Chemosensitivity and multidrug resistance to antineoplastic drugs in retinoblastoma cell lines.

abstract：BACKGROUND:Since the anti-HER2 monoclonal antibody trastuzumab made its triumphant advance into breast cancer therapy, new selective agents, including pan-HER inhibitors are entering clinical practice. MATERIALS AND METHODS:This study investigates the expression of the four HER-family members, HER1-4, in 48 primary br...

journal_title：Anticancer research

authors： Fuchs IB,Siemer I,Bühler H,Schmider A,Henrich W,Lichtenegger W,Schaller G,Kuemmel S

更新日期：2006-11-01 00:00:00

abstract：:The therapeutic opportunities for an improved management of malignant bone disease are currently extensively studied. The conventional management of symptomatic bone lesions in patients with advanced cancer involves various combinations of local and systemic standard anticancer therapies and the symptomatic treatment ...

journal_title：Anticancer research

authors： Lüftner D,Henschke P,Possinger K

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND/AIM:KRAS and BRAF are two genes commonly mutated in colorectal cancer (CRC). Even though BRAF is a downstream target of KRAS in the MAPK signalling pathway, KRAS- and BRAF-mutated CRCs are found to display several different clinical and histopathological features. We investigated whether a differential expre...

journal_title：Anticancer research

authors： Lundberg IV,Wikberg ML,Ljuslinder I,Li X,Myte R,Zingmark C,Löfgren-Burström A,Edin S,Palmqvist R

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Randomized controlled trials had demonstrated local therapy, such as radiotherapy, can improve outcomes of patients with lung cancer with oligometastatic disease (OMD). However, the definition of OMD is not uniform and the European Society for Radiotherapy and Oncology (ESTRO) and European Organisation for R...

journal_title：Anticancer research

authors： Chen HJ,Tu CY,Hsia TC,Fang HY,Chen CH,Chen SC,Li CH,Liao YM,Hsieh CY,Lein MY,Liang JA,Chien CR

更新日期：2020-10-01 00:00:00

abstract：:Upper gastrointestinal malignancies are associated with a high disease burden worldwide, and esophageal and gastric cancers represent the most common entities. Given a lack of early characteristic symptoms and potent screening instruments, the majority of patients present with advanced disease at the time of diagnosis...

journal_title：Anticancer research

authors： Bolm L,Käsmann L,Paysen A,Karapetis C,Rades D,Wellner UF,Keck T,Watson DI,Hummel R,Hussey DJ

更新日期：2018-06-01 00:00:00

abstract：AIM:To identify predictors of poor prognosis of patients with colon cancer (CC) who underwent surgery with curative intent, we investigated the association between the albumin to globulin ratio (AGR) with clinicopathological findings such as overall (OS) and disease-free (DFS) survival. PATIENTS AND METHODS:We conduct...

journal_title：Anticancer research

authors： Fujikawa H,Toiyama Y,Inoue Y,Imaoka H,Shimura T,Okigami M,Yasuda H,Hiro J,Yoshiyama S,Saigusa S,Kobayashi M,Ohi M,Araki T,Mohri Y,Kusunoki M

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:Live animal studies using an inoculation model of breast cancer indicate that anaesthetic drugs and techniques differentially affect cancer metastasis, inversely related to Natural Killer (NK) cell and T lymphocyte levels. Clinical histological studies demonstrate that the distribution of these immune cells ...

journal_title：Anticancer research

authors： Desmond F,McCormack J,Mulligan N,Stokes M,Buggy DJ

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:A nodular lymphocyte predominant Hodgkin's lymphoma (NLPHL) is a lymphoproliferative neoplasm with a fair prognosis, but the possibility of a malignant transformation into a diffuse large B-cell lymphoma (DLBCL) is high. DLBCL progresses aggressively. Introduction of rituximab into therapy had led to improve...

journal_title：Anticancer research

authors： Gutsch J,Werthmann PG,Rosenwald A,Kienle GS

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:In patients with melanoma, early dissemination via lymphatic and hematogenous routes is frequently seen. Thus, besides clinical follow-up examination and imaging, reliable melanoma-specific serological tumor markers are needed. PATIENTS AND METHODS:We retrospectively compared two serum markers for melanoma,...

journal_title：Anticancer research

authors： Uslu U,Schliep S,Schliep K,Erdmann M,Koch HU,Parsch H,Rosenheinrich S,Anzengruber D,Bosserhoff AK,Schuler G,Schuler-Thurner B

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:Oral squamous cell carcinoma (OSCC) is a multifactorial neoplasm related to tobacco smoke, alcohol consumption and molecular genetic changes such as p53 mutations. The human tumor suppressor gene TP53 contains single nucleotide polymorphism that encodes either arginin (Arg) or proline (Pro) at amino acid cod...

journal_title：Anticancer research

authors： Drummond SN,De Marco L,Pordeus Ide A,Barbosa AA,Gomez RS

更新日期：2002-11-01 00:00:00

abstract：UNLABELLED:The aim this study was to assess the efficacy of cisplatin-epirubicin-vinorelbine, as primary chemotherapy, in reducing the tumour burden in T2-3 N0-2 breast carcinomas. Breast conservative surgery (BCS) rate, clinical and pathological complete response (pCR), toxicity and 5-year disease-free survival (DFS) ...

