Global Analysis of miRNA-mRNA Interaction Network in Breast Cancer with Brain Metastasis.

abstract：BACKGROUND:Amrubicin is an active agent for the treatment of small-cell lung cancer (SCLC). However, there have been no reports of long-term amrubicin use. PATIENTS AND METHODS:Twelve patients with SCLC who were treated with eight or more cycles of amrubicin chemotherapy were retrospectively reviewed. RESULTS:The med...

journal_title：Anticancer research

authors： Higashiguchi M,Suzuki H,Hirashima T,Kobayashi M,Goya S,Okamoto N,Matsuura Y,Tamiya M,Morishita N,Kawase I

更新日期：2012-04-01 00:00:00

abstract：AIM:This study analyzed the effect of metastasectomy on overall mortality (OM) and perioperative outcomes in patients with metastatic renal cell carcinoma (mRCC) treated exclusively with targeted therapy. MATERIALS AND METHODS:Using the Surveillance, Epidemiology, and End Results (SEER) database (2006-2015), Kaplan-Me...

journal_title：Anticancer research

authors： Palumbo C,Pecoraro A,Knipper S,Rosiello G,Tian Z,Shariat SF,Simeone C,Briganti A,Saad F,Berruti A,Antonelli A,Karakiewicz PI

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:Neuroendocrine (NE) carcinomas of the lung exhibit expression of various stem cell antigens, and except for carcinoid tumours, carry a poor prognosis. Despite the fact that 10%-30% of all non-small cell lung carcinomas (NSCLC) which are not classified as NE carcinomas also show expression of NE markers, data...

journal_title：Anticancer research

authors： Gottschling S,Jensen K,Herth FJ,Thomas M,Schnabel PA,Herpel E

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:The effectiveness of mammographic screening in women aged over 50 years has been confirmed in the United States and Europe, but its effectiveness in women aged from 40 to 49 years remains controversial. The optimum age for effective screening of subjects for breast cancer by mammography in Japan was studied ...

journal_title：Anticancer research

authors： Morimoto T,Sasa M,Yamaguchi T,Kondo H,Akaiwa H,Sagara Y

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND:High thymidine kinase (TK) activity in cancer cells could counteract adjuvant chemotherapy directed at the inhibition of de novo DNA synthesis. TK is an independent prognostic factor in breast cancer patients receiving adjuvant chemotherapy. MATERIAL AND METHODS:In this paper, we describe the effects of ext...

journal_title：Anticancer research

authors： Span P,Heuvel J,Romain S,Piffanelli A,Martin PM,Geurts-Moespot A,Sweep F

更新日期：2000-03-01 00:00:00

abstract：:Dimethylsilane tetramines are structural analogues of spermine with a (CH3)2 Si-group incorporated into the central carbon chain. They have potential as anticancer drugs. Their cytotoxic effect was considered to rely mainly on their polyamine antagonist property. In order to obtain new ideas about cellular mechanisms,...

journal_title：Anticancer research

authors： Le Roch N,Douaud F,Havouis R,Delcros JG,Vaultier M,Moulinoux JP,Seiler N

更新日期：2002-11-01 00:00:00

abstract：:The neurogenic rat tumour BT4A was serially transplanted to the dorsum of the right hind leg of BD IX rats. The tumours were treated with water bath heating at 44.0 degrees C for one hour alone or combined with bleomycin or BCNU, both given intraperitoneally at a dose of 20 mg/kg. Bleomycin alone had no effect on tumo...

journal_title：Anticancer research

authors： Dahl O,Mella O

更新日期：1982-11-01 00:00:00

abstract：AIM:To compare a new-generation fecal immunochemical test (FIT) with the leading guaiac-based test in detection of fecal occult blood (FOB) in colonoscopy-referral patients. PATIENTS AND METHODS:A cohort of 300 patients referred for colonoscopy was examined by two different tests for FOB: ColonView quick test (CV) (FI...

journal_title：Anticancer research

authors： Vasilyev S,Smirnova E,Popov D,Semenov A,Eklund C,Hendolin P,Paloheimo L,Syrjänen K

更新日期：2015-05-01 00:00:00

abstract：:Mdm2 (murine double minute 2) is an oncogene, first identified in BALB/c 3T3 cells. Over-expression and gene amplification of Mdm2 were found in a variety of human cancers. Recently, Mdm2 was found to be an E3 ubiquitin ligase that promotes degradation of p53, which contributes significantly to its oncogenic activity....

journal_title：Anticancer research

authors： Swaroop M,Sun Y

更新日期：2003-07-01 00:00:00

abstract：:Small cell lung cancer (SCLC) cells express cholinergic nicotinic receptors on their membranes, and the stimulatory effect on cell growth of nicotine has been described in cell cultures. We investigated three SCLC cell lines, all showing high levels of fluorescence intensity when labeled with FITC alpha-bungarotoxin i...

