Transformation of rat fibroblasts by TGF-beta and EGF induces sensitivity for intercellular induction of apoptosis.

abstract：BACKGROUND/AIM:Silencing mediator of retinoid and thyroid receptors (SMRT) is a nuclear corepressor in thyroid and estrogen hormones pathways. The aim was to evaluate SMRT expression in relation to thyroid hormone levels and prognostic markers in breast cancer (BC). PATIENTS AND METHODS:Serum and tumor tissues were ob...

journal_title：Anticancer research

authors： Nisman B,Allweis TM,Carmon E,Kadouri L,Maly B,Maimon O,Meierovich A,Peretz T

更新日期：2020-11-01 00:00:00

abstract：:Gross cystic disease (GCD) represents an advanced form of fibrocystic disease of the breast. Bearers of macrocysts have been reported to be at risk of developing breast cancer. Natural killer (NK) cells are a lymphocyte subset deeply involved in immunosurveillance against neoplasia. We investigated whether breast cyst...

journal_title：Anticancer research

authors： Ardizzoja M,Masera RG,Tacconis P,Sartori ML,Arisio R,Massobrio M,Angeli A

更新日期：1994-03-01 00:00:00

abstract：:Brain tumors were induced in inbred Fischer rats (F344) by administration of methylnitrosourea in the drinking water. One of the induced tumors, a pleomorphic glioma (78-219), was established in vitro and propagated as 78FR-G-219 permanent cell line. The tumorigenicity of the established line was investigated by intra...

journal_title：Anticancer research

authors： Stavrou D,Bilzer T,Anzil AP,Hultén M,Kaldrymidou E

更新日期：1981-01-01 00:00:00

abstract：:Throughout the world, breast cancer is among the major causes of cancer-related death and is the most common cancer found in women. The development of cancer molecular knowledge has surpassed the novel concept of cancer biology and unraveled principle targets for anticancer drug developments and treatment strategies. ...

journal_title：Anticancer research

authors： Tungsukruthai S,Petpiroon N,Chanvorachote P

更新日期：2018-05-01 00:00:00

abstract：:Tricot et al have reported that the nucleoside analog tiazofurin can induce hematologic remissions in patients with chronic myelogenous leukemia in blast crisis (CML-BC). These reports prompted us to begin a derivative, phase II trial of tiazofurin in CML-BC to determine if the promising findings reported by these inv...

journal_title：Anticancer research

authors： Wright DG,Boosalis MS,Waraska K,Oshry LJ,Weintraub LR,Vosburgh E

更新日期：1996-11-01 00:00:00

abstract：UNLABELLED:Malignant pleural mesothelioma is a rare tumour. A three-modal strategy, comprising of surgery, radiotherapy and chemotherapy has been shown to be essential for appropriate management. Current literature evidences the importance of radiation therapy in the adjuvant setting for local control of the disease, a...

journal_title：Anticancer research

authors： Takanen S,Resuli B,Graziano V,Parisi A,Lisi R,Raffetto N,Tombolini V

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:Breast cancer grows in a hormone-rich environment which influences its biological features and thus, ultimately, its clinical behavior. Circulating hormone levels were measured in premenopausal and postmenopausal breast cancer patients prior to surgery, and correlated with all available clinical and biologic...

journal_title：Anticancer research

authors： Hernández L,Nuñez-Villarl MJ,Martínez-Arribas F,Pollán M,Schneider J

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND/AIM:γ-Glutamylcyclotransferase (GGCT), a key enzyme involved in glutathione metabolism, catalyzes a specific reaction that generates 5-oxoproline and free amino acids from the γ-glutamyl peptide. Inhibition of GGCT is a promising therapeutic strategy for the treatment of various cancers. MATERIALS AND METHO...

journal_title：Anticancer research

authors： Hanada E,Kageyama S,Murai R,Kubota S,Ii H,Nakata S,Kita H,Kawauchi A,Chano T

更新日期：2019-04-01 00:00:00

abstract：:The development of multidrug resistance (MDR) causes difficulties in the chemotherapy of of human cancer. Investigation of the possibility of reversal of MDR has been greatly aided by the use of cell lines with acquired resitance to anticancer agents in vitro or transfected with the mdrl gene. The aim of this study wa...

journal_title：Anticancer research

authors： Gyémánt N,Tanaka M,Molnár P,Deli J,Mándoky L,Molnár J

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to examine the efficacy of anticoagulant fondaparinux postoperatively for preventing recurrence after curative resection of colorectal cancer with lymphnode metastasis. PATIENTS AND METHODS:The records of 279 patients who underwent curative resection of colorectal cancer with l...

journal_title：Anticancer research

authors： Yamaoka Y,Ikeda M,Ikenaga M,Murakami H,Haraguchi N,Miyake M,Yamamoto K,Asaoka T,Nishikawa K,Miyamoto A,Miyazaki M,Hirao M,Nakamori S,Sekimoto M

