Abstract:
BACKGROUND:Recently, it has become obvious that the HMGB1 protein can act as a proinflammatory and proangiogenic mediator when actively secreted by macrophages or passively released from necrotic cells playing an important role in the pathogenesis of several diseases including cancer. MATERIALS AND METHODS:The absolute and relative amount of HMGB1 was measured with an ELISA in different effusion types. RESULTS:The amount of HMGB1 protein in the samples differed between 0.0004% and 0.0025% of the total sample protein. The mean values of transudates were significantly (p<0.001) lower than the mean values of exudates. CONCLUSION:HMGB1, a so-called danger signalling protein, was found to be highly expressed in human pleural and peritoneal effusions due to cancer and inflammation. Compared to transudates the average level of HMGB1 was significantly higher in exudates. These results underline the characteristics of HMGB1 as a possible target for treatment in advanced cancer as well.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Winter N,Meyer A,Richter A,Krisponeit D,Bullerdiek Jsubject
Has Abstractpub_date
2009-12-01 00:00:00pages
5013-7issue
12eissn
0250-7005issn
1791-7530pii
29/12/5013journal_volume
29pub_type
杂志文章abstract::The multistep nature of cancer suggested from chemical carcinogenesis studies, epidemiological data and cell culture experiments could be explained by the occurrence of somatic mutations resulting in inappropriate expression of normal cellular sequences which have an intrinsic potential of becoming cancer genes. The d...
journal_title:Anticancer research
pub_type: 杂志文章
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journal_title:Anticancer research
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journal_title:Anticancer research
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更新日期:2000-11-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
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journal_title:Anticancer research
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journal_title:Anticancer research
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journal_title:Anticancer research
pub_type: 杂志文章
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journal_title:Anticancer research
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journal_title:Anticancer research
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doi:
更新日期:1999-03-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2006-11-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章,评审
doi:
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:1988-07-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:1999-01-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2007-11-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
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更新日期:1993-01-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章,收录出版
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pub_type: 临床试验,杂志文章
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journal_title:Anticancer research
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更新日期:1998-07-01 00:00:00
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journal_title:Anticancer research
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2011-12-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
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