journal_title：Anticancer research

authors： Pratesi G,Cervi S,Balsari A,Bondiolotti G,Vicentini LM

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND:During the progression from low-grade dysplastic nodule (DN) to progressed hepatocellular carcinoma (HCC), intranodular portal tracts gradually disappear, while unpaired arteries develop increasingly. Contrast-enhanced ultrasound (CEUS) is highly accurate in depicting intranodular vascularity. This study eva...

journal_title：Anticancer research

authors： Giorgio A,Calisti G,di Sarno A,Farella N,de Stefano G,Scognamiglio U,Giorgio V

更新日期：2011-11-01 00:00:00

abstract：:An in vitro cell line (HT 58) has been established from a human (B) NHL xenograft. The lymphoma cells in culture retained their lymphoblastic appearance, DNA-content, IgM/lambda monoclonality and many immunophenotypic markers. The clonal chromosomal abnormalities involved the chromosomes 1, 2, 3 and 14. The cells expr...

journal_title：Anticancer research

authors： Kopper L,Bankfalvi A,Mihalik R,Nagy P,Fulop C,Sarmay G

更新日期：1991-07-01 00:00:00

abstract：BACKGROUND:Primary small cell carcinoma of the ovary (SCCO) is rare, making prognosis and outcomes largely undefined. PATIENTS AND METHODS:Using case listing session of SEER 18 (1973-2010), we examined outcomes for patients with SCCO. Analyses were conducted with SEER(*)Stat 8.1.2, Microsoft Excel 2007 and GraphPad Pr...

journal_title：Anticancer research

authors： Jamy O,Yaghmour G,Hare F,Martin MG

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:Cancer of the small intestine is a rare disease, and its clinical features have not been clearly elucidated. Techniques such as double balloon endoscopy and capsule endoscopy allow the preoperative diagnosis of cancer of the small intestine, but this cancer is often detected at an advanced state and in many ...

journal_title：Anticancer research

authors： Higashi D,Ishibashi Y,Tamura T,Nii K,Egawa Y,Koga M,Tomiyasu T,Harimura T,Tanaka R,Futatsuki R,Noda S,Futami K,Maekawa T,Takaki Y,Hirai F,Matsui T

更新日期：2010-08-01 00:00:00

abstract：:This review presents the clinical pharmacokinetics of the marketed therapeutic monoclonal antibodies used in oncology. Aspects regarding absorption, tissue distribution, elimination as well as factors influencing pharmacokinetics, pharmacodynamics and kinetic interactions are also discussed. ...

journal_title：Anticancer research

authors： Levêque D,Wisniewski S,Jehl F

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND/AIM:We evaluated the clinical feasibility and surgical outcomes of robotic-assisted transperitoneal infrarenal para-aortic lymphadenectomy (TIPAL) in patients with gynecological malignancies. PATIENTS AND METHODS:The perioperative outcomes in 90 patients with gynecological malignancies who underwent laparos...

journal_title：Anticancer research

authors： Lee HJ,Lee YH,Chong GO,Hong DG,Lee YS

更新日期：2017-12-01 00:00:00

abstract：:Single agent carboplatin has demonstrated antitumoral activity in patients with advanced breast cancer. Thirty patients with inoperable locally advanced and/or metastatic breast cancer were treated with carboplatin (300 mg/m2) in combination with cyclophosphamide (600 mg/m2) and 5-fluorouracil (500 mg/m2) given on day...

journal_title：Anticancer research

authors： Closon MT,Verbeke L,Kains JP,Tijtgat J,Schallier D

更新日期：1995-03-01 00:00:00

abstract：BACKGROUND:Since tumor markers can be increased in the course of many benign diseases, the aim of this study was to verify if this also occurs in the course of rheumatic diseases. MATERIALS AND METHODS:We investigated the incidence and characteristics of Tumor M2-PK in the EDTA-plasma of 137 patients suffering from rh...

journal_title：Anticancer research

authors： Oremek GM,Müller R,Sapoutzis N,Wigand R

更新日期：2003-03-01 00:00:00

abstract：BACKGROUND:The mitochondrial protein translocase of inner mitochondrial membrane 17 homolog A (TIMM17A) has been identified as a biomarker of breast cancer. The present study aimed to investigate the biological role of TIMM17A in human breast cancer cells. MATERIALS AND METHODS:Anti-TIMM17A transgenes were stably tran...

journal_title：Anticancer research

authors： Yang X,Si Y,Tao T,Martin TA,Cheng S,Yu H,Li J,He J,Jiang WG

更新日期：2016-03-01 00:00:00

abstract：:The effect of conagenin (CNG) on intestinal toxicity induction by 5-fluorouracil (5-Fu) was investigated. In mice given sublethal doses of 5-Fu (50mg/kg, i.v.) for 5 consecutive days, a decrease in body weight and diarrhea accompanied with hemorrhaging of the duodenum, atrophy of cecum and reduced small intestine leng...

