Is FDG-PET/CT Useful for Diagnosing Pulmonary Metastasis in Patients with Soft Tissue Sarcoma?

Abstract:

BACKGROUND/AIM:In patients with soft tissue sarcoma (STS), distinguishing small metastatic pulmonary nodules from benign ones remains difficult. This study aimed to determine the accuracy of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) in detecting pulmonary metastasis and identify factors affecting sensitivity with STS. MATERIALS AND METHODS:The clinical records and chest CT and FDG-PET/CT scans of 102 patients with STS were reviewed to determine the presence of pulmonary nodules. RESULTS:A significant relationship was observed between nodule size and maximum standardized uptake value (SUVmax). For nodules smaller than 5 mm, only 10 out of 76 metastatic pulmonary nodules exhibited FDG accumulation, showing a weak correlation between nodule size and SUVmax Conclusion: The role of FDG-PET/CT in differentiating metastatic from benign pulmonary nodules was unsatisfactory, especially for small nodules. Careful follow-up using CT scan may still be appropriate for diagnosing pulmonary nodules smaller than 5 mm.

journal_name

Anticancer Res

journal_title

Anticancer research

authors

Hagi T,Nakamura T,Sugino Y,Matsubara T,Asanuma K,Sudo A

doi

10.21873/anticanres.12638

subject

Has Abstract

pub_date

2018-06-01 00:00:00

pages

3635-3639

issue

6

eissn

0250-7005

issn

1791-7530

pii

38/6/3635

journal_volume

38

pub_type

杂志文章
  • Growth regulation effects of gonadotropin induced steroidogenic response in human ovarian cancer.

    abstract:BACKGROUND:Despite a substantial body of epidemiological evidence, there is only a limited indication that gonadotropins and steroids have growth regulating functions in ovarian cancer. To elucidate the role of gonadotropins in regulating steroid metabolism in human ovarian cancer, we analyzed the modulation of estradi...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Kraemer S,Jaeger WH,Lang N

    更新日期:2001-05-01 00:00:00

  • Selective cytotoxicity of L-glutamic acid gamma-monohydroxamate (GAH) for melanoma tumor cells.

    abstract::We have previously shown that L-glutamic acid gamma-monohydroxamate (GAH) exhibits an antitumor activity, both in vitro and in vivo. In this report we explore the selective cytotoxicity of GAH in vitro by comparing the survival of tumor and normal cells. GAH exerts an irreversible delayed effect with tumoral cells and...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Thomasset N,Chabanas A,Tournaire R,Malley S,Navarro C,Lawrence JJ,Doré JF,Vila J

    更新日期:1993-09-01 00:00:00

  • The prognostic significance of HER2 positivity for advanced gastric cancer patients undergoing first-line modified FOLFOX-6 regimen.

    abstract:AIM:We aimed to clarify the prognostic significance of HER2 positivity in advanced gastric cancer. PATIENTS AND METHODS:The cohort included patients with initially metastatic or recurrent gastric cancer treated with first-line modified FOLFOX-6. The HER2 status was analyzed according to modified scoring criteria speci...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Kim JW,Im SA,Kim M,Cha Y,Lee KH,Keam B,Kim MA,Han SW,Oh DY,Kim TY,Kim WH,Bang YJ

    更新日期:2012-04-01 00:00:00

  • Stimulation by estrogen and progesterone of the in vivo growth of transformed murine Leydig cells only at the limited early phase of growth.

    abstract::B-1 F is a cell line established from estrogen-responsive murine Leydig cell tumor and maintained in vitro. We investigated the effects of steroid hormones on the growth of tumors produced by the inoculation of B-1 F cells into mice. When tumor tissues were transplanted into castrated male mice, injections of estradio...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Yamamoto T,Li I,Uchida N,Nishizawa Y,Yamamoto R,Terada N,Taniguchi H,Matsumoto K,Sato B

    更新日期:1992-09-01 00:00:00

  • The sequential model of Barrett's esophagus and adenocarcinoma induced by duodeno-esophageal reflux without exogenous carcinogens.

    abstract:BACKGROUND:The experiment was designed to sequentially examine the histogenesis of Barrett's esophagus and esophageal adenocarcinoma induced by duodenal reflux without exogenous carcinogens. MATERIALS AND METHODS:Wistar male rats, 200 in all, each weighing approximately 250 g were used. The totally gastrectomized anim...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Sato T,Miwa K,Sahara H,Segawa M,Hattori T

    更新日期:2002-01-01 00:00:00

  • Day Surgery Management of Early Breast Cancer: Feasibility and Psychological Outcomes.

