Paclitaxel immunoconjugate for the specific treatment of ovarian cancer in vitro.

abstract：BACKGROUND:Fulvestrant ('Faslodex') is a new type of oestrogen receptor (ER) antagonist that down-regulates the ER and has no known agonist effects. PATIENTS AND METHODS:In this open-label, Phase II trial, 30 postmenopausal Japanese women with hormone-sensitive advanced breast cancer, who had progressed on tamoxifen/t...

journal_title：Anticancer research

authors： Watanabe T,Sano M,Ohno S,Inaji H,Nishimura R,Shin E,Nomura Y,Morris C

更新日期：2004-03-01 00:00:00

abstract：BACKGROUND:Hepsin is a type II transmembrane serine protease originally identified in the human liver as a cDNA clone. Hepsin was found to be significantly overexpressed in cancer samples compared to matched various tissues (e.g. prostate, renal, ovarian carcinoma). The purpose of the present study was to examine hepsi...

journal_title：Anticancer research

authors： Matsuo T,Nakamura K,Takamoto N,Kodama J,Hongo A,Abrzua F,Nasu Y,Kumon H,Hiramatsu Y

更新日期：2008-01-01 00:00:00

abstract：:Although some types of intestinal metaplasia are considered to be potentially pre-malignant lesions leading to gastric carcinoma, their high frequency and variability limit their usefulness as early markers of malignant progression. The present study was carried out to search for parameters which could be used in conj...

journal_title：Anticancer research

authors： Blasco-Olaetxea E,Loizate A,Eizagirre B,Garcia-Tamayo J

更新日期：1996-03-01 00:00:00

abstract：BACKGROUND:Oral squamous cell carcinoma (OSCC) is a multifactorial neoplasm related to tobacco smoke, alcohol consumption and molecular genetic changes such as p53 mutations. The human tumor suppressor gene TP53 contains single nucleotide polymorphism that encodes either arginin (Arg) or proline (Pro) at amino acid cod...

journal_title：Anticancer research

authors： Drummond SN,De Marco L,Pordeus Ide A,Barbosa AA,Gomez RS

更新日期：2002-11-01 00:00:00

abstract：AIM:We examined whether the perioperative systemic inflammation score (SIS), which describes systemic inflammation and/or malnutrition, affected the tumor recurrence and survival in advanced gastric cancer patients. PATIENTS AND METHODS:The study retrospectively analyzed 160 patients with stage II/III gastric cancer w...

journal_title：Anticancer research

authors： Hara K,Aoyama T,Yamada T,Nakazono M,Nagasawa S,Shimoda Y,Kumazu Y,Numata M,Hayashi T,Tamagawa H,Shiozawa M,Morinaga S,Yukawa N,Rino Y,Masuda M,Ogata T,Oshima T

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND/AIM:Quinazolinone is a privileged chemical structure employed for targeting various types of cancer. This study aimed to demonstrate the antitumor activity of synthesized 6,7-disubstituted-2-(3-fluorophenyl) quinazolines (HoLu-11 to HoLu-14). MATERIALS AND METHODS:The cytotoxicity was assessed by the sulfor...

journal_title：Anticancer research

authors： Lai KC,Chia YT,Yih LH,Lu YL,Chang ST,Hong ZX,Chen TL,Hour MJ

更新日期：2021-01-01 00:00:00

abstract：:We report here the first orthotopic transplant model for human ovarian cancer. Histologically-intact patient specimens of ovarian cancer were transplanted by microsurgical techniques under the capsule of the nude mouse ovary. The human tumors grew locally and gave rise to a patient-like metastatic pattern including th...

journal_title：Anticancer research

authors： Fu X,Hoffman RM

更新日期：1993-03-01 00:00:00

abstract：: Aim: The aim of the study was to assess possible correlation of fluorogeoxyglucose (FDG) uptake and iodine-related attenuation values derived from positron-emission tomography/computed tomography (PET/CT) using single-source dual-energy CT scan (DE-CT) in non-small cell lung cancer (NSCLC). Materi...

journal_title：Anticancer research

authors： Baxa J,Matouskova T,Ludvik J,Sedlmair M,Flohr T,Schmidt B,Bejcek J,Pesek M,Ferda J

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:Melanoma is characterized by high resistance to chemotherapy. The aim of this study was to investigate combined effects of doxorubicin and parthenolide on melanoma cells. MATERIALS AND METHODS:Thiazolyl blue tetrazolium bromide (MTT) assay and flow cytometry were used to evaluate viability. The p53 levels a...

journal_title：Anticancer research

authors： Wozniak M,Szulawska-Mroczek A,Hartman ML,Nejc D,Czyz M

更新日期：2013-08-01 00:00:00

abstract：:The attempts to identify, isolate and characterize cancer stem cell populations are mostly dependent on cell-surface markers. In breast cancer, several putative breast cancer stem cell (BCSC) markers have already been reported, but the agreement on their phenotypic characterization is still absent. In fact, it became ...

