Abstract：
BACKGROUND/AIM:Changes in epidermal growth factor receptor (EGFR) are commonly found in cancer progression, signaling a poor outcome in patients. In the present study, we aimed to investigate whether nimotuzumab could be of benefit for cholangiocarcinoma (CCA) treatment. MATERIALS AND METHODS:The expression of EGFR was explored using immunohistochemical staining in cases divided into groups with low and high expression. The effect of nimotuzumab on CCA cell growth, metastasis and the molecular mechanisms by which nimotuzumab inhibits CCA cell metastasis were evaluated. RESULTS:The expression of EGFR was high in 55% of patients with CCA. This was significantly correlated with a shorter survival of patients. CCA cells treated with nimotuzumab showed inhibited cell growth. Moreover, nimotuzumab inhibited CCA cell metastasis via induction of E-cadherin and suppression of zinc finger protein SNAI1 (SNAIL1), vimentin and matrix metalloproteinase 9 (MMP9) expression. CONCLUSION:Nimotuzumab appears to inhibit cell metastasis via suppression of the epithelial-mesenchymal transition process. Therefore, nimotuzumab should be considered as a potential therapeutic agent against CCA.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Padthaisong S,Thanee M,Techasen A,Namwat N,Yongvanit P,Liwatthakun A,Hankla K,Sangkhamanon S,Loilome Wdoi
10.21873/anticanres.11729subject
Has Abstractpub_date
2017-07-01 00:00:00pages
3591-3597issue
7eissn
0250-7005issn
1791-7530pii
37/7/3591journal_volume
37pub_type
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journal_title：Anticancer research
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journal_title：Anticancer research
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