Clinicopathological implications of EpCAM expression in adenocarcinoma of the lung.

abstract：BACKGROUND/AIM:4-methylumbelliferone (4-MU) has received considerable attention due to its potential for cancer treatment since it inhibits cell proliferation, migration and invasion. An increasing body of evidence suggests that extracellular matrix (e.g. hyaluronan) and nutrients (e.g. glucose) in the tumor microenvir...

journal_title：Anticancer research

authors： Wang R,Zhou W,Wang J,Liu Y,Chen Y,Jiang S,Luo X,Stupack DG,Luo N

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:Pemetrexed and erlotinib represent novel agents for the treatment of non-small cell lung cancer (NSCLC). The role of sequential treatment in NSCLC has not been elucidated yet. We compared the efficacy of second-line pemetrexed followed by third-line erlotinib (P-E) to treatment with the reverse sequence (E-P...

journal_title：Anticancer research

authors： Fiala O,Pesek M,Finek J,Benesova L,Bortlicek Z,Minarik M

更新日期：2013-08-01 00:00:00

abstract：AIM:To compare a new-generation fecal immunochemical test (FIT) with the leading guaiac-based test in detection of fecal occult blood (FOB) in colonoscopy-referral patients. PATIENTS AND METHODS:A cohort of 300 patients referred for colonoscopy was examined by two different tests for FOB: ColonView quick test (CV) (FI...

journal_title：Anticancer research

authors： Vasilyev S,Smirnova E,Popov D,Semenov A,Eklund C,Hendolin P,Paloheimo L,Syrjänen K

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND/AIM:Although the advent of Helicobacter pylori eradication and global societal changes are widely assumed to impact on gastric cancer (GC)-related mortality, there is remarkable little quantitative and qualitative insight into the nature of its effects. Here, we exploited a nationwide reporting system to inv...

journal_title：Anticancer research

authors： Yin J,Song JN,Bai ZG,Cai J,Zhang J,Zheng Z,Wu HW,Ye PP,Gao X,Zhang ZT

更新日期：2017-08-01 00:00:00

abstract：:Human vaginal malignant melanoma represents rare gynecological malignancies of poor prognosis. We have established a melanoma tumor line in nude mice, designated Mela-1, and have examined the histological and biological characteristics of this tumor. The Mela-1 tumor has preserved the histological, histochemical and b...

journal_title：Anticancer research

authors： Sawada M,Terada N,Nishizawa Y,Ito S,Wakamatsu K,Takemura K,Yamamoto T,Ozaki M,Sakamoto H,Tanizawa O

更新日期：1994-07-01 00:00:00

abstract：:During postnatal development, the formation of new blood vessels is possible only through angiogenesis. The initial growth of solid neoplasms, including childhood brain tumors, during the genetically determined stages of carcinogenesis, even at clinically undetectable sizes (a few mm3), depends upon the continuous for...

journal_title：Anticancer research

authors： Bodey B,Bodey B Jr,Siegel SE,Kaiser HE

更新日期：1998-05-01 00:00:00

abstract：:Four heart hormones, namely atrial natriuretic peptide (ANP), long-acting natriuretic peptide (LANP), vessel dilator and kaliuretic peptide reduce up to 97% of cancer cells in vitro. These four cardiac hormones eliminate up to 80% of human pancreatic adenocarcinomas, two-thirds of human breast carcinomas and up to 86%...

journal_title：Anticancer research

authors： Vesely DL

更新日期：2016-11-01 00:00:00

abstract：:The purpose of this study was to assess the contribution of techentium-99m methoxyisobutylisonitrile (Tc-99m sestamibi) scintimammography in the diagnosis of breast cancer in 32 female patients with indeterminate mammographic probability of malignancy because of mammographically dense breasts. All the breast masses we...

journal_title：Anticancer research

authors： Sun SS,Hsieh JF,Tsai SC,Ho YJ,Kao CH

更新日期：2000-09-01 00:00:00

abstract：:A plethora of contradictory research surrounds vitamin D and its influence on health and disease. This may, in part, result from analytical difficulties with regard to measuring vitamin D metabolites in serum. Indeed, variation exists between analytical techniques and assays used for the determination of serum 25-hydr...

journal_title：Anticancer research

authors： Stokes CS,Lammert F,Volmer DA

更新日期：2018-02-01 00:00:00

abstract：:Ten patients with advanced renal cell carcinoma were given combined chemoendocrine treatment with tegafur and tamoxifen. Patients were orally administered 800 mg/body tegafur and 20 mg/body tamoxifen daily. One patient was assessed as CR, three as PR, two as NC and four as PD. One out of two patients with estrogen rec...

journal_title：Anticancer research

authors： Wada T,Nishiyama K,Maeda M,Hara S,Tanaka N,Yasutomi M,Kurita T

更新日期：1995-07-01 00:00:00

abstract：BACKGROUND:Intronic microRNAs (miRNAs) are considered to be transcribed using their host gene promoter. However, about one third of intronic miRNAs are predicted to have independent promoter elements. MATERIALS AND METHODS:Human breast cancer cells were cultured under normoxia or hypoxia, and expression levels of intr...

