Relationships between cathepsin-D, pS2 protein and hormonal receptors in breast cancer cytosols: inconsistency with their established prognostic significance.

abstract：BACKGROUND/AIM:To identify the clinical and dosimetric predictors of severe acute radiation esophagitis (RE) in patients with non-small cell lung cancer (NSCLC) treated with accelerated hyperfractionated concurrent chemoradiotherapy (AH-CCRT) with concomitant boost technique. PATIENTS AND METHODS:A total of 159 patien...

journal_title：Anticancer research

authors： Wada K,Kishi N,Kanayama N,Hirata T,Ueda Y,Kawaguchi Y,Morimoto M,Konishi K,Imamura F,Ogawa K,Teshima T

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Axillary dissection is routinely conducted for all patients with sentinel node (SN)-positive breast cancer. Metastasis to non SNs is not often found after axillary dissection in patients with SN-positive breast cancer. Thus, we investigated clinicopathological features, including immune cells in peripheral b...

journal_title：Anticancer research

authors： Ishizuka Y,Horimoto Y,Nakamura M,Arakawa A,Fujita T,Iijima K,Saito M

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:This study was performed to determine whether drug action on breast tumours could also be analysed using a cell turnover index (CTI), a composite measurement of both proliferation and apoptosis. MATERIALS AND METHODS:Data were obtained from a randomized, placebo-controlled trial comparing three single doses...

journal_title：Anticancer research

authors： Bundred NJ,Anderson E,Nicholson RI,Dowsett M,Dixon M,Robertson JF

更新日期：2002-07-01 00:00:00

abstract：:The centrifugal spreading of multicellular aggregates from a DMH induced colon adenocarcinoma cell line from rats was observed in vitro. Various concentrations of pentagastrin were added to the culture medium. Controls included medium alone or culture medium containing different concentrations of either NH4OH or NaOH ...

journal_title：Anticancer research

authors： Schallier D,Van der Elst J,De Neve W,Storme G

更新日期：1986-03-01 00:00:00

abstract：:A new cell line, designated CC2/CUHK2, was established from a squamous carcinoma of the uterine cervix from a Chinese patient. The cell line grew well without interruption for over 12 months and over 90 passages. The doubling time of CC2/CUHK2 was 72 hours at passage 57. When seeded at a density of 1.5 x 10(3) cells p...

journal_title：Anticancer research

authors： Ho TH,Chew EC,Tam JS,Hou HJ,Yam HF,Chew-Cheng SB,Wong FW

更新日期：1993-07-01 00:00:00

abstract：BACKGROUND/AIM:To describe real clinical outcomes when using systemic therapy to treat non-small cell lung cancer (NSCLC) patients who have anaplastic lymphoma kinase (ALK) fusion gene mutation. PATIENTS AND METHODS:We performed a retrospective chart review from April 2008 to March 2019 sourced from 16 medical institu...

journal_title：Anticancer research

authors： Okauchi S,Numata T,Nawa T,Ichimura H,Saito T,Hayashihara K,Yamada H,Satoh H,Endo T,Inage Y,Kaburagi T,Kiyoshima M,Yamada Y,Tamura T,Saito K,Inagaki M,Hizawa N,Sato Y,Shiozawa T,Sekine I,Ishikawa H,Kurihima K,S

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND/AIM:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising candidate for cancer therapy due to its selective ability to induce apoptosis of cancer cells. However, some cancer cells are resistant to TRAIL. Here, we demonstrated that treatment with TRAIL, in combination with equol, sens...

journal_title：Anticancer research

authors： Kim EY,Kim AK

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:Malignant transformation in endometriosis is a rare but well known complication. However, detailed mechanisms of malignant transition and tumourigenesis in endometriosis remain unknown. We here describe the case of an endometrioid carcinoma arisen in endometriotic ovarian cyst fulfilling Sampson's criteria f...

journal_title：Anticancer research

authors： Noack F,Schmidt H,Buchweitz O,Malik E,Horny HP

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Aggrecan, the large aggregating proteoglycan, is a major component of the cartilage extracellular matrix. The C-terminal globular domain (G3) of the aggrecan molecule exhibits a pattern of alternative splicing that involves three exons. Each corresponds to a subdomain, epidermal growth factor 1(EGF1), EGF2, ...

journal_title：Anticancer research

authors： Matsui Y,Araki N,Tsuboi H,Tsumaki N,Nakata K,Kawabata H,Eyre DR,Yoshikawa H

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND/AIM:An active metabolite of the anti-leukemia agent clofarabine (Cl-F-ara-A) is an intracellular triphosphate form, Cl-F-ara-ATP. Monitoring this active form could provide crucial information for optimizing treatment regimens based on Cl-F-ara-A. A simple, isocratic HPLC method was developed. MATERIALS AND ...

journal_title：Anticancer research

authors： Yamauchi T,Nishi R,Ueda T

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND:Most patients with pancreatic adenocarcinoma are diagnosed with locally advanced (unresectable) or metastatic disease. The aim of this study was to investigate possible prognostic factors of survival in such patients. PATIENTS AND METHODS:Two hundred and fifteen patients were studied retrospectively. Twenty...

