Abstract:
BACKGROUND:Resistance to paclitaxel (PTX) is a major concern in treating ovarian cancer. Thus, agents effective in taxane-resistant tumours are highly sought. It has recently been shown that albendazole (ABZ) is a potent inhibitor of cell proliferation, angiogenesis and tumour growth. This study was designed to examine the efficacy of ABZ in PTX-resistant human ovarian cancer 1A9PTX22 cells. MATERIALS AND METHODS:Using both the parent PTX-sensitive 1A9 and PTX-resistant sub-line 1A9PTX22 cells, the effects of both drugs on cell proliferation, tubulin polymerisation and microtubule distribution across the cell was investigated. RESULTS:Comparison of the inhibitory concentration to achieve 50% cell death (IC(50)) revealed that, unlike PTX, ABZ is highly efficacious in inhibiting proliferation of 1A9PTX22 cells. The finding that ABZ but not PTX is highly effective in disrupting tubulin polymerisation in these cells confirmed involvement of the tubulin pathway. CONCLUSION:Data from this study suggest that ABZ is effective in suppressing growth of PTX-resistant ovarian tumour cells.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Chu SW,Badar S,Morris DL,Pourgholami MHsubject
Has Abstractpub_date
2009-10-01 00:00:00pages
3791-6issue
10eissn
0250-7005issn
1791-7530pii
29/10/3791journal_volume
29pub_type
杂志文章abstract:AIM:Human papillomavirus (HPV) is a risk factor for oropharyngeal squamous cell carcinoma (OPSCC), with an increasing incidence. The present study aimed to determine the changing incidence of HPV in patients with OPSCC in the period 1980-2009 and its influence on survival. PATIENTS AND METHODS:We randomly sampled 158 ...
journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2015-07-01 00:00:00
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journal_title:Anticancer research
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2010-11-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2014-12-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
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更新日期:1986-07-01 00:00:00
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pub_type: 历史文章,杂志文章
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更新日期:2016-01-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章,多中心研究
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更新日期:2016-05-01 00:00:00
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journal_title:Anticancer research
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更新日期:2003-09-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2002-11-01 00:00:00
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journal_title:Anticancer research
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doi:
更新日期:2007-07-01 00:00:00
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journal_title:Anticancer research
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更新日期:2016-04-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2011-08-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2008-07-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2010-11-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章,多中心研究
doi:
更新日期:2016-06-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:1999-03-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2014-08-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:1994-03-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:1996-09-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2012-05-01 00:00:00
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journal_title:Anticancer research
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doi:
更新日期:1999-11-01 00:00:00
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journal_title:Anticancer research
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doi:
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journal_title:Anticancer research
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更新日期:2015-06-01 00:00:00
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journal_title:Anticancer research
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更新日期:2020-04-01 00:00:00
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journal_title:Anticancer research
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doi:
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:1996-09-01 00:00:00
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journal_title:Anticancer research
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doi:
更新日期:2012-02-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2001-03-01 00:00:00
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journal_title:Anticancer research
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