Combined oral topotecan plus carboplatin in relapsed or advanced cervical cancer: a GINECO phase I-II trial.

abstract：BACKGROUND:The secretory epithelial cells of the prostate gland use sophisticated vehicles in the form of prostasomes to relay important information to sperm cells in semen. This prostasome-forming and secretory ability of the epithelial cells is also preserved in poorly differentiated prostate cancer cells. The aim of...

journal_title：Anticancer research

authors： Ronquist KG,Ronquist G,Larsson A,Carlsson L

更新日期：2010-02-01 00:00:00

abstract：:Several lines of evidence have recently been presented indicating that proteins previously referred to as Mr 62,000-67,000 transformation-associated secreted phosphoprotein, 2ar, osteopontin, bone sialoprotein I, and 44K Dal bone phosphoprotein are all very likely encoded by the same gene. We have found that markedly ...

journal_title：Anticancer research

authors： Senger DR,Perruzzi CA,Papadopoulos A

更新日期：1989-09-01 00:00:00

abstract：BACKGROUND/AIM:Leiomyosarcoma is an extremely rare, small bowel neoplasm (2% of all gastrointestinal tumours). Early diagnosis is challenging due to the slow growth of the cancer. The biological behaviour of this group of tumours is aggressive, and the first-line treatment is surgical resection. PATIENTS AND METHODS:T...

journal_title：Anticancer research

authors： Ferrari C,DI Domenico S,Mascherini M,Santoliquido M,Mastracci L,DE Cian F

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:Epstein-Barr virus-associated gastric carcinoma (EBV-GC) has been characterized as a special gastric cancer subset. Lifestyle and other major factors that may contribute to EBV-GC and non-EBV-GC were investigated here. MATERIALS AND METHODS:A total of 247 patients with gastric cancer were interviewed, clini...

journal_title：Anticancer research

authors： Kim RH,Chang MS,Kim HJ,Song KS,Kim YS,Choi BY,Kim WH

更新日期：2010-06-01 00:00:00

abstract：:Tenascin is a multifunctional extracellular matrix glycoprotein generally expressed in epithelial tumors at sites of epithelial tumor-mesenchymal tissue interface. Studies so far have indicated that mesenchymal cells are a major source of tenascin in tumor tissues. The present study evaluated biopsies and surgically r...

journal_title：Anticancer research

authors： Mori M,Muramatsu Y,Yamada K,Shrestha P,Takai Y

更新日期：1996-09-01 00:00:00

abstract：BACKGROUND:Despite a substantial body of epidemiological evidence, there is only a limited indication that gonadotropins and steroids have growth regulating functions in ovarian cancer. To elucidate the role of gonadotropins in regulating steroid metabolism in human ovarian cancer, we analyzed the modulation of estradi...

journal_title：Anticancer research

authors： Kraemer S,Jaeger WH,Lang N

更新日期：2001-05-01 00:00:00

abstract：:Twelve inoperable lung cancer patients were treated with a combination chemotherapy of cisplatinum (CDDP) and etoposide (VP16), as a continuous infusion for 5 days, every 21 days, and with a daily oral administration of GaCl3. Dosages of CDDP and VP16 were adapted in order to obtain an area under the curve (AUC) of 80...

journal_title：Anticancer research

authors： Collery P,Morel M,Desoize B,Millart H,Perdu D,Prevost A,Vallerand H,Pechery C,Choisy H,Etienne JC

更新日期：1991-07-01 00:00:00

abstract：:Development and progression of tumours is generally driven by an accumulation of genetic alterations. In this study we correlated chromosome 17 aneuploidy to invasiveness of bladder cancer by the method of fluorescence in situ hybridisation (FISH) in urinary cytospins. We investigated the value of FISH compared to DNA...

journal_title：Anticancer research

authors： Krause FS,Feil G,Zumbrägel A,Bichler KH

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND/AIM:Lobarstin is a metabolite occurring from the Antarctic lichen Stereocaulon alpnum. Human glioblastoma is highly resistant to chemotherapy with temozolomide. Lobarstin was examined for its effect on glioblastoma. MATERIALS AND METHODS:Temozolomide-resistant T98G cells were subjected to toxicity test with...

journal_title：Anticancer research

authors： Kim S,Jo S,Lee H,Kim TU,Kim IC,Yim JH,Chung H

更新日期：2013-12-01 00:00:00

abstract：:In order to improve the knowledge of prolactin receptors (PRL-R) in human breast tumors, we studied PRL-R modulation by lactogenic and steroid hormones in the PRL-R rich human breast cancer cell-line, T-47 D. The PRL-R were assayed on a preparation of cell total membranes. We demonstrated an abnormal homologous in vit...

journal_title：Anticancer research

authors： Leroy-Martin B,Peyrat JP

更新日期：1989-05-01 00:00:00

abstract：AIM:Late oral mucosa changes after radiotherapy for head and neck cancer have been poorly studied. This study aimed to determine long-term effects of radiotherapy on oral mucosa using exfoliative oral cytology. PATIENTS AND METHODS:Fifty patients with cancer were enrolled, five of whom in order to validate microscopic...