journal_title：Anticancer research

authors： Papadoniou N,Kosmas C,Gennatas K,Polyzos A,Mouratidou D,Skopelitis E,Tzivras M,Sougioultzis S,Papastratis G,Karatzas G,Papalambros E,Tsavaris N

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND/AIM:The hormonally-active form of vitamin D, 1,25(OH)2D3, demonstrated activity against oral squamous cell carcinoma (OSCC). Cytochrome P450scc (CYP11A1)-derived vitamin D hydroxyderivatives, such as 20(OH)D3 and 1,20(OH)2D3, have overlapping beneficial effects with 1,25(OH)2D3 without causing hypercalcemia....

journal_title：Anticancer research

authors： Oak ASW,Bocheva G,Kim TK,Brożyna AA,Janjetovic Z,Athar M,Tuckey RC,Slominski AT

更新日期：2020-05-01 00:00:00

abstract：AIM:To examine the relationship between symptomatic radiation pneumonitis and lung dose-volume parameters for patients receiving accelerated partial breast irradiation (APBI) using three dimensional-conformal radiotherapy (3D-CRT). PATIENTS AND METHODS:The prescribed radiation dose was 30 Gy in 5 fractions over 10 day...

journal_title：Anticancer research

authors： Shikama N,Kumazaki YU,Miyazawa K,Miyaura K,Kato S,Nakamura N,Kawamori J,Shimizuguchi T,Saito N,Saeki T

更新日期：2016-05-01 00:00:00

abstract：:The prognostic and predictive role of p53 overexpression in breast cancer samples is usually investigated by using molecular biology or immunohistochemical methods. However, the results are to date controversial, and this is in part due to the methodological pitfalls of both the methods. To study the possibility of ov...

journal_title：Anticancer research

authors： Dittadi R,Brazzale A,Mione R,Di Fresco S,Gatti C,Vinante O,Bassan F,Nascimben O,Gion M

更新日期：1997-11-01 00:00:00

abstract：BACKGROUND/AIM:Reportedly, hypertension tends to be associated with response to bevacizumab therapy, because bevacizumab suppresses vascular nitric oxide production. In this study we examined the predictive value of nitric oxide in bevacizumab-treated non-small cell lung cancer (NSCLC) patients. PATIENTS AND METHODS:F...

journal_title：Anticancer research

authors： Muto S,Takagi H,Owada Y,Inoue T,Watanabe Y,Yamaura T,Fukuhara M,Okabe N,Matsumura Y,Hasegawa T,Osugi J,Hoshino M,Higuchi M,Shio Y,Suzuki H

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:PSMA expression varies among prostate cell lines. We examined the role of CpG methylation and histone deacetylation in PSMA transcriptional repression in prostate cell lines. MATERIALS AND METHODS:The methylation status of a PSMA CpG island was investigated in LNCaP, DU145 and PC3 prostate cell lines. Cells...

journal_title：Anticancer research

authors： Noss KR,Singal R,Grimes SR

更新日期：2002-05-01 00:00:00

abstract：:Lymphocytes isolated from the peripheral blood of patients with chronic lymphocytic leukemia (CLL) and from healthy donors were studied for membrane fluidity and lipid phase separation. The degree of fluidity of the surface membrane lipids was estimated by fluorescence polarization analysis using the probe 1,6-dipheny...

journal_title：Anticancer research

authors： Deliconstantinos G,Daefler S,Krueger GR

更新日期：1987-05-01 00:00:00

abstract：BACKGROUND/AIM:Peripheral neurotoxicity is a dose-limiting factor of many chemotherapeutic agents, including cisplatin. Mesenchymal stem cells are promising for the treatment of several neurological disorders, and our aim was to verify the neuroprotective potential of human mesenchymal stem cells (hMSCs) on dorsal root...

journal_title：Anticancer research

authors： Scuteri A,Ravasi M,Monfrini M,Milano A,D'Amico G,Miloso M,Tredici G

更新日期：2015-10-01 00:00:00

abstract：:Three sublines have been derived from the parental line Mv1Lu by transfection with normal and mutated Ha-ras, and myc oncogenes, and subsequent cloning. All the oncogenes have increased the growth rate of the cell in vitro, increased their plating efficiency in monolayer and suspension, and reduced their serum depende...

journal_title：Anticancer research

authors： Khan MZ,Spandidos DA,Kerr DJ,McNicol AM,Lang JC,De Ridder L,Freshney RI

更新日期：1991-05-01 00:00:00

abstract：AIM:The present study investigated the clinical significance of tartrate-resistant acid phosphatase type-5 (ACP5) expression in gastric cancer. MATERIALS AND METHODS:In 150 specimens of gastric cancer and adjacent normal mucosa, expression of ACP5 protein and mRNA and was determined by immunohistochemical staining and...

journal_title：Anticancer research

authors： Kawamura M,Tanaka K,Toiyama Y,Okugawa Y,Okigami M,Yasuda H,Saigusa S,Ohi M,Inoue Y,Uchida K,Mohri Y,Kusunoki M