    abstract:BACKGROUND/AIM:Breast cancer treatment represents a substantial amount of health-care costs and has a negative impact on womens' psychological health. Day-Surgery managment (DS) is a favorable alternative to a classic inpatient setting. In our prospective study we evaluated DS-treatment feasibility in terms of patient ...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:10.21873/anticanres.13451

    authors: Susini T,Carriero C,Tani F,Mattioli G,Renda I,Biglia N,Nori J,Vanzi E,Bianchi S

    更新日期:2019-06-01 00:00:00

  • Pharmacokinetics and toxicity of an early single intravesical instillation of gemcitabine after endoscopic resection of superficial bladder cancer.

    abstract:BACKGROUND:The tolerability and plasma absorption of gemcitabine administered at 40 mg/ml after small and extensive endoscopic transurethral resection of bladder tumors (TURB) were evaluated. PATIENTS AND METHODS:Nine patients with a history of recurrent superficial bladder cancer were eligible for a single immediate,...

    journal_title:Anticancer research

    pub_type: 临床试验,杂志文章

    doi:

    authors: Campodonico F,Mattioli F,Manfredi V,Capponi G,Pasquini P,Martelli A,Maffezzini M

    更新日期:2007-03-01 00:00:00

  • Concomitant radiochemotherapy with temozolomide in non-selected patients with newly diagnosed high-grade gliomas.

    abstract:BACKGROUND:Malignant gliomas still present a medical challenge, despite decades of continuous extensive research with optimization of surgical techniques, radiotherapy and systemic treatments. PATIENTS AND METHODS:From 1999 to 2004, 104 patients with WHO grade III and IVgliomas underwent surgery and received concomita...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Eberlein KH,Nagel B,Franz K,Imhoff D,Seifert V,Boettcher HD,Mose S

    更新日期:2006-11-01 00:00:00

  • Decreased immunoexpression of standard form of CD44 is an independent favourable predictor of nodal metastasis in colorectal carcinoma.

    abstract:BACKGROUND:CD44 is a transmembrane glycoprotein and is associated with cell-matrix and cell-cell interactions. CD44 expression was shown to be relevant to tumour progression in various types of human cancer. The objective of this study was to investigate the relationship between the expression levels of the standard fo...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Al-Maghrabi J,Gomaa W,Buhmeida A,Al-Qahtani M,Al-Ahwal M

    更新日期:2012-08-01 00:00:00

  • A facile microfluidic method for production of liposomes.

    abstract:BACKGROUND:Ethanol injection is widely used in liposome preparation. However, the parameters determining particle size distribution of the liposomal preparation has not been fully defined. MATERIALS AND METHODS:A syringe pump-driven microfluidic injection device was used to produce liposomes under different conditions...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Pradhan P,Guan J,Lu D,Wang PG,Lee LJ,Lee RJ

    更新日期:2008-03-01 00:00:00

  • Brief Pain Inventory (BPI) Health Survey After Midline Laparotomy With the Rectus Sheath Block (RSB) Analgesia: A Randomised Trial of Patients With Cancer and Benign Disease.

    abstract:BACKGROUND/AIM:Our original hypothesis was that the rectus sheath block (RSB) analgesia could enhance patient satisfaction and decrease pain following midline laparotomy. PATIENTS AND METHODS:Initially, 56 patients were randomized into four groups; control group (n=12), single-dose (n=16), repeated-dose (n=12) and con...

    journal_title:Anticancer research

    pub_type: 杂志文章,随机对照试验

    doi:10.21873/anticanres.13890

    authors: Kuosmanen V,Ruottinen M,Rahkola D,Saimanen I,Kaaronen V,Selander T,Purdy M,Kokki H,Kokki M,Eskelinen M

    更新日期:2019-12-01 00:00:00

  • All-trans retinoic acid modulates cancer stem cells of glioblastoma multiforme in an MAPK-dependent manner.

    abstract::Glioblastoma multiforme (GBM), a grade IV glioma, appears to harbor therapy-resistant cancer stem cells (CSCs) that are the major cause of recurrence. All-trans retinoic acid (ATRA), a derivative of retinoid, is capable of differentiating a variety of stem cells, as well as normal neural progenitor cells, and down-reg...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Karsy M,Albert L,Tobias ME,Murali R,Jhanwar-Uniyal M

    更新日期:2010-12-01 00:00:00

  • Clinical outcomes after first-line EGFR inhibitor treatment for patients with NSCLC, EGFR mutation, and poor performance status.

    abstract:BACKGROUND:The phase II NEJ001 trial suggested that gefitinib was active against advanced non-small cell lung cancer (NSCLC) even in patients with poor performance status (PS). Clinical response among the patients harboring epidermal growth factor receptor (EGFR) mutation with poor PS is fair; however, gefitinib does n...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Okuma Y,Hosomi Y,Nagamata M,Yamada Y,Sekihara K,Kato K,Hishima T,Okamura T

    更新日期:2013-11-01 00:00:00

  • Partial Body UV Exposure in Chronic Kidney Disease and Extrarenal Vitamin D Metabolism.

