Abstract：
AIM:We investigated the immunohistochemical expression of estrogen receptors alpha (ERalpha) and beta (ERbeta) in pituitary adenoma subtypes combined with clinicopathological factors. MATERIALS AND METHODS:Pituitary adenomas (n=75) were immunostained for ERalpha and ERbeta using the streptavidin-biotin-peroxidase complex method with a monoclonal ERalpha antibody and polyclonal ERbeta antibody. RESULTS:Nuclear immunoreactivity for both receptors was highest among PRL, FSH/LH, null cell, and GH adenomas. ACTH, silent subtypes I and II corticotrophs, and subtype III adenomas were the least immunoreactive for both receptors. ACTH adenomas expressed significantly less ERalpha than FSH-LH, GH, and null cell adenomas. A significantly elevated ERalpha expression was observed in macroadenomas compared to microadenomas and non-invasive compared to invasive tumors. CONCLUSION:ERalpha and ERbeta are differentially expressed in the various pituitary adenoma subtypes suggesting a cell-specific function for these receptors. To elucidate the role of ERalpha in tumor size and invasiveness, additional studies are required.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Manoranjan B,Salehi F,Scheithauer BW,Rotondo F,Kovacs K,Cusimano MDsubject
Has Abstractpub_date
2010-07-01 00:00:00pages
2897-904issue
7eissn
0250-7005issn
1791-7530pii
30/7/2897journal_volume
30pub_type
杂志文章abstract：AIM:The aim of the present study was to investigate the prognostic impact of central nervous system metastases (CNS) after acquired resistance to epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI) in EGFR-mutant non-small cell lung cancer (NSCLC). PATIENTS AND METHODS:We defined CNS-collapse as de...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2015-02-01 00:00:00
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journal_title：Anticancer research
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更新日期：2015-02-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
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更新日期：2009-06-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2004-09-01 00:00:00
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journal_title：Anticancer research
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更新日期：1983-07-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2004-03-01 00:00:00
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journal_title：Anticancer research
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doi：
更新日期：1993-09-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
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更新日期：1997-07-01 00:00:00
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journal_title：Anticancer research
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doi：
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journal_title：Anticancer research
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doi：
更新日期：2008-07-01 00:00:00
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doi：
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2009-07-01 00:00:00
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journal_title：Anticancer research
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更新日期：2014-09-01 00:00:00
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更新日期：2002-09-01 00:00:00
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更新日期：2016-08-01 00:00:00
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journal_title：Anticancer research
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doi：
更新日期：2014-03-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1996-07-01 00:00:00
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journal_title：Anticancer research
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doi：
更新日期：1998-09-01 00:00:00
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更新日期：2011-03-01 00:00:00
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