journal_title：Anticancer research

authors： Barni S,Visini M,Piazza E,Ionta MT,Ardizzoia A,Arnoldi E,Fava S,Pinotti G,Torretta F,Corradini G,Villa S,Nosenzo AM,Massidda B,Cazzaniga ME

更新日期：2007-07-01 00:00:00

abstract：:Human peripheral blood monocytes derived from normal donors, melanoma patients (MP) before and after chemotherapy (MPa) were assayed for their capacity to inhibit SK-MEL-28 melanoma cell growth in vitro; in addition, growth modulating effects by prothymosin alpha 1 (ProTa) were studied. After preincubation with or wit...

journal_title：Anticancer research

authors： Garbin F,Eckert K,Büttner P,Garbe C,Maurer HR

更新日期：1994-11-01 00:00:00

abstract：BACKGROUND:Pemetrexed and erlotinib represent different agents commonly used for the second-line treatment of patients with advanced-stage non-small cell lung cancer (NSCLC). PATIENTS AND METHODS:We analyzed data of 137 patients with advanced-stage non-squamous NSCLC treated with pemetrexed or erlotinib in the second ...

journal_title：Anticancer research

authors： Fiala O,Pesek M,Finek J,Svaton M,Minarik M,Benesova L,Bortlicek Z,Kucera R,Topolcan O

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND/AIM:The purpose of this study was to identify adverse prognostic factors for patients with advanced esophageal cancer undergoing chemotherapy with docetaxel, cisplatin and 5-fluorouracil (DCF). PATIENTS AND METHODS:The study cohort comprised of 45 patients with advanced esophageal cancer who underwent induc...

journal_title：Anticancer research

authors： Nakajima M,Muroi H,Kikuchi M,Takahashi M,Ihara K,Shida Y,Kurayama E,Ogata H,Yamaguchi S,Sasaki K,Sakai M,Sohda M,Miyazaki T,Kuwano H,Kato H

更新日期：2018-02-01 00:00:00

abstract：:Two different techniques [reduction of a tetrazolium derivative (MTT) and 3HTdR uptake assays] were compared in order to evaluate the cytotoxic effects of different chemotherapeutic agents in vitro. The cytotoxicities of Melphalan, hexamethylmelamine and seven derivatives, and daunorubicin were measured on P388D1 mous...

journal_title：Anticancer research

authors： Arnould R,Dubois J,Abikhalil F,Libert A,Ghanem G,Atassi G,Hanocq M,Lejeune FJ

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND/AIM:To investigate whether high-dose-rate (HDR) intracavitary brachytherapy (IBT) dose ratios can predict treatment outcomes in patients with stage IIB cervical cancer. PATIENTS AND METHODS:Ninety-three patients treated with weekly cisplatin-based concurrent chemoradiotherapy and HDR IBT were analyzed. Pote...

journal_title：Anticancer research

authors： Cho O,Noh OK,Oh YT,Chang SJ,Chun M

更新日期：2017-01-01 00:00:00

abstract：:The expression of a cell surface-associated sialoglycoprotein (LEA.135), which has been shown to be significantly associated with decreased incidence of recurrence and increased overall survival of patients with primary invasive breast carcinoma, was evaluated in a retrospective study to identify subsets of patients w...

journal_title：Anticancer research

authors： Baltayan A,Naritoku WY,Chaiwun B,Tsao-Wei DD,Groshen S,Hern RA,Gusterson BA,Taylor CR,Imam SA

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND/AIM:Malignant tumors of the salivary glands are rare and heterogeneous, with more than 20 subtypes, and classified mainly by histopathology. Their diagnosis is often challenging and their etiology unknown. Here, the possible association between human polyomaviruses (PyVs) and one or more salivary gland tumor...

journal_title：Anticancer research

authors： Ramqvist T,Ursu RG,Haeggblom L,Mirzaie L,Gahm C,Hammarstedt-Nordenvall L,Dalianis T,Näsman A

更新日期：2018-05-01 00:00:00

abstract：:The limited restriction of eucaryotic chromosomes would facilitate our understanding of the aberrant genomes of genetic diseases and cancer. We have described methods for methylating eucaryotic chromosomes embedded in agarose plugs. We now describe how Cla I methylase can be utilized in a methylation-dependent restric...

journal_title：Anticancer research

authors： Wilson WW,Mebane EW,Hoffman RM

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:Warthin-like mucoepidermoid carcinoma is a newly recognized rare entity and could be misdiagnosed as a benign Warthin tumor. We report such a case of a 36-year-old male who presented with a left parotid gland mass. CASE REPORT:Fine-needle aspiration showed features suggestive of Warthin tumor. Following par...