更新日期：2016-10-01 00:00:00

abstract：:A paclitaxel derivative was used for the preparation of a drug immunoconjugate for the specific targeting to ovarian cancer cells by the BCM43/2E5 monoclonal antibody. To determine the efficiency of conjugation we developed two reproducible immunoassays. Paclitaxel was detected on the conjugate by a paclitaxel immunoa...

journal_title：Anticancer research

authors： Jaime J,Pagé M

更新日期：2001-03-01 00:00:00

abstract：BACKGROUND:Apolipoprotein E (APOE), a lipid transport protein that has a key role in the lipoprotein metabolism, is expressed by macrophages under the control of the transcription factor Liver X Receptor (LXR), an oxysterol-activated transcriptional factor involved in cholesterol metabolism. Recent work has shown that ...

journal_title：Anticancer research

authors： El Roz A,Bard JM,Valin S,Huvelin JM,Nazih H

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Locally recurrent rate of advanced head and neck squamous cell carcinoma (HNSCC) still remains high and the treatment is controversial. PATIENTS AND METHODS:We retrospectively analyzed ninety-three patients with recurrent advanced oral cancer from 2009 to 2013. Sixty-four patients are in the docetaxel with ...

journal_title：Anticancer research

authors： Yang WC,Chen CH,Tang JY,Wu CF,Liu YC,Sun Y,Lin SF

更新日期：2014-07-01 00:00:00

abstract：:Inflammatory bowel diseases (IBD) are associated with an increased risk of colitis-associated colorectal carcinoma (CAC). CAC is one of the most important causes of morbidity and mortality in patients with Crohn's disease and ulcerative colitis. The aim of the present review was to discuss the most important signaling...

journal_title：Anticancer research

authors： Romano M,DE Francesco F,Zarantonello L,Ruffolo C,Ferraro GA,Zanus G,Giordano A,Bassi N,Cillo U

更新日期：2016-04-01 00:00:00

abstract：:Radiomics, an emerging field in radiation therapy, is hypothesized to improve classification of tumour risk and prognosis. Despite encouraging results, there are issues of practicality and interpretation of radiomic data. This study investigates the emerging role of radiomics in tumour risk classification and prognosi...

journal_title：Anticancer research

authors： Li Wen Y,Leech M

更新日期：2020-07-01 00:00:00

abstract：:In tumor cells, doxorubicin (DOX) is excreted by P-glycoprotein (P-gp) and the multidrug resistance-associated protein (mrp). Both transporters might also be involved in cellular regulatory volume decrease (RVD). To study the hepatobiliary excretion of DOX during RVD, isolated livers of Wistar and multidrug resistance...

journal_title：Anticancer research

authors： Gaugg M,Haslmayer P,Jäger W,Thalhammer T

更新日期：2001-07-01 00:00:00

abstract：:Eight patients with metastatic hypernephroma were treated with constant infusion recombinant Interleukin-2 (rIL-2), changes in renal and hepatic function and protein levels were monitored during 2 cycles of treatment. The rIL-2 infusion caused a reversible fall in ures and a non-reversible rise in creatinine. Liver fu...

journal_title：Anticancer research

authors： Ubhi SS,Horsburgh T,Veitch PS,Bell PR

更新日期：1991-11-01 00:00:00

abstract：:Cisplatin is one of the most widely used and effective chemotherapeutic agents for the treatment of several human malignancies. Although the effectiveness of cisplatin is high, its toxicities justify the demand for improved formulations of this drug. A liposomal formulation of cisplatin, Lipoplatin, was developed in o...

journal_title：Anticancer research

authors： Devarajan P,Tarabishi R,Mishra J,Ma Q,Kourvetaris A,Vougiouka M,Boulikas T

更新日期：2004-07-01 00:00:00

abstract：:p63 expression was evaluated in a tissue microarray of prostate tissues including benign glands, prostatic intraepithelial neoplasia and prostatic carcinoma. Immunostaining with anti-p63 antibody was restricted to basal cell nuclei. Detectable p63 was found in immortalized and early passage cell cultures, but not in s...

journal_title：Anticancer research

authors： Davis LD,Zhang W,Merseburger A,Young D,Xu L,Rhim JS,Moul JW,Srivastava S,Sesterhenn IA

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND:Large adrenal tumors (LATs, ≥6 cm) are uncommon and associated with malignancy in 25% of cases. Their surgical management remains debatable. The aim of the present report was to evaluate the current incidence, nature and management of LAT. PATIENTS AND METHODS:We carried out a retrospective review of LATs m...

journal_title：Anticancer research

authors： Mege D,Taieb D,Lowery A,Loundou A,DE Micco C,Castinetti F,Morange I,Henry JF,Sebag F

更新日期：2014-05-01 00:00:00

abstract：:The influence of psychoactive and nonpsychoactive cannabinoids on macromolecular biosynthesis and cell proliferation was compared in normal and transformed human cells which differ with respect to their abilities to metabolize polycyclic hydrocarbon-containing carcinogens. delta 9-THC, delta 8-THC, 11-OH-delta 9-THC, ...