journal_title：Anticancer research

authors： Kondo H,Shimono Y,Mukohyama J,Tanaka Y,Shibuya N,Minami H,Kakeji Y,Suzuki A

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:Glioblastoma multiforme is the most common and most aggressive type of primary brain tumor, accounting for 52% of all primary brain tumor cases and 20% of all intracranial tumors. Recently, evidence for a viral cause has been postulated, possibly SV40 or more likely cytomegalovirus (CMV). One report indicate...

journal_title：Anticancer research

authors： Lehrer S,Labombardi V,Green S,Pessin-Minsley MS,Germano IM,Rosenzweig KE

更新日期：2011-03-01 00:00:00

abstract：:This report describes a precise molecular analysis of a rare case of Philadelphia chromosome (Ph) positive acute myeloid leukemia (AML) (FAB classification M2). Phenotypic markers were positive for cells of the myeloid lineage, but negative for B cell and T cell lineage. The leukemic cells carried a Philadelphia chrom...

journal_title：Anticancer research

authors： Yoshida A,Kishi S,Kita K,Kamada N,Nakamura T,Ueda T

更新日期：1997-01-01 00:00:00

abstract：PURPOSE:Despite more than four decades of fluoro-pyrimidine treatment in different cancers, the optimal schedule is still not known. The plasma half-life of 5-fluorouracil (5-FU) is extremely short and continuous infusion has gained popularity. In this study we explored whether repeated bolus 5-FU injections could impr...

journal_title：Anticancer research

authors： Berglund A,Carlsson G,Gustavsson B,Frödin JE,Ragnhammar P,Glimelius B

更新日期：2003-03-01 00:00:00

abstract：:The antitumoral and immunostimulating properties of rViscumin (recombinant mistletoe lectin) were investigated in two mouse tumor models. After intravenous inoculation with RAW-117-P or L-1 sarcoma cells in Balb/c mice, rViscumin was given s.c. at non-toxic doses ranging from 0.3 to 150 ng rViscumin/kg. One set of exp...

journal_title：Anticancer research

authors： Schaffrath B,Mengs U,Schwarz T,Hilgers RD,Beuth J,Möckel B,Lentzen H,Gerstmayer B

更新日期：2001-11-01 00:00:00

abstract：:The question remains as to whether metastatic cells (cancer seed) that eventually colonize a particular organ (cancer soil) have specific properties that distinguish them from the other cells of the primary tumor. However until recently there have not been model systems in which this question could be fully answered. ...

journal_title：Anticancer research

authors： Togo S,Wang X,Shimada H,Moossa AR,Hoffman RM

更新日期：1995-05-01 00:00:00

abstract：BACKGROUND/AIM:To clarify whether renal dysfunction affects the incidence of adverse events associated with oxaliplatin, the present study was designed to investigate the relationship between creatinine clearance (Ccr) and the incidence of oxaliplatin-related adverse events. PATIENTS AND METHODS:A total of 287 CRC pat...

journal_title：Anticancer research

authors： Watanabe D,Fujii H,Yamada Y,Iihara H,Ishihara T,Matsuhashi N,Takahashi T,Yoshida K,Suzuki A

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND/AIM:To compare the GeneXpert® O6-methylguanine DNA methyltransferase (MGMT) methylation prototype (GX MGMT) assay with pyrosequencing in glioblastomas. MATERIALS AND METHODS:The MGMT methylation status was retrospectively assessed in formalin-fixed paraffin embedded (FFPE) tumor blocks from 262 glioblastoma...

journal_title：Anticancer research

authors： Filipits M,Preusser M,Hainfellner JA,Spiegl-Kreinecker S,Berghoff AS,Lai EW,Kocmond K,Kohlway A,Weidler J,Bates M,Corless C

更新日期：2020-11-01 00:00:00

abstract：:Evidence exists that estrogen metabolism has a role in the pathogenesis of recurrent respiratory papillomatosis (RRP). This disease has a papillomavirus etiology and is characterized by recurrent benign tumors with a significant propensity to become malignant. We have measured the systemic transformation of estrogen u...

journal_title：Anticancer research

authors： Auborn K,Abramson A,Bradlow HL,Sepkovic D,Mullooly V

更新日期：1998-11-01 00:00:00

abstract：AIM:To investigate the clinical significance of ATP-binding cassette transporter 11 (ABCC11) protein expression in colon cancer. MATERIALS AND METHODS:One hundred thirty nine patients with colon cancer resection between 2009 and 2011 were enrolled. The relationship with immunohistochemical ABCC11 staining and clinicop...

journal_title：Anticancer research

authors： Yamada Y,Yoshimatsu K,Yokomizo H,Okayama S,Shiozawa S

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:We conducted a phase II study of topotecan (Tp) with cisplatin (CDDP) in previously untreated Japanese patients with extensive-disease small cell lung cancer (ED-SCLC). PATIENTS AND METHODS:In stage 1, a total of 30 patients were allocated to Tp 0.65 mg/m(2) with CDDP 60 mg/m(2) day 1 or Tp 1.00 mg/m(2) wit...

