Prothymosin alpha augments deficient antitumor activity of monocytes from melanoma patients in vitro.

abstract：:Development of multidrug-resistance (MDR) remains a major cause of failure in the treatment of cancer with chemotherapeutic agents. In our efforts to explore alternative treatment regimens for multidrug-resistant tumors we have examined the sensitivity of MDR tumor cell lines to lymphokine activated killer (LAK) cells...

journal_title：Anticancer research

authors： Gautam SC,Chikkala NF,Lewis I,Grabowski DR,Finke JH,Ganapathi R

更新日期：1992-05-01 00:00:00

abstract：:Over 80% of clinically manifested prostate cancers respond to androgen withdrawal. Several alternatives to castration have been explored. Since a growth promoting role for androstenedione has been suggested, we investigated the effect of inhibition of 3 beta-hydroxy-steroid-dehydrogenase (3 beta-HSD), a key enzyme inv...

journal_title：Anticancer research

authors： Geldof AA,Dijkstra I,Newling DW,Rao BR

更新日期：1995-07-01 00:00:00

abstract：BACKGROUND:Chkl is a checkpoint gene that is activated after DNA damage. It phosphorylates and inactivates Cdc25C at the late G2 phase. The inactivation of Cdc25C and consequently, the inactivation of Cdc2, are required for the G2 arrest induced by DNA damage. METHODS:We treated 184B5 cell line and its E6 transformed ...

journal_title：Anticancer research

authors： Luo Y,Rockow-Magnone SK,Joseph MK,Bradner J,Butler CC,Tahir SK,Han EK,Ng SC,Severin JM,Gubbins EJ,Reilly RM,Rueter A,Simmer RL,Holzman TF,Giranda VL

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Prostate cancer metastases to bone are associated with significant morbidity and mortality. Presently, there is little known about the biological interaction between prostate cancer cells and bone. Development of an animal model using adult human bone will enhance our ability to study the biology of prostate...

journal_title：Anticancer research

authors： Tsingotjidou AS,Zotalis G,Jackson KR,Sawyers C,Puzas JE,Hicks DG,Reiter R,Lieberman JR

更新日期：2001-03-01 00:00:00

abstract：:Methyl-tertiary-butyl ether (MTBE) is a ubiquitous oxygen-bearing additive used to reduce engine knocking and obtain cleaner gasoline combustion. Conflicting data have been reported about a possible carcinogenic role of MTBE in humans. In this study we evaluated the effects of MTBE on cell growth and transformation in...

journal_title：Anticancer research

authors： Iavicoli I,Carelli G,Ardito R,Cittadini A,Sgambato A

更新日期：2002-07-01 00:00:00

abstract：BACKGROUND/AIM:To clarify whether renal dysfunction affects the incidence of adverse events associated with oxaliplatin, the present study was designed to investigate the relationship between creatinine clearance (Ccr) and the incidence of oxaliplatin-related adverse events. PATIENTS AND METHODS:A total of 287 CRC pat...

journal_title：Anticancer research

authors： Watanabe D,Fujii H,Yamada Y,Iihara H,Ishihara T,Matsuhashi N,Takahashi T,Yoshida K,Suzuki A

更新日期：2020-01-01 00:00:00

abstract：:T-CAR1 is a human carcinoma cell line established from a brain metastasis. The tumour cells overexpress EGFR and contain an amplified EGFR gene. In vitro in the presence of 5% human serum the tumour cells grow as adherent cells in monolayer. Shortly after exposure to EGF a large number of tumour cells round up and det...

journal_title：Anticancer research

authors： Torp SH,Helseth E,Unsgaard G,Dalen A

更新日期：1995-05-01 00:00:00

abstract：BACKGROUND/AIM:The aim of this study was to evaluate the impact of laparoscopic gastrectomy (LG) for gastric cancer on long-term survival in patients with postoperative infectious complications (PIC). PATIENTS AND METHODS:A total of 608 patients who underwent gastrectomy were classified into two groups based on the su...

journal_title：Anticancer research

authors： Nagata H,Tsujimoto H,Kouzu K,Itazaki Y,Ishibashi Y,Tsuchiya S,Sugihara T,Ito N,Harada M,Nomura S,Kishi Y,Ueno H

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:Aggrecan, the large aggregating proteoglycan, is a major component of the cartilage extracellular matrix. The C-terminal globular domain (G3) of the aggrecan molecule exhibits a pattern of alternative splicing that involves three exons. Each corresponds to a subdomain, epidermal growth factor 1(EGF1), EGF2, ...

journal_title：Anticancer research

authors： Matsui Y,Araki N,Tsuboi H,Tsumaki N,Nakata K,Kawabata H,Eyre DR,Yoshikawa H

更新日期：2002-11-01 00:00:00

abstract：:In a retrospective study, immunohistochemical determinations of p53 were performed on paraffinised tissue sections of 243 patients with node negative breast cancer. These patients were primary treated in the years 1980-1986 at the UFK-Würzburg. A complete follow up could be performed in 92% of all cases. The median fo...