journal_title：Anticancer research

authors： DA Cruz Paula A,Lopes C

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND/AIM:We previously identified that promoter DNA methylation of cysteine dioxygenase type 1 (CDO1) and homeobox only protein homeobox (HOPX) were both cancer specific, and have a clinical potential as prognostic biomarkers in breast cancer (BC). The present study compared the differential prognostic relevance ...

journal_title：Anticancer research

authors： Tanaka Y,Kosaka Y,Waraya M,Yokota K,Harada H,Kaida T,Kikuchi M,Minatani N,Nishimiya H,Katoh H,Sengoku N,Watanabe M,Yamashita K

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:Antibodies against human epidermal growth factor receptor 2 (HER2) affect metastatic breast cancer cells and cardiac myocytes. Guidelines recommend evaluation of cardiac ejection fraction (EF) every 3 months despite little supporting evidence for this need. We assessed the impact of EF screening on clinical ...

journal_title：Anticancer research

authors： Mescher C,Ding C,Defor T,Konety S,Blaes A

更新日期：2017-07-01 00:00:00

abstract：:Mast cells are frequently found in close proximity to blood vessels and have been implicated in tumour angiogenesis. The aim of the present ultrastructural study was to characterize, in detail, the mutual association between mast cells and microvasculature in 9 cases of advanced gastric carcinoma. Perivascular mast ce...

journal_title：Anticancer research

authors： Caruso RA,Ieni A,Fabiano V,Basile G,Inferrera C

更新日期：2004-07-01 00:00:00

abstract：:We describe the case of a patient with terminal adenocarcinoma of the lung with no response to lymphokine-activated killer (LAK) cell therapy alone who distinctly responded clinically to a combination of high-dose glucocorticoids (GC) and LAK cell therapy, administered by chance. However, after decreasing the dose of ...

journal_title：Anticancer research

authors： Kato M,Goto S,Soma G

更新日期：2010-08-01 00:00:00

abstract：:Small cell carcinomas of the gastrointestinal tract are rare and clinically aggressive tumors. A case is presented of a 70 year-old woman who presented with small bowel obstruction and was found to have a cecal mass. She underwent right hemicolectomy, and histopathology showed a small cell carcinoma arising in the bac...

journal_title：Anticancer research

authors： Saif MW

更新日期：2013-04-01 00:00:00

abstract：:Moxa smoke induced internucleosomal DNA fragmentation in human promyelocytic leukemic HL-60 cells, but not in other cell lines. The cytotoxic activity of Moxa smoke was significantly reduced by a popular antioxidant, N-acetyl-L-cysteine (NAC). Moxa smoke showed oxidation potential (measured by NO monitor) and produced...

journal_title：Anticancer research

authors： Hitosugi N,Ohno R,Hatsukari I,Nakamura S,Mizukami S,Nagasaka H,Matsumoto I,Satoh K,Negoro T,Hashimoto K,Sakagami H

更新日期：2002-01-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a deadly malignant disease with extremely poor prognosis. Many therapeutic modalities have been proposed, but considerable uncertainty still remains about their effectiveness. Inositol hexaphosphate (IP6), a naturally occurring polyphosphorylated carbohydrate, has novel anti-cancer fu...

journal_title：Anticancer research

authors： Vucenik I,Zhang ZS,Shamsuddin AM

更新日期：1998-11-01 00:00:00

abstract：:Human urothelial cell lines of non-malignant and malignant origin were classified into three grades of transformation, i.e. TGr I, TGr II, and TGr III, which differ from primary and early cultures of normal bladder mucosa (TGr 0) by growth in the absence of fibroblasts, prolonged survival, increasing chromosomal abnor...

journal_title：Anticancer research

authors： Christensen B,Kieler J,Vilien M,Don P,Wang CY,Wolf H

更新日期：1984-11-01 00:00:00

abstract：AIM:To report the outcome of radiation therapy (RT) +/- chemotherapy in HIV-seropositive patients with Head and Neck Squamous Cell Carcinoma (HNSCC). PATIENTS AND METHODS:This is the largest single-Institution retrospective study to date, consisting of 73 HIV patients with HNSCC treated from January 1997-2010. The med...

journal_title：Anticancer research

authors： Mourad WF,Hu KS,Shasha D,Concert C,Ishihara D,Lin W,Gamez ME,Lukens JN,Shourbaji RA,Ryniak M,Li Z,Culliney BE,Khorsandi AS,Tran T,Jacobson A,Manolidis S,Schantz S,Urken M,Persky MS,Harrison LB

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:In patients with melanoma, early dissemination via lymphatic and hematogenous routes is frequently seen. Thus, besides clinical follow-up examination and imaging, reliable melanoma-specific serological tumor markers are needed. PATIENTS AND METHODS:We retrospectively compared two serum markers for melanoma,...

journal_title：Anticancer research

authors： Uslu U,Schliep S,Schliep K,Erdmann M,Koch HU,Parsch H,Rosenheinrich S,Anzengruber D,Bosserhoff AK,Schuler G,Schuler-Thurner B