journal_title：Anticancer research

authors： Hosomi Y,Shibuya M,Niho S,Ichinose Y,Kiura K,Sakai H,Takeda K,Kudo S,Eguchi K,Matsui K,Masuda N,Ando M,Watanabe K

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:The validation of potential molecular targets in head and neck squamous cell carcinoma (SCC) is mandatory. β-Catenin and E-cadherin are crucial for cancer progression through epithelial-mesenchymal transition. We analyzed the effect of the tyrosine kinase inhibitors nilotinib, dasatinib, erlotinib and gefiti...

journal_title：Anticancer research

authors： Kramer B,Hock C,Schultz JD,Lammert A,Kuhlin B,Birk R,Hörmann K,Aderhold C

更新日期：2017-06-01 00:00:00

abstract：:For the determination of LDL receptor expression on living human cells two monoclonal antibodies specific for the extracellular domain of LDL receptor were established using affinity-purified LDL receptor and carrier-conjugated LDL receptor peptide 163-174 as immunizing antigens. The 125I-labeled antibodies were used ...

journal_title：Anticancer research

authors： Menrad A,Anderer FA

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:F-Box protein 45 (FBXO45) is reported to be associated with cancer aggressiveness. We investigated the relationship between FBXO45 and clinicopathological factors in gastric cancer (GC). MATERIALS AND METHODS:We used immunohistochemistry to investigate FBXO45 expression in 104 GC samples; the prognostic val...

journal_title：Anticancer research

authors： Kogure N,Yokobori T,Ogata K,Altan B,Mochiki E,Ohno T,Toyomasu Y,Yanai M,Kimura A,Yanoma T,Suzuki M,Bai T,Asao T,Kuwano H

更新日期：2017-01-01 00:00:00

abstract：:Four cases of canine lymphoma are presented, including histological examination and cytogenetic investigation. The first case showed a derivative chromosome 13, the second case showed a clonal trisomy 8 and the third case showed a complex karyotype with a clonal trisomy 13 and additional clonal trisomies of the chromo...

journal_title：Anticancer research

authors： Winkler S,Murua Escobar H,Reimann-Berg N,Bullerdiek J,Nolte I

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND/AIM:To investigate the impact of inguinal lymph node dissection (ILND) following neoadjuvant chemoradiotherapy (NACRT) for rectal cancer patients with ILN metastasis. PATIENTS AND METHODS:Forty-three patients with rectal cancer underwent NACRT followed by curative surgery between January 2005 and December 2...

journal_title：Anticancer research

authors： Ueta K,Matsuda T,Yamashita K,Hasegawa H,Mukohyama J,Yamamoto M,Matsuda Y,Kanaji S,Oshikiri T,Nakamura T,Suzuki S,Kakeji Y

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:Green tea polyphenols (GTPs) have been proposed as promising candidates for chemoprevention. However, GTPs levels are maintained relatively low in the blood and are chemically-unstable. Lipid-soluble tea polyphenols (LTPs) are products of modified GTPs with ester linkage with fatty acids. LTPs are lipophilic...

journal_title：Anticancer research

authors： Shen T,Khor SC,Zhou F,Duan T,Xu YY,Zheng YF,Hsu S,DE Stefano J,Yang J,Xu LH,Zhu XQ

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:We hypothesized that ancestry-mediated methylated DNA changes may drive racial and ethnic disparity in prostate cancer (PCa). To test this hypothesis, we analyzed genetic ancestry and association with DNA methylation changes in PCa disparity. MATERIALS AND METHODS:Pyrosequencing and ancestry informative mar...

journal_title：Anticancer research

authors： Apprey V,Wang S,Tang W,Kittles RA,Southerland WM,Ittmann M,Kwabi-Addo B

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND/AIM:Perioperative intra-abdominal infection has been reported as a risk factor for metastasis. The aim of this study was to investigate the mechanism by which peritonitis induces immunosuppression in the lung, which in turn promotes lung metastasis. MATERIALS AND METHODS:C57BL/6 mice were intravenously admi...

journal_title：Anticancer research

authors： Arimoto A,Yamashita K,Hasegawa H,Sugita Y,Fukuoka E,Tanaka T,Suzuki S,Kakeji Y

更新日期：2018-07-01 00:00:00

abstract：:The authors report their experience in the radioimmunodetection of recurrent colorectal cancer in comparison with traditional examinations. 485 patients were studied after radical surgery for colorectal cancer: 168 (Group 1) were studied with a radioimmunoassisted follow-up plan including: Immunoscintigraphy (IS), ser...

journal_title：Anticancer research

authors： Prati U,Roveda L,Cantoni A,Saponaro R,Bosi F,Sandolo R,Zonta A

更新日期：1995-05-01 00:00:00