journal_title：Anticancer research

authors： Kawatsu M,Yamashita T,Ishizuka M,Takeuchi T

更新日期：1996-09-01 00:00:00

abstract：:Taking into account the possible regulatory influences of the beta-adrenergic system on lymphocyte proliferation as well as the proposed role of cyclic 3'-5'-adenosine monophosphate (cAMP) in the modulation of multidrug resistance (MDR) in tumour cells, we have tried to assess the status of the interactions between th...

journal_title：Anticancer research

authors： D'Amico C,Crescimanno M,Armata MG,Leonardi V,Palazzoadriano M,D'Alessandro N

更新日期：1992-11-01 00:00:00

abstract：BACKGROUND/AIM:We aimed to investigate the efficacy of immune-cell therapy in terms of the survival of patients with neuroendocrine carcinoma of the uterine cervix (NECC), which lacks standardized therapeutic approaches. PATIENTS AND METHODS:We identified 17 patients who were diagnosed as having NECC and treated with ...

journal_title：Anticancer research

authors： Goto S,Terao Y,Kamigaki T,Takimoto R,Naitoh K,Makita K,Yasumoto K,Okada S,Takizawa K,Yokomichi N,Suzuki N,Takeda S

更新日期：2020-08-01 00:00:00

abstract：:The triterpenoid fraction (100 and 200 mg/kg) of the fruit bodies of Ganoderma lucidum inhibited primary solid-tumor growth in the spleen, liver metastasis and secondary metastatic tumor growth in the liver in intrasplenic Lewis lung carcinoma (LLC)-implanted mice. In addition, the triterpenoid fraction (800 microgram...

journal_title：Anticancer research

authors： Kimura Y,Taniguchi M,Baba K

更新日期：2002-11-01 00:00:00

abstract：:The majority of human tumors display a high rate of glycolysis under aerobic conditions. This phenomenon was recognized approximately seven decades ago and is known as the Warburg effect. Several key enzymes required to maintain this high level of glucose metabolism are found in tumor cells. The effects of the glycoly...

journal_title：Anticancer research

authors： Nam SO,Yotsumoto F,Miyata K,Shirasu N,Miyamoto S,Kuroki M

更新日期：2013-07-01 00:00:00

abstract：:Telomeres, the tandem-repeated hexamers at the termini of mammalian chromosomes, form protective complexes in association with specific proteins that together with telomerase, a specialised telomere-synthesizing enzyme, regulate telomere length. Telomere shortening is associated with cellular senescence and is implica...

journal_title：Anticancer research

authors： Bekaert S,De Meyer T,Van Oostveldt P

更新日期：2005-07-01 00:00:00

abstract：BACKGROUND/AIM:We evaluated the efficacy and safety of carbon-ion radiotherapy (CIRT) alone for Stage III non-small-cell lung cancer (NSCLC). PATIENTS AND METHODS:Data of 65 patients (median age=73 years) with Stage III NSCLC who underwent CIRT alone in the QST Hospital, Chiba, Japan, between 1997 and 2015 were retros...

journal_title：Anticancer research

authors： Anzai M,Yamamoto N,Hayashi K,Nakajima M,Nomoto A,Ogawa K,Tsuji H

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Carbohydrate antigen 15-3 (CA15-3), Kerbs von den Lungen (KL-6) and breast cancer antigen 225 (BCA225) are widely used tumor markers for breast and lung cancer respectively. PATIENTS AND METHODS:We analyzed 460 Japanese volunteers for 99 items on blood examination including 27 serum tumor markers. Correlati...

journal_title：Anticancer research

authors： Ri G,Ohno S,Yamamoto T,Ito E,Furutani M,Furutani Y,Umeda Y,Tsukahara T,Hagita N,Matsuoka R

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND/AIM:Despite recent introduction of several novel agents, limited data exist regarding parameters that help predict the progression of non-metastatic castration-resistant prostate cancer (nmCRPC). The objective of this study was to identify prognostic predictors in nmCRPC patients. PATIENTS AND METHODS:This ...

journal_title：Anticancer research

authors： Miyake H,Watanabe K,Matsushita Y,Watanabe H,Tamura K,Motoyama D,Ito T,Sugiyama T,Otsuka A

更新日期：2020-02-01 00:00:00

abstract：:The influence of human stromal fibroblasts cultured from normal, non-malignant and malignant breast tissues on in vivo growth of human breast tumour cells was studied. Earlier appearance and increased incidence were observed when low cell inocula of breast MDA-MB 231 tumour cells were coinjected with fibroblasts from ...

journal_title：Anticancer research

authors： Brouty-Boye D,Raux H

更新日期：1993-07-01 00:00:00

abstract：:A possible influence of tamoxifen (TAM) treatment on the measurable content of some steroid hormone receptors (i.e. ER, PgR, AR) from primary breast cancers has been evaluated. In eleven postmenopausal women, two biopsies were taken from the same tumor, the first biopsy before starting endocrine treatment, and a secon...

journal_title：Anticancer research

authors： Lundgren S,Søreide JA,Lea OA

更新日期：1994-05-01 00:00:00