journal_title：Anticancer research

authors： Massaro P,Corbella F,DI Liberto R,Paolini A,Pasi F,Tinelli C,DE Silvestri A,Nano R

更新日期：2014-02-01 00:00:00

abstract：:The cyclin-dependent kinase inhibitor p21WAF1 participates in cell growth, differentiation, and apoptosis. p21WAF1 can be induced by green tea polyphenol EGCG in several cancer cell types, but its role in the oral cancer cell response to EGCG is not known. We found that EGCG upregulates p21WAF1 in an oral carcinoma ce...

journal_title：Anticancer research

authors： Hsu S,Farrey K,Wataha J,Lewis J,Borke J,Singh B,Qin H,Lapp C,Lapp D,Nguyen T,Schuster G

更新日期：2005-01-01 00:00:00

abstract：AIM:Apocrine breast carcinoma often lacks estrogen receptor (ER), progesterone receptor (PgR), and human epidermal growth factor receptor type-2 (HER2) expression. Accordingly, development of a new treatment strategy is important for this type of cancer. The growth stimulus through the androgen receptor (AR) can be a c...

journal_title：Anticancer research

authors： Sasahara M,Matsui A,Ichimura Y,Hirakata Y,Murata Y,Marui E

更新日期：2014-03-01 00:00:00

abstract：:One hundred and eighty-seven patients with a transitional cell bladder cancer were followed by retrospectively for a mean of 9.5 years. Clinical stage (p less than 0.0001), histological grade (p less than 0.0001), papillary (p less than 0.0001), SPF (p less than 0.0001), M/V index (p less than 0.0001), MAI (p less tha...

journal_title：Anticancer research

authors： Lipponen PK,Eskelinen MJ,Kiviranta J,Nordling S

更新日期：1991-03-01 00:00:00

abstract：BACKGROUND:Investigation of transcription regulators in carcinoma can contribute greatly to clarifying the biological character of the carcinoma. In this study, we examined the expression of ets-1 and ets-2, prominent transcription regulators belonging to the ets family, in various colonic tissues. MATERIALS AND METHO...

journal_title：Anticancer research

authors： Ito Y,Takeda T,Okada M,Matsuura N

更新日期：2002-05-01 00:00:00

abstract：BACKGROUND:Interleukin 32 (IL32) is an intracellular pluripotent cytokine produced by epithelial cells, monocytes, T-lymphocytes and natural killer cells and seems to be involved in the pathogenesis of cancer and inflammatory diseases. Our purpose was to assess the role of protein expression and genetic polymorphisms o...

journal_title：Anticancer research

authors： Shamoun L,Kolodziej B,Andersson RE,Dimberg J

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:The mitochondrial protein translocase of inner mitochondrial membrane 17 homolog A (TIMM17A) has been identified as a biomarker of breast cancer. The present study aimed to investigate the biological role of TIMM17A in human breast cancer cells. MATERIALS AND METHODS:Anti-TIMM17A transgenes were stably tran...

journal_title：Anticancer research

authors： Yang X,Si Y,Tao T,Martin TA,Cheng S,Yu H,Li J,He J,Jiang WG

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Solar ultraviolet-B (UVB) and vitamin D have been found inversely correlated with cancer incidence, mortality, and survival rates in many studies. MATERIALS AND METHODS:In this work, two sets of cancer data were used: age-adjusted cancer incidence and mortality rates in 2002 for 21 Western developed countri...

journal_title：Anticancer research

authors： Grant WB

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND/AIM:The aim of this study was to evaluate the impact of laparoscopic gastrectomy (LG) for gastric cancer on long-term survival in patients with postoperative infectious complications (PIC). PATIENTS AND METHODS:A total of 608 patients who underwent gastrectomy were classified into two groups based on the su...

journal_title：Anticancer research

authors： Nagata H,Tsujimoto H,Kouzu K,Itazaki Y,Ishibashi Y,Tsuchiya S,Sugihara T,Ito N,Harada M,Nomura S,Kishi Y,Ueno H

更新日期：2020-12-01 00:00:00

abstract：:Urinary gonadotropin peptide (UGP) has been measured in gynecological and urological cancers, but its usefulness in the diagnosis of cancers of digestive organs has not been investigated. In this report, UGP was measured by sandwich enzyme immunoassay in 311 patients, including 166 patients with cancers of digestive o...

journal_title：Anticancer research

authors： Motoo Y,Watanabe H,Yamaguchi Y,Mouri I,Fujii T,Yamakawa O,Satomura Y,Okai T,Sawabu N

更新日期：1996-07-01 00:00:00

abstract：BACKGROUND/AIM:γ-Glutamylcyclotransferase (GGCT), a key enzyme involved in glutathione metabolism, catalyzes a specific reaction that generates 5-oxoproline and free amino acids from the γ-glutamyl peptide. Inhibition of GGCT is a promising therapeutic strategy for the treatment of various cancers. MATERIALS AND METHO...

