Abstract:
BACKGROUND:Gemcitabine (2'-deoxy-2'-difluorodeoxycytidine: Gemzar) (GEM) appears to be the only effective anticancer drug for pancreatic cancer, but it has little impact on outcome due to a high level of inherent and acquired tumor resistance. Our previous proteomic study demonstrated that the expression of three spots of heat-shock protein 27 (HSP27) was increased in GEM-resistant pancreatic cancer cells and could play a role in determining the sensitivity of pancreatic cancer to GEM. MATERIALS AND METHODS AND RESULTS:In the present study, using one-dimensional and two-dimensional Western blotting, we elucidated that these three spots of HSP27 were phosphorylated in GEM-resistant pancreatic cancer cell line, KLM1-R. CONCLUSION:Phosphorylated HSP27 may play an important role in the resistance to GEM, and it could also be a possible biomarker for predicting the response of pancreatic cancer patients to treatment with GEM.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Taba K,Kuramitsu Y,Ryozawa S,Yoshida K,Tanaka T,Maehara S,Maehara Y,Sakaida I,Nakamura Ksubject
Has Abstractpub_date
2010-07-01 00:00:00pages
2539-43issue
7eissn
0250-7005issn
1791-7530pii
30/7/2539journal_volume
30pub_type
杂志文章abstract:BACKGROUND/AIM:Forodesine inhibits purine nucleoside phosphorylase, resulting in an accumulation of intracellular dGTP and consequently cell death. 9-β-D-Arabinofuranosylguanine (ara-G) is an active compound of nelarabine that is intracellularly phosphorylated to a triphosphate form, which inhibits DNA synthesis. Both ...
journal_title:Anticancer research
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journal_title:Anticancer research
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journal_title:Anticancer research
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journal_title:Anticancer research
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章
doi:
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更新日期:2013-02-01 00:00:00
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doi:
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doi:
更新日期:2010-12-01 00:00:00
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doi:
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pub_type: 杂志文章
doi:
更新日期:2006-01-01 00:00:00
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更新日期:2014-04-01 00:00:00
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