    abstract:BACKGROUND/AIM:Exposure of the skin to sunshine is the major natural source of vitamin D. In order to imitate this natural production of vitamin D for patients with chronic kidney disease, hemodialysis patients were exposed three times a week to radiation of the front part of both legs to normalize the vitamin D status...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:10.21873/anticanres.12342

    authors: Krause R,Stange R,Roth HJ,Kaase H,Michalsen A,Holick MF

    更新日期:2018-02-01 00:00:00

  • Augmentation of antitumor effect of endogenously induced tumor necrosis factor by cyclophosphamide.

    abstract::The antitumor effect of endogenous tumor necrosis factor (en-TNF) with cyclophosphamide (CY) was analyzed using the murine Meth A tumor model. En-TNF was induced by the administration of interferon-gamma (4 micrograms/kg: 1 x 10(4) units/ mouse) as a primer and Streptococcus preparation OK-432 (100 KE/kg) as a trigger...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Inagawa H,Ohshiro S,Nishizawa T,Goto S,Soma G,Mizuno D

    更新日期:1997-01-01 00:00:00

  • Gypenosides induced apoptosis in human colon cancer cells through the mitochondria-dependent pathways and activation of caspase-3.

    abstract::The effects of the gypenosides (Gyp), a component of Gynostemma pentaphyllum Makino, on the cell viability, cell cycle and induction of apoptosis were investigated in human colon cancer colo 205 cells. Gyp was cytotoxic to colo 205 cells with an IC50 of 113.5 microg/ml. The decreasing number of viable cells appeared t...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Chen JC,Lu KW,Lee JH,Yeh CC,Chung JG

    更新日期:2006-11-01 00:00:00

  • From Inflammation to Cancer in Inflammatory Bowel Disease: Molecular Perspectives.

    abstract::Inflammatory bowel diseases (IBD) are associated with an increased risk of colitis-associated colorectal carcinoma (CAC). CAC is one of the most important causes of morbidity and mortality in patients with Crohn's disease and ulcerative colitis. The aim of the present review was to discuss the most important signaling...

    journal_title:Anticancer research

    pub_type: 杂志文章,评审

    doi:

    authors: Romano M,DE Francesco F,Zarantonello L,Ruffolo C,Ferraro GA,Zanus G,Giordano A,Bassi N,Cillo U

    更新日期:2016-04-01 00:00:00

  • Expression of metastasis associated proteins, CD44v6 and NM23-H1, in pediatric acute lymphoblastic leukemia.

    abstract::Two metastasis-associated proteins, CD44v6 and NM23-H1, are expressed by normal lymphoid cells, the former serving as activation marker and the latter as a constitutive protein. CD44v6 is considered as a marker of poor prognosis of various hematological cancers but its expression was not demonstrated in childhood acut...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Magyarosy E,Sebestyén A,Timár J

    更新日期:2001-01-01 00:00:00

  • Long Noncoding RNA, ANRIL, Regulates the Proliferation of Head and Neck Squamous Cell Carcinoma.

    abstract:BACKGROUND/AIM:ANRIL is a long noncoding RNA located on INK4 locus, which encodes p15 and p16 that cause G1 phase arrest in the cell cycle. ANRIL positively regulates proliferation of several kinds of cancer cells such as lung and gastric cancers. This study, examined the effect of ANRIL in head and neck squamous cell ...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:10.21873/anticanres.13564

    authors: Matsunaga N,Wakasaki T,Yasumatsu R,Kotake Y

    更新日期:2019-08-01 00:00:00

  • Anaemia and other predictors of fatigue among patients on palliative therapy for advanced cancer.

    abstract::The association of anaemia and other predictors of fatigue was studied in cancer patients on palliative treatment. A cohort of 128 consecutive patients (61 men and 67 women, mean age 63.6 years; range 36-85) was interviewed using the Edmonton Symptom Assessment System (ESAS) questionnaire, with 11 items describing can...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Latvala A,Syrjänen K,Salmenoja H,Salminen E

    更新日期:2009-07-01 00:00:00

  • Two-dimensional gel analysis of p53-mediated changes in protein expression.

    abstract::The p53 gene product suppresses both tumor cell growth and the cellular transformation process promoted by oncogenes. Although several genes are known to be positively regulated by p53, it is unclear how many gene expression events are involved in p53-mediated growth arrest and apoptosis. Two-dimensional gel electroph...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Maxwell SA

    更新日期:1994-11-01 00:00:00

  • Mechanistic studies on N-benzyladriamycin-14-valerate (AD 198), a highly lipophilic alkyl adriamycin analog.

    abstract::AD 198, a novel lipophilic N-alkyl derivative of adriamycin (ADR) and a potential anticancer agent for preclinical development, was studied for its effects on the activities of DNA and RNA polymerases in vitro and its ability to bind DNA. AD 198, which contains a benzyl substituent on the glycosidic amine, was found t...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Lameh J,Chuang LF,Israel M,Chuang RY

    更新日期:1988-07-01 00:00:00

  • In vitro studies of human bladder cancer.

    abstract::Explantation and cultivation in vitro of 55 human biopsies of histologically normal urothelial tissue, and 63 biopsies from transitional cell carcinomas (TCC) revealed a primary success rate of about 75% and a secondary success rate of about 50% with no significant differences, between normal and TCC derived cultures....