journal_title：Anticancer research

authors： Green LG,Stein JL,Stein GS

更新日期：1983-05-01 00:00:00

abstract：:Due to their estrogen-mimicking ability, pesticides are considered as prime etiological suspects of increasing tumor incidence, although a direct link is still undefined. The present study aimed to identify the effect of xenoestrogens (lindane, propoxur and endosulfan) at 20 mg/l each on tumorigenesis, by evaluating e...

journal_title：Anticancer research

authors： Bharathi SP,Raj HM,Jain S,Banerjee BD,Ahmed T,Arora VK

更新日期：2013-01-01 00:00:00

abstract：AIM:To compare a new-generation fecal immunochemical test (FIT) with the leading guaiac-based test in detection of fecal occult blood (FOB) in colonoscopy-referral patients. PATIENTS AND METHODS:A cohort of 300 patients referred for colonoscopy was examined by two different tests for FOB: ColonView quick test (CV) (FI...

journal_title：Anticancer research

authors： Vasilyev S,Smirnova E,Popov D,Semenov A,Eklund C,Hendolin P,Paloheimo L,Syrjänen K

更新日期：2015-05-01 00:00:00

abstract：:MicroRNAs (miRNA) are a class of small noncoding RNAs that regulate the expression of their target genes. The aim of the present study was to explore the effects of miR-206 on laryngeal suamous cell carcinoma (LSCC) cells. The expression level of miR-206 was quantified by qRT-PCR in primary LSCC tissues and correspond...

journal_title：Anticancer research

authors： Zhang T,Liu M,Wang C,Lin C,Sun Y,Jin D

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND/AIM:KRAS and BRAF are two genes commonly mutated in colorectal cancer (CRC). Even though BRAF is a downstream target of KRAS in the MAPK signalling pathway, KRAS- and BRAF-mutated CRCs are found to display several different clinical and histopathological features. We investigated whether a differential expre...

journal_title：Anticancer research

authors： Lundberg IV,Wikberg ML,Ljuslinder I,Li X,Myte R,Zingmark C,Löfgren-Burström A,Edin S,Palmqvist R

更新日期：2018-02-01 00:00:00

abstract：:It is generally agreed that most malignancies, particularly those that arise "spontaneously", are caused by randomly occurring mutations at specific sites of the genome. Hence oncogenesis of these spontaneous tumors can be described by stochastic mathematical models. In this paper we offer a mathematical approach to o...

journal_title：Anticancer research

authors： Derkinderen DJ,Boxma OJ,Koten JW,Den Otter W

更新日期：1990-03-01 00:00:00

abstract：:Combined treatment of interleukin-2 (IL-2), 5-fluorouracil (5-FU) and mitomycin C (MMC) is reported to be effective against hepatic metastasis of colon carcinoma. To clarify this modality, we investigated lymphokine activated killer (LAK) activity of human peripheral lymphocytes on colon cancer cell lines by 51Cr rele...

journal_title：Anticancer research

authors： Ishihara M,Kubota T,Watanabe M,Kawano Y,Narai S,Yasui N,Otani Y,Teramoto T,Kitajima M

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND:Neuroendocrine (NE) carcinomas of the lung exhibit expression of various stem cell antigens, and except for carcinoid tumours, carry a poor prognosis. Despite the fact that 10%-30% of all non-small cell lung carcinomas (NSCLC) which are not classified as NE carcinomas also show expression of NE markers, data...

journal_title：Anticancer research

authors： Gottschling S,Jensen K,Herth FJ,Thomas M,Schnabel PA,Herpel E

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND/AIM:Tumor recurrence complicates more than half of patients at 5 years after primary hepatocellular carcinoma (HCC) resection. Repeat open liver resection (ROLR) is the standard procedure for patients eligible for repeat resection, whereas laparoscopic repeat liver resection (RLLR) has been proposed as an al...

journal_title：Anticancer research

authors： Machairas N,Papaconstantinou D,Stamopoulos P,Prodromidou A,Garoufalia Z,Spartalis E,Kostakis ID,Sotiropoulos GC

更新日期：2018-05-01 00:00:00

abstract：OBJECTIVE:Matrix metalloproteinase-2 (MMP-2) and its tissue inhibitor (TIMP-2) are important regulators of cancer invasion and metastasis. Their associations to high-risk (HR) human papillomavirus (HPV) in cervical intra-epithelial neoplasia (CIN) and cervical cancer (CC) are unexplored and their prognostic significanc...

journal_title：Anticancer research

authors： Branca M,Ciotti M,Giorgi C,Santini D,Di Bonito L,Costa S,Benedetto A,Bonifacio D,Di Bonito P,Paba P,Accardi L,Syrjänen S,Favalli C,Syrjänen K,HPV-PathogenISS Study Group.

更新日期：2006-03-01 00:00:00