Abstract：
BACKGROUND:Radiotherapy (RT) with or without chemotherapy (CT) plays an important role as exclusive treatment in patients with head and neck squamous cell cancer (HNSCC). Unfortunately, in some cases, benefit for patients is not recorded and only treatment-related complications are registered. MATERIALS AND METHODS:Data relating to Akt1 single nucleotide polymorphism (SNP) and response to treatment of 46 patients treated with exclusive RT or RT-CT for HNSCC were evaluated. RESULTS:For heterozygous patients median overall survival was 28.5 months, while for the wild-type group median overall survival was 10.9 (p=0.019). Three-year survival was 85% for mutated Akt1 homozygosis and 40% for patients with a heterozygous status (p=0.019, hazard ratio (HR)=7.960). CONCLUSION:SNP of rs2498804 can recognize patients resistant to RT-CT. Further studies are needed to confirm our data and to investigate the role of Akt SNPs in HNSCC patients.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Pasqualetti F,Bocci G,Mey V,Menghini V,Montrone S,Cocuzza P,Ferrazza P,Seccia V,Delishaj D,Orlandini C,Fabrini MG,Danesi Rsubject
Has Abstractpub_date
2015-01-01 00:00:00pages
269-71issue
1eissn
0250-7005issn
1791-7530pii
35/1/269journal_volume
35pub_type
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