Abstract:
BACKGROUND/AIM:The significance of microvascular invasion (MVI) of hepatocellular carcinoma (HCC) after radiofrequency ablation (RFA) is unknown. PATIENTS AND METHODS:We studied 149 patients with solitary small-sized HCC (≤3 cm) who underwent hepatectomy, and developed a predictive model of MVI using independent factors related to the presence of MVI. The predictive model was applied to 159 patients who underwent RFA, and their outcomes were examined. RESULTS:A multivariate analysis revealed that α-fetoprotein ≥15 ng/ml (relative risk (RR) 3.05, p=0.02), des-γ-carboxy prothrombin ≥100 mAU/ml (RR 4.19, p=0.003), and tumor size ≥2 cm (RR 3.37, p=0.03) were independent risk factors of MVI. Among the patients who underwent RFA, the survival in patients with risk factors 2-3 was significantly worse, and local recurrence was more frequently obserbed than those with 0-1. CONCLUSION:When an HCC tumor is expected to display MVI, RFA may not be suitable in terms of poorer survival and local disease-control rates.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Imai K,Yamashita YI,Yusa T,Nakao Y,Itoyama R,Nakagawa S,Okabe H,Chikamoto A,Ishiko T,Baba Hdoi
10.21873/anticanres.12322subject
Has Abstractpub_date
2018-02-01 00:00:00pages
1053-1060issue
2eissn
0250-7005issn
1791-7530pii
38/2/1053journal_volume
38pub_type
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doi:
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journal_title:Anticancer research
pub_type: 临床试验,杂志文章
doi:
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journal_title:Anticancer research
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journal_title:Anticancer research
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doi:
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doi:
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
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