journal_title：Anticancer research

authors： Kristen P,Müller JG,Caffier H

更新日期：1997-07-01 00:00:00

abstract：:Hereditary Non-polyposis Colorectal Cancer (HNPCC) has only recently been found to be linked to genetic loci. Clinical means of characterizing subjects at increased familial risk remain valid. If conservative criteria for HNPCC are not met, there remains a sufficiently high risk to first-degree relatives of colorectal...

journal_title：Anticancer research

authors： Lynch PM

更新日期：1994-07-01 00:00:00

abstract：BACKGROUND:Principal caregivers (PCs) of cancer patients experience high levels of stress that may significantly impact their quality of life (QoL). PCs' QoL during early phases of the disease (when patients were still on chemotherapy) were assessed. PATIENTS AND METHODS:The PCs of all patients meeting the inclusion c...

journal_title：Anticancer research

authors： Pellegrino R,Formica V,Portarena I,Mariotti S,Grenga I,Del Monte G,Roselli M

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND:Although well-acknowledged in vivo, spontaneous death of cancer cells in vitro is less widely appreciated. MATERIALS AND METHODS:Colony formation was studied in untreated control plates of standard clonogenic assays and measurements of actual and potential doubling times performed in asynchronous cultures o...

journal_title：Anticancer research

authors： Warenius H,Kyritsi L,Grierson I,Howarth A,Seabra L,Jones M,Thomas C,Browning P,White R

更新日期：2009-06-01 00:00:00

abstract：:The small molecular weight protein (p7) was overexpressed in the human ovarian carcinoma cell lines, SKVLB600 (selected for vinblastine resistance from SKOV3 cells). OVCAR 4/ADR100 (selected for doxorubicin resistance from NIH:OVCAR4) and (OVCAR4/VBL200 (selected for vinblastine resistance from NIH:OVCAR4). Trace amou...

journal_title：Anticancer research

authors： Yang X,Pagé M

更新日期：1996-01-01 00:00:00

abstract：:Two different techniques [reduction of a tetrazolium derivative (MTT) and 3HTdR uptake assays] were compared in order to evaluate the cytotoxic effects of different chemotherapeutic agents in vitro. The cytotoxicities of Melphalan, hexamethylmelamine and seven derivatives, and daunorubicin were measured on P388D1 mous...

journal_title：Anticancer research

authors： Arnould R,Dubois J,Abikhalil F,Libert A,Ghanem G,Atassi G,Hanocq M,Lejeune FJ

更新日期：1990-01-01 00:00:00

abstract：:Immunohistochemical analysis of the p53 tumor suppressor gene was performed in 69 human pancreatic ductal adenocarcinomas, using a highly specific anti-p53 antibody. Nuclear immunoreactivity was found in 40 tumors, yielding an overall frequency of 58%. Immunoblotting confirmed that nuclear immunoreactivity was associa...

journal_title：Anticancer research

authors： Yokoyama M,Yamanaka Y,Friess H,Buchler M,Korc M

更新日期：1994-11-01 00:00:00

abstract：BACKGROUND:In order to investigate the mechanism of the effects of the anticancer drug adamantyl maleimide (AMI) on the in vitro growth of a human gastric carcinoma cell line (SC-M1), the membrane protein conformation on the cell surface after treatment with AMI was studied. MATERIALS AND METHODS:The interaction of AM...

journal_title：Anticancer research

authors： Wang JJ,Chi CW,Lin SY,Chern YT

更新日期：1997-09-01 00:00:00

abstract：BACKGROUND/AIM:An active metabolite of the anti-leukemia agent clofarabine (Cl-F-ara-A) is an intracellular triphosphate form, Cl-F-ara-ATP. Monitoring this active form could provide crucial information for optimizing treatment regimens based on Cl-F-ara-A. A simple, isocratic HPLC method was developed. MATERIALS AND ...

journal_title：Anticancer research

authors： Yamauchi T,Nishi R,Ueda T

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND/AIM:Osteosarcoma originates from mesenchymal stem cells with impaired bone differentiation. In the present study we investigated the effect of ascorbic acid (AsA) on osteogenic differentiation and apoptosis of the MG-63 osteosarcoma cell line. MATERIALS AND METHODS:We evaluated the expression of runt-relate...

journal_title：Anticancer research

authors： Valenti MT,Zanatta M,Donatelli L,Viviano G,Cavallini C,Scupoli MT,Dalle Carbonare L

更新日期：2014-04-01 00:00:00

abstract：:Radiomics, an emerging field in radiation therapy, is hypothesized to improve classification of tumour risk and prognosis. Despite encouraging results, there are issues of practicality and interpretation of radiomic data. This study investigates the emerging role of radiomics in tumour risk classification and prognosi...

journal_title：Anticancer research

authors： Li Wen Y,Leech M

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND/AIM:In patients with soft tissue sarcoma (STS), distinguishing small metastatic pulmonary nodules from benign ones remains difficult. This study aimed to determine the accuracy of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) in detecting pulmonary metastasis and identi...

