A correlative approach for the identification of antimutagens that demonstrate chemopreventive activity.

abstract：BACKGROUND:No investigation of amrubicin monotherapy in pre-treated advanced non-small cell lung cancer (NSCLC) patients has yet been reported. PATIENTS AND METHODS:The records were reviewed of NSCLC patients who had received amrubicin monotherapy between 2003 and 2007 with the following eligibility criteria:previousl...

journal_title：Anticancer research

authors： Igawa S,Takahashi T,Nakamura Y,Tsuya A,Ono A,Shukuya T,Murakami H,Endo M,Yamamoto N

更新日期：2008-11-01 00:00:00

abstract：BACKGROUND:The E-cadherin/beta-catenin complex plays a crucial role in epithelial cell-cell adhesion and in the maintenance of tissue architecture. We previously reported aberrant expression of beta-catenin in endometrial carcinomas. However, the expression and correlation of E-cadherin and beta-catenin in normal and m...

journal_title：Anticancer research

authors： Shih HC,Shiozawa T,Miyamoto T,Kashima H,Feng YZ,Kurai M,Konishi I

更新日期：2004-11-01 00:00:00

abstract：:The antitumor effect of a polyamine biosynthetic pathway inhibitor methylglyoxal bis(cyclopentylamidinohydrazone) (MGBCP) on human osteosarcoma cell lines such as KHOS-240S, MG-63 and G-292 cells, and its effect in combination with anticancer drugs such as methotrexate (MTX), adriamycin (ADM) and 4-hydroperoxyfosfamid...

journal_title：Anticancer research

authors： Sonoda J,Hibasami H,Yamada H,Fujinami S,Nakashima K,Ogihara Y

更新日期：1995-05-01 00:00:00

abstract：BACKGROUND:The determination of dihydropyrimidine dehydrogenase (DPD) deficiency is important in avoiding severe 5-fluorouracil (FU) toxicity. The dihydrouracil (UH2)-uracil (Ura) ratio (UH2/Ura) in plasma might be an important indicator of the risk of 5-FU catabolic deficiency. In order to clarify this possibility, th...

journal_title：Anticancer research

authors： Nakayama Y,Matsumoto K,Inoue Y,Katsuki T,Kadowaki K,Shibao K,Tsurudome Y,Hirata K,Sako T,Nagata N,Itoh H

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND/AIM:Long-term results of a study investigating potential prognostic factors for treatment outcomes in patients with stage III esophageal cancer are presented. PATIENTS AND METHODS:In 64 patients, the impact of tumor cell expression of erythropoietin (EPO) and erythropoietin-receptor (EPO-R) and ten addition...

journal_title：Anticancer research

authors： Rades D,Bajrovic A,Schild SE,Thorns C,Kilic E

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:Melanoma cells express the nuclear vitamin D receptor (VDR), indicating that malignant melanoma represents a promising target for treatment with 1,25-dihydroxyvitamin D3 (1,25(OH)(2)D(3)) or its analogs. We previously showed that some melanoma cell lines are resistant to the antiproliferative effects of 1,25...

journal_title：Anticancer research

authors： Essa S,Reichrath S,Mahlknecht U,Montenarh M,Vogt T,Reichrath J

更新日期：2012-01-01 00:00:00

abstract：:Immunoreactivity of monoclonal anti-cytokeratin KL1, PKK1, K8.12 and anti-actin antibodies in 101 cases of diseased human breast lesions showed irregular keratin distribution in luminal cells of terminal ductal-lobular unit and basal layer cells of the interlobular and main duct. Actin staining was confined to myoepit...

journal_title：Anticancer research

authors： Wada T,Yasutomi M,Yamada K,Hashimura K,Kunikata M,Tanaka T,Huang JW,Mori M

