Abstract:
:Matrix metalloproteinase-7 (MMP-7), MMP-9, MMP-13, and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) are considered to have important roles in the invasiveness and outcomes of colorectal cancer (CRC). This study examined the clinicopathological significance of the relative expression of these genes in patients with colorectal cancer, especially as related to liver metastasis. The study analysed surgical specimens of cancer tissue and adjacent normal mucosa obtained from 202 patients with untreated colorectal cancer. MMP-7, MMP-9, MMP-13, TIMP-1, and beta-actin mRNA of cancer tissue and adjacent normal mucosa were measured by quantitative real-time, reverse-transcriptase polymerase chain reaction. Expression levels of MMP-7, MMP-9, MMP-13 and TIMP-1 were higher in cancer tissue than in adjacent normal mucosa. On analysis of the relations between gene expression and clinicopathological factors, MMP-13 expression was found to correlate with liver metastasis. Moreover, MMP-13 expression levels were higher in tumour tissue with liver metastasis than in that without liver metastasis. It is concluded that MMP-13 gene expression is a useful predictor of liver metastasis in patients with CRC.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Yamada T,Oshima T,Yoshihara K,Tamura S,Kanazawa A,Inagaki D,Yamamoto N,Sato T,Fujii S,Numata K,Kunisaki C,Shiozawa M,Morinaga S,Akaike M,Rino Y,Tanaka K,Masuda M,Imada Tsubject
Has Abstractpub_date
2010-07-01 00:00:00pages
2693-9issue
7eissn
0250-7005issn
1791-7530pii
30/7/2693journal_volume
30pub_type
杂志文章abstract:BACKGROUND:Endometrial carcinoma is a well known complex gynecological disorder. Our team suggests that this tumor is related to immortalization-up-regulated protein 1 and 2 (imup-1, imup-2), which are known to be involved in SV40-mediated immortalization. PATIENTS AND METHODS:RT-PCR and immunohistochemical staining w...
journal_title:Anticancer research
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journal_title:Anticancer research
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journal_title:Anticancer research
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doi:
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journal_title:Anticancer research
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journal_title:Anticancer research
pub_type: 杂志文章,评审
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journal_title:Anticancer research
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journal_title:Anticancer research
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