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Kieler J,Christensen B,Ottesen S,Tromholt V,Ostrowski K

    更新日期:1987-09-01 00:00:00

  • Irofulven (6-hydroxymethylacylfulvene, MGI 114) induces caspase 8 and 9-mediated apoptosis in human pancreatic adenocarcinoma cells.

    abstract:BACKGROUND:Irofulven (MGI 114) is a novel, clinically active sesquiterpene whose mechanism of action is not fully understood. We sought to identify apoptotic effectors induced by this agent in human pancreatic cancer cells. MATERIALS AND METHODS:MTT assay was used to assess IC50-Apoptosis was quantitated by flow cytom...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Wang W,Waters SJ,MacDonald JR,Von Hoff DD,Strodel WE,Miller AR

    更新日期:2001-05-01 00:00:00

  • Radiofrequency Heat Ablation and Vertebroplasty in the treatment of neoplastic vertebral body fractures.

    abstract:BACKGROUND:Metastatic cancer is the most common malignant disease of the skeletal system. Traditionally, conventional fractionated external beam radiotherapy has been the treatment of choice. Recently, minimally invasive surgical techniques (MISS) have been added to the therapeutic armamentarium. The purpose of our stu...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Masala S,Roselli M,Massari F,Fiori R,Ursone A,Fossile E,Laudisi A,Simonetti G

    更新日期:2004-09-01 00:00:00

  • Analysis of EBV latency by EBER in situ hybridization in nasopharyngeal carcinoma Spanish patients.

    abstract:BACKGROUND:The aim of this study was to analyse the Epstein-Barr virus (EBV) latency by detecting the EBV-associated latent small nuclear RNAs (EBER), in a group of biopsies from Spanish patients with diagnosed nasopharyngeal carcinoma (NPC). MATERIALS AND METHODS:NPC paraffin samples with the presence of EBV demonstr...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Burgos JS,Vera-Sempere FJ

    更新日期:2001-11-01 00:00:00

  • Retinoic acid combined with GM-CSF induces morphological changes with segmented nuclei in human myeloblastic leukemia ML-1 cells.

    abstract::The effects of all-trans retinoic acid (ATRA), either alone or in combination with GM-CSF, on the induction of differentiation of a human myeloblastic leukemia cell line, ML-1, were investigated. ATRA alone caused only slight induction of NBT-reducing activity even at a high concentration (10(-7) M), but when combined...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Oka Y,Takeda K

    更新日期:1997-05-01 00:00:00

  • Construction and transfection of a ribozyme targeting human caspase-3.

    abstract::Caspase-3 is a key executioner cysteine protease involved in programmed cell death or apoptosis. A ribozyme to human caspase-3 was designed, tested by in vitro cleavage, and transfected into a drug-resistant variant (DLKP-A5F) of a human lung carcinoma cell line (DLKP). By both stable and transient transfection, this ...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Cronin D,Daly C,O'Doherty T,Heenan M,Scanlon KJ,Clynes M

    更新日期:2004-03-01 00:00:00

  • Safety of Prophylactic Gastrostomy Tube Placement and Gastrostomy Tube Usage in Patients Treated by Radio(chemo)therapy for Head and Neck Cancer.

    abstract:BACKGROUND:A gastrostomy feeding tube is one method for long-term feeding support in patients undergoing radio(chemo)therapy for head and neck cancer (HNC). The aim of this study was to analyze the safety of prophylactic gastrostomy tube placement and usage in HNSCC patients. PATIENTS AND METHODS:HNC patients undergoi...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:10.21873/anticanres.14059

    authors: Sieron HL,Eberle F,Gress TM,Mahnken AH,Wiegand S

    更新日期:2020-02-01 00:00:00

  • Whole-transcriptome analysis reveals established and novel associations with TMPRSS2:ERG fusion in prostate cancer.

    abstract:BACKGROUND/AIM:Shortcomings of current methods of prostate cancer detection call for improved biomarkers. The transmembrane protease, serine 2:ets-related gene (TMPRSS2:ERG) gene fusion leads to the overexpression of ERG, an E-twenty six (ETS) family transcription factor, and is the most prevalent genetic lesion in pro...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Chow A,Amemiya Y,Sugar L,Nam R,Seth A

    更新日期:2012-09-01 00:00:00