更新日期：1991-11-01 00:00:00

abstract：:Uncertainty exists about the adequate treatment of adult patients with unresectable, primary, biopsy-proven glioblastoma multiforme (GBM), because the different options for this group of patients have not been evaluated in randomized clinical trials to date. Usually, these patients are lumped together in studies of ra...

journal_title：Anticancer research

authors： Nieder C,Grosu AL,Astner S,Molls M

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND/AIM:Interleukin-32 (IL32) has been newly-identified as a proinflammatory cytokine. In the present study, we aimed to clarify the clinical role of IL32-positive cells in esophageal squamous cell cancer (ESCC) and regulatory T-cell (Treg) infiltration in the stroma. A total of 179 patients with ESCC who underw...

journal_title：Anticancer research

authors： Nabeki B,Ishigami S,Uchikado Y,Sasaki K,Kita Y,Okumura H,Arigami T,Kijima Y,Kurahara H,Maemura K,Natsugoe S

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:Bipolar radiofrequency ablation (RFA) can avoid complications such as thermal tissue damage, a possible consequence of monopolar RFA. However, basic studies about the dosage/effect relationship of bipolar systems are missing. This is systematic research on ex vivo beef livers to find which capacity parameter...

journal_title：Anticancer research

authors： Zurbuchen U,Frericks B,Roggan A,Lehmann K,Bössenroth D,Buhr HJ,Ritz JP

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND/AIM:Seizures represent a major problem for patients with brain metastases. This study evaluated the role of seizures in patients receiving single-fraction radiosurgery (SRS) or multi-fraction stereotactic radiotherapy (FSRT). PATIENTS AND METHODS:This retrospective study included 195 patients receiving SRS ...

journal_title：Anticancer research

authors： Rades D,Witteler J,Kjaer TW,Tvilsted S,Schild SE

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Expression of novel stem cell-associated marker human embryonic stem cell 77 (HES77) was studied in rectal neuroendocrine tumors (NETs), which comprise 10 to 15% of gastroenteropancreatic NETs, some with metastatic potential. MATERIALS AND METHODS:WHO 2010 classification was applied, and immunohistochemical...

journal_title：Anticancer research

authors： Jernman J,Hagström J,Mäenpää H,Välimäki MJ,Haapasalo H,Nilsson O,Fermér C,Haglund C,Arola J

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND/AIM:Few studies have examined the genetic role of matrix metalloproteinases (MMPs) to early detection or prediction in gastric cancer development. In this study, the contribution of MMP7 promoter (A-181G and C-153T) polymorphic genotypes to gastric cancer risk in Taiwanese was investigated for the first time...

journal_title：Anticancer research

authors： Fu CK,Chien YC,Chuang HY,Wang YC,Hwang JJ,Yang MD,Yu CC,Chen JC,Chang WS,Bau DT,Tsai CW

更新日期：2020-02-01 00:00:00

abstract：:We demonstrate here the visualization of the cancer metastatic process in live tissue in vivo by green fluorescent protein (GFP) expression. The human lung adenocarcinoma cell-line Anip 973 was transfected with the humanized GFP-S65T cDNA and stable high-level GFP-expressing transfectants were established. GFP transfe...

journal_title：Anticancer research

authors： Chishima T,Miyagi Y,Wang X,Tan Y,Shimada H,Moossa A,Hoffman RM

更新日期：1997-07-01 00:00:00

abstract：AIM:To evaluate the clinical results of two-step intensity-modulated radiation therapy (IMRT) for oropharyngeal cancer. PATIENTS AND METHODS:Eighty patients were treated with two-step IMRT between 2002 and 2014. Whole-neck radiotherapy (44.0-50.0 Gy/22-25 fractions) was delivered by IMRT, followed by boost IMRT to the...

journal_title：Anticancer research

authors： Tatebe H,Doi H,Ishikawa K,Kawakami H,Yokokawa M,Nakamatsu K,Kanamori S,Shibata T,Kitano M,Nishimura Y