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:The antitumor effect exerted by tumor necrosis factor (TNF) is characteristic in that it causes central necrosis of the tumor mass. Viable tumor cells surrounding the tumor mass remain, however, even after most of the mass is necrotized, and these cells gradually regrow and form tumors. To overcome this, we ...

journal_title：Anticancer research

authors： Inagawa H,Nishizawa T,Honda T,Nakamoto T,Takagi K,Soma G

更新日期：1998-09-01 00:00:00

abstract：AIM:The aim of the present study was to detect the relative expressions of p53, p21(Waf1/Cip1), p27(Kip1) Bcl-2 and cleaved caspase-3 in cervical lesion samples from Brazilian women by immunohistochemistry. MATERIALS AND METHODS:A total of 230 cervical biopsies in paraffin-embedded blocks were studied: 43 were invasiv...

journal_title：Anticancer research

authors： Dobo C,Oshima CT,De Oliveira Lima F,Gomes TS,Stávale JN,Arias V,Ribeiro DA,Focchi GR

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:Cancer of the oesophagus is the most common gastrointestinal malignancy in South African blacks. The aim of this study was to determine the reversible and irreversible lipid peroxidation in cancer of the oesophagus; a feature that has not been assessed before in this or other cancer tissue. METHODS:Biopsies...

journal_title：Anticancer research

authors： Levy RD,Oosthuizen MM,Degiannis E,Lambrechts H

更新日期：1998-03-01 00:00:00

abstract：:Iceland has a total population of 300,000 inhabitants. All patients consulting for symptoms of the lower digestive tract during a four-year period (2003-2006) were subjected to a colonoscopic examination; all polyps were endoscopically removed. Out of the total 3,037 colorectal adenomas (CRAs), 308 (10.2%) were tradit...

journal_title：Anticancer research

authors： Rubio CA,Jónasson JG

更新日期：2015-09-01 00:00:00

abstract：:NMR spectroscopy was used to analyse perchloric acid extracts of normal human brain, murine brain cell cultures, glioblastoma tissue and the glioblastoma cell line U-87. 1H NMR spectra revealed the presence of elevated levels of UDP-N-acetylglucosamine and UDP-N-acetylgalactosamine in glioblastoma extracts and the gli...

journal_title：Anticancer research

authors： Sonnewald U,Isern E,Gribbestad IS,Unsgård G

更新日期：1994-05-01 00:00:00

abstract：:We present a new approach towards the detection of the mRNAs in formalin-fixed, paraffin-embedded samples using a reverse transcriptase (RT)-polymerase chain reaction (PCR). The total RNAs were extracted from 10-micron-thick sections and were reverse-transcribed, then the RT-products were subjected to PCR amplificatio...

journal_title：Anticancer research

authors： Tachibana M,Shinagawa Y,Kawamata H,Omotehara F,Horiuchi H,Ohkura Y,Kubota K,Imai Y,Fujibayashi T,Fujimori T

更新日期：2003-05-01 00:00:00

abstract：:Treatment of patients with glioblastoma improved dramatically when concomitant and adjuvant temozolomide was added to external radiation therapy. The addition of this new treatment schedule as well as the improvements in individually-tailored radiation treatment, has resulted in a larger proportion of patients being f...

journal_title：Anticancer research

authors： Johansson F,Ekman S,Blomquist E,Henriksson R,Bergström S,Bergqvist M

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND/AIM:Second mitochondria-derived activator of caspase (Smac) is a proapoptogenic mitochondrial protein that antagonizes inhibitors of apoptosis proteins (IAPs), resulting in induction of apoptosis. In the present study we investigated the effects of a Smac mimetic in combination with doxorubicin against osteo...

journal_title：Anticancer research

authors： Kamata E,Kawamoto T,Ueha T,Hara H,Fukase N,Minoda M,Morishita M,Takemori T,Fujiwara S,Nishida K,Kuroda R,Kurosaka M,Akisue T

更新日期：2017-11-01 00:00:00

abstract：:The immune system is part of the homeostasis system. Our research is focused on ways to maintain health, with an emphasis on the role of macrophages. We have hypothesized that tissue macrophages form a systemic network which we believe contributes to the homeostasis system, and have named it the 'macrophage network.' ...

journal_title：Anticancer research

authors： Taniguchi Y,Yoshioka N,Nishizawa T,Inagawa H,Kohchi C,Soma G

更新日期：2009-03-01 00:00:00

abstract：BACKGROUND/AIM:Triple-negative breast cancers (TNBC) lack expression of three important receptors, and have limited treatment options. High expression of junctional adhesion molecule-A (JAM-A) has been linked with aggressive tumor phenotypes including TNBC. This study aimed to evaluate the bioactivity of a JAM-A-down-r...

journal_title：Anticancer research

authors： Vellanki SH,Cruz RGB,Richards CE,Smith YE,Hudson L,Jahns H,Hopkins AM

更新日期：2019-03-01 00:00:00