journal_title：Anticancer research

authors： Hanada E,Kageyama S,Murai R,Kubota S,Ii H,Nakata S,Kita H,Kawauchi A,Chano T

更新日期：2019-04-01 00:00:00

abstract：:Transcatheter embolization is considered to be less effective for early-stage hepatocellular carcinomas (HCCs) without a hypervascular arterial supply. In the present case report, a 65-year-old male with hepatitis type C and non-hypervascular HCC located in the hepatic hilum was successfully treated by bland transarte...

journal_title：Anticancer research

authors： Tanaka T,Maeda S,Nishiofuku H,Masada T,Sato T,Anai H,Sakaguchi H,Kichikawa K

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND/AIM:γδ T cells mediate cytotoxicity against prostate cancer (PCa) cells in vitro; however, the clinical efficacy of γδ T cell-targeted immunotherapy for recurrent and metastatic PCa is unsatisfactory. We hypothesized that the resistance of recurrent and metastatic PCa to γδ T cells is related to the presence...

journal_title：Anticancer research

authors： Miyashita M,Tomogane M,Nakamura Y,Shimizu T,Fujihara A,Ukimura O,Ashihara E

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:A number of association studies have focused on the effect of polymorphisms related to DNA repair or the xenobiotic pathway, on the susceptibility to gastric cancer (GC). Here, the possible association between common polymorphisms in the X-ray repair cross-complementing groups (XRCC) 1, and glutathione-S-tra...

journal_title：Anticancer research

authors： Tahara T,Shibata T,Nakamura M,Yamashita H,Yoshioka D,Okubo M,Yonemura J,Ishizuka T,Maruyama N,Kamano T,Kamiya Y,Fujita H,Nakagawa Y,Nagasaka M,Iwata M,Yamada H,Hirata I,Arisawa T

更新日期：2011-02-01 00:00:00

abstract：:In previous studies performed by our group, we observed that 2-deoxyglucose blocked the acidification of the medium used for culture of colon cancer cells caused by incubation with biguanides and it had an additive inhibitory effect on growth. In the present work, we found that 3-bromopyruvate can also prevent the low...

journal_title：Anticancer research

authors： Lea MA,Qureshi MS,Buxhoeveden M,Gengel N,Kleinschmit J,Desbordes C

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:The epithelial-mesenchymal transition is a critical early event in the invasion and metastasis of many types of cancer, including colorectal cancer (CRC). Chronic inflammation is an inducer of several cancer types and inflammatory cytokines have been implicated in tumor invasion. MATERIALS AND METHODS:Human...

journal_title：Anticancer research

authors： Bowen KA,Doan HQ,Zhou BP,Wang Q,Zhou Y,Rychahou PG,Evers BM

更新日期：2009-11-01 00:00:00

abstract：AIM:The aim of the study was to identify novel biomarkers that are vital for improving management of patients with gastric cancer (GC). MATERIALS AND METHODS:An RNA-sequencing analysis was conducted using gastric tissue from patients with metastatic GC. In vitro cell functions were evaluated by siRNA-mediated knockdow...

journal_title：Anticancer research

authors： Sawaki K,Kanda M,Umeda S,Miwa T,Tanaka C,Kobayashi D,Hayashi M,Yamada S,Nakayama G,Omae K,Koike M,Kodera Y

更新日期：2019-11-01 00:00:00

abstract：:Several lines of evidence have postulated that reduction in the activity of lipoprotein lipase (LPL) is involved in cachexia induction in cancer patients. Recently we have demonstrated that murine melanoma B16 has the ability to reduce the LPL activity and thereby induce cachexia symptoms in mice following intraperito...

journal_title：Anticancer research

authors： Tsujimoto S,Kawamura I,Inami M,Lacey E,Nishigaki F,Naoe Y,Manda T,Goto T

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND/AIM:The success of proteasome inhibitors in therapy of multiple myeloma has led to their use for other malignancies. For the proteasome inhibitor bortezomib, combination therapies with histone deacetylase inhibitors, which up-regulate ubiquitin-proteasome system (UPS)-related enzymes, produce a beneficial ef...

journal_title：Anticancer research

authors： Takenokuchi M,Miyamoto K,Saigo K,Taniguchi T

更新日期：2015-06-01 00:00:00

abstract：:E-selectin which is expressed on endothelial cells plays an important role in the adhesion of cancer cells to the vascular endothelium, being the ligand for a carbohydrate antigen expressed on cancer cells. In this study, the clinical usefulness of this protein was examined. E-selectin was expressed on the endothelial...

journal_title：Anticancer research

authors： Matsuura N,Narita T,Mitsuoka C,Kimura N,Kannagi R,Imai T,Funahashi H,Takagi H

更新日期：1997-03-01 00:00:00