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Adverse Prognostic Factors of Advanced Esophageal Cancer in Patients Undergoing Induction Therapy with Docetaxel, Cisplatin and 5-Fluorouracil.

Abstract：

BACKGROUND/AIM:The purpose of this study was to identify adverse prognostic factors for patients with advanced esophageal cancer undergoing chemotherapy with docetaxel, cisplatin and 5-fluorouracil (DCF). PATIENTS AND METHODS:The study cohort comprised of 45 patients with advanced esophageal cancer who underwent induction DCF therapy followed by esophagectomy or chemoradiotherapy. Treatment outcomes and factors affecting early recurrence and death were analyzed. RESULTS:Overall 3-year survival was 61.4%, and 3-year disease-free survival was 44.7%. Clinically evident lymph node metastasis and clinical stage were associated with recurrence within 1 year and death within 2 years. Low maximum standardized uptake value (SUVmax) after induction DCF therapy and small decreases in SUVmax from pre- to post-DCF therapy were also predictors of recurrence and poor prognosis. CONCLUSION:Induction DCF therapy may be ineffective for advanced-stage esophageal cancer and clinical lymph node metastasis (≥N2, ≥stage IIIB). Moreover, small decreases in SUVmax DCF therapy are associated with early disease relapse and death.

journal_name

Anticancer Res

journal_title

Anticancer research

authors

Nakajima M,Muroi H,Kikuchi M,Takahashi M,Ihara K,Shida Y,Kurayama E,Ogata H,Yamaguchi S,Sasaki K,Sakai M,Sohda M,Miyazaki T,Kuwano H,Kato H

doi

10.21873/anticanres.12302

subject

Has Abstract

pub_date

2018-02-01 00:00:00

pages

911-918

issue

2

eissn

0250-7005

issn

1791-7530

pii

38/2/911

journal_volume

38

pub_type

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