journal_title：Anticancer research

authors： Zhang D,Liao X,Tang Y,Meyer RG,VAN Dyke DL,Liu X,Islam MN,Lai J

更新日期：2019-06-01 00:00:00

abstract：:Growth inhibitory activity of YM881 (SMANCS) against 3 human cultured cell lines and one rat cultured cell line derived from glioma cells was assessed quantitatively. YM881 showed potent cytotoxicity against all glioma cell lines tested; the IC50 of this drug was 1.9-8.4 micrograms/ml. YM881 may be classified as a con...

journal_title：Anticancer research

authors： Kuratsu J,Takaki S,Kochi M,Mihara Y,Ushio Y

更新日期：1991-11-01 00:00:00

abstract：BACKGROUND:The recent availability of a monoclonal antibody against human telomerase reverse transcriptase (hTERT) has enabled us to investigate the telomerase activity of tissue specimens more easily than by classical TRAP assay. In this study, we studied teromerase activity in thyroid tumors using this antibody. MAT...

journal_title：Anticancer research

authors： Ito Y,Yoshida H,Tomoda C,Uruno T,Takamura Y,Miya A,Kobayashi K,Matsuzuka F,Kuma K,Miyauchi A

更新日期：2005-01-01 00:00:00

abstract：UNLABELLED:Malignant pleural mesothelioma is a rare tumour. A three-modal strategy, comprising of surgery, radiotherapy and chemotherapy has been shown to be essential for appropriate management. Current literature evidences the importance of radiation therapy in the adjuvant setting for local control of the disease, a...

journal_title：Anticancer research

authors： Takanen S,Resuli B,Graziano V,Parisi A,Lisi R,Raffetto N,Tombolini V

更新日期：2012-04-01 00:00:00

abstract：OBJECTIVE:The authors report their experience in patients with adjuvant systemic 2-interferon with the aim of defining the effectiveness, side-effects, indications and limitations of this treatment. MATERIALS AND METHODS:From January 1989 to December 1996, 123 patients with genital, anorectal and perineal HPV lesions ...

journal_title：Anticancer research

authors： Scala M,Bonelli G,Gipponi M,Margarino G,Muzza A

更新日期：2002-03-01 00:00:00

abstract：BACKGROUND:Recent developments in detection of micrometastasis have revealed a considerable incidence of systemic disease in patients who would previously have been diagnosed as having solid tumours only. The purpose of this study was to investigate the prevalence and clinical significance of circulating carcinoma cell...

journal_title：Anticancer research

authors： Nakamura T,Yasumura T,Hayashi K,Eguchi R,Ide H,Takasaki K,Kasajima T

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND AND AIM:The Seventh American Joint Committee on Cancer (AJCC)/TNM classification defined that the classification for adenocarcinoma of the esophagogastric junction (AEG) was included in the esophageal category. However, there still remain various classifications in AEG such as the Seventh AJCC/TNM of the eso...

journal_title：Anticancer research

authors： Kawaguchi T,Komatsu S,Ichikawa D,Kubota T,Okamoto K,Shiozaki A,Fujiwara H,Konishi H,Morimura R,Murayama Y,Kuriu Y,Ikoma H,Nakanishi M,Sakakura C,Otsuji E

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND/AIM:Oral cancer represents approximately 2.5% of all cancers in the United States, with five- and 10-year survival rates of 62% and 51%. In the present study, lyophilized strawberries (LS) were evaluated for their potential to inhibit tumorigenesis in the hamster cheek pouch (HCP) model of oral cancer and fo...

journal_title：Anticancer research

authors： Casto BC,Knobloch TJ,Galioto RL,Yu Z,Accurso BT,Warner BM

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND/AIM:Gefitinib and erlotinib were shown to be particularly effective in a clinically selected subpopulation of non-small cell lung cancer patients (NSCLC): adenocarcinoma histology, non-smoking status, Asian origin and female gender have been associated with improved clinical benefit compared to the unselecte...

journal_title：Anticancer research

authors： Bonanno L,Schiavon M,Nardo G,Bertorelle R,Bonaldi L,Galligioni A,Indraccolo S,Pasello G,Rea F,Favaretto A

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:Molecular alterations such as DNA microsatellite instability (MSI/RER), single nucleotide polymorphism (SNP) and loss of heterozygosity (LOH) can occur throughout the genome and be associated with different types of cancer. In the present study, we aimed at detecting molecular alterations within the mismatch...

journal_title：Anticancer research

authors： Arzimanoglou II,Hansen LL,Chong D,Li Z,Psaroudi MC,Dimitrakakis C,Jacovina AT,Shevchuk M,Reid L,Hajjar KA,Vassilaros S,Michalas S,Gilbert F,Chervenak FA,Barber HR

更新日期：2002-03-01 00:00:00

abstract：:Four human melanoma cell lines with different copy numbers of chromosomes 9 and 21q, as studied by the G-band technique, fluorescent in situ hybridisation (FISH) and Polymerase chain reaction (PCR), were tested for their sensitivity to Interferon-alpha (IFN-alpha) and Interferon-beta (IFN-beta) in relation to dosage o...

journal_title：Anticancer research

authors： Köpf J,Hanson C,Delle U,Weimarck A,Stierner U

更新日期：1996-03-01 00:00:00