更新日期：2018-02-01 00:00:00

abstract：UNLABELLED:The quantity and quality of circulating DNA fragments was analyzed by quantitative real-time polymerase chain reactions (qPCR) in plasma from patients with esophageal carcinomas, in order to assess their diagnostic value. PATIENTS AND METHODS:Plasma was collected preoperatively from 24 patients with esophag...

journal_title：Anticancer research

authors： Tomita H,Ichikawa D,Ikoma D,Sai S,Tani N,Ikoma H,Fujiwara H,Kikuchi S,Okamoto K,Ochiai T,Otsuji E

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND:In order to decrease surgery-related morbidity, we evaluated the reliability of the evaluation of lymph node metastasis in patients with uterine corpus cancer by positron-emission tomography (PET) with 2-[(18)F]fluoro-2-deoxy-D-glucose (FDG) before surgical staging. MATERIALS AND METHODS:Patients with newly...

journal_title：Anticancer research

authors： Klar M,Meyer PT,Hancke K,Brink I,Orlowska-Volk M,Gitsch G,Denschlag D

更新日期：2010-09-01 00:00:00

abstract：:Adult lymphoblastic lymphoma (LBL) can be of T-cell or B-cell lineage. However, the clinical significance of immunophenotypes is largely unknown. We conducted a retrospective study to compare T-cell LBL with its B-cell counterpart. Between 1983 and 1995, 50 adult patients were diagnosed as LBL at National Taiwan Unive...

journal_title：Anticancer research

authors： Yeh KH,Cheng AL,Su IJ,Lin MT,Tien HF,Shen MC,Wang CH,Chen YC

更新日期：1997-05-01 00:00:00

abstract：BACKGROUND:Amrubicin is an active agent for the treatment of small-cell lung cancer (SCLC). However, there have been no reports of long-term amrubicin use. PATIENTS AND METHODS:Twelve patients with SCLC who were treated with eight or more cycles of amrubicin chemotherapy were retrospectively reviewed. RESULTS:The med...

journal_title：Anticancer research

authors： Higashiguchi M,Suzuki H,Hirashima T,Kobayashi M,Goya S,Okamoto N,Matsuura Y,Tamiya M,Morishita N,Kawase I

更新日期：2012-04-01 00:00:00

abstract：:Gastric involvement is unusual in primary mediastinal large B-cell lymphoma (PMLBCL), which has not yet been adequately studied. The aim of this retrospective study was to investigate the frequency of gastric involvement in 204 consecutive patients with PMLBCL that presented at 23 hospitals in Greece. Two out of 204 p...

journal_title：Anticancer research

authors： Papageorgiou SG,Sachanas S,Pangalis GA,Tsopra O,Levidou G,Foukas P,Rondogianni P,Sotiropoulos V,Ioannidou HD,Gassiamis A,Iliakis T,Korkolopoulou P,Angelopoulou MK,Pappa V,Konstantopoulos K,Vassilakopoulos TP

更新日期：2014-11-01 00:00:00

abstract：:In a previous study we determined that the fine needle aspiration (FNA) biopsy of thyroid produces 16% of false-negative cases (FNC). In order to determine the value of quantitative cytology (QC) as a tool for predicting the FNC result, thirty-seven cases, 18 of which were operated (histologically benign: 13; malignan...

journal_title：Anticancer research

authors： Liautaud-Roger F,Dufer J,Pluot M,Delisle MJ,Coninx P

更新日期：1989-01-01 00:00:00

abstract：:We have established a hepatocarcinoma cell line (LFCl2A) that produces voluminous tumors when injected into syngeneic Commentary rats. We have previously shown that when these cells were transfected with an episomal vector expressing the antisense IGFI cDNA the transduced cells partly lost their tumorigenic properties...

journal_title：Anticancer research

authors： Lafarge-Frayssinet C,Martin C,Van Binh PN,Achard-Ellouk S,Duc HT,Frayssinet C,Cardoso G,Desauty G,Warnet JM,Bréchot C,Sarasin A