更新日期：2014-07-01 00:00:00

abstract：:We investigated the immunohistochemical expression of p21/waf1 protein in 59 cases of nasopharyngeal carcinomas (NPC) and compared p21 expression with PCNA, p53 and mdm2 protein expression. We found p21, PCNA, p53 and mdm2 in 59/59, 59/59, 18/59 and 12/59 nasopharyngeal carcinomas, respectively. We observed a tendency...

journal_title：Anticancer research

authors： Kouvidou C,Stefanaki K,Dai Y,Tzardi M,Koutsoubi K,Darivianaki K,Karidi E,Rontogianni D,Zois E,Kakolyris S,Georgoulias V,Delides G,Kanavaros P

更新日期：1997-07-01 00:00:00

abstract：:Autophagy is an evolutionarily-conserved catabolic process which furthers cell survival, especially in times of nutritional stress. Whilst being by itself a pro-survival mechanism, it has many areas of overlap with apoptosis. Autophagic cell death is recognised as a subset of programmed cell death, with features more ...

journal_title：Anticancer research

authors： Wazir U,Khanzada ZS,Jiang WG,Sharma AK,Kasem A,Mokbel K

更新日期：2014-01-01 00:00:00

abstract：:Rauscher erythroleukemia virus of the mouse was originally isolated from an animal bearing a lymphocytic neoplasm. In order to control extraneous influences on leukemia development, we modulated thymus-dependent and bursa-dependent lymphatic tissues and the granulopoietic and erythropoietic components of hemoreticular...

journal_title：Anticancer research

authors： Henkel B,Krueger GR

更新日期：1986-07-01 00:00:00

abstract：BACKGROUND:The tumor-suppressive effects of rabbit anti-p53 antibodies on chemically induced rat colon cancer were demonstrated previously (Cancer J, 10:116-120, 1997). METHODS:In this communication, the spleen's role in the immune response of rats to cancer and vaccination was evaluated histologically and immunohisto...

journal_title：Anticancer research

authors： Ben-Hur H,Gurevich P,Zion H,Berman V,Tendler Y,Sandler B,Zinder O,Zusman I

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND:Prognosis of renal cell carcinoma (RCC) differs within the same stage and grade. Our aim was to investigate the incidence of COX-2 in primary RCC tumors at different stages according to the occurrence of metastasis, and the impact of this biomarker on the survival of RCC patients. PATIENTS AND METHODS:The c...

journal_title：Anticancer research

authors： Kankuri-Tammilehto MK,Söderström KO,Pelliniemi TT,Vahlberg T,Pyrhönen SO,Salminen EK

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND:Gingival squamous cell carcinoma (SCC) cells frequently invade mandibular bone, and this destruction is associated with a worse prognosis. However, the relationship between bone destruction and associated factors is unclear. In this study, the role and diagnostic utility of transforming growth factor-beta (T...

journal_title：Anticancer research

authors： Goda T,Shimo T,Yoshihama Y,Hassan NM,Ibaragi S,Kurio N,Okui T,Honami T,Kishimoto K,Sasaki A

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND:Ewing's sarcoma cell lines may represent a good in vitro model for the understanding of tumor biology in this heterogeneous group of diseases. In the present study, we report the establishment and characterization of a primary Ewing's sarcoma cell line (LDS-Falck 01). MATERIALS AND METHODS:LDS-Falck 01 was ...

journal_title：Anticancer research

authors： Schiavo R,Tullio C,La Grotteria M,Andreotti IC,Scarpati B,Romiti L,Bozzi F,Pedrazzoli P,Siena S

更新日期：2007-09-01 00:00:00

abstract：:Homogeneous subpopulations, which are endowed with low or high metastatic potential, were selected from Lewis lung carcinoma (3LL) in an attempt to correlate metastatic phenotype with specific properties of tumor cells. Since the growth of malignant cells at secondary sites could depend on their ability to respond to ...

journal_title：Anticancer research

authors： Perrotti D,Cimino L,Falcioni R,Tibursi G,Gentileschi MP,Sacchi A

更新日期：1990-11-01 00:00:00

abstract：BACKGROUND:F-Box protein 45 (FBXO45) is reported to be associated with cancer aggressiveness. We investigated the relationship between FBXO45 and clinicopathological factors in gastric cancer (GC). MATERIALS AND METHODS:We used immunohistochemistry to investigate FBXO45 expression in 104 GC samples; the prognostic val...

journal_title：Anticancer research

authors： Kogure N,Yokobori T,Ogata K,Altan B,Mochiki E,Ohno T,Toyomasu Y,Yanai M,Kimura A,Yanoma T,Suzuki M,Bai T,Asao T,Kuwano H

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Viscum album agglutinin-1 (VAA-1) is assumed to be the biologically most active ingredient of misteltoe extracts that are often used as adjuvant cancer therapy. To develop new approaches for lung cancer treatment, we evaluated the antineoplastic activity of VAA-1 alone and in combination with other chemother...

journal_title：Anticancer research

authors： Siegle I,Fritz P,McClellan M,Gutzeit S,Mürdter TE

更新日期：2001-07-01 00:00:00