journal_title：Anticancer research

authors： Hagi T,Nakamura T,Sugino Y,Matsubara T,Asanuma K,Sudo A

更新日期：2018-06-01 00:00:00

abstract：:We studied a consecutive series of 54 cases of lower lip squamous cell carcinoma (LLSCC) in order to identify any variables which might predict the development of lymph node metastases. The cases were divided into 38 tumors without metastases (group I) and 16 tumors with lymph node metastases (group II). The following...

journal_title：Anticancer research

authors： Rodolico V,Daniele E,Leonardi V,Marra G,Luciani A,Settineri G,Tralongo V

更新日期：1998-03-01 00:00:00

abstract：:We describe the case of an 80-year-old man with hepatocellular carcinoma (HCC) who developed tracheal obstruction due to peritracheal lymph node metastasis. A metastatic tumor that protruded into the airway was ablated using a neodymium yttrium-aluminium-garnet laser and then a self-expandable metallic stent (SEMS) wa...

journal_title：Anticancer research

authors： Hamai Y,Hihara J,Aoki Y,Taomoto J,Kishimoto I,Kobayashi Y,Miyata Y,Aikata H,Chayama K,Okada M

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:The BCL2 proto-oncogene in non-Hodgkin's lymphoma is a dominant inhibitor of apoptosis. The goal of this work was to develop a (177)Lu-labeled anti-BCL2-peptide nucleic acid (PNA) conjugate designed for dual modality NHL therapy, i.e., simultaneous down-regulation of BCL2-mediated resistance to apoptosis and...

journal_title：Anticancer research

authors： Balkin ER,Jia F,Miller WH,Lewis MR

更新日期：2011-10-01 00:00:00

abstract：:Adult lymphoblastic lymphoma (LBL) can be of T-cell or B-cell lineage. However, the clinical significance of immunophenotypes is largely unknown. We conducted a retrospective study to compare T-cell LBL with its B-cell counterpart. Between 1983 and 1995, 50 adult patients were diagnosed as LBL at National Taiwan Unive...

journal_title：Anticancer research

authors： Yeh KH,Cheng AL,Su IJ,Lin MT,Tien HF,Shen MC,Wang CH,Chen YC

更新日期：1997-05-01 00:00:00

abstract：AIM:To identify patients with breast cancer at risk for cardiotoxicity, we evaluated homoarginine (HA) behavior during adjuvant treatment. PATIENTS AND METHODS:Eighty-one patients received radiotherapy (RT) with or without endocrine treatment, and 19 received chemotherapy, RT and endocrine therapy. Serum HA, asymmetri...

journal_title：Anticancer research

authors： Aula H,Skyttä T,Tuohinen S,Luukkaala T,Hämäläinen M,Virtanen V,Raatikainen P,Moilanen E,Kellokumpu-Lehtinen PL

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND/AIM:Pelvic exenteration is a radical procedure for certain advanced or recurrent gynaecological cancers, performed with curative or palliative intent. Its validity has evolved as operative mortality and morbidity have improved. This surgery was evaluated to determine the validity of these claims. PATIENTS A...

journal_title：Anticancer research

authors： Soeda S,Furukawa S,Sato T,Ueda M,Kamo N,Endo Y,Kojima M,Nomura S,Kataoka M,Fujita S,Endo H,Takahashi T,Watanabe T,Yamada H,Fujimori K

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:Gastrointestinal stromal tumors are uncommon intra-abdominal tumors. In fewer than 5% of cases, they originate primarily from the mesentery, omentum or peritoneum and these extra-gastrointestinal stromal tumors tend to have characteristics similar to gastrointestinal stromal. CASE REPORT:We report a case of...

journal_title：Anticancer research

authors： Rediti M,Pellegrini E,Molinara E,Cerullo C,Fonte C,Lunghi A,Iori A,Neri B

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:miR-96 is reported to inhibit reversion cysteine-rich Kazal motif (RECK), which is associated with tumor invasion, in solid cancer types (e.g. breast cancer, non-small cell lung cancer, esophageal cancer). The purpose of this study is to clarify whether miR-96 is similarly associated with tumor invasion in c...

journal_title：Anticancer research

authors： Iseki Y,Shibutani M,Maeda K,Nagahara H,Fukuoka T,Matsutani S,Hirakawa K,Ohira M

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:Fulvestrant ('Faslodex') is a new type of oestrogen receptor (ER) antagonist that down-regulates the ER and has no known agonist effects. PATIENTS AND METHODS:In this open-label, Phase II trial, 30 postmenopausal Japanese women with hormone-sensitive advanced breast cancer, who had progressed on tamoxifen/t...

journal_title：Anticancer research

authors： Watanabe T,Sano M,Ohno S,Inaji H,Nishimura R,Shin E,Nomura Y,Morris C

更新日期：2004-03-01 00:00:00