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND:PS2-expression is controlled by estrogens and is a prognostic factor for long-term and post-relapse survival. Breast carcinomas associated with a BRCA1 mutation (BRCA1-BC'S) exhibit many specific features, particularly for ER expression. Our purpose was to determine if pS2-expression was different in BRCA1-B...

journal_title：Anticancer research

authors： Charafe-Jauffre E,Eisinger F,Mathoulin-Portier MP,Sobol H,Jacquemier J

更新日期：2001-07-01 00:00:00

abstract：:The radical modulation activity of hot water and NaOH extracts of the thorn apple of Crataegus Cuneata Sieb. et. Zucc. was investigated, using ESR spectroscopy. The radical intensity of sodium ascorbate was slightly reduced at lower concentrations of the extracts, but it was synergistically enhanced at higher concentr...

journal_title：Anticancer research

authors： Satoh K,Anzai S,Sakagami H

更新日期：1998-07-01 00:00:00

abstract：:Small cell lung cancer is known to carry a high capacity to metastasize in various sites including bone marrow. We here review the respective sensitivities of classical cyto-histological methods and of more recently described techniques such as cell cultures, immunostaining with monoclonal antibodies and magnetic reso...

journal_title：Anticancer research

authors： Trillet-Lenoir VN,Arpin D,Brune J

更新日期：1994-11-01 00:00:00

abstract：:Gallic acid induced apoptotic cell death in human promyelocytic leukemia HL-60 cells. The effect of gallic acid was significantly reduced by blocking the free hydroxyl or carboxyl group with acetyl, methyl, ethyl, n-propyl or isoamyl group. This was paralleled with the decrease in the intensity of both gallate radical...

journal_title：Anticancer research

authors： Sakagami H,Satoh K,Hatano T,Yoshida T,Okuda T

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND/AIM:The associations between emotional personality, proximity and authenticity in patient-physician communication during breast cancer (BC) consultations are rarely considered together in a prospective study. We, therefore, investigated emotional personality/proximity versus authenticity in patient-physician...

journal_title：Anticancer research

authors： Eskelinen M,Korhonen R,Selander T,Ollonen P

更新日期：2015-03-01 00:00:00

abstract：:BPA (bisphenol A or 2,2-bis(4-hydroxy-phenol)propane) and hydroquinone (HQ, 1,4-benzenediol) are present in dental resin materials, and small quantities of these substances may be eluted from the resins. Recently, attention has focused on the estrogen-like and carcinogenic adverse effects of BPA and HQ. Thus, it is im...

journal_title：Anticancer research

authors： Terasaka H,Kadoma Y,Sakagami H,Fujisawa S

更新日期：2005-05-01 00:00:00

abstract：:The effect of treatment schedule on the antitumor activity of a new platinum derivative, glycolate-0,0'-diammineplatinum (II) (254S) compared with cis- diamminedichloroplatinum (II) (CDDP) was investigated using ascites L1210 leukemia and solid Lewis lung carcinoma. The drugs were given i.p. by three treatments: as a ...

journal_title：Anticancer research

authors： Suzumura Y,Kato T,Ueda R,Ota K

更新日期：1989-07-01 00:00:00

abstract：BACKGROUND:Tenascin-C (TNC) is an extracellular matrix glycoprotein, usually derived from myofibroblasts in the cancer microenvironment. Recently, however, the significance of tumor-derived TNC in initiation of cancer metastasis was disclosed. We investigated the clinical significance of cancer-derived TNC in colorecta...

journal_title：Anticancer research

authors： Takahashi Y,Sawada G,Kurashige J,Matsumura T,Uchi R,Ueo H,Ishibashi M,Takano Y,Akiyoshi S,Iwaya T,Eguchi H,Sudo T,Sugimachi K,Yamamoto H,Doki Y,Mori M,Mimori K

更新日期：2013-05-01 00:00:00