D,Förster E,Osma A,Adamietz IA,Zieren J,Fakhrian K

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:Pulmonary complications (PCs) after esophagectomy for patients with esophageal cancer have been correlated with prolonged hospital stays and in-hospital mortality. Previous studies have shown that minimally-invasive esophagectomy (MIE) is associated with a lower rate of PCs compared to conventional open surg...

journal_title：Anticancer research

authors： Kubo N,Ohira M,Yamashita Y,Sakurai K,Toyokawa T,Tanaka H,Muguruma K,Shibutani M,Yamazoe S,Kimura K,Nagahara H,Amano R,Ohtani H,Yashiro M,Maeda K,Hirakawa K

更新日期：2014-05-01 00:00:00

abstract：OBJECTIVE:The effectiveness and improvement in quality of life (QOL) of a long-acting formulation of octreotide (LAR) administration for cancer patients, with chronic loperamide-refractory diarrhea not attributed to medical therapy, were investigated. PATIENTS AND METHODS:Twenty-nine patients with chronic loperamide-r...

journal_title：Anticancer research

authors： Mystakidou K,Katsouda E,Tsilika E,Smyrniotis V,Vassiliou I,Tsiatas M,Vlahos L

更新日期：2006-05-01 00:00:00

abstract：:Consumption of dietary fat has been linked to the high incidence of certain cancers. However, recent research has stimulated interest in conjugated linoleic acid (CLA), a newly recognized anticarcinogenic fatty acid. Human MCF-7 breast cancer cells were incubated for 12 d in culture medium supplemented with various co...

journal_title：Anticancer research

authors： Shultz TD,Chew BP,Seaman WR

更新日期：1992-11-01 00:00:00

abstract：:This study investigates the treatment management and survival of inoperable advanced non-small cell lung cancer (NSCLC) patients. The objective was to treat all patients with induction chemotherapy and then to stratify them for surgery, radiotherapy, second-line chemotherapy or supportive treatment. Of the 359 patient...

journal_title：Anticancer research

authors： Stathopoulos GP,Dafni UG,Malamos NA,Rigatos S,Kouvatseas G,Moschopoulos N

更新日期：1999-07-01 00:00:00

abstract：BACKGROUND:A case control association study was carried out to investigate polymorphisms in genes CYP1A1 (3801T > C), GSTM1, and GSTT1 (null genotypes) and oral squamous cell carcinoma (OSCC), including a correlation with some histopathological findings (tumor size, lymph node invasion and degree of tumor differentiati...

journal_title：Anticancer research

authors： Losi-Guembarovski R,Cólus IM,De Menezes RP,Poliseli F,Chaves VN,Kuasne H,Leichsenring A,Guembarovski AL,Oliveira BW,Ramos G,Cavalcanti TC,Mizuno LT,Cavalli IJ,Ribeiro EM

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND:Oxidised ferrocenium compounds often possess antineoplastic activity. In contrast, reduced ferrocene derivatives frequently only show activity if cell components can oxidise them inside cells to the ferrocenium species. Ferrocene compounds having the lowest formal reduction potential are normally expected to...

journal_title：Anticancer research

authors： Swarts JC,Vosloo TG,Cronje SJ,Du Plessis WC,Van Rensburg CE,Kreft E,Van Lier JE

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:Gingival squamous cell carcinoma (SCC) cells frequently invade mandibular bone, and this destruction is associated with a worse prognosis. However, the relationship between bone destruction and associated factors is unclear. In this study, the role and diagnostic utility of transforming growth factor-beta (T...

journal_title：Anticancer research

authors： Goda T,Shimo T,Yoshihama Y,Hassan NM,Ibaragi S,Kurio N,Okui T,Honami T,Kishimoto K,Sasaki A

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND/AIM:The deacetylase sirtuin1 (SIRT1) inhibits tumor suppressor p53 and may promote tumorigenesis; however, SIRT1 effects on leukemia cells are controversial. The aim of this study was to clarify the activity of SIRT1 in leukemia cells. MATERIALS AND METHODS:The effects of SIRT1 inhibition or activation and ...

journal_title：Anticancer research

authors： Okasha SM,Itoh M,Tohda S

更新日期：2020-06-01 00:00:00