Abstract：
BACKGROUND/AIM:To identify the clinical and dosimetric predictors of severe acute radiation esophagitis (RE) in patients with non-small cell lung cancer (NSCLC) treated with accelerated hyperfractionated concurrent chemoradiotherapy (AH-CCRT) with concomitant boost technique. PATIENTS AND METHODS:A total of 159 patients who underwent AH-CCRT (64 Gy in 40 fractions twice daily) were retrospectively identified. Severe RE was designated as grade 3 or higher according to the Common Terminology Criteria for Adverse Events, version 4.0. RESULTS:The incidence rate of grade 3 RE was 15.1% (24/159). The multivariate analysis that incorporated the Eastern Cooperative Oncology Group performance status (ECOG PS, ≥1 vs. 0) and the relative esophagus volume irradiated with at least 60 Gy (V60) was optimal. Patients with a V60 of ≥15% had a 37.8% risk of grade 3 RE compared to a 6.1% risk among those with a V60 of <15%. CONCLUSION:ECOG PS (≥1 vs. 0) and the V60 were found to be significant risk factors for severe RE in NSCLC patients who underwent AH-CCRT.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Wada K,Kishi N,Kanayama N,Hirata T,Ueda Y,Kawaguchi Y,Morimoto M,Konishi K,Imamura F,Ogawa K,Teshima Tdoi
10.21873/anticanres.13139subject
Has Abstractpub_date
2019-01-01 00:00:00pages
491-497issue
1eissn
0250-7005issn
1791-7530pii
39/1/491journal_volume
39pub_type
杂志文章abstract：:Peripheral blood cells of cancer patients with advanced renal carcinoma and treated with interleukin-2 by intravenous application were studied by electron microscopy at different intervals from the beginning of rIL-2 administration. Morphofunctional modifications of lymphocytes, circulating hystiocytes containing phag...
